Response of psoriasis to a lymphocyte-selective toxin (DAB389IL-2) suggests a primary immune, but not keratinocyte, pathogenic basis. Academic Article uri icon

Overview

abstract

  • Psoriasis is a hyperproliferative and inflammatory skin disorder of unknown aetiology. A fusion protein composed of human interleukin-2 and fragments of diphtheria toxin (DAB389IL-2), which selectively blocks the growth of activated lymphocytes but not keratinocytes, was administered systemically to ten patients to gauge the contribution of activated T cells to the disease. Four patients showed striking clinical improvement and four moderate improvement, after two cycle of low dose IL-2-toxin. The reversal of several molecular markers of epidermal dysfunction was associated with a marked reduction in intraepidermal CD3+ and CD8+ T cells, suggesting a primary immunological basis for this widespread disorder.

publication date

  • May 1, 1995

Research

keywords

  • Diphtheria Toxin
  • Immunotoxins
  • Interleukin-2
  • Psoriasis
  • T-Lymphocytes

Identity

Scopus Document Identifier

  • 0028990380

PubMed ID

  • 7585092

Additional Document Info

volume

  • 1

issue

  • 5