Cyclosporin A enhances T cell-mediated induction of E-selectin. Academic Article uri icon

Overview

abstract

  • In a fetal intestinal organ culture model of intestinal inflammation, activation of T cells by a lectin, superantigen or anti-CD3 antibodies induces E-selectin expression which peaks 6-10 h after activation and disappears by 24 h. We now show that addition of cyclosporin A (Cys A) increases the number of E-selectin-expressing endothelial cells and the intensity of expression, and it prolongs expression up to at least 60 h after stimulation. The dynamics of E-selectin expression on tumor necrosis factor activated human umbilical vein endothelial cell cultures is not affected by Cys A. Furthermore, other immunosuppressive agents FK506 and dexamethasone inhibit E-selectin expression, indicating that the enhancement observed in the presence of Cys A is not a consequence of general immunosuppression.

publication date

  • November 1, 1993

Research

keywords

  • Cell Adhesion Molecules
  • Cyclosporine
  • T-Lymphocytes

Identity

Scopus Document Identifier

  • 0027362479

PubMed ID

  • 7693482

Additional Document Info

volume

  • 23

issue

  • 11