Temporal pattern of internucleosomal DNA fragmentation in the striatum and hippocampus after transient forebrain ischemia. Academic Article uri icon

Overview

abstract

  • Transient forebrain ischemia in rodents caused internucleosomal DNA fragmentation that appeared in the striatum 24 h after reperfusion, and in the hippocampus 72 h after reperfusion. Gel electrophoresis and an in situ technique to label 3' termini of endonuclease generated DNA fragments demonstrated similar temporal patterns. These data show that endonuclease activation accompanies the demise of selectively vulnerable neurons following transient forebrain ischemia.

publication date

  • February 17, 1995

Research

keywords

  • DNA
  • Hippocampus
  • Ischemic Attack, Transient
  • Neostriatum
  • Nucleosomes
  • Prosencephalon

Identity

Scopus Document Identifier

  • 0028942179

Digital Object Identifier (DOI)

  • 10.1016/0304-3940(95)11310-s

PubMed ID

  • 7777186

Additional Document Info

volume

  • 186

issue

  • 2-3