Massive deep vein thrombosis in a patient with antithrombin III deficiency undergoing ovarian stimulation for in vitro fertilization. uri icon

Overview

abstract

  • OBJECTIVE: To present the first report of a thromboembolic complication in early pregnancy after ovarian hyperstimulation for IVF in a patient with AT III deficiency who was treated successfully and subsequently delivered a healthy male infant at 32 weeks of gestation. DESIGN: Case report. SETTING: Hospital-based clinic for reproductive medicine. PATIENT: A 28-year-old woman who consulted our IVF clinic with a 3.5-year history of primary infertility. INTERVENTIONS: Intravenous heparin therapy. RESULTS: The patient responded adequately to heparin therapy and was discharged home on SC heparin. A primary cesarean section was performed at 32 weeks of gestation because of poor fetal growth and transverse lie. CONCLUSIONS: We stress the importance of obtaining a thorough personal and family history before initiation of ovarian hyperstimulation. Measuring activity of AT III, protein C, and protein S in patients with a suspicious history of thromboembolic episodes occurring at an early age may lead to the implementation of appropriate prophylactic measures, preventing potentially life-threatening complications.

publication date

  • March 1, 1995

Research

keywords

  • Antithrombin III Deficiency
  • Fertilization in Vitro
  • Heparin
  • Ovulation Induction
  • Pregnancy Complications, Cardiovascular
  • Pregnancy Complications, Hematologic
  • Thromboembolism
  • Thrombophlebitis

Identity

Scopus Document Identifier

  • 0028938630

PubMed ID

  • 7851607

Additional Document Info

volume

  • 63

issue

  • 3