Heterogeneity of stem cells in severe combined immunodeficiency. Academic Article uri icon

Overview

abstract

  • Two patients with severe combined immunodeficiency disease (SCID) having variable B-cell development have been shown to have marrow precursors of lymphoid cells which can be induced in vitro by thymic factors to express certain T-cell surface characteristics (HTLA+ phenotypes). Their marrow cells could not, however, be induced by these same factors to develop the E-rosette marker or functional activities of T lymphocytes. The marrow of these children also showed, when compared to that of normal adults, a different distribution of cellular elements on density gradient fractionation. The findings support the view that the disorder under study has a different pathogenesis from other forms of SCID previously analysed.

publication date

  • September 1, 1976

Research

keywords

  • Hematopoietic Stem Cells
  • Immunologic Deficiency Syndromes

Identity

PubMed Central ID

  • PMC1541399

Scopus Document Identifier

  • 0017097303

PubMed ID

  • 786520

Additional Document Info

volume

  • 25

issue

  • 3