The effect of treatment with interleukin-1 and tumor necrosis factor on Pseudomonas aeruginosa lung infection in a granulocytopenic mouse model. Academic Article uri icon

Overview

abstract

  • The efficacy of treatment with interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF alpha) on Pseudomonas aeruginosa pneumonia was evaluated in a granulocytopenic mouse model. Combined intravenous administration of 2000 U IL-1 beta plus 2000 U TNF alpha significantly diminished mortality from aerosol challenge with P. aeruginosa. Mice treated with IL-1 beta, TNF alpha, or both also exhibited a significant enhancement in pulmonary clearance of P. aeruginosa. Combined cytokine administration induced an increase in the pulmonary content of myeloperoxidase activity. Mature leukocytes were not detected in either circulation or bronchoalveolar lavage fluid from granulocytopenic, cytokine-treated mice. In conclusion, IL-1 beta and TNF alpha treatment exhibited a synergistic protective effect from pulmonary P. aeruginosa challenge in granulocytopenic hosts, probably due to enhancement of nonspecific antibacterial mechanisms.

publication date

  • November 1, 1994

Research

keywords

  • Interleukin-1
  • Lung Diseases
  • Pseudomonas aeruginosa
  • Tumor Necrosis Factor-alpha

Identity

Scopus Document Identifier

  • 0027944825

Digital Object Identifier (DOI)

  • 10.1006/clin.1994.1196

PubMed ID

  • 7923933

Additional Document Info

volume

  • 73

issue

  • 2