Immunological studies of aging. IV. The contribution of thymic involution to the immune deficiencies of aging mice and reversal with thymopoietin32-36. Academic Article uri icon

Overview

abstract

  • Aged mice preferentially lose the capacity to make IgG and high affinity PFC after immunization with the T-dependent antigen DNP-BGG. We have found that thymectomy accelerates the appearances of these immune deficiencies associated with aging. When splenocytes from old mice are transferred to young lethally irradiated, syngeneic mice and the recipients immunized 7 wk later, the number of IgG and high affinity PFC was increased compared to the response of old splenocytes transferred to young thymectomized mice. These immune deficiencies of aged mice were also reversed when old mice were treated with thymopoietin in vivo or splenocytes from old mice were incubated with thymopoietin before adoptive transfer to young irradiated, thymectomized syngeneic mice. The T-cell independent response to DNP-Ficoll was less impaired than the T-cell dependent response to DNP-BGG in old animals. These data suggest that a decline in thymic function that occurs during aging may contribute to the immunological deficiencies of old animals.

publication date

  • October 1, 1978

Research

keywords

  • Aging
  • Thymopoietins
  • Thymus Gland
  • Thymus Hormones

Identity

PubMed Central ID

  • PMC2185027

Scopus Document Identifier

  • 0018166880

PubMed ID

  • 81262

Additional Document Info

volume

  • 148

issue

  • 4