Therapeutic uses of recombinant complement protein inhibitors. Review uri icon

Overview

abstract

  • In conclusion, it is apparent that researchers are poised at the threshold of developing inhibitors of complement activation from the molecules in the RCA family. By creating soluble forms of these protective proteins for in vivo administration, or by making transgenic animals expressing these proteins or their derivatives, it may be possible to inhibit complement-mediated pathology stemming from autoimmune disease, reperfusion injuries, and physical trauma. This technology combined with current attempts to protect allografts from cellular rejection with monoclonal antibodies against members of the integrin family of adhesion molecules [52] makes it possible that the excessive mortality due to the severe shortage of human donor organs could be overcome by the use of xenografts.

publication date

  • January 1, 1994

Research

keywords

  • Complement Inactivator Proteins
  • Inflammation

Identity

PubMed Central ID

  • PMC7101590

Scopus Document Identifier

  • 0028120820

Digital Object Identifier (DOI)

  • 10.1007/BF01837368

PubMed ID

  • 8153875

Additional Document Info

volume

  • 15

issue

  • 4