Treatment of gancyclovir resistant cytomegalovirus with foscarnet: a report of two cases occurring after bone marrow transplantation. uri icon

Overview

abstract

  • Cytomegalovirus (CMV) infection is common in patients who undergo allogeneic bone marrow transplantation. Gancyclovir is useful in treating CMV infections. Resistance to gancyclovir is rare and has, thus far, not been reported in the setting of BMT. Two patients with CMV infections unresponsive to gancyclovir were successfully treated with foscarnet. 10-15% of CMV infections are resistant initially or develop resistance to gancyclovir. Both patients had an adequate trial of gancyclovir and resistance developed over time. While we did not document resistance in the laboratory there was dramatic clinical improvement with foscarnet.

publication date

  • February 1, 1994

Research

keywords

  • Bone Marrow Transplantation
  • Cytomegalovirus Infections
  • Foscarnet
  • Ganciclovir

Identity

Scopus Document Identifier

  • 0028289322

PubMed ID

  • 8180611

Additional Document Info

volume

  • 12

issue

  • 5-6