Mapping of the genes for human endoplasmic reticular heat shock protein gp96/grp94. Academic Article uri icon

Overview

abstract

  • The murine tumor rejection antigen gp96 (TRA1, mapped to mouse chromosome 10) is a member of the heat shock protein family. Using a fragment of the murine gp96 cDNA as a probe, three gp96-related human genes have been isolated and structurally characterized. They have been mapped to human chromosomes 1 (p22), 12 (q24.2-->q24.3), and 15 (q25-->q26) by Southern blot hybridization and in situ hybridization of gene-specific probes. Only one of the genes, designated TRA1 (human chromosome 12) is a coding gene; the other genes (TRA1P1 and TRAP2) appear to be independently derived, processed pseudogenes.

publication date

  • January 1, 1993

Research

keywords

  • Antigens, Neoplasm
  • Chromosomes, Human, Pair 1
  • Chromosomes, Human, Pair 12
  • Chromosomes, Human, Pair 15
  • Endoplasmic Reticulum
  • Heat-Shock Proteins
  • Membrane Glycoproteins

Identity

Scopus Document Identifier

  • 0027238241

Digital Object Identifier (DOI)

  • 10.1007/BF01233956

PubMed ID

  • 8460400

Additional Document Info

volume

  • 19

issue

  • 1