Apolipoprotein E in sporadic and familial Creutzfeldt-Jakob disease. Academic Article uri icon

Overview

abstract

  • We assessed the apolipoprotein E (ApoE) genotype in 49 sporadic and ten familial Creutzfeldt-Jakob disease (CJD) patients, in seven healthy siblings with a PRNP mutation and in 84 controls. In sporadic CJD, ApoE genotypes and allelic frequencies do not significantly differ from that of controls. No influence of ApoE genotypes on age at onset was found. In familial cases, the disease appeared in mutated subjects showing the same ApoE genotype as members who have not yet developed CJD. Our results provide further evidence that ApoE is not a risk factor for CJD.

publication date

  • October 20, 1995

Research

keywords

  • Apolipoproteins E
  • Creutzfeldt-Jakob Syndrome

Identity

Scopus Document Identifier

  • 0028849971

Digital Object Identifier (DOI)

  • 10.1016/0304-3940(95)12030-8

PubMed ID

  • 8584252

Additional Document Info

volume

  • 199

issue

  • 2