Abnormalities of antioxidant metabolism in a case of Friedreich's disease. Academic Article uri icon

Overview

abstract

  • We report a patient with Friedreich's disease (FD) who exhibited abnormalities of antioxidant metabolism, including decreased levels of glutathione peroxidase, glutathione reductase, and selenium, and an increased lipid peroxide index. These abnormalities became normal after treatment with N-acetylcysteine, selenium, and low-dose vitamin E therapy. Treatment was associated with a decreased rate of clinical decline. FD is a neurodegenerative disorder that may be related to disturbed antioxidant metabolism; the disorder may be treatable with antioxidant compounds.

publication date

  • June 1, 1996

Research

keywords

  • Acetylcysteine
  • Antioxidants
  • Myoclonus

Identity

PubMed ID

  • 8726547

Additional Document Info

volume

  • 19

issue

  • 3