Is there a role for high-dose chemotherapy with stem cell rescue for brain stem tumors of childhood? uri icon

Overview

abstract

  • Diffuse pontine tumors are highly lethal and conventional therapy with irradiation provides long-term survival to a very small proportion of the patients. We have reported promising results using high-dose chemotherapy with autologous stem cell rescue in patients with recurrent high-grade astrocytomas in other anatomic locations, but our results and those of others have been very discouraging in children with brain stem tumors. Alternative strategies need to be developed for this highly lethal disease.

publication date

  • January 1, 1996

Research

keywords

  • Astrocytoma
  • Cerebellar Neoplasms
  • Cerebellopontine Angle
  • Dose-Response Relationship, Drug
  • Etoposide
  • Thiotepa

Identity

Scopus Document Identifier

  • 0029907691

PubMed ID

  • 8933570

Additional Document Info

volume

  • 24

issue

  • 5