Neocytolysis: physiological down-regulator of red-cell mass. uri icon



  • It is usually considered that red-cell mass is controlled by erythropoietin-driven bone marrow red-cell production, and no physiological mechanisms can shorten survival of circulating red cells. In adapting to acute plethora in microgravity, astronauts' red-cell mass falls too rapidly to be explained by diminished red-cell production. Ferrokinetics show no early decline in erythropolesis, but red cells radiolabelled 12 days before launch survive normally. Selective destruction of the youngest circulating red cells-a process we call neocytolysis-is the only plausible explanation. A fall in erythropoietin below a threshold is likely to initiate neocytolysis, probably by influencing surface-adhesion molecules. Recognition of neocytolysis will require re-examination of the pathophysiology and treatment of several blood disorders, including the anaemia of renal disease.

publication date

  • May 10, 1997



  • Apoptosis
  • Erythrocyte Aging
  • Erythrocyte Volume
  • Space Flight


Scopus Document Identifier

  • 0030938226

PubMed ID

  • 9149714

Additional Document Info


  • 349


  • 9062