Rapid induction of B-cell lymphomas by avian leukosis virus. Academic Article uri icon

Overview

abstract

  • Avian leukosis viruses (ALVs) that induce rapid B-cell lymphomas integrate into the c-myb gene and produce an ALV-myb read-through RNA, which is spliced to produce a truncated Myb protein. The genetic determinants of such recombinant ALVs have been mapped to a 42-nt deletion within the gag gene. This deletion increases splicing efficiency since it is located within a negative regulator of splicing. We propose that the deletion leads to increased production of Myb protein by increasing splicing of an ALV-myb pre-mRNA.

publication date

  • April 1, 1997

Research

keywords

  • Avian Leukosis Virus
  • Lymphoma, B-Cell

Identity

Scopus Document Identifier

  • 0030744821

PubMed ID

  • 9209336

Additional Document Info

volume

  • 11 Suppl 3