Stereochemical influence on the stability of radio-metal complexes in vivo. Synthesis and evaluation of the four stereoisomers of 2-(p-nitrobenzyl)-trans-CyDTPA. Academic Article uri icon

Overview

abstract

  • Distinct differences in in vivo stability of the two diastereomeric C-Functionalized CyDTPA chelating agents, (CHX-A DTPA and CHX-B DTPA, both racemates), as recently reported prompted further investigation as to why differences in configuration produced striking effects on the in vivo stability of their yttrium complexes. To this end, the four individual component stereoisomers of CHX-A and CHX-B were synthesized and ability to bind yttrium was investigated both in vitro and in vivo.

publication date

  • October 1, 1997

Research

keywords

  • Chelating Agents
  • Isothiocyanates
  • Pentetic Acid

Identity

Scopus Document Identifier

  • 0030785406

PubMed ID

  • 9370037

Additional Document Info

volume

  • 5

issue

  • 10