HMPAO SPECT brain imaging in treatment-resistant depression. Academic Article uri icon



  • 1. There is little published research on brain function in treatment-resistant depression (TRD). This study examined regional cerebral blood flow using 99mTechnetium-hexamethylpropanolamine oxime (HMPAO) single photon emission computed tomography in 8 patients with a history of TRD, 13 depressed patients without TRD (non-TRD) and 16 normal controls. 2. Relative HMPAO activity in selected brain regions revealed a significant increase in hippocampus-amygdala activity in TRD patients compared to non-TRD patients and healthy controls. The mean value of relative HMPAO activity did not differ in any other brain region, nor were there any differences in right-left symmetry among the subject groups. 3. The observation of increased hippocampus-amygdala HMPAO activity in TRD patients suggests that functional abnormalities in limbic circuitry may play a role in the pathophysiology of treatment-resistance.

publication date

  • October 1, 1997



  • Brain
  • Depressive Disorder
  • Technetium Tc 99m Exametazime
  • Tomography, Emission-Computed, Single-Photon


Scopus Document Identifier

  • 0030725924

PubMed ID

  • 9421825

Additional Document Info


  • 21


  • 7