Immunoreactivity for A103, an antibody to melan-A (Mart-1), in adrenocortical and other steroid tumors. Academic Article uri icon

Overview

abstract

  • The Melan-A (MART-1) gene encodes an antigen recognized by cytotoxic T cells. It has been said to be restricted in its expression to melanocytes. However, here we report the presence of immunoreactivity for A103, an antibody to Melan-A, in five adrenocortical adenomas, 16 primary and 13 metastatic adrenocortical carcinomas, four Leydig cell tumors of the testis, and three Sertoli-Leydig cell tumors of the ovary. To evaluate the potential diagnostic role of this antibody, we studied immunoreactivity for A103 in 111 carcinomas, 40 germ cell tumors, and 33 miscellaneous nonmelanocytic epithelioid tumors. All of them were negative for A103. Our findings suggest that once melanoma is excluded, A103 can aid in the recognition of steroid hormone-producing tumors and may be particularly useful in the diagnosis of adrenocortical carcinoma. The presence of immunoreactivity for A103 practically excludes any other carcinoma that may enter into the differential diagnosis of adrenocortical tumors.

publication date

  • January 1, 1998

Research

keywords

  • Adrenal Cortex Neoplasms
  • Adrenocortical Adenoma
  • Adrenocortical Carcinoma
  • Antibodies, Neoplasm
  • Antigens, Neoplasm
  • Neoplasm Proteins
  • Urogenital Neoplasms

Identity

Scopus Document Identifier

  • 0031985748

PubMed ID

  • 9422316

Additional Document Info

volume

  • 22

issue

  • 1