Assessment of a new dipstick test in screening for microalbuminuria in patients with hypertension.
Academic Article
Overview
abstract
The prevalence of elevated urinary albumin levels is significantly greater in hypertensive than in normotensive subjects. To determine the sensitivity and specificity of a new dipstick test for microalbunimuria (the Micral-Test), 171 hypertensive patients were studied at a union-sponsored hypertension treatment program. Sensitivity, specificity, predictive values, and correlation coefficients between urinary albumin concentration results obtained by the Micral-Test and by nephelometry were determined in three urine samples. Sensitivity values of the Micral-Test, compared with 24-h nephelometry, were 81%, 75%, and 92% in a 24-h, overnight, and random sample, respectively. Specificity values were 89%, 90%, and 63% in the three samples, respectively. Positive predictive value ranged from 41% to 67%, whereas negative predictive value ranged from 93% to 97%. Correlation coefficients between the logarithms of albumin concentrations obtained from the three different urine specimens using nephelometry fell between 0.71 and 0.78, whereas those obtained with the Micral-Test fell between 0.49 and 0.71, and across techniques, 0.29 to 0.53 (all P < .001). Results obtained with both nephelometry and the Micral-Test using overnight and random urine collections approximated those obtained with 24-h collection. These results, coupled with the ease and convenience of both specimen collection and the Micral-Test itself, support the use of the test as a valuable screening tool for microalbuminuria in patients with hypertension.
