selected publications
- Timely targeted testing for hereditary cancer syndromes - Importance of clinician-facilitated cascade testing in the first year post-diagnosis. Gynecologic oncology. 2024 Academic Article GET IT
- Considering screening for hereditary cancer syndromes at the time of obstetrical prenatal carrier screening. Cancer. 2024 Academic Article GET IT
- Ataxia telangiectasia-mutated rs56009889 and risk of common cancers. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). 2024 Academic Article GET IT
- Genomic characterization of Escherichia coli harbor a polyketide synthase ( pks ) island associated with colorectal cancer (CRC) development. 2024 GET IT
- Frameshift mutations in peripheral blood as a biomarker for surveillance of lynch syndrome. Journal of the National Cancer Institute. 2024 Academic Article GET IT
- Chromatin Remodeling in Patient-Derived Colorectal Cancer Models. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024 Academic Article GET IT
- Genomic Landscape of Lynch Syndrome Colorectal Neoplasia Identifies Shared Mutated Neoantigens for Immunoprevention. Gastroenterology. 2024 Academic Article GET IT
- Organoids and metastatic orthotopic mouse model for mismatch repair-deficient colorectal cancer. Frontiers in oncology. 2023 Academic Article GET IT
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Lynch syndrome cancer vaccines: A roadmap for the development of precision immunoprevention strategies.
Frontiers in oncology.
2023
Review
GET IT
Times cited: 12 - Agr2-associated ER stress promotes adherent-invasive E. coli dysbiosis and triggers CD103+ dendritic cell IL-23-dependent ileocolitis. Cell reports. 2022 Academic Article GET IT
- What happens in the long term: Uptake of cancer surveillance and prevention strategies among at-risk relatives with pathogenic variants detected via cascade testing. Cancer. 2022 Academic Article GET IT
- Barriers to completion of cascade genetic testing: how can we improve the uptake of testing for hereditary breast and ovarian cancer syndrome?. Familial cancer. 2022 Academic Article GET IT
- A pan-cancer mycobiome analysis reveals fungal involvement in gastrointestinal and lung tumors. Cell. 2022 Academic Article GET IT
- Plakoglobin and High-Mobility Group Box 1 Mediate Intestinal Epithelial Cell Apoptosis Induced by Clostridioides difficile TcdB. mBio. 2022 Academic Article GET IT
- Cascade Testing for Hereditary Cancer Syndromes: Should We Move Toward Direct Relative Contact? A Systematic Review and Meta-Analysis. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2022 Review GET IT
- Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries. Nature genetics. 2022 Academic Article GET IT
- Vaccines for immunoprevention of DNA mismatch repair deficient cancers. Journal for immunotherapy of cancer. 2022 Review GET IT
- Germline Pathogenic Variants Impact Clinicopathology of Advanced Lung Cancer. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2022 Academic Article GET IT
- Room for improvement in capturing cancer family history in a gynecologic oncology outpatient setting. Gynecologic oncology reports. 2022 Academic Article GET IT
- A full-proteome, interaction-specific characterization of mutational hotspots across human cancers. Genome research. 2021 Academic Article GET IT
- A 3D structural SARS-CoV-2-human interactome to explore genetic and drug perturbations. Nature methods. 2021 Academic Article GET IT
- Recurrent Frameshift Neoantigen Vaccine Elicits Protective Immunity With Reduced Tumor Burden and Improved Overall Survival in a Lynch Syndrome Mouse Model. Gastroenterology. 2021 Academic Article GET IT
- Sequencing at lymphoid neoplasm susceptibility loci maps six myeloma risk genes. Human molecular genetics. 2021 Academic Article GET IT
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Achieving universal genetic assessment for women with ovarian cancer: Are we there yet? A systematic review and meta-analysis.
Gynecologic oncology.
2021
Information Resource
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Times cited: 49 - Meeting Report: Translational Advances in Cancer Prevention Agent Development Meeting. Journal of cancer prevention. 2021 Academic Article GET IT
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Novel ultra-rare exonic variants identified in a founder population implicate cadherins in schizophrenia.
Neuron.
2021
Academic Article
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Times cited: 18 -
The cancer microbiome atlas: a pan-cancer comparative analysis to distinguish tissue-resident microbiota from contaminants.
Cell host & microbe.
2021
Academic Article
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Times cited: 114 - Facilitated cascade testing (FaCT): a randomized controlled trial. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. 2020 Academic Article GET IT
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Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis.
Nature.
2020
Academic Article
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Times cited: 153 -
Inherited Rare, Deleterious Variants in ATM Increase Lung Adenocarcinoma Risk.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
2020
Academic Article
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Times cited: 1 -
Naproxen chemoprevention promotes immune activation in Lynch syndrome colorectal mucosa.
Gut.
2020
Academic Article
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Times cited: 41 -
Cancer Moonshot Immuno-Oncology Translational Network (IOTN): accelerating the clinical translation of basic discoveries for improving immunotherapy and immunoprevention of cancer.
Journal for immunotherapy of cancer.
2020
Information Resource
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Times cited: 9 -
Cascading After Peridiagnostic Cancer Genetic Testing: An Alternative to Population-Based Screening.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2020
Academic Article
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Times cited: 67 -
Prospective Feasibility Trial of a Novel Strategy of Facilitated Cascade Genetic Testing Using Telephone Counseling.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2020
Academic Article
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Times cited: 55 -
Have Cells Harboring the HIV Reservoir Been Immunoedited?.
Frontiers in immunology.
2019
Academic Article
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Times cited: 15 -
Immune Activation in Mismatch Repair-Deficient Carcinogenesis: More Than Just Mutational Rate.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2019
Information Resource
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Times cited: 62 - ETHE1 overexpression promotes SIRT1 and PGC1α mediated aerobic glycolysis, oxidative phosphorylation, mitochondrial biogenesis and colorectal cancer. Oncotarget. 2019 Academic Article GET IT
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Exome sequencing identifies germline variants in DIS3 in familial multiple myeloma.
Leukemia.
2019
Article
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Times cited: 29 -
Toward automation of germline variant curation in clinical cancer genetics.
Genetics in medicine : official journal of the American College of Medical Genetics.
2019
Academic Article
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Times cited: 27 -
Case-control analysis identifies shared properties of rare germline variation in cancer predisposing genes.
European journal of human genetics : EJHG.
2019
Academic Article
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Times cited: 5 - The application of precision medicine in diagnosing familial Mediterranean fever. Leukemia & lymphoma. 2019 Letter GET IT
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Proteomic characterization of outer membrane vesicles from gut mucosa-derived fusobacterium nucleatum.
Journal of proteomics.
2019
Academic Article
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Times cited: 9 -
Intestinal crypts recover rapidly from focal damage with coordinated motion of stem cells that is impaired by aging.
Scientific reports.
2018
Academic Article
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Times cited: 25 -
High-depth whole genome sequencing of an Ashkenazi Jewish reference panel: enhancing sensitivity, accuracy, and imputation.
Human genetics.
2018
Academic Article
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Times cited: 18 -
Germline Lysine-Specific Demethylase 1 (LSD1/KDM1A) Mutations Confer Susceptibility to Multiple Myeloma.
Cancer research.
2018
Academic Article
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Times cited: 59 -
Novel pedigree analysis implicates DNA repair and chromatin remodeling in multiple myeloma risk.
PLoS genetics.
2018
Academic Article
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Times cited: 27 -
Mutation Detection in Patients With Advanced Cancer by Universal Sequencing of Cancer-Related Genes in Tumor and Normal DNA vs Guideline-Based Germline Testing.
JAMA.
2017
Academic Article
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Times cited: 367 - GeMSTONE: orchestrated prioritization of human germline mutations in the cloud. Nucleic acids research. 2017 Academic Article GET IT
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Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing.
Nature medicine.
2017
Academic Article
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Times cited: 291 - Inhibition of colorectal cancer genomic copy number alterations and chromosomal fragile site tumor suppressor FHIT and WWOX deletions by DNA mismatch repair. Oncotarget. 2017 Academic Article GET IT
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A Notch positive feedback in the intestinal stem cell niche is essential for stem cell self-renewal.
Molecular systems biology.
2017
Academic Article
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Times cited: 35 -
A Recurrent ERCC3 Truncating Mutation Confers Moderate Risk for Breast Cancer.
Cancer discovery.
2016
Academic Article
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Times cited: 41 - A recellularized human colon model identifies cancer driver genes. Nature biotechnology. 2016 Academic Article GET IT
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Notch signalling regulates asymmetric division and inter-conversion between lgr5 and bmi1 expressing intestinal stem cells.
Scientific reports.
2016
Academic Article
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Times cited: 33 -
A long non-coding RNA targets microRNA miR-34a to regulate colon cancer stem cell asymmetric division.
eLife.
2016
Academic Article
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Times cited: 118 -
NOTCH Signaling Regulates Asymmetric Cell Fate of Fast- and Slow-Cycling Colon Cancer-Initiating Cells.
Cancer research.
2016
Academic Article
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Times cited: 46 -
A miR-34a-Numb Feedforward Loop Triggered by Inflammation Regulates Asymmetric Stem Cell Division in Intestine and Colon Cancer.
Cell stem cell.
2016
Academic Article
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Times cited: 127 -
American Society of Clinical Oncology Policy Statement Update: Genetic and Genomic Testing for Cancer Susceptibility.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2015
Academic Article
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Times cited: 327 -
Germline ETV6 Mutations Confer Susceptibility to Acute Lymphoblastic Leukemia and Thrombocytopenia.
PLoS genetics.
2015
Academic Article
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Times cited: 125 -
Comprehensive models of human primary and metastatic colorectal tumors in immunodeficient and immunocompetent mice by chemokine targeting.
Nature biotechnology.
2015
Academic Article
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Times cited: 27 -
miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β.
Nature communications.
2015
Academic Article
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Times cited: 110 -
PMS2 monoallelic mutation carriers: the known unknown.
Genetics in medicine : official journal of the American College of Medical Genetics.
2015
Review
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Times cited: 49 -
A phase IIa randomized, double-blind trial of erlotinib in inhibiting epidermal growth factor receptor signaling in aberrant crypt foci of the colorectum.
Cancer prevention research (Philadelphia, Pa.).
2015
Academic Article
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Times cited: 2 -
A massively parallel pipeline to clone DNA variants and examine molecular phenotypes of human disease mutations.
PLoS genetics.
2014
Academic Article
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Times cited: 37 -
Polymorphisms in alcohol metabolism genes ADH1B and ALDH2, alcohol consumption and colorectal cancer.
PloS one.
2013
Academic Article
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Times cited: 31 -
Integrative annotation of variants from 1092 humans: application to cancer genomics.
Science (New York, N.Y.).
2013
Academic Article
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Times cited: 290 -
A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia.
Nature genetics.
2013
Academic Article
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Times cited: 252 -
Turkey must end violent response to protests.
Science (New York, N.Y.).
2013
Letter
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Times cited: 1 -
Asymmetric division: a marker for cancer stem cells in early stage tumors?.
Oncotarget.
2013
Editorial Article
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Times cited: 31 -
Dissecting disease inheritance modes in a three-dimensional protein network challenges the "guilt-by-association" principle.
American journal of human genetics.
2013
Academic Article
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Times cited: 37 -
Unbiased metabolite profiling indicates that a diminished thymidine pool is the underlying mechanism of colon cancer chemoprevention by alpha-difluoromethylornithine.
Cancer discovery.
2013
Academic Article
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Times cited: 40 -
Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.
Science signaling.
2013
Academic Article
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Times cited: 30 -
A microRNA miR-34a-regulated bimodal switch targets Notch in colon cancer stem cells.
Cell stem cell.
2013
Academic Article
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Times cited: 323 -
Pharmacological inhibition of polycomb repressive complex-2 activity induces apoptosis in human colon cancer stem cells.
Experimental cell research.
2013
Academic Article
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Times cited: 40 -
Inhibition of PRC2 histone methyltransferase activity increases TRAIL-mediated apoptosis sensitivity in human colon cancer cells.
Journal of cellular physiology.
2013
Academic Article
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Times cited: 41 -
Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies.
PLoS genetics.
2013
Academic Article
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Times cited: 43 -
Chemokine 25-induced signaling suppresses colon cancer invasion and metastasis.
The Journal of clinical investigation.
2012
Academic Article
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Times cited: 62 -
Rare de novo germline copy-number variation in testicular cancer.
American journal of human genetics.
2012
Academic Article
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Times cited: 17 -
The estrogen-responsive Agr2 gene regulates mammary epithelial proliferation and facilitates lobuloalveolar development.
Developmental biology.
2012
Academic Article
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Times cited: 26 -
miR-23a promotes the transition from indolent to invasive colorectal cancer.
Cancer discovery.
2012
Academic Article
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Times cited: 133 -
Genetic polymorphisms in fatty acid metabolism genes and colorectal cancer.
Mutagenesis.
2012
Academic Article
GET IT
Times cited: 38 -
Three-dimensional reconstruction of protein networks provides insight into human genetic disease.
Nature biotechnology.
2012
Academic Article
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Times cited: 311 -
Frequency domain analysis reveals external periodic fluctuations can generate sustained p53 oscillation.
PloS one.
2011
Academic Article
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Times cited: 7 -
Phase IIA trial testing erlotinib as an intervention against intraductal pancreatic mucinous neoplasms.
Cancer prevention research (Philadelphia, Pa.).
2011
Academic Article
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Times cited: 5 -
Mouse models of inherited cancer syndromes.
Hematology/oncology clinics of North America.
2010
Information Resource
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Times cited: 6 -
The class I HDAC inhibitor MGCD0103 induces cell cycle arrest and apoptosis in colon cancer initiating cells by upregulating Dickkopf-1 and non-canonical Wnt signaling.
Oncotarget.
2010
Academic Article
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Times cited: 61 -
A molecular signature of normal breast epithelial and stromal cells from Li-Fraumeni syndrome mutation carriers.
Oncotarget.
2010
Academic Article
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Times cited: 30 -
Clinical genetics of hereditary colorectal cancer.
Hematology/oncology clinics of North America.
2010
Information Resource
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Times cited: 24 -
Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer.
Cancer prevention research (Philadelphia, Pa.).
2010
Academic Article
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Times cited: 65 -
NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer.
Cancer research.
2010
Academic Article
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Times cited: 256 -
Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2-/- mice.
Developmental biology.
2009
Academic Article
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Times cited: 187 -
Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer.
Cancer research.
2009
Academic Article
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Times cited: 68 -
Survival of distinct Asian groups among colorectal cancer cases in California.
Cancer.
2009
Academic Article
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Times cited: 19 -
A population-based, descriptive analysis of malignant intraductal papillary mucinous neoplasms of the pancreas.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
2008
Academic Article
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Times cited: 16 -
Effects of socioeconomic status and treatment disparities in colorectal cancer survival.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
2008
Academic Article
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Times cited: 148 -
Novel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression.
PLoS genetics.
2008
Academic Article
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Times cited: 30 -
Accurate classification of MLH1/MSH2 missense variants with multivariate analysis of protein polymorphisms-mismatch repair (MAPP-MMR).
Human mutation.
2008
Academic Article
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Times cited: 92 -
Impaired placental trophoblast lineage differentiation in Alkbh1(-/-) mice.
Developmental dynamics : an official publication of the American Association of Anatomists.
2008
Academic Article
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Times cited: 61 -
Race, socioeconomic status, treatment, and survival time among pancreatic cancer cases in California.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
2007
Academic Article
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Times cited: 102 -
Pharmacogenomics of colorectal cancer prevention and treatment.
Cancer investigation.
2006
Information Resource
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Times cited: 9 -
A role for the MutL mismatch repair Mlh3 protein in immunoglobulin class switch DNA recombination and somatic hypermutation.
Journal of immunology (Baltimore, Md. : 1950).
2006
Academic Article
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Times cited: 34 -
Molecular models for the tissue specificity of DNA mismatch repair-deficient carcinogenesis.
Nucleic acids research.
2006
Information Resource
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Times cited: 90 -
Kinetics of cancer: a method to test hypotheses of genetic causation.
BMC cancer.
2005
Academic Article
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Times cited: 4 -
Expression of the MutL homologue hMLH3 in human cells and its role in DNA mismatch repair.
Cancer research.
2005
Academic Article
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Times cited: 91 - What are SNPs and haplotypes and how will they help us manage the prevention of adult cancer?. Current oncology reports. 2005 Information Resource GET IT
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Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I.
The Journal of cell biology.
2005
Academic Article
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Times cited: 99 -
Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse.
Cancer research.
2005
Academic Article
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Times cited: 75 -
Low allele frequency of MLH1 D132H in American colorectal and endometrial cancer patients.
Diseases of the colon and rectum.
2005
Academic Article
GET IT
Times cited: 14 -
CDX2 polymorphisms, RNA expression, and risk of colorectal cancer.
Cancer research.
2005
Academic Article
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Times cited: 28 -
The MLH1 D132H variant is associated with susceptibility to sporadic colorectal cancer.
Nature genetics.
2004
Academic Article
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Times cited: 88 -
Identification and characterization of Grainyhead-like epithelial transactivator (GET-1), a novel mammalian Grainyhead-like factor.
Developmental dynamics : an official publication of the American Association of Anatomists.
2003
Academic Article
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Times cited: 53 -
Family with acute myelocytic leukemia, breast, ovarian, and gastrointestinal cancer.
Cancer genetics and cytogenetics.
2002
Academic Article
GET IT
Times cited: 7 -
Meiotic arrest and aneuploidy in MLH3-deficient mice.
Nature genetics.
2002
Academic Article
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Times cited: 267 -
A nonsense mutation in MLH1 causes exon skipping in three unrelated HNPCC families.
Cancer research.
2001
Academic Article
GET IT
Times cited: 29 -
Germline and somatic mutation analyses in the DNA mismatch repair gene MLH3: Evidence for somatic mutation in colorectal cancers.
Human mutation.
2001
Academic Article
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Times cited: 60 -
MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability.
Nature genetics.
2000
Academic Article
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Times cited: 256 -
Constitutive retinoid receptors expressed from adenovirus vectors that specifically activate chromosomal target genes required for differentiation of promyelocytic leukemia and teratocarcinoma cells.
Journal of virology.
1996
Academic Article
GET IT
Times cited: 6 -
Identification of a novel zinc finger protein binding a conserved element critical for Pit-1-dependent growth hormone gene expression.
Genes & development.
1993
Academic Article
GET IT
Times cited: 113 -
A negative retinoic acid response element in the rat oxytocin promoter restricts transcriptional stimulation by heterologous transactivation domains.
Proceedings of the National Academy of Sciences of the United States of America.
1992
Academic Article
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Times cited: 64 -
Regulation of gene expression by thyroid hormones and retinoic acid.
Genetic engineering.
1992
Information Resource
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Times cited: 3 -
The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptors.
Cell.
1991
Academic Article
GET IT
Times cited: 453 -
Positive and negative regulation of gene transcription by a retinoic acid-thyroid hormone receptor heterodimer.
Cell.
1989
Academic Article
GET IT
Times cited: 349