Biochemical pharmacology
Journal
Overview
publication venue for
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A p38 MAP kinase inhibitor suppresses osteoclastogenesis and alleviates ovariectomy-induced bone loss through the inhibition of bone turnover..
226.
2024
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Pterostilbene-isothiocyanate impedes RANK/TRAF6 interaction to inhibit osteoclastogenesis, promoting osteogenesis in vitro and alleviating glucocorticoid induced osteoporosis in rats..
206.
2022
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Pterostilbene-isothiocyanate inhibits breast cancer metastasis by selectively blocking IKK-β/NEMO interaction in cancer cells..
192.
2021
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Hippocampal mitogen-activated protein kinase phosphatase-1 regulates behavioral and systemic effects of chronic corticosterone administration..
190.
2021
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The active second-generation proteasome inhibitor oprozomib reverts the oxaliplatin-induced neuropathy symptoms..
182.
2020
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RGFP966, a histone deacetylase 3 inhibitor, promotes glioma stem cell differentiation by blocking TGF-β signaling via SMAD7..
180.
2020
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Immunoproteasome inhibitor DPLG3 attenuates experimental colitis by restraining NF-κB activation..
177.
2020
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Pyroptotic and apoptotic cell death in iNOS and nNOS overexpressing K562 cells: A mechanistic insight..
176.
2019
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The mTOR inhibitor everolimus overcomes CXCR4-mediated resistance to histone deacetylase inhibitor panobinostat through inhibition of p21 and mitotic regulators..
168.
2019
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Olaparib induces browning of in vitro cultures of human primary white adipocytes..
167.
2019
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Alkylphenol inverse agonists of HCN1 gating: H-bond propensity, ring saturation and adduct geometry differentially determine efficacy and potency..
163.
2019
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Repositioning of anti-cancer drug candidate, AZD7762, to an anti-allergic drug suppressing IgE-mediated mast cells and allergic responses via the inhibition of Lyn and Fyn..
154.
2018
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Metformin represses glucose starvation induced autophagic response in microvascular endothelial cells and promotes cell death..
132.
2017
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Metformin improves endothelial function in aortic tissue and microvascular endothelial cells subjected to diabetic hyperglycaemic conditions..
98.
2015
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Reducing inflammation and rescuing FTD-related behavioral deficits in progranulin-deficient mice with α7 nicotinic acetylcholine receptor agonists..
97.
2015
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Somatostatin preserved blood brain barrier against cytokine induced alterations: possible role in multiple sclerosis..
86.
2013
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Lamotrigine is a substrate for OCT1 in brain endothelial cells..
83.
2011
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Modulation of AT-1R/AMPK-MAPK cascade plays crucial role for the pathogenesis of diabetic cardiomyopathy in transgenic type 2 diabetic (Spontaneous Diabetic Torii) rats..
83.
2011
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High density micromass cultures of a human chondrocyte cell line: a reliable assay system to reveal the modulatory functions of pharmacological agents..
82.
2011
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Transcriptional and post-transcriptional regulation of iNOS expression in human chondrocytes..
79.
2009
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Retinoid metabolism and ALDH1A2 (RALDH2) expression are altered in the transgenic adenocarcinoma mouse prostate model..
78.
2009
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Expression and transcriptional regulation of ABC transporters and cytochromes P450 in hCMEC/D3 human cerebral microvascular endothelial cells..
77.
2008
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Homeostasis of retinol in lecithin: retinol acyltransferase gene knockout mice fed a high retinol diet..
75.
2008
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14-3-3 protein regulates Ask1 signaling and protects against diabetic cardiomyopathy..
75.
2008
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Gene expression profiling elucidates a specific role for RARgamma in the retinoic acid-induced differentiation of F9 teratocarcinoma stem cells..
75.
2007
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Comparative effects of torasemide and furosemide in rats with heart failure..
75.
2007
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Histamine H3-receptor signaling in cardiac sympathetic nerves: Identification of a novel MAPK-PLA2-COX-PGE2-EP3R pathway..
73.
2007
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8-Chloro-adenosine inhibits growth at least partly by interfering with actin polymerization in cultured human lung cancer cells..
72.
2006
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Mechanism for the inhibition of transglutaminase 2 by cystamine..
69.
2005
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Catalase induces the expression of inducible nitric oxide synthase through activation of NF-kappaB and PI3K signaling pathway in Raw 264.7 cells..
68.
2004
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Leptomycin B-induced apoptosis is mediated through caspase activation and down-regulation of Mcl-1 and XIAP expression, but not through the generation of ROS in U937 leukemia cells..
68.
2004
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Tetrandrine-induced apoptosis is mediated by activation of caspases and PKC-delta in U937 cells..
67.
2004
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Protective role of heme oxygenase-1 induction in carbon tetrachloride-induced hepatotoxicity..
66.
2003
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Accompanying protein alterations in malignant cells with a microtubule-polymerizing drug-resistance phenotype and a primary resistance mechanism..
62.
2001
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The effect of high molecular phospholipase A2 inhibitors on 3T6 fibroblast proliferation..
61.
2001
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Inhibition of select mitochondrial enzymes in PC12 cells exposed to S-(1,1,2,2-tetrafluoroethyl)-L-cysteine..
58.
1999
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Role of leukocyte influx in tissue prostaglandin H synthase-2 overexpression induced by phorbol ester and arachidonic acid in skin..
58.
1999
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Induction by interleukin-1beta peptide of prostaglandin E2 formation via enhanced prostaglandin H synthase-2 expression in 3T6 fibroblasts..
56.
1998
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Inhibition of drug-naive and -resistant leukemia cell proliferation by low molecular weight thiols..
55.
1998
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Heme oxygenase induction with attenuation of experimentally induced corneal inflammation..
53.
1997
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Cell cycle-dependent inhibition of the proliferation of human neural tumor cell lines by iron chelators..
51.
1996
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Retrovirus-mediated transfer of the human O6-methylguanine-DNA methyltransferase gene into a murine hematopoietic stem cell line and resistance to the toxic effects of certain alkylating agents..
51.
1996
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Regulation of interleukin-1-beta-stimulated inducible nitric oxide synthase expression in cultured vascular smooth muscle cells by hemostatic proteins..
51.
1996
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Antiproliferative activity of the topoisomerase I inhibitors topotecan and camptothecin, on sub- and postconfluent tumor cell cultures..
48.
1994
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Differential induction of glutathione S-transferase in rat aorta versus liver..
47.
1994
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Conversion of T-kinin to bradykinin by the rat kidney..
47.
1994
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Chemosensitivity to the indoloquinone EO9 is correlated with DT-diaphorase activity and its gene expression..
47.
1994
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Early response gene induction following DNA damage in astrocytoma cell lines..
45.
1993
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Evidence for a bioactive clonidine-displacing substance in peripheral tissues and serum..
44.
1992
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CD4(81-92)-based peptide derivatives. Structural requirements for blockade of HIV infection, blockade of HIV-induced syncytium formation, and virostatic activity in vitro..
43.
1992
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Alpha-adrenoceptor activation of polyphosphoinositide hydrolysis in the rat tail artery..
40.
1990
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Actions of orally administered organotin compounds on heme metabolism and cytochrome P-450 content and function in intestinal epithelium..
38.
1989
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Lack of effect by prostaglandin F2 alpha and verapamil on calcium uptake by isolated corpora lutea from pseudopregnant rats..
38.
1989
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Alpha adrenoceptor sites in vascular smooth muscle. Differentiation by selective antagonist binding..
37.
1988
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Changes in cytosolic free calcium with 1,2,3,4-tetrahydro-5-aminoacridine, 4-aminopyridine and 3,4-diaminopyridine..
37.
1988
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Effects of prochlorperazine on the function of integral membrane proteins..
37.
1988
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Hormonal regulation of heme oxygenase induction in avian hepatocyte culture..
34.
1985
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Altered induction response of hepatic cytochrome P-450 to phenobarbital, 3-methylcholanthrene, and beta-naphthoflavone in organotin-treated animals..
34.
1985
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Prostaglandins and cyclic nucleotides. Modulators of arterial cholesterol metabolism..
34.
1985
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Thiamin antagonists and the release of acetylcholine and norepinephrine from brain slices..
33.
1984
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Tyrosine hydroxylase activation. Comparison of in vitro phosphorylation and in vivo administration of haloperidol..
31.
1982
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Decreases in the release of acetylcholine in vitro with low oxygen..
31.
1982
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Synthetic N-dimethyl beta-endorphin, a stabilized opioid peptide..
30.
1981
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Studies on the metabolic pathway of the acetyl group for acetylcholine synthesis..
29.
1980
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Protection by tris(hydroxymethyl)-aminomethane against behavioral and neurochemical effects of hypoxia..
28.
1979
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Proportional inhibition of acetylcholine synthesis accompanying impairment of 3-hydroxybutyrate oxidation in rat brain slices..
28.
1979
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Phospholipid-induced activation of tyrosine hydroxylase from rat brain striatal synaptosomes..
25.
1976
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Microscope immersion oils: effects of skin application on cutaneous and hepatic drug-metabolizing enzymes..
24.
1975
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Psychotomimetics as anticholinergic agents. I. 1-Cyclohexylpiperidine derivatives: anticholinesterase activity and antagonistic activity to acetylcholine..
23.
1974
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BIOCHEMICAL AND BEHAVIOURAL ALTERATIONS FOLLOWING 6-HYDROXYDOPAMINE ADMINISTRATION INTO BRAIN..
23.
1974
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Chlorcyclizine N-demethylase activity in chick embryo hepatic cell culture..
22.
1973
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Spectrophotometric and manometric studies of NADPH and NADH oxidase activities of rat liver microsomes: effects of drugs and adenine nucleotides..
14.
1965
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THE SUBCELLULAR LOCALIZATION OF BRAIN-STEM NOREPINEPHRINE AND 5-HYDROXYTRYPTAMINE IN STRESSED RATS..
13.
1964
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BRAIN AMINES: RESPONSE TO PHYSIOLOGICAL STRESS..
12.
1963
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A Festschrift in honor of David J. Triggle..
98.
2015
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Challenges in the Biomedical Research Enterprise in the 21st century: Antecedents in the writings of David Triggle.
2015
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The answer is not 42.
2015
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Nicotine signaling and progression of chronic kidney disease in smokers.
2013
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A perspective on autophagy and transcription factor EB in Alcohol-Associated Alzheimer's disease.
2023
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