Does congenital cytomegalovirus infection contribute to the development of acute lymphoblastic leukemia in children? Review uri icon

Overview

abstract

  • Cytomegalovirus (CMV) is a ubiquitous herpesvirus that has a profound impact on the host immune system. Congenital cytomegalovirus (cCMV) infection modulates neonatal immune cell compartments, yet the full impact of in utero exposure on developing fetal immune cells remains poorly characterized. A series of recent studies have identified a potential link between cCMV infection and the development of acute lymphoblastic leukemia (ALL) in childhood. Here, we review the emerging evidence linking CMV and ALL risk, discuss what is known about the causes of childhood ALL, and propose how CMV infection in early life may confer increased ALL risk.

publication date

  • April 17, 2023

Research

keywords

  • Cytomegalovirus Infections
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma

Identity

Scopus Document Identifier

  • 85152532859

Digital Object Identifier (DOI)

  • 10.1016/j.coviro.2023.101325

PubMed ID

  • 37075577

Additional Document Info

volume

  • 60