selected publications
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MET Exon 14-altered Lung Cancers and MET Inhibitor Resistance.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2020
Academic Article
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Times cited: 38 -
Phase III study of selpercatinib versus chemotherapy ± pembrolizumab in untreated RET positive non-small-cell lung cancer.
Future oncology (London, England).
2020
Academic Article
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Times cited: 6 -
TRK xDFG Mutations Trigger a Sensitivity Switch from Type I to II Kinase Inhibitors.
Cancer discovery.
2020
Academic Article
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Times cited: 39 -
Therapeutic Potential of Afatinib in NRG1 Fusion-Driven Solid Tumors: A Case Series.
The oncologist.
2020
Academic Article
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Times cited: 34 - NRG1 fusion-driven tumors: biology, detection, and the therapeutic role of afatinib and other ErbB-targeting agents. Annals of oncology : official journal of the European Society for Medical Oncology. 2020 Information Resource GET IT
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The METeoric rise of MET in lung cancer.
Cancer.
2020
Information Resource
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Times cited: 6 -
Efficacy of Selpercatinib in RET Fusion-Positive Non-Small-Cell Lung Cancer.
The New England journal of medicine.
2020
Academic Article
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Times cited: 564 -
Efficacy of Selpercatinib in RET-Altered Thyroid Cancers.
The New England journal of medicine.
2020
Academic Article
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Times cited: 66 - Clinical implications of drug-induced liver injury in early-phase oncology clinical trials. Cancer. 2020 Academic Article GET IT
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ROS1-dependent cancers - biology, diagnostics and therapeutics.
Nature reviews. Clinical oncology.
2020
Information Resource
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Times cited: 14 -
CNS Metastases in Patients With MET Exon 14-Altered Lung Cancers and Outcomes With Crizotinib.
JCO precision oncology.
2020
Academic Article
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Times cited: 20 -
Progresses Toward Precision Medicine in RET-altered Solid Tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2020
Information Resource
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Times cited: 4 -
An umbrella approach to test lung cancer therapies.
Nature.
2020
Article
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Times cited: 1 -
COVID-19 in patients with lung cancer.
Annals of oncology : official journal of the European Society for Medical Oncology.
2020
Academic Article
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Times cited: 196 -
MET-dependent solid tumours - molecular diagnosis and targeted therapy.
Nature reviews. Clinical oncology.
2020
Information Resource
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Times cited: 201 -
Characterization of on-target adverse events caused by TRK inhibitor therapy.
Annals of oncology : official journal of the European Society for Medical Oncology.
2020
Academic Article
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Times cited: 43 -
Enrichment of kinase fusions in ESR1 wild-type, metastatic breast cancer revealed by a systematic analysis of 4854 patients.
Annals of oncology : official journal of the European Society for Medical Oncology.
2020
Academic Article
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Times cited: 20 -
Repotrectinib Exhibits Potent Antitumor Activity in Treatment-Naïve and Solvent-Front-Mutant ROS1-Rearranged Non-Small Cell Lung Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2020
Academic Article
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Times cited: 16 -
MAPK Pathway Alterations Correlate with Poor Survival and Drive Resistance to Therapy in Patients with Lung Cancers Driven by ROS1 Fusions.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2020
Academic Article
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Times cited: 37 -
Larotrectinib in patients with TRK fusion-positive solid tumours: a pooled analysis of three phase 1/2 clinical trials.
The Lancet. Oncology.
2020
Academic Article
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Times cited: 686 -
KRAS as a druggable target in NSCLC: Rising like a phoenix after decades of development failures.
Cancer treatment reviews.
2020
Information Resource
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Times cited: 96 -
RET Solvent Front Mutations Mediate Acquired Resistance to Selective RET Inhibition in RET-Driven Malignancies.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
2020
Academic Article
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Times cited: 208 -
TRK Fusions Are Enriched in Cancers with Uncommon Histologies and the Absence of Canonical Driver Mutations.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2019
Academic Article
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Times cited: 117 -
Entrectinib in ROS1 fusion-positive non-small-cell lung cancer: integrated analysis of three phase 1-2 trials.
The Lancet. Oncology.
2019
Academic Article
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Times cited: 369 -
Entrectinib in patients with advanced or metastatic NTRK fusion-positive solid tumours: integrated analysis of three phase 1-2 trials.
The Lancet. Oncology.
2019
Academic Article
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Times cited: 1182 -
Activating mutations in CSF1R and additional receptor tyrosine kinases in histiocytic neoplasms.
Nature medicine.
2019
Academic Article
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Times cited: 137 -
Five-Year Survival and Correlates Among Patients With Advanced Melanoma, Renal Cell Carcinoma, or Non-Small Cell Lung Cancer Treated With Nivolumab.
JAMA oncology.
2019
Academic Article
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Times cited: 412 -
Optimizing the sequencing of tyrosine kinase inhibitors (TKIs) in epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer (NSCLC).
Lung cancer (Amsterdam, Netherlands).
2019
Information Resource
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Times cited: 165 -
Frequency and outcomes of brain metastases in patients with HER2-mutant lung cancers.
Cancer.
2019
Academic Article
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Times cited: 55 -
Four-year survival with nivolumab in patients with previously treated advanced non-small-cell lung cancer: a pooled analysis.
The Lancet. Oncology.
2019
Academic Article
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Times cited: 257 -
Resistance to TRK inhibition mediated by convergent MAPK pathway activation.
Nature medicine.
2019
Academic Article
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Times cited: 158 -
NTRK fusion detection across multiple assays and 33,997 cases: diagnostic implications and pitfalls.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.
2019
Academic Article
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Times cited: 404 -
Immune checkpoint inhibitors for patients with advanced lung cancer and oncogenic driver alterations: results from the IMMUNOTARGET registry.
Annals of oncology : official journal of the European Society for Medical Oncology.
2019
Academic Article
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Times cited: 937 - Real-World Outcomes of an Automated Physician Support System for Genome-Driven Oncology. JCO precision oncology. 2019 Academic Article GET IT
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MET IHC Is a Poor Screen for MET Amplification or MET Exon 14 Mutations in Lung Adenocarcinomas: Data from a Tri-Institutional Cohort of the Lung Cancer Mutation Consortium.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
2019
Academic Article
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Times cited: 123 -
Response to Selective RET Inhibition With LOXO-292 in a Patient With RET Fusion-Positive Lung Cancer With Leptomeningeal Metastases.
JCO precision oncology.
2019
Academic Article
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Times cited: 41 -
A Prospective Study of Circulating Tumor DNA to Guide Matched Targeted Therapy in Lung Cancers.
Journal of the National Cancer Institute.
2019
Academic Article
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Times cited: 98 -
A Phase Ib/II Study of Ramucirumab in Combination with Emibetuzumab in Patients with Advanced Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2019
Academic Article
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Times cited: 10 -
Immunophenotype and Response to Immunotherapy of RET-Rearranged Lung Cancers.
JCO precision oncology.
2019
Academic Article
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Times cited: 113 -
Larotrectinib Demonstrates CNS Efficacy in TRK Fusion-Positive Solid Tumors.
2019
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Times cited: 15 -
Impact of MET inhibitors on survival among patients with non-small cell lung cancer harboring MET exon 14 mutations: a retrospective analysis.
Lung cancer (Amsterdam, Netherlands).
2019
Academic Article
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Times cited: 81 -
Acquired MET Exon 14 Alteration Drives Secondary Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in EGFR-Mutated Lung Cancer.
JCO precision oncology.
2019
Academic Article
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Times cited: 50 -
High Yield of RNA Sequencing for Targetable Kinase Fusions in Lung Adenocarcinomas with No Mitogenic Driver Alteration Detected by DNA Sequencing and Low Tumor Mutation Burden.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2019
Academic Article
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Times cited: 313 -
Exceptional responders with invasive mucinous adenocarcinomas: a phase 2 trial of bortezomib in patients with KRAS G12D-mutant lung cancers.
Cold Spring Harbor molecular case studies.
2019
Academic Article
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Times cited: 23 -
The repertoire of genetic alterations in salivary duct carcinoma including a novel HNRNPH3-ALK rearrangement.
Human pathology.
2019
Academic Article
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Times cited: 37 -
Afatinib in patients with metastatic or recurrent HER2-mutant lung cancers: a retrospective international multicentre study.
European journal of cancer.
2019
Academic Article
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Times cited: 71 -
Colorectal Carcinomas Containing Hypermethylated MLH1 Promoter and Wild-Type BRAF/KRAS Are Enriched for Targetable Kinase Fusions.
Cancer research.
2019
Academic Article
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Times cited: 114 -
Expanding the Molecular Characterization of Thoracic Inflammatory Myofibroblastic Tumors beyond ALK Gene Rearrangements.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
2018
Academic Article
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Times cited: 66 -
NTRK fusion-positive cancers and TRK inhibitor therapy.
Nature reviews. Clinical oncology.
2018
Information Resource
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Times cited: 1037 -
A Phase I/Ib Trial of the VEGFR-Sparing Multikinase RET Inhibitor RXDX-105.
Cancer discovery.
2018
Academic Article
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Times cited: 95 -
Activation of KRAS Mediates Resistance to Targeted Therapy in MET Exon 14-mutant Non-small Cell Lung Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2018
Academic Article
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Times cited: 92 -
PD-L1 expression, tumor mutational burden, and response to immunotherapy in patients with MET exon 14 altered lung cancers.
Annals of oncology : official journal of the European Society for Medical Oncology.
2018
Academic Article
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Times cited: 242 -
Acquired ALK and RET Gene Fusions as Mechanisms of Resistance to Osimertinib in EGFR-Mutant Lung Cancers.
JCO precision oncology.
2018
Academic Article
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Times cited: 85 -
Genomic Heterogeneity Underlies Mixed Response to Tropomyosin Receptor Kinase Inhibition in Recurrent Glioma.
JCO precision oncology.
2018
Academic Article
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Times cited: 3 -
Tumor Mutation Burden and Efficacy of EGFR-Tyrosine Kinase Inhibitors in Patients with EGFR-Mutant Lung Cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2018
Academic Article
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Times cited: 254 -
Clinicopathologic Features of Non-Small-Cell Lung Cancer Harboring an NTRK Gene Fusion.
JCO precision oncology.
2018
Academic Article
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Times cited: 198 -
Entrectinib: an orally available, selective tyrosine kinase inhibitor for the treatment of NTRK, ROS1, and ALK fusion-positive solid tumors.
Therapeutics and clinical risk management.
2018
Review
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Times cited: 89 -
Frequency of Brain Metastases and Multikinase Inhibitor Outcomes in Patients With RET-Rearranged Lung Cancers.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
2018
Academic Article
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Times cited: 150 -
CT features of HER2-mutant lung adenocarcinomas.
Clinical imaging.
2018
Information Resource
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Times cited: 8 -
Learning All That We Can From MyPathway.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2018
Article
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Times cited: 1 -
NTRK Fusions Define a Novel Uterine Sarcoma Subtype With Features of Fibrosarcoma.
The American journal of surgical pathology.
2018
Academic Article
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Times cited: 181 -
RET fusions in a small subset of advanced colorectal cancers at risk of being neglected.
Annals of oncology : official journal of the European Society for Medical Oncology.
2018
Academic Article
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Times cited: 41 -
Tumor-Agnostic Drug Development.
American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting.
2018
Academic Article
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Times cited: 32 -
Response to ERBB3-Directed Targeted Therapy in NRG1-Rearranged Cancers.
Cancer discovery.
2018
Academic Article
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Times cited: 151 -
Efficacy of Larotrectinib in TRK Fusion-Positive Cancers in Adults and Children.
The New England journal of medicine.
2018
Academic Article
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Times cited: 2062 -
HER kinase inhibition in patients with HER2- and HER3-mutant cancers.
Nature.
2018
Academic Article
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Times cited: 588 -
Targeting RET-driven cancers: lessons from evolving preclinical and clinical landscapes.
Nature reviews. Clinical oncology.
2017
Information Resource
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Times cited: 253 -
RASA1 and NF1 are Preferentially Co-Mutated and Define A Distinct Genetic Subset of Smoking-Associated Non-Small Cell Lung Carcinomas Sensitive to MEK Inhibition.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2017
Academic Article
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Times cited: 51 -
Pan-Trk Immunohistochemistry Is an Efficient and Reliable Screen for the Detection of NTRK Fusions.
The American journal of surgical pathology.
2017
Academic Article
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Times cited: 375 -
Fusions in solid tumours: diagnostic strategies, targeted therapy, and acquired resistance.
Nature reviews. Clinical oncology.
2017
Information Resource
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Times cited: 123 -
Successful Targeted Therapy of Refractory Pediatric ETV6-NTRK3 Fusion-Positive Secretory Breast Carcinoma.
JCO precision oncology.
2017
Academic Article
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Times cited: 52 -
Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target.
Nature communications.
2017
Academic Article
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Times cited: 56 -
A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors.
Cancer discovery.
2017
Academic Article
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Times cited: 339 -
Combination MET- and EGFR-directed therapy in MET-overexpressing non-small cell lung cancers: time to move on to better biomarkers?.
Translational lung cancer research.
2017
Editorial Article
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Times cited: 6 - Targeting RET-rearranged lung cancers with multikinase inhibitors. Oncoscience. 2017 Editorial Article GET IT
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The activity, safety, and evolving role of brigatinib in patients with ALK-rearranged non-small cell lung cancers.
OncoTargets and therapy.
2017
Information Resource
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Times cited: 51 -
Changing the Therapeutic Landscape in Non-small Cell Lung Cancers: the Evolution of Comprehensive Molecular Profiling Improves Access to Therapy.
Current oncology reports.
2017
Information Resource
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Times cited: 33 -
Prospective Comprehensive Molecular Characterization of Lung Adenocarcinomas for Efficient Patient Matching to Approved and Emerging Therapies.
Cancer discovery.
2017
Academic Article
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Times cited: 490 -
Targeting RET in Patients With RET-Rearranged Lung Cancers: Results From the Global, Multicenter RET Registry.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2017
Academic Article
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Times cited: 294 -
A phase 1b dose expansion study of the pan-class I PI3K inhibitor buparlisib (BKM120) plus carboplatin and paclitaxel in PTEN deficient tumors and with dose intensified carboplatin and paclitaxel.
Investigational new drugs.
2017
Academic Article
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Times cited: 12 -
Safety and Antitumor Activity of the Multitargeted Pan-TRK, ROS1, and ALK Inhibitor Entrectinib: Combined Results from Two Phase I Trials (ALKA-372-001 and STARTRK-1).
Cancer discovery.
2017
Academic Article
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Times cited: 661 -
Antitumor Activity of RXDX-105 in Multiple Cancer Types with RET Rearrangements or Mutations.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2016
Academic Article
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Times cited: 65 -
Cabozantinib in patients with advanced RET-rearranged non-small-cell lung cancer: an open-label, single-centre, phase 2, single-arm trial.
The Lancet. Oncology.
2016
Academic Article
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Times cited: 372 -
Targeted therapy outcomes in RET-rearranged lung cancers: drug or driver?.
The Lancet. Respiratory medicine.
2016
Article
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Times cited: 1 -
Targeting MET in Lung Cancer: Will Expectations Finally Be MET?.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
2016
Information Resource
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Times cited: 299 -
Clinical outcomes with pemetrexed-based systemic therapies in RET-rearranged lung cancers.
Annals of oncology : official journal of the European Society for Medical Oncology.
2016
Academic Article
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Times cited: 97 -
MET Exon 14 Alterations in Lung Cancer: Exon Skipping Extends Half-Life.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2016
Academic Article
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Times cited: 42 -
Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma Reveals Small Cell Carcinoma-like and Non-Small Cell Carcinoma-like Subsets.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2016
Academic Article
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Times cited: 356 -
Beyond the dose-limiting toxicity period: Dermatologic adverse events of patients on phase 1 trials of the Cancer Therapeutics Evaluation Program.
Cancer.
2016
Academic Article
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Times cited: 10 -
Impact of Concurrent PIK3CA Mutations on Response to EGFR Tyrosine Kinase Inhibition in EGFR-Mutant Lung Cancers and on Prognosis in Oncogene-Driven Lung Adenocarcinomas.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
2015
Academic Article
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Times cited: 81 -
A prospective study of total plasma cell-free DNA as a predictive biomarker for response to systemic therapy in patients with advanced non-small-cell lung cancers.
Annals of oncology : official journal of the European Society for Medical Oncology.
2015
Academic Article
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Times cited: 49 -
Acquired Resistance of EGFR-Mutant Lung Cancer to a T790M-Specific EGFR Inhibitor: Emergence of a Third Mutation (C797S) in the EGFR Tyrosine Kinase Domain.
JAMA oncology.
2015
Article
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Times cited: 213 -
From genotype to phenotype: Are there imaging characteristics associated with lung adenocarcinomas harboring RET and ROS1 rearrangements?.
Lung cancer (Amsterdam, Netherlands).
2015
Academic Article
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Times cited: 23 -
Structural insight into selectivity and resistance profiles of ROS1 tyrosine kinase inhibitors.
Proceedings of the National Academy of Sciences of the United States of America.
2015
Academic Article
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Times cited: 100 -
Toxicity Attribution in Phase I Trials: Evaluating the Effect of Dose on the Frequency of Related and Unrelated Toxicities.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2015
Academic Article
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Times cited: 17 -
Response to MET inhibitors in patients with stage IV lung adenocarcinomas harboring MET mutations causing exon 14 skipping.
Cancer discovery.
2015
Academic Article
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Times cited: 490 -
Broad, Hybrid Capture-Based Next-Generation Sequencing Identifies Actionable Genomic Alterations in Lung Adenocarcinomas Otherwise Negative for Such Alterations by Other Genomic Testing Approaches.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2015
Academic Article
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Times cited: 234 -
MAP2K1 (MEK1) Mutations Define a Distinct Subset of Lung Adenocarcinoma Associated with Smoking.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2014
Academic Article
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Times cited: 117 -
A prospective study of tumor suppressor gene methylation as a prognostic biomarker in surgically resected stage I to IIIA non-small-cell lung cancers.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
2014
Academic Article
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Times cited: 34 -
RET mutations in neuroendocrine tumors: including small-cell lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
2014
Editorial Article
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Times cited: 10 -
Trial of a 5-day dosing regimen of temozolomide in patients with relapsed small cell lung cancers with assessment of methylguanine-DNA methyltransferase.
Lung cancer (Amsterdam, Netherlands).
2014
Academic Article
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Times cited: 50 -
Response to Cabozantinib in patients with RET fusion-positive lung adenocarcinomas.
Cancer discovery.
2013
Academic Article
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Times cited: 436 -
Identification of KIF5B-RET and GOPC-ROS1 fusions in lung adenocarcinomas through a comprehensive mRNA-based screen for tyrosine kinase fusions.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2012
Academic Article
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Times cited: 168 -
Squamous-cell carcinomas of the lung: emerging biology, controversies, and the promise of targeted therapy.
The Lancet. Oncology.
2012
Information Resource
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Times cited: 142 -
Systemic approaches for multifocal bronchioloalveolar carcinoma: is there an appropriate target?.
Oncology (Williston Park, N.Y.).
2010
Information Resource
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Times cited: 5 -
Extraskeletal myxoid chondrosarcoma: a retrospective review from 2 referral centers emphasizing long-term outcomes with surgery and chemotherapy.
Cancer.
2008
Academic Article
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Times cited: 123