MET Exon 14 Alterations in Lung Cancer: Exon Skipping Extends Half-Life.

Overview

MET exon 14 alterations are a diverse group of mutations, many of which disrupt splice acceptor or donor sites leading to exon 14 skipping, impaired receptor degradation, and oncogenic transformation. These alterations are clinically targetable with MET-directed therapy. Clin Cancer Res; 22(12); 2832-4. ©2016 AACRSee related article by Tong et al., p. 3048.

Clinical cancer research : an official journal of the American Association for Cancer Research Journal