selected publications
- Divergent Cl- and H+ pathways underlie transport coupling and gating in CLC exchangers and channels. eLife. 2020 Academic Article GET IT
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What biologists want from their chloride reporters - a conversation between chemists and biologists.
Journal of cell science.
2020
Review
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Times cited: 1 - Reconstitution of Proteoliposomes for Phospholipid Scrambling and Nonselective Channel Assays. 2020 GET IT
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Membrane lipids are both the substrates and a mechanistically responsive environment of TMEM16 scramblase proteins.
Journal of computational chemistry.
2019
Academic Article
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Times cited: 1 -
Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca2+-bound nhTMEM16.
Nature communications.
2019
Academic Article
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Times cited: 3 -
The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.
Nature communications.
2019
Academic Article
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Times cited: 13 -
Structural basis of Ca2+-dependent activation and lipid transport by a TMEM16 scramblase.
eLife.
2019
Academic Article
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Times cited: 28 -
Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase.
Nature communications.
2018
Academic Article
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Times cited: 25 -
Out-of-the-groove transport of lipids by TMEM16 and GPCR scramblases.
Proceedings of the National Academy of Sciences of the United States of America.
2018
Academic Article
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Times cited: 15 -
Known structures and unknown mechanisms of TMEM16 scramblases and channels.
The Journal of general physiology.
2018
Academic Article
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Times cited: 28 -
Probing the conformation of a conserved glutamic acid within the Cl- pathway of a CLC H+/Cl- exchanger.
The Journal of general physiology.
2017
Comment
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Times cited: 9 -
The nhTMEM16 Scramblase Is Also a Nonselective Ion Channel.
Biophysical journal.
2016
Academic Article
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Times cited: 34 -
CELL SIGNALING. Lipids link ion channels and cancer.
Science (New York, N.Y.).
2015
Article
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Times cited: 21 -
Structure and gating of CLC channels and exchangers.
The Journal of physiology.
2015
Review
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Times cited: 32 -
A Proteoliposome-Based Efflux Assay to Determine Single-molecule Properties of Cl- Channels and Transporters.
Journal of visualized experiments : JoVE.
2015
Academic Article
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Times cited: 2 -
Unveiling the secret lives of glutamate transporters: VGLUTs engage in multiple transport modes.
Neuron.
2014
Article
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Times cited: 1 -
Nucleotide binding triggers a conformational change of the CBS module of the magnesium transporter CNNM2 from a twisted towards a flat structure.
The Biochemical journal.
2014
Academic Article
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Times cited: 19 -
TMEM16 proteins: unknown structure and confusing functions.
Journal of molecular biology.
2014
Review
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Times cited: 84 -
Conformational changes required for H(+)/Cl(-) exchange mediated by a CLC transporter.
Nature structural & molecular biology.
2014
Academic Article
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Times cited: 38 - Unveiling the secret lives of glutamate transporters: VGLUTs engage in multiple transport modes. Urology. 2014 Article GET IT
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Purified TMEM16A is sufficient to form Ca2+-activated Cl- channels.
Proceedings of the National Academy of Sciences of the United States of America.
2013
Academic Article
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Times cited: 70 -
Ca2+-dependent phospholipid scrambling by a reconstituted TMEM16 ion channel.
Nature communications.
2013
Academic Article
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Times cited: 138 -
Synergistic substrate binding determines the stoichiometry of transport of a prokaryotic H(+)/Cl(-) exchanger.
Nature structural & molecular biology.
2012
Academic Article
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Times cited: 48 -
PIP2-mediated HCN3 channel gating is crucial for rhythmic burst firing in thalamic intergeniculate leaflet neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2011
Academic Article
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Times cited: 24 -
A dystroglycan mutation associated with limb-girdle muscular dystrophy.
The New England journal of medicine.
2011
Academic Article
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Times cited: 184 -
Proton block of the CLC-5 Cl-/H+ exchanger.
The Journal of general physiology.
2010
Academic Article
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Times cited: 22 -
CLC channels and transporters: proteins with borderline personalities.
Biochimica et biophysica acta.
2010
Review
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Times cited: 80 -
Basis of substrate binding and conservation of selectivity in the CLC family of channels and transporters.
Nature structural & molecular biology.
2009
Academic Article
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Times cited: 77 -
Ion permeation through a Cl--selective channel designed from a CLC Cl-/H+ exchanger.
Proceedings of the National Academy of Sciences of the United States of America.
2008
Academic Article
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Times cited: 81 -
To ATP or not to ATP: this is the question.
The Journal of general physiology.
2008
Conference Paper
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Times cited: 4 -
Uncoupling and turnover in a Cl-/H+ exchange transporter.
The Journal of general physiology.
2007
Academic Article
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Times cited: 99 -
Synergism between halide binding and proton transport in a CLC-type exchanger.
Journal of molecular biology.
2006
Academic Article
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Times cited: 81 -
Separate ion pathways in a Cl-/H+ exchanger.
The Journal of general physiology.
2005
Academic Article
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Times cited: 156 -
Secondary active transport mediated by a prokaryotic homologue of ClC Cl- channels.
Nature.
2004
Academic Article
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Times cited: 477 -
Ionic currents mediated by a prokaryotic homologue of CLC Cl- channels.
The Journal of general physiology.
2004
Academic Article
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Times cited: 111 -
Conformational changes in the C terminus of Shaker K+ channel bound to the rat Kvbeta2-subunit.
Proceedings of the National Academy of Sciences of the United States of America.
2003
Academic Article
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Times cited: 47 -
Conformational changes in the pore of CLC-0.
The Journal of general physiology.
2003
Academic Article
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Times cited: 69 -
Conservation of chloride channel structure revealed by an inhibitor binding site in ClC-1.
Neuron.
2003
Academic Article
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Times cited: 138 -
A biological role for prokaryotic ClC chloride channels.
Nature.
2002
Academic Article
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Times cited: 160 -
Mechanisms of block of muscle type CLC chloride channels (Review).
Molecular membrane biology.
2002
Review
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Times cited: 26 -
Molecular requisites for drug binding to muscle CLC-1 and renal CLC-K channel revealed by the use of phenoxy-alkyl derivatives of 2-(p-chlorophenoxy)propionic acid.
Molecular pharmacology.
2002
Academic Article
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Times cited: 39 -
Drastic reduction of the slow gate of human muscle chloride channel (ClC-1) by mutation C277S.
The Journal of physiology.
2001
Academic Article
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Times cited: 44 -
Mechanism of block of single protopores of the Torpedo chloride channel ClC-0 by 2-(p-chlorophenoxy)butyric acid (CPB).
The Journal of general physiology.
2001
Academic Article
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Times cited: 32 -
Fast and slow gating relaxations in the muscle chloride channel CLC-1.
The Journal of general physiology.
2000
Academic Article
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Times cited: 91 -
Pharmacological characterization of chloride channels belonging to the ClC family by the use of chiral clofibric acid derivatives.
Molecular pharmacology.
2000
Academic Article
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Times cited: 56 -
Chloride channels activated by hypotonicity in N2A neuroblastoma cell line.
Experimental brain research.
1999
Academic Article
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Times cited: 22