Accardi, Alessio

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selected publications

Structure and function of the human apoptotic scramblase Xkr4. 2024 GET IT
Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants. Nature. 2024 Academic Article GET IT
Structural basis of closed groove scrambling by a TMEM16 protein. Nature structural & molecular biology. 2024 Academic Article GET IT
Author Correction: Structural basis of pH-dependent activation in a CLC transporter. 2024 GET IT
Structural basis of pH-dependent activation in a CLC transporter. Nature structural & molecular biology. 2024 Academic Article GET IT
Structural basis of closed groove scrambling by a TMEM16 protein. 2023 GET IT
Structural basis of closed groove scrambling by a TMEM16 protein. 2023 GET IT
Backbone amides are determinants of Cl^- selectivity in CLC ion channels. Nature communications. 2022 Academic Article GET IT
TMEM16 scramblases thin the membrane to enable lipid scrambling. Nature communications. 2022 Academic Article GET IT
Not so transport incompetent after all: Revisiting a CLC-7 mutant sheds new mechanistic light on lysosomal physiology. The Journal of general physiology. 2021 Article GET IT
A quantitative flux assay for the study of reconstituted Cl^- channels and transporters. Methods in enzymology. 2021 Article GET IT
Divergent Cl^- and H⁺ pathways underlie transport coupling and gating in CLC exchangers and channels. eLife. 2020 Academic Article GET IT
Times cited: 10
What biologists want from their chloride reporters - a conversation between chemists and biologists. Journal of cell science. 2020 Information Resource GET IT
Times cited: 8
Reconstitution of Proteoliposomes for Phospholipid Scrambling and Nonselective Channel Assays. Methods in molecular biology (Clifton, N.J.). 2020 Article GET IT
Times cited: 2
Membrane lipids are both the substrates and a mechanistically responsive environment of TMEM16 scramblase proteins. Journal of computational chemistry. 2019 Academic Article GET IT
Times cited: 13
Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca²⁺-bound nhTMEM16. Nature communications. 2019 Academic Article GET IT
Times cited: 21
The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K. Nature communications. 2019 Academic Article GET IT
Times cited: 95
Structural basis of Ca²⁺-dependent activation and lipid transport by a TMEM16 scramblase. eLife. 2019 Academic Article GET IT
Times cited: 82
Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase. Nature communications. 2018 Academic Article GET IT
Times cited: 61
Out-of-the-groove transport of lipids by TMEM16 and GPCR scramblases. Proceedings of the National Academy of Sciences of the United States of America. 2018 Academic Article GET IT
Times cited: 42
The nhTMEM16 Scramblase Is Also a Nonselective Ion Channel. Biophysical journal. 2016 Academic Article GET IT
Times cited: 59
Structure and gating of CLC channels and exchangers. The Journal of physiology. 2015 Information Resource GET IT
Times cited: 54
A Proteoliposome-Based Efflux Assay to Determine Single-molecule Properties of Cl- Channels and Transporters. Journal of visualized experiments : JoVE. 2015 Academic Article GET IT
Times cited: 5
Nucleotide binding triggers a conformational change of the CBS module of the magnesium transporter CNNM2 from a twisted towards a flat structure. The Biochemical journal. 2014 Academic Article GET IT
Times cited: 38
TMEM16 proteins: unknown structure and confusing functions. Journal of molecular biology. 2014 Information Resource GET IT
Times cited: 121
Conformational changes required for H(+)/Cl(-) exchange mediated by a CLC transporter. Nature structural & molecular biology. 2014 Academic Article GET IT
Times cited: 58
Purified TMEM16A is sufficient to form Ca2+-activated Cl- channels. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 91
Ca2+-dependent phospholipid scrambling by a reconstituted TMEM16 ion channel. Nature communications. 2013 Academic Article GET IT
Times cited: 189
Synergistic substrate binding determines the stoichiometry of transport of a prokaryotic H(+)/Cl(-) exchanger. Nature structural & molecular biology. 2012 Academic Article GET IT
Times cited: 63
PIP2-mediated HCN3 channel gating is crucial for rhythmic burst firing in thalamic intergeniculate leaflet neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 Academic Article GET IT
Times cited: 35
Proton block of the CLC-5 Cl-/H+ exchanger. The Journal of general physiology. 2010 Academic Article GET IT
Times cited: 25
CLC channels and transporters: proteins with borderline personalities. Biochimica et biophysica acta. 2010 Information Resource GET IT
Times cited: 89
Basis of substrate binding and conservation of selectivity in the CLC family of channels and transporters. Nature structural & molecular biology. 2009 Academic Article GET IT
Times cited: 91
Ion permeation through a Cl--selective channel designed from a CLC Cl-/H+ exchanger. Proceedings of the National Academy of Sciences of the United States of America. 2008 Academic Article GET IT
Times cited: 92
Uncoupling and turnover in a Cl-/H+ exchange transporter. The Journal of general physiology. 2007 Academic Article GET IT
Times cited: 117
Synergism between halide binding and proton transport in a CLC-type exchanger. Journal of molecular biology. 2006 Academic Article GET IT
Times cited: 84
Separate ion pathways in a Cl-/H+ exchanger. The Journal of general physiology. 2005 Academic Article GET IT
Times cited: 185
Secondary active transport mediated by a prokaryotic homologue of ClC Cl- channels. Nature. 2004 Academic Article GET IT
Times cited: 490
Ionic currents mediated by a prokaryotic homologue of CLC Cl- channels. The Journal of general physiology. 2004 Academic Article GET IT
Times cited: 127
Conformational changes in the C terminus of Shaker K+ channel bound to the rat Kvbeta2-subunit. Proceedings of the National Academy of Sciences of the United States of America. 2003 Academic Article GET IT
Times cited: 53
Conformational changes in the pore of CLC-0. The Journal of general physiology. 2003 Academic Article GET IT
Times cited: 75
Conservation of chloride channel structure revealed by an inhibitor binding site in ClC-1. Neuron. 2003 Academic Article GET IT
Times cited: 141
A biological role for prokaryotic ClC chloride channels. Nature. 2002 Academic Article GET IT
Times cited: 163
Mechanisms of block of muscle type CLC chloride channels (Review). Molecular membrane biology. 2002 Information Resource GET IT
Times cited: 26
Molecular requisites for drug binding to muscle CLC-1 and renal CLC-K channel revealed by the use of phenoxy-alkyl derivatives of 2-(p-chlorophenoxy)propionic acid. Molecular pharmacology. 2002 Academic Article GET IT
Times cited: 39
Drastic reduction of the slow gate of human muscle chloride channel (ClC-1) by mutation C277S. The Journal of physiology. 2001 Academic Article GET IT
Times cited: 45
Mechanism of block of single protopores of the Torpedo chloride channel ClC-0 by 2-(p-chlorophenoxy)butyric acid (CPB). The Journal of general physiology. 2001 Academic Article GET IT
Times cited: 33
Fast and slow gating relaxations in the muscle chloride channel CLC-1. The Journal of general physiology. 2000 Academic Article GET IT
Times cited: 100
Pharmacological characterization of chloride channels belonging to the ClC family by the use of chiral clofibric acid derivatives. Molecular pharmacology. 2000 Academic Article GET IT
Times cited: 56
Chloride channels activated by hypotonicity in N2A neuroblastoma cell line. Experimental brain research. 1999 Academic Article GET IT
Times cited: 23

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Research

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Funding awarded

Structure and function of chloride channels, transporters and scramblases awarded by National Institute of General Medical Sciences Principal Investigator 2024 - 2028
Structural basis of apoptotic scrambling awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2024 - 2028
missing activity Principal Investigator 2023 - 2024
missing activity Principal Investigator 2019 - 2024
missing activity Principal Investigator 2019 - 2023

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Background

education and training

Ph.D., University of Genoa (Italy) 2002
Laurea (BS/MS), University of Rome I "La Sapienza" (Italy) 1997

Contact

full name

Alessio Accardi

primary email

ala2022@med.cornell.edu

VIVO Weill Cornell Medical College

Alessio Accardi Professor of Physiology and Biophysics in Anesthesiology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email