Orr, Adam

Publications

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selected publications

Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology. Nature metabolism. 2025 Academic Article GET IT
Times cited: 5
Identifying Links between Alzheimer's Disease and Type 2 Diabetes through Proteomics. Journal of proteome research. 2025 Information Resource GET IT
Neuroimmune signaling mediates astrocytic nucleocytoplasmic disruptions and stress granule formation associated with TDP-43 pathology. Neurobiology of disease. 2025 Academic Article GET IT
Times cited: 1
Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology. bioRxiv : the preprint server for biology. 2024 Article GET IT
Hippocampal astrocytes induce sex-dimorphic effects on memory. Cell reports. 2024 Academic Article GET IT
Times cited: 15
Astrocytes in selective vulnerability to neurodegenerative disease. Trends in neurosciences. 2024 Information Resource GET IT
Times cited: 32
Systems-level analyses dissociate genetic regulators of reactive oxygen species and energy production. Proceedings of the National Academy of Sciences of the United States of America. 2024 Academic Article GET IT
Times cited: 18
Systems-level analyses dissociate genetic regulators of reactive oxygen species and energy production. bioRxiv : the preprint server for biology. 2023 Article GET IT
Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines. Science advances. 2023 Academic Article GET IT
Times cited: 34
Quantitative Proteomic Analysis Reveals apoE4-Dependent Phosphorylation of the Actin-Regulating Protein VASP. Molecular & cellular proteomics : MCP. 2023 Academic Article GET IT
Times cited: 6
Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia. Molecular neurodegeneration. 2022 Academic Article GET IT
Times cited: 81
The use of site-specific suppressors to measure the relative contributions of different mitochondrial sites to skeletal muscle superoxide and hydrogen peroxide production. Redox biology. 2019 Academic Article GET IT
Times cited: 61
To be or not to be pink(1): contradictory findings in an animal model for Parkinson's disease. Brain communications. 2019 Academic Article GET IT
Times cited: 27
Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function. Journal of Alzheimer's disease : JAD. 2019 Academic Article GET IT
Times cited: 76
Plate-Based Measurement of Superoxide and Hydrogen Peroxide Production by Isolated Mitochondria. Methods in molecular biology (Clifton, N.J.). 2018 Academic Article GET IT
Times cited: 13
Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons. eNeuro. 2017 Academic Article GET IT
Times cited: 19
Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease. Neurochemistry international. 2017 Academic Article GET IT
Times cited: 41
Suppressors of Superoxide-H₂O₂ Production at Site I_Q of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury. Cell metabolism. 2016 Academic Article GET IT
Times cited: 199
Suppressors of superoxide production from mitochondrial complex III. Nature chemical biology. 2015 Academic Article GET IT
Times cited: 183
Production of superoxide/H2O2 by dihydroorotate dehydrogenase in rat skeletal muscle mitochondria. Free radical biology & medicine. 2014 Academic Article GET IT
Times cited: 75
Novel inhibitors of mitochondrial sn-glycerol 3-phosphate dehydrogenase. PloS one. 2014 Academic Article GET IT
Times cited: 58
Inhibitors of ROS production by the ubiquinone-binding site of mitochondrial complex I identified by chemical screening. Free radical biology & medicine. 2013 Academic Article GET IT
Times cited: 73
The role of mitochondrial function and cellular bioenergetics in ageing and disease. The British journal of dermatology. 2013 Information Resource GET IT
Times cited: 256
Sites of reactive oxygen species generation by mitochondria oxidizing different substrates. Redox biology. 2013 Academic Article GET IT
Times cited: 532
NF-κB activity is inversely correlated to RNF11 expression in Parkinson's disease. Neuroscience letters. 2013 Academic Article GET IT
Times cited: 24
Sites of superoxide and hydrogen peroxide production during fatty acid oxidation in rat skeletal muscle mitochondria. Free radical biology & medicine. 2013 Academic Article GET IT
Times cited: 110
A refined analysis of superoxide production by mitochondrial sn-glycerol 3-phosphate dehydrogenase. The Journal of biological chemistry. 2012 Academic Article GET IT
Times cited: 151
Native rates of superoxide production from multiple sites in isolated mitochondria measured using endogenous reporters. Free radical biology & medicine. 2012 Academic Article GET IT
Times cited: 142
Mitochondrial complex II can generate reactive oxygen species at high rates in both the forward and reverse reactions. The Journal of biological chemistry. 2012 Academic Article GET IT
Times cited: 581
Comparative distribution of protein components of the A20 ubiquitin-editing complex in normal human brain. Neuroscience letters. 2012 Academic Article GET IT
Times cited: 20
Neuronal RING finger protein 11 (RNF11) regulates canonical NF-κB signaling. Journal of neuroinflammation. 2012 Academic Article GET IT
Times cited: 17
A reduction in ATP demand and mitochondrial activity with neural differentiation of human embryonic stem cells. Journal of cell science. 2011 Academic Article GET IT
Times cited: 158
Impaired mitochondrial trafficking in Huntington's disease. Biochimica et biophysica acta. 2009 Information Resource GET IT
Times cited: 62
Adenosine A(2A) receptor mediates microglial process retraction. Nature neuroscience. 2009 Academic Article GET IT
Times cited: 308
A FRET-based method to study protein thiol oxidation in histological preparations. Free radical biology & medicine. 2008 Academic Article GET IT
Times cited: 30
Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease. Human molecular genetics. 2008 Academic Article GET IT
Times cited: 141
Sex-dependent effect of BAG1 in ameliorating motor deficits of Huntington disease transgenic mice. The Journal of biological chemistry. 2008 Academic Article GET IT
Times cited: 30
Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice. The Journal of cell biology. 2008 Academic Article GET IT
Times cited: 154
N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 Academic Article GET IT
Times cited: 363

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Research

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Funding awarded

Uncovering Dementia-Related Lipid Alterations and Mechanisms in Astrocytes awarded by National Institute on Aging Co-Investigator 2024 - 2026
Defining the Effects of Astrocytic TDP-43 Dysregulation on Hippocampal Function awarded by National Institute of Neurological Disorders & Stroke Co-Investigator 2020 - 2026
Mitochondrial Complex III Free Radicals in Dementia-Related Proteinopathy and Neuroinflammation awarded by National Institute on Aging Co-Investigator 2020 - 2026

Complex III-derived reactive oxygen species in mitochondrial-nuclear crosstalk in Alzheimer''s disease and related dementias awarded by National Institute on Aging Co-Principal Investigator 2025 - 2030

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Background

education and training

Ph.D., Emory University 2008
B.S., Trinity College 2000

Contact

full name

Adam Orr

VIVO Weill Cornell Medical College

Adam Orr Assistant Professor of Research in Neuroscience

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name