My research interests are primarily centered around complex diseases, with a specific focus on cancer. I am considering integrated omics technologies, such as metabolomics, proteomics and transcriptomics, as a powerful tool which could be used to identify novel targets for more effective and rational treatment strategies in the field of oncology. Furthermore, I am seeing translation of multiomics strategies into the clinical pipeline as a critical step which can accelerate both diagnostics and treatment modalities.

Therefore, Halama lab is taking a multidisciplinary approach, bridging the gap between clinical and basic research to gain a comprehensive understanding of cancer and its underlying mechanisms. This is achieved by close collaboration with clinicians which enables combination of insights from both clinical and laboratory settings, thus developing a holistic perspective that can lead to innovative solutions and advancements in cancer research and treatment.

My lab is focusing on both clinical and basic research. In the context of clinical research, we are actively developing strategies for tissue sample collection from the operating theater, designed to facilitate multi-omics profiling. This approach is meant to provide a better understanding of dysregulated tumor metabolism and its interplay with the micro and macro (host) environment. Our aim is to identify metabolic and molecular features contributing to cancer resistance which could be further probed as biomarkers as well as novel treatment targets. In our basic lab approach, we use in vitro and in ovo models to investigate the role of dysregulated cancer metabolism in drug resistance and metastasis. Our aim is to uncover metabolic vulnerabilities within cancer that can be leveraged as potential treatment targets.

Grants

I have a teaching experience in the field of biochemistry, particularly focusing on metabolic syndrome and the Warburg effect. My expertise lies in the foundational aspects of biochemistry, which are integral to the medical curriculum. Additionally, I co-direct a new program dedicated to assisting medical students in preparing for the USMLE/IFOM exams, ensuring their success in these critical assessments.

Furthermore, I co-direct an area of concentration course that aims to equip future clinicians with the essential knowledge and skills necessary for engaging in research activities. This course facilitates a bridge between clinical practice and scientific inquiry.

I am passionate about implementation of new technologies and currently I am assessing virtual reality (VR) solutions in my teaching methods to explore how this technology can enhance the learning experience for Generation Z students. This approach reflects my interest to adapt and modernize pedagogical methods to meet the evolving needs of students in the digital age.