Laughney, Ashley

Publications

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selected publications

Micronuclear collapse from oxidative damage. Science (New York, N.Y.). 2024 Academic Article GET IT
Lineage-specific intolerance to oncogenic drivers restricts histological transformation. Science (New York, N.Y.). 2024 Academic Article GET IT
Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation. Nature cancer. 2024 Academic Article GET IT
Non-cell-autonomous cancer progression from chromosomal instability. Nature. 2023 Academic Article GET IT
Modeling collective cell behavior in cancer: Perspectives from an interdisciplinary conversation. Cell systems. 2023 Academic Article GET IT
Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in BRCA1 or BRCA2. Science translational medicine. 2023 Academic Article GET IT
Times cited: 1
Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression. Nature communications. 2022 Academic Article GET IT
Times cited: 33
Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression. Nature communications. 2021 Academic Article GET IT
Times cited: 32
Cancer metastasis as a non-healing wound. British journal of cancer. 2021 Information Resource GET IT
High-resolution mouse subventricular zone stem-cell niche transcriptome reveals features of lineage, anatomy, and aging. Proceedings of the National Academy of Sciences of the United States of America. 2020 Academic Article GET IT
Times cited: 38
Regenerative lineages and immune-mediated pruning in lung cancer metastasis. Nature medicine. 2020 Academic Article GET IT
Times cited: 262
Adult Human Glioblastomas Harbor Radial Glia-like Cells. Stem cell reports. 2020 Academic Article GET IT
Times cited: 30
L1CAM defines the regenerative origin of metastasis-initiating cells in colorectal cancer. Nature cancer. 2020 Academic Article GET IT
Times cited: 163
Urothelial organoids originating from Cd49f^high mouse stem cells display Notch-dependent differentiation capacity. Nature communications. 2019 Academic Article GET IT
Times cited: 45
A Markov chain for numerical chromosomal instability in clonally expanding populations. PLoS computational biology. 2018 Academic Article GET IT
Times cited: 16
Chromosomal instability drives metastasis through a cytosolic DNA response. Nature. 2018 Academic Article GET IT
Times cited: 1065
Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle. Science translational medicine. 2015 Academic Article GET IT
Times cited: 286
Dynamics of Tumor Heterogeneity Derived from Clonal Karyotypic Evolution. Cell reports. 2015 Academic Article GET IT
Times cited: 53
Numerical chromosomal instability mediates susceptibility to radiation treatment. Nature communications. 2015 Academic Article GET IT
Times cited: 63
Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin. Science translational medicine. 2014 Academic Article GET IT
Times cited: 75
In vivo imaging of multidrug resistance using a third generation MDR1 inhibitor. Bioconjugate chemistry. 2014 Academic Article GET IT
Times cited: 20
A photoactivatable drug-caged fluorophore conjugate allows direct quantification of intracellular drug transport. Chemical communications (Cambridge, England). 2013 Academic Article GET IT
Times cited: 15
Direct identification of breast cancer pathologies using blind separation of label-free localized reflectance measurements. Biomedical optics express. 2013 Academic Article GET IT
Times cited: 12
System analysis of spatial frequency domain imaging for quantitative mapping of surgically resected breast tissues. Journal of biomedical optics. 2013 Academic Article GET IT
Times cited: 48
Scanning in situ spectroscopy platform for imaging surgical breast tissue specimens. Optics express. 2013 Academic Article GET IT
Spectral discrimination of breast pathologies in situ using spatial frequency domain imaging. Breast cancer research : BCR. 2013 Academic Article GET IT
Times cited: 80
Scatter spectroscopic imaging distinguishes between breast pathologies in tissues relevant to surgical margin assessment. Clinical cancer research : an official journal of the American Association for Cancer Research. 2012 Academic Article GET IT
Times cited: 43
Dark-field scanning in situ spectroscopy platform for broadband imaging of resected tissue. Optics letters. 2011 Academic Article GET IT
Times cited: 11
Measurement of pressure-displacement kinetics of hemoglobin in normal breast tissue with near-infrared spectral imaging. Applied optics. 2009 Academic Article GET IT
Times cited: 30

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Research

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Funding awarded

A systems-level approach to therapeutically target STING in cancer awarded by National Cancer Institute Principal Investigator 2025 - 2030
Dissecting the impact of tumor-intrinsic chromosomal instability on the cancer ecosystem awarded by National Cancer Institute Principal Investigator 2023 - 2028
SatSeq: a scalable platform to effectively target multi-modal proteins in cancer awarded by Pershing Square Sohn Cancer Research Alliance, The Principal Investigator 2024 - 2027
Probing cytosolic nucleic acid sensing pathways in cancer awarded by National Cancer Institute Principal Investigator 2021 - 2025
Uncovering transcriptional vulnerabilities in latent metastasis awarded by Burroughs Wellcome Fund Principal Investigator 2019 - 2025
Role of the smooth muscle layer in bladder cancer biology and progression: a systems and experimental approach awarded by National Cancer Institute Principal Investigator 2023 - 2024

"Novel Mouse Models for Quantitative Understanding of Baseline and Therapy-Driven Evolution of Prostate Cancer Metastasis" awarded by National Cancer Institute Co-Investigator 2023 - 2028
Targeting immune evasion in gastroesophageal cancer awarded by Stand Up To Cancer Co-Investigator 2023 - 2026

Targeting immune evasion in gastroesophageal cancer awarded by Stand Up To Cancer Co-Principal Investigator 2023 - 2026

Multi-cellular interactions defining the human brain metastatic niche awarded by National Institute of Child Health & Human Development Principal Investigator Subaward 2023 - 2028

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Background

education and training

Ph.D., Dartmouth College 2012
B.S., University of Vermont 2007

Contact

full name

Ashley Laughney

primary email

asl4003@med.cornell.edu

VIVO Weill Cornell Medical College

Ashley Laughney Associate Professor of Physiology and Biophysics

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email