Laughney, Ashley

Publications

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selected publications

Micronuclear collapse from oxidative damage. Science (New York, N.Y.). 2024 Academic Article GET IT
Lineage-specific intolerance to oncogenic drivers restricts histological transformation. Science (New York, N.Y.). 2024 Academic Article GET IT
Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation. Nature cancer. 2024 Academic Article GET IT
Times cited: 12
Non-cell-autonomous cancer progression from chromosomal instability. Nature. 2023 Academic Article GET IT
Modeling collective cell behavior in cancer: Perspectives from an interdisciplinary conversation. Cell systems. 2023 Academic Article GET IT
Times cited: 5
Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in BRCA1 or BRCA2. Science translational medicine. 2023 Academic Article GET IT
Times cited: 1
Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression. Nature communications. 2022 Academic Article GET IT
Times cited: 37
Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression. Nature communications. 2021 Academic Article GET IT
Times cited: 34
Cancer metastasis as a non-healing wound. British journal of cancer. 2021 Information Resource GET IT
How Has the COVID-19 Pandemic Changed How You Will Approach Research and Lab Work in the Future?. Cell systems. 2020 Academic Article GET IT
High-resolution mouse subventricular zone stem-cell niche transcriptome reveals features of lineage, anatomy, and aging. Proceedings of the National Academy of Sciences of the United States of America. 2020 Academic Article GET IT
Times cited: 39
Adult Human Glioblastomas Harbor Radial Glia-like Cells. 2020 GET IT
Times cited: 2
Regenerative lineages and immune-mediated pruning in lung cancer metastasis. Nature medicine. 2020 Academic Article GET IT
Times cited: 275
Adult Human Glioblastomas Harbor Radial Glia-like Cells. Stem cell reports. 2020 Academic Article GET IT
Times cited: 31
L1CAM defines the regenerative origin of metastasis-initiating cells in colorectal cancer. Nature cancer. 2020 Academic Article GET IT
Times cited: 170
Urothelial organoids originating from Cd49f^high mouse stem cells display Notch-dependent differentiation capacity. Nature communications. 2019 Academic Article GET IT
Times cited: 48
A Markov chain for numerical chromosomal instability in clonally expanding populations. PLoS computational biology. 2018 Academic Article GET IT
Times cited: 16
Chromosomal instability drives metastasis through a cytosolic DNA response. Nature. 2018 Academic Article GET IT
Times cited: 1099
Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle. Science translational medicine. 2015 Academic Article GET IT
Times cited: 289
Dynamics of Tumor Heterogeneity Derived from Clonal Karyotypic Evolution. Cell reports. 2015 Academic Article GET IT
Times cited: 93
Numerical chromosomal instability mediates susceptibility to radiation treatment. Nature communications. 2015 Academic Article GET IT
Times cited: 66
Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin. Science translational medicine. 2014 Academic Article GET IT
Times cited: 75
In vivo imaging of multidrug resistance using a third generation MDR1 inhibitor. Bioconjugate chemistry. 2014 Academic Article GET IT
Times cited: 20
A photoactivatable drug-caged fluorophore conjugate allows direct quantification of intracellular drug transport. Chemical communications (Cambridge, England). 2013 Academic Article GET IT
Times cited: 15
Direct identification of breast cancer pathologies using blind separation of label-free localized reflectance measurements. Biomedical optics express. 2013 Academic Article GET IT
Times cited: 12
System analysis of spatial frequency domain imaging for quantitative mapping of surgically resected breast tissues. Journal of biomedical optics. 2013 Academic Article GET IT
Times cited: 48
Scanning in situ spectroscopy platform for imaging surgical breast tissue specimens. Optics express. 2013 Academic Article GET IT
Times cited: 8
Spectral discrimination of breast pathologies in situ using spatial frequency domain imaging. Breast cancer research : BCR. 2013 Academic Article GET IT
Times cited: 82
Scatter spectroscopic imaging distinguishes between breast pathologies in tissues relevant to surgical margin assessment. Clinical cancer research : an official journal of the American Association for Cancer Research. 2012 Academic Article GET IT
Times cited: 43
Dark-field scanning in situ spectroscopy platform for broadband imaging of resected tissue. Optics letters. 2011 Academic Article GET IT
Times cited: 11
Automated classification of breast pathology using local measures of broadband reflectance. Journal of biomedical optics. 2010 Academic Article GET IT
Times cited: 31
Measurement of pressure-displacement kinetics of hemoglobin in normal breast tissue with near-infrared spectral imaging. Applied optics. 2009 Academic Article GET IT
Times cited: 30

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Research

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Co-investigator Network

Funding awarded

A systems-level approach to therapeutically target STING in cancer awarded by National Cancer Institute Principal Investigator 2025 - 2030
Dissecting the impact of tumor-intrinsic chromosomal instability on the cancer ecosystem awarded by National Cancer Institute Principal Investigator 2023 - 2028
SatSeq: a scalable platform to effectively target multi-modal proteins in cancer awarded by Pershing Square Sohn Cancer Research Alliance, The Principal Investigator 2024 - 2027
Uncovering transcriptional vulnerabilities in latent metastasis awarded by Burroughs Wellcome Fund Principal Investigator 2019 - 2026
Role of the smooth muscle layer in bladder cancer biology and progression: a systems and experimental approach awarded by National Cancer Institute Principal Investigator 2022 - 2025
Probing cytosolic nucleic acid sensing pathways in cancer awarded by National Cancer Institute Principal Investigator 2021 - 2025

"Novel Mouse Models for Quantitative Understanding of Baseline and Therapy-Driven Evolution of Prostate Cancer Metastasis" awarded by National Cancer Institute Co-Investigator 2023 - 2028

Targeting immune evasion in gastroesophageal cancer awarded by Stand Up To Cancer Co-Principal Investigator 2023 - 2026

Multi-cellular interactions defining the human brain metastatic niche awarded by National Institute of Child Health & Human Development Principal Investigator Subaward 2023 - 2028

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Background

education and training

Ph.D., Dartmouth College 2012
B.S., University of Vermont 2007

Contact

full name

Ashley Laughney

primary email

asl4003@med.cornell.edu

VIVO Weill Cornell Medical College

Ashley Laughney Associate Professor of Physiology and Biophysics

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email