My laboratory utilizes high-throughput single cell sequencing and quantitative imaging technologies, as well as mouse models of metastasis, to mechanistically dissect tumour cell heterogeneity through the lens of tissue regeneration and repair. We are systematically dissecting lineage-specific immune vulnerabilities across epithelial cell states observed in development and cancer progression by combining single cell methods with targeted perturbations. By integrating systems biology methods within a hypothesis driven framework, our goal is to better understand how developmental plasticity amongst individual cancer cells shapes immune susceptibility and lethal transitions like metastasis or the emergence of drug resistance.