Barany, Francis

Publications

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selected publications

Combinatorial Ubiquitination REal-time PROteolysis (CURE-PROs): A Modular Platform for Generating Reversible, Self-Assembling Bifunctional Targeted Degraders. Journal of medicinal chemistry. 2024 Academic Article GET IT
Times cited: 3
Reversible Assembly of Proteolysis Targeting Chimeras. ACS chemical biology. 2023 Academic Article GET IT
Multi-CpG linear regression models to accurately predict paclitaxel and docetaxel activity in cancer cell lines. Advances in cancer research. 2022 Review GET IT
A Unified Transcriptional, Pharmacogenomic, and Gene Dependency Approach to Decipher the Biology, Diagnostic Markers, and Therapeutic Targets Associated with Prostate Cancer Metastasis. Cancers. 2021 Academic Article GET IT
Times cited: 6
Solid-phase XRN1 reactions for RNA cleavage: application in single-molecule sequencing. Nucleic acids research. 2021 Academic Article GET IT
Times cited: 5
MGMT Epigenetics: The Influence of Gene Body Methylation and Other Insights Derived from Integrated Methylomic, Transcriptomic, and Chromatin Analyses in Various Cancer Types. Current cancer drug targets. 2021 Academic Article GET IT
Times cited: 2
PROTACs: Promising Approaches for Epigenetic Strategies to Overcome Drug Resistance. Current cancer drug targets. 2021 Information Resource GET IT
Application of Multiplex Bisulfite PCR-Ligase Detection Reaction-Real-Time Quantitative PCR Assay in Interrogating Bioinformatically Identified, Blood-Based Methylation Markers for Colorectal Cancer. The Journal of molecular diagnostics : JMD. 2020 Academic Article GET IT
Times cited: 6
Novel, Self-Assembling Dimeric Inhibitors of Human β Tryptase. Journal of medicinal chemistry. 2020 Academic Article GET IT
Times cited: 7
Single-molecule detection of cancer mutations using a novel PCR-LDR-qPCR assay. Human mutation. 2020 Academic Article GET IT
Times cited: 8
Prediction of blood-based biomarkers and subsequent design of bisulfite PCR-LDR-qPCR assay for breast cancer detection. BMC cancer. 2020 Academic Article GET IT
Times cited: 12
Can CpG methylation serve as surrogate markers for immune infiltration in cancer? 2019 GET IT
Times cited: 10
Pathways- and epigenetic-based assessment of relative immune infiltration in various types of solid tumors. 2019 GET IT
Times cited: 5
A Multiplex PCR/LDR Assay for Viral Agents of Diarrhea with the Capacity to Genotype Rotavirus. Scientific reports. 2018 Academic Article GET IT
Times cited: 2
A Novel, Nonpeptidic, Orally Active Bivalent Inhibitor of Human β-Tryptase. Pharmacology. 2018 Academic Article GET IT
Times cited: 8
Target-Directed Self-Assembly of Homodimeric Drugs Against β-Tryptase. ACS medicinal chemistry letters. 2018 Academic Article GET IT
Times cited: 5
Immune infiltration, glioma stratification, and therapeutic implications. Translational cancer research. 2016 Academic Article GET IT
Times cited: 12
A Multiplex PCR/LDR Assay for the Simultaneous Identification of Category A Infectious Pathogens: Agents of Viral Hemorrhagic Fever and Variola Virus. PloS one. 2015 Academic Article GET IT
Times cited: 17
Reversible linkage of two distinct small molecule inhibitors of Myc generates a dimeric inhibitor with improved potency that is active in myc over-expressing cancer cell lines. PloS one. 2015 Academic Article GET IT
Times cited: 14
High incidence of LRAT promoter hypermethylation in colorectal cancer correlates with tumor stage. Medical oncology (Northwood, London, England). 2014 Academic Article GET IT
Times cited: 8
A multiplex PCR/LDR assay for simultaneous detection and identification of the NIAID category B bacterial food and water-borne pathogens. Diagnostic microbiology and infectious disease. 2014 Academic Article GET IT
Times cited: 13
Modular microfluidic system fabricated in thermoplastics for the strain-specific detection of bacterial pathogens. Lab on a chip. 2012 Academic Article GET IT
Times cited: 35
Fully integrated thermoplastic genosensor for the highly sensitive detection and identification of multi-drug-resistant tuberculosis. Angewandte Chemie (International ed. in English). 2012 Academic Article GET IT
Times cited: 41
Molecular profiling of colon tumors: the search for clinically relevant biomarkers of progression, prognosis, therapeutics, and predisposition. Annals of surgical oncology. 2011 Review GET IT
Times cited: 52
High-throughput selection, enumeration, electrokinetic manipulation, and molecular profiling of low-abundance circulating tumor cells using a microfluidic system. Analytical chemistry. 2011 Academic Article GET IT
Times cited: 163
Ligase detection reaction generation of reverse molecular beacons for near real-time analysis of bacterial pathogens using single-pair fluorescence resonance energy transfer and a cyclic olefin copolymer microfluidic chip. Analytical chemistry. 2010 Academic Article GET IT
Times cited: 31
Gene dysregulations driven by somatic copy number aberrations-biological and clinical implications in colon tumors: a paper from the 2009 William Beaumont Hospital Symposium on Molecular Pathology. The Journal of molecular diagnostics : JMD. 2010 Review GET IT
Times cited: 24
Improved testing for microsatellite instability in colorectal cancer using a simplified 3-marker assay. Annals of surgical oncology. 2010 Academic Article GET IT
Times cited: 18
Loss of imprinting and marked gene elevation are 2 forms of aberrant IGF2 expression in colorectal cancer. International journal of cancer. 2010 Academic Article GET IT
Times cited: 51
PCR/LDR/universal array platforms for the diagnosis of infectious disease. Methods in molecular biology (Clifton, N.J.). 2010 Academic Article GET IT
Times cited: 6
KRAS mutation and microsatellite instability: two genetic markers of early tumor development that influence the prognosis of colorectal cancer. Annals of surgical oncology. 2009 Academic Article GET IT
Times cited: 86
Association of survival and disease progression with chromosomal instability: a genomic exploration of colorectal cancer. Proceedings of the National Academy of Sciences of the United States of America. 2009 Academic Article GET IT
Times cited: 315
Genome-wide autozygosity mapping in human populations. Genetic epidemiology. 2009 Academic Article GET IT
Times cited: 49
Emerging paradigms in cancer genetics: some important findings from high-density single nucleotide polymorphism array studies. Cancer research. 2009 Review GET IT
Times cited: 44
Ligase detection reaction for the analysis of point mutations using free-solution conjugate electrophoresis in a polymer microfluidic device. Electrophoresis. 2008 Academic Article GET IT
Times cited: 23
CpG island methylator phenotype associates with low-degree chromosomal abnormalities in colorectal cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2008 Academic Article GET IT
Times cited: 89
Detection and serotyping of dengue virus in serum samples by multiplex reverse transcriptase PCR-ligase detection reaction assay. Journal of clinical microbiology. 2008 Academic Article GET IT
Times cited: 49
Genetic variants in germline TP53 and MDM2 SNP309 are not associated with early onset colorectal cancer. Journal of surgical oncology. 2008 Academic Article GET IT
Times cited: 7
Development of multiplex PCR-ligase detection reaction assay for detection of West Nile virus. Journal of clinical microbiology. 2008 Academic Article GET IT
Times cited: 36
c-Met gene amplification is associated with advanced stage colorectal cancer and liver metastases. Cancer letters. 2008 Academic Article GET IT
Times cited: 163
The signatures of autozygosity among patients with colorectal cancer. Cancer research. 2008 Academic Article GET IT
Times cited: 43
MDM2 gene amplification is correlated to tumor progression but not to the presence of SNP309 or TP53 mutational status in primary colorectal cancers. Molecular cancer research : MCR. 2008 Academic Article GET IT
Times cited: 42
Expression of L1-CAM and ADAM10 in human colon cancer cells induces metastasis. Cancer research. 2007 Academic Article GET IT
Times cited: 154
Serial processing of biological reactions using flow-through microfluidic devices: coupled PCR/LDR for the detection of low-abundant DNA point mutations. The Analyst. 2007 Academic Article GET IT
Times cited: 43
Multiplexed identification of blood-borne bacterial pathogens by use of a novel 16S rRNA gene PCR-ligase detection reaction-capillary electrophoresis assay. Journal of clinical microbiology. 2007 Academic Article GET IT
Times cited: 38
Switching base preferences of mismatch cleavage in endonuclease V: an improved method for scanning point mutations. Nucleic acids research. 2006 Academic Article GET IT
Times cited: 12
GROalpha is highly expressed in adenocarcinoma of the colon and down-regulates fibulin-1. Clinical cancer research : an official journal of the American Association for Cancer Research. 2006 Academic Article GET IT
Times cited: 50
Harnessing asymmetrical substrate recognition by thermostable EndoV to achieve balanced linear amplification in multiplexed SNP typing. Biochemistry and cell biology = Biochimie et biologie cellulaire. 2006 Academic Article GET IT
Times cited: 3
Relationship of gene expression and chromosomal abnormalities in colorectal cancer. Cancer research. 2006 Academic Article GET IT
Times cited: 211
Multiplexed profiling of candidate genes for CpG island methylation status using a flexible PCR/LDR/Universal Array assay. Genome research. 2005 Academic Article GET IT
Times cited: 34
Ligase detection reaction/hybridization assays using three-dimensional microfluidic networks for the detection of low-abundant DNA point mutations. Analytical chemistry. 2005 Academic Article GET IT
Times cited: 71
Detection of the BRAF V600E mutation in melanocytic lesions using the ligase detection reaction. Journal of cutaneous pathology. 2005 Academic Article GET IT
Times cited: 35
Fabrication of DNA microarrays onto poly(methyl methacrylate) with ultraviolet patterning and microfluidics for the detection of low-abundant point mutations. Analytical biochemistry. 2005 Academic Article GET IT
Times cited: 74
Classification of BRCA1 missense variants of unknown clinical significance. Journal of medical genetics. 2005 Academic Article GET IT
Times cited: 83
Applications of the universal DNA microarray in molecular medicine. Methods in molecular medicine. 2005 Academic Article GET IT
Times cited: 13
High sensitivity EndoV mutation scanning through real-time ligase proofreading. Nucleic acids research. 2004 Academic Article GET IT
Times cited: 27
Unique ligation properties of eukaryotic NAD+-dependent DNA ligase from Melanoplus sanguinipes entomopoxvirus. Biochimica et biophysica acta. 2004 Academic Article GET IT
Times cited: 14
Harmonized microarray/mutation scanning analysis of TP53 mutations in undissected colorectal tumors. Human mutation. 2004 Academic Article GET IT
Times cited: 18
Capillary and microelectrophoretic separations of ligase detection reaction products produced from low-abundant point mutations in genomic DNA. Electrophoresis. 2004 Academic Article GET IT
Times cited: 100
Rapid and sensitive p53 alteration analysis in biopsies from lung cancer patients using a functional assay and a universal oligonucleotide array: a prospective study. Clinical cancer research : an official journal of the American Association for Cancer Research. 2004 Academic Article GET IT
Times cited: 28
The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability. Proceedings of the National Academy of Sciences of the United States of America. 2003 Academic Article GET IT
Times cited: 170
Automated, multiplex assay for high-frequency microsatellite instability in colorectal cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2003 Academic Article GET IT
Times cited: 32
HER 2/neu expression and gene amplification in colon cancer. International journal of cancer. 2003 Academic Article GET IT
Times cited: 80
Approaching real-time molecular diagnostics: single-pair fluorescence resonance energy transfer (spFRET) detection for the analysis of low abundant point mutations in K-ras oncogenes. Journal of the American Chemical Society. 2003 Academic Article GET IT
Times cited: 134
Microarrays assembled in microfluidic chips fabricated from poly(methyl methacrylate) for the detection of low-abundant DNA mutations. Analytical chemistry. 2003 Academic Article GET IT
Times cited: 143
Mutational analysis of endonuclease V from Thermotoga maritima. Biochemistry. 2002 Academic Article GET IT
Times cited: 24
An endonuclease/ligase based mutation scanning method especially suited for analysis of neoplastic tissue. Oncogene. 2002 Academic Article GET IT
Times cited: 38
Multiple cleavage activities of endonuclease V from Thermotoga maritima: recognition and strand nicking mechanism. Biochemistry. 2001 Academic Article GET IT
Times cited: 48
Detecting colorectal cancer in stool with the use of multiple genetic targets. Journal of the National Cancer Institute. 2001 Academic Article GET IT
Times cited: 314
Universal DNA array detection of small insertions and deletions in BRCA1 and BRCA2. Nature biotechnology. 2000 Academic Article GET IT
Times cited: 183
Ligation reaction specificities of an NAD(+)-dependent DNA ligase from the hyperthermophile Aquifex aeolicus. Nucleic acids research. 2000 Academic Article GET IT
Times cited: 40
Improved fidelity of thermostable ligases for detection of microsatellite repeat sequences using nucleoside analogs. Nucleic acids research. 1999 Academic Article GET IT
Times cited: 10
Ligase-based detection of mononucleotide repeat sequences. Nucleic acids research. 1999 Academic Article GET IT
Times cited: 21
Universal DNA microarray method for multiplex detection of low abundance point mutations. Journal of molecular biology. 1999 Academic Article GET IT
Times cited: 288
Ligase detection reaction for identification of low abundance mutations. Clinical biochemistry. 1999 Academic Article GET IT
Times cited: 45
Nucleotide analogs and new buffers improve a generalized method to enrich for low abundance mutations. Nucleic acids research. 1999 Academic Article GET IT
Times cited: 9
Nucleotide analogs facilitate base conversion with 3' mismatch primers. Nucleic acids research. 1999 Academic Article GET IT
Times cited: 37
Biochemical properties of a high fidelity DNA ligase from Thermus species AK16D. Nucleic acids research. 1999 Academic Article GET IT
Times cited: 83
Multiplex PCR/LDR for detection of K-ras mutations in primary colon tumors. Oncogene. 1999 Academic Article GET IT
Times cited: 147
Identification of TaqI endonuclease active site residues by Fe2+-mediated oxidative cleavage. The Journal of biological chemistry. 1998 Academic Article GET IT
Times cited: 26
Cloning and thermostability of TaqI endonuclease isoschizomers from Thermus species SM32 and Thermus filiformis Tok6A1. The Biochemical journal. 1998 Academic Article GET IT
Times cited: 9
Nucleotide sequences and gene organization of TaqI endonuclease isoschizomers from Thermus sp. SM32 and Thermus filiformis Tok6A1. Gene. 1997 Academic Article GET IT
Times cited: 8
Identification of non-amplifying CYP21 genes when using PCR-based diagnosis of 21-hydroxylase deficiency in congenital adrenal hyperplasia (CAH) affected pedigrees. Human molecular genetics. 1996 Academic Article GET IT
Times cited: 117
Identification of essential residues in Thermus thermophilus DNA ligase. Nucleic acids research. 1996 Academic Article GET IT
Times cited: 66
Improving the fidelity of Thermus thermophilus DNA ligase. Nucleic acids research. 1996 Academic Article GET IT
Times cited: 178
Detection of steroid 21-hydroxylase alleles using gene-specific PCR and a multiplexed ligation detection reaction. Genomics. 1995 Academic Article GET IT
Times cited: 105
Stringent and relaxed specificities of TaqI endonuclease: interactions with metal cofactors and DNA sequences. Biochemistry. 1995 Academic Article GET IT
Times cited: 23
Photoaffinity cross-linking of TaqI restriction endonuclease using an aryl azide linked to the phosphate backbone. Gene. 1995 Academic Article GET IT
Times cited: 42
Interaction of TaqI endonuclease with the phosphate backbone. Effects of stereospecific phosphate modification. The Journal of biological chemistry. 1994 Academic Article GET IT
Times cited: 18
Confirmation of mutant alpha 1 Na,K-ATPase gene and transcript in Dahl salt-sensitive/JR rats. Hypertension (Dallas, Tex. : 1979). 1994 Academic Article GET IT
Times cited: 30
Hyperkalemic periodic paralysis: rapid molecular diagnosis and relationship of genotype to phenotype in 12 families. Neurology. 1993 Academic Article GET IT
Times cited: 35
Transcriptional analysis of the active X-chromosome in normal and clonal hematopoiesis. Blood. 1993 Article GET IT
Times cited: 35
Discrimination of Listeria monocytogenes from other Listeria species by ligase chain reaction. Applied and environmental microbiology. 1992 Academic Article GET IT
Times cited: 35
Characterization of steady state, single-turnover, and binding kinetics of the TaqI restriction endonuclease. The Journal of biological chemistry. 1992 Academic Article GET IT
Times cited: 59
DNA recognition of base analogue and chemically modified substrates by the TaqI restriction endonuclease. The Journal of biological chemistry. 1992 Academic Article GET IT
Times cited: 26
Cloning and sequencing of genes encoding the TthHB8I restriction and modification enzymes: comparison with the isoschizomeric TaqI enzymes. Gene. 1992 Academic Article GET IT
Times cited: 40
Correlation between insertion mutant activities and amino acid sequence identities of the TaqI and TthHB8 restriction endonucleases. Gene. 1992 Academic Article GET IT
Times cited: 8
The corrected nucleotide sequences of the TaqI restriction and modification enzymes reveal a thirteen-codon overlap. Gene. 1992 Academic Article GET IT
Times cited: 21
Cloning, overexpression and nucleotide sequence of a thermostable DNA ligase-encoding gene. Gene. 1991 Academic Article GET IT
Times cited: 73
Mapping catalytically important regions of an enzyme using two-codon insertion mutagenesis: a case study correlating beta-lactamase mutants with the three-dimensional structure. Gene. 1991 Academic Article GET IT
Times cited: 12
Genetic disease detection and DNA amplification using cloned thermostable ligase. Proceedings of the National Academy of Sciences of the United States of America. 1991 Academic Article GET IT
Times cited: 683
Observation of arginyl-deoxyoligonucleotide interactions in Taq I endonuclease by detection of specific 1H NMR signals from 140kD [N eta 1, N eta 2, 15N Arg]Taq I/oligomer complexes. Biochemical and biophysical research communications. 1989 Academic Article GET IT
Times cited: 6
How TaqI endonuclease recognizes its cognate sequence. Gene. 1988 Academic Article GET IT
Times cited: 1
Overproduction, purification and crystallization of TaqI restriction endonuclease. Gene. 1988 Academic Article GET IT
Times cited: 26
The TaqI 'star' reaction: strand preferences reveal hydrogen-bond donor and acceptor sites in canonical sequence recognition. Gene. 1988 Academic Article GET IT
Times cited: 25
A genetic system for isolation and characterization of TaqI restriction endonuclease mutants. Gene. 1987 Academic Article GET IT
Times cited: 35
Two-codon insertion mutagenesis of plasmid genes by using single-stranded hexameric oligonucleotides. Proceedings of the National Academy of Sciences of the United States of America. 1985 Academic Article GET IT
Times cited: 88
Comparison of transformation mechanisms of Haemophilus parainfluenzae and Haemophilus influenzae. Journal of bacteriology. 1985 Academic Article GET IT
Times cited: 14
Single-stranded hexameric linkers: a system for in-phase insertion mutagenesis and protein engineering. Gene. 1985 Academic Article GET IT
Times cited: 108
Directional transport and integration of donor DNA in Haemophilus influenzae transformation. Proceedings of the National Academy of Sciences of the United States of America. 1983 Academic Article GET IT
Times cited: 40
Transformasomes: specialized membranous structures that protect DNA during Haemophilus transformation. Proceedings of the National Academy of Sciences of the United States of America. 1983 Academic Article GET IT
Times cited: 87
Genetic transformation of Streptococcus pneumoniae by DNA cloned into the single-stranded bacteriophage f1. Journal of bacteriology. 1983 Academic Article GET IT
Times cited: 6
Staphylococcal plasmids that replicate and express erythromycin resistance in both Streptococcus pneumoniae and Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 1982 Academic Article GET IT
Times cited: 21
Genetic transformation of Streptococcus pneumoniae by heterologous plasmid deoxyribonucleic acid. Journal of bacteriology. 1980 Academic Article GET IT
Times cited: 30

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Research

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Co-investigator Network

Funding awarded

RCA with Oxford Nanopore Technologies PLC awarded by Oxford Nanopore Technologies PLC Principal Investigator 2023 - 2025
missing activity Principal Investigator 2021 - 2024

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Background

education and training

Ph.D., The Rockefeller University 1981
B.A., University of Illinois 1976

Contact

full name

Francis Barany

primary email

barany@med.cornell.edu

External Relationships

externalRelationships

Relationships and collaborations with for-profit and not-for-profit organizations are of vital importance to our faculty because these exchanges of scientific information foster innovation. As experts in their fields, WCM physicians and scientists are sought after by many organizations to consult and educate. WCM and its faculty make this information available to the public, thus creating a transparent environment.
Other Interests refers to miscellaneous financial interests not covered in other categories (e.g., stipends, anything of monetary value)Other Interest:
Acuamark Diagnostics; BlinkBio Inc.; Circulogene; TwiXimo Therapeutics, Inc.
Ownership refers to any financial stake an individual owns in any company (e.g., stock options, equity interest)Ownership:
Acuamark Diagnostics; BlinkBio Inc.; Circulogene; TwiXimo Therapeutics, Inc.
Proprietary Interest refers to ownership of intellectual property rights (e.g., trademarks, patents, royalty income)Proprietary Interest:
Acuamark Diagnostics; BlinkBio Inc.; Circulogene; TwiXimo Therapeutics, Inc.

VIVO Weill Cornell Medical College

Francis Barany Professor of Microbiology and Immunology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

External Relationships

externalRelationships