Kühn, Bernhard

Publications

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selected publications

Elimination of 15N-thymidine after oral administration in human infants. PloS one. 2024 Academic Article GET IT
Interdependent changes of nuclear lamins, nuclear pore complexes, and ploidy regulate cellular regeneration and stress response in the heart. Nucleus (Austin, Tex.). 2023 Review GET IT
Anomalous peroxidase activity of cytochrome c is the primary pathogenic target in Barth syndrome. Nature metabolism. 2023 Academic Article GET IT
Protocol to image and quantify nuclear pore complexes using high-resolution laser scanning confocal microscopy. STAR protocols. 2023 Academic Article GET IT
Changes in nuclear pore numbers control nuclear import and stress response of mouse hearts. Developmental cell. 2022 Academic Article GET IT
Times cited: 10
Measuring cardiomyocyte cell-cycle activity and proliferation in the age of heart regeneration. American journal of physiology. Heart and circulatory physiology. 2022 Review GET IT
Times cited: 24
Histone deacetylase 1 controls cardiomyocyte proliferation during embryonic heart development and cardiac regeneration in zebrafish. PLoS genetics. 2021 Academic Article GET IT
Times cited: 6
Polyploid cardiomyocytes: implications for heart regeneration. Development (Cambridge, England). 2021 Academic Article GET IT
Times cited: 22
Design and rationale of a clinical trial to increase cardiomyocyte division in infants with tetralogy of Fallot. International journal of cardiology. 2021 Academic Article GET IT
Times cited: 10
Use of stable isotope-tagged thymidine and multi-isotope imaging mass spectrometry (MIMS) for quantification of human cardiomyocyte division. Nature protocols. 2021 Academic Article GET IT
Times cited: 8
Generation of Human Induced Pluripotent Stem Cells and Differentiation into Cardiomyocytes. Methods in molecular biology (Clifton, N.J.). 2021 Academic Article GET IT
Times cited: 4
Isolation and Characterization of Intact Cardiomyocytes from Frozen and Fresh Human Myocardium and Mouse Hearts. Methods in molecular biology (Clifton, N.J.). 2021 Academic Article GET IT
Times cited: 7
Lamin B2 Levels Regulate Polyploidization of Cardiomyocyte Nuclei and Myocardial Regeneration. Developmental cell. 2020 Academic Article GET IT
Times cited: 60
Control of cytokinesis by β-adrenergic receptors indicates an approach for regulating cardiomyocyte endowment. Science translational medicine. 2019 Academic Article GET IT
Times cited: 77
Regenerating Hearts by Arresting Development With Hypothyroidism. Circulation research. 2019 Comment GET IT
Dusp6 attenuates Ras/MAPK signaling to limit zebrafish heart regeneration. Development (Cambridge, England). 2018 Academic Article GET IT
Times cited: 55
Humanin is an endogenous activator of chaperone-mediated autophagy. The Journal of cell biology. 2017 Academic Article GET IT
Times cited: 76
Mechanisms of Cardiomyocyte Proliferation and Differentiation in Development and Regeneration. Current cardiology reports. 2017 Review GET IT
Times cited: 37
Neuregulin-1 Administration Protocols Sufficient for Stimulating Cardiac Regeneration in Young Mice Do Not Induce Somatic, Organ, or Neoplastic Growth. PloS one. 2016 Academic Article GET IT
Times cited: 17
A cryoinjury model in neonatal mice for cardiac translational and regeneration research. Nature protocols. 2016 Academic Article GET IT
Times cited: 45
Deep sequencing reveals cell-type-specific patterns of single-cell transcriptome variation. Genome biology. 2015 Academic Article GET IT
Times cited: 71
Neuregulin stimulation of cardiomyocyte regeneration in mice and human myocardium reveals a therapeutic window. Science translational medicine. 2015 Academic Article GET IT
Times cited: 179
Cardiac regeneration based on mechanisms of cardiomyocyte proliferation and differentiation. Stem cell research. 2014 Review GET IT
Times cited: 109
Muscling up the heart: a preadolescent cardiomyocyte proliferation contributes to heart growth. Circulation research. 2014 Comment GET IT
Times cited: 3
New mechanistic and therapeutic targets for pediatric heart failure: report from a National Heart, Lung, and Blood Institute working group. Circulation. 2014 Conference Paper GET IT
Times cited: 46
Signalling between microvascular endothelium and cardiomyocytes through neuregulin. Cardiovascular research. 2014 Review GET IT
Times cited: 60
Subcellular RNA sequencing reveals broad presence of cytoplasmic intron-sequence retaining transcripts in mouse and rat neurons. PloS one. 2013 Academic Article GET IT
Times cited: 30
Moderate and high amounts of tamoxifen in αMHC-MerCreMer mice induce a DNA damage response, leading to heart failure and death. Disease models & mechanisms. 2013 Academic Article GET IT
Times cited: 118
ERBB2 inhibition and heart failure. The New England journal of medicine. 2013 Letter GET IT
Times cited: 3
Cardiomyocyte proliferation contributes to heart growth in young humans. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 580
Intrapericardial delivery of gelfoam enables the targeted delivery of Periostin peptide after myocardial infarction by inducing fibrin clot formation. PloS one. 2012 Academic Article GET IT
Times cited: 40
The role of neuregulin/ErbB2/ErbB4 signaling in the heart with special focus on effects on cardiomyocyte proliferation. American journal of physiology. Heart and circulatory physiology. 2012 Review GET IT
Times cited: 110
Taking a load off: nuclear remodeling after mechanically supporting the failing human heart. Circulation. 2010 Comment GET IT
Times cited: 2
Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury. Cell. 2009 Academic Article GET IT
Times cited: 783
Etiology, management, and outcome of pediatric pericardial effusions. Pediatric cardiology. 2007 Academic Article GET IT
Times cited: 43
Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair. Nature medicine. 2007 Academic Article GET IT
Times cited: 554
Predictors of outcome of myocarditis. Pediatric cardiology. 2004 Academic Article GET IT
Times cited: 35
G-protein betagamma-subunits contribute to the coupling specificity of the beta2-adrenergic receptor to G(s). Naunyn-Schmiedeberg's archives of pharmacology. 2002 Academic Article GET IT
Times cited: 17
The luteinizing hormone receptor activates phospholipase C via preferential coupling to Gi2. Biochemistry. 1999 Academic Article GET IT
Times cited: 46
G proteins of the Gq family couple the H2 histamine receptor to phospholipase C. Molecular endocrinology (Baltimore, Md.). 1996 Academic Article GET IT
Times cited: 76
Involvement of Gs and Gi proteins in dual coupling of the luteinizing hormone receptor to adenylyl cyclase and phospholipase C. The Journal of biological chemistry. 1996 Academic Article GET IT
Times cited: 126

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Research

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Funding awarded

(DIVERSITY SUPPLEMENT) Mechanistic clinical trial of Beta-blocker administration for reactivating cardiomyocyte division in Tetralogy of Fallot awarded by National Heart, Lung, & Blood Institute Principal Investigator 2024 - 2026
Mechanistic clinical trial of Beta-blocker administration for reactivating cardiomyocyte division in Tetralogy of Fallot awarded by National Heart, Lung, & Blood Institute Principal Investigator 2024 - 2026
Quantification of the decline of heart muscle cell proliferation and its reversal in pediatric patients awarded by National Heart, Lung, & Blood Institute Principal Investigator 2024 - 2025
Lamin B2 regulates nuclear remodeling in cardiomyocyte terminal differentiation awarded by National Heart, Lung, & Blood Institute Principal Investigator 2024 - 2025

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Background

education and training

M.D., Free University of Berlin, Faculty of Human Medicine (Germany) 1999
M.D., Free University of Berlin, Faculty of Human Medicine (Germany) 1997

Contact

full name

Bernhard Kühn

primary email

bek4011@med.cornell.edu

webpage

Clinical Profile

VIVO Weill Cornell Medical College

Bernhard Kühn Professor of Pediatrics

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage