Signalling between microvascular endothelium and cardiomyocytes through neuregulin. Review uri icon

Overview

abstract

  • Heterocellular communication in the heart is an important mechanism for matching circulatory demands with cardiac structure and function, and neuregulins (Nrgs) play an important role in transducing this signal between the hearts' vasculature and musculature. Here, we review the current knowledge regarding Nrgs, explaining their roles in transducing signals between the heart's microvasculature and cardiomyocytes. We highlight intriguing areas being investigated for developing new, Nrg-mediated strategies to heal the heart in acquired and congenital heart diseases, and note avenues for future research.

publication date

  • January 29, 2014

Research

keywords

  • Endothelium
  • Microvessels
  • Myocytes, Cardiac
  • Neuregulins
  • Signal Transduction

Identity

PubMed Central ID

  • PMC3989448

Scopus Document Identifier

  • 84897511037

Digital Object Identifier (DOI)

  • 10.1093/cvr/cvu021

PubMed ID

  • 24477642

Additional Document Info

volume

  • 102

issue

  • 2