Brennan, Cameron W.

Publications

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selected publications

Genomic Correlates of Disease Progression and Treatment Response in Prospectively Characterized Gliomas. Clinical cancer research : an official journal of the American Association for Cancer Research. 2019 Academic Article GET IT
Times cited: 110
Sequencing and curation strategies for identifying candidate glioblastoma treatments. BMC medical genomics. 2019 Academic Article GET IT
Times cited: 7
CHD4 regulates the DNA damage response and RAD51 expression in glioblastoma. Scientific reports. 2019 Academic Article GET IT
Times cited: 28
Mutant and Wild-Type Isocitrate Dehydrogenase 1 Share Enhancing Mechanisms Involving Distinct Tyrosine Kinase Cascades in Cancer. Cancer discovery. 2019 Academic Article GET IT
Times cited: 18
EGFR amplification and classical subtype are associated with a poor response to bevacizumab in recurrent glioblastoma. Journal of neuro-oncology. 2019 Academic Article GET IT
Times cited: 34
Tracking tumour evolution in glioma through liquid biopsies of cerebrospinal fluid. Nature. 2019 Academic Article GET IT
Times cited: 382
Genome-wide methylomic and transcriptomic analyses identify subtype-specific epigenetic signatures commonly dysregulated in glioma stem cells and glioblastoma. Epigenetics. 2018 Academic Article GET IT
Times cited: 30
Metabolic Imaging of the Human Brain with Hyperpolarized ¹³C Pyruvate Demonstrates ¹³C Lactate Production in Brain Tumor Patients. Cancer research. 2018 Academic Article GET IT
Times cited: 178
Multicenter Phase IB Trial of Carboxyamidotriazole Orotate and Temozolomide for Recurrent and Newly Diagnosed Glioblastoma and Other Anaplastic Gliomas. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2018 Academic Article GET IT
Times cited: 36
Incidence of Prolonged Systemic Steroid Treatment after Surgery for Acoustic Neuroma and Its Implications. Journal of neurological surgery. Part B, Skull base. 2018 Academic Article GET IT
Mutant-IDH1-dependent chromatin state reprogramming, reversibility, and persistence. Nature genetics. 2017 Academic Article GET IT
Times cited: 135
Integrating Proteomics and Transcriptomics for Systematic Combinatorial Chimeric Antigen Receptor Therapy of AML. Cancer cell. 2017 Academic Article GET IT
Times cited: 228
Multicenter phase II study of temozolomide and myeloablative chemotherapy with autologous stem cell transplant for newly diagnosed anaplastic oligodendroglioma. Neuro-oncology. 2017 Academic Article GET IT
Times cited: 24
Genetic driver mutations define the expression signature and microenvironmental composition of high-grade gliomas. Glia. 2017 Academic Article GET IT
Times cited: 52
EGFR and PDGFRA co-expression and heterodimerization in glioblastoma tumor sphere lines. Scientific reports. 2017 Academic Article GET IT
Times cited: 30
Ibrutinib Unmasks Critical Role of Bruton Tyrosine Kinase in Primary CNS Lymphoma. Cancer discovery. 2017 Academic Article GET IT
Times cited: 308
Prior malignancies in patients harboring glioblastoma: an institutional case-study of 2164 patients. Journal of neuro-oncology. 2017 Information Resource GET IT
Times cited: 3
Clinical outcomes of patients with limited brain metastases treated with hypofractionated (5×6Gy) conformal radiotherapy. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 2017 Academic Article GET IT
Times cited: 18
Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies. Cell reports. 2016 Academic Article GET IT
Times cited: 420
Ultrasmall dual-modality silica nanoparticle drug conjugates: Design, synthesis, and characterization. Bioorganic & medicinal chemistry. 2015 Academic Article GET IT
Times cited: 28
Long-term risk of radionecrosis and imaging changes after stereotactic radiosurgery for brain metastases. Journal of neuro-oncology. 2015 Academic Article GET IT
Times cited: 227
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. The New England journal of medicine. 2015 Academic Article GET IT
Times cited: 2395
Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo. Science translational medicine. 2015 Academic Article GET IT
Times cited: 247
CLK2 Is an Oncogenic Kinase and Splicing Regulator in Breast Cancer. Cancer research. 2015 Academic Article GET IT
Times cited: 40
Sleeping Beauty mouse models identify candidate genes involved in gliomagenesis. PloS one. 2014 Academic Article GET IT
Times cited: 19
Outcomes and prognostic factors in women with 1 to 3 breast cancer brain metastases treated with definitive stereotactic radiosurgery. International journal of radiation oncology, biology, physics. 2014 Academic Article GET IT
Times cited: 30
Phase II study of bevacizumab, temozolomide, and hypofractionated stereotactic radiotherapy for newly diagnosed glioblastoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2014 Academic Article GET IT
Times cited: 86
Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesis. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 72
Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations. Nature genetics. 2014 Academic Article GET IT
Times cited: 488
Transcriptional diversity of long-term glioblastoma survivors. Neuro-oncology. 2014 Academic Article GET IT
Times cited: 66
Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge. Nature reviews. Cancer. 2014 Information Resource GET IT
Times cited: 432
Suppression of microRNA-9 by mutant EGFR signaling upregulates FOXP1 to enhance glioblastoma tumorigenicity. Cancer research. 2014 Academic Article GET IT
Times cited: 58
A phase 2 trial of stereotactic radiosurgery boost after surgical resection for brain metastases. International journal of radiation oncology, biology, physics. 2014 Academic Article GET IT
Times cited: 204
Acute inflammatory reactions to hemostatic materials mimicking post-operative intracranial abscess. Interdisciplinary Neurosurgery: Advanced Techniques and Case Management. 2014 Article GET IT
Quantitative assessment of intragenic receptor tyrosine kinase deletions in primary glioblastomas: their prevalence and molecular correlates. Acta neuropathologica. 2013 Academic Article GET IT
Times cited: 24
The somatic genomic landscape of glioblastoma. Cell. 2013 Academic Article GET IT
Times cited: 3643
Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine. Oncotarget. 2013 Academic Article GET IT
Times cited: 205
CSF-1R inhibition alters macrophage polarization and blocks glioma progression. Nature medicine. 2013 Academic Article GET IT
Times cited: 1746
Double minute chromosomes in glioblastoma multiforme are revealed by precise reconstruction of oncogenic amplicons. Cancer research. 2013 Academic Article GET IT
Times cited: 83
Tumor-infiltrating lymphocytes in glioblastoma are associated with specific genomic alterations and related to transcriptional class. Clinical cancer research : an official journal of the American Association for Cancer Research. 2013 Academic Article GET IT
Times cited: 167
A survey of intragenic breakpoints in glioblastoma identifies a distinct subset associated with poor survival. Genes & development. 2013 Academic Article GET IT
Times cited: 64
An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science (New York, N.Y.). 2013 Academic Article GET IT
Times cited: 946
Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO. Science (New York, N.Y.). 2013 Academic Article GET IT
Times cited: 679
TRIM3, a tumor suppressor linked to regulation of p21(Waf1/Cip1.). Oncogene. 2013 Academic Article GET IT
Times cited: 50
MEF promotes stemness in the pathogenesis of gliomas. Cell stem cell. 2012 Academic Article GET IT
Times cited: 39
Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis. Nature genetics. 2012 Academic Article GET IT
Times cited: 667
The role of radiotherapy following gross-total resection of atypical meningiomas. Journal of neurosurgery. 2012 Academic Article GET IT
Times cited: 112
Passenger deletions generate therapeutic vulnerabilities in cancer. Nature. 2012 Academic Article GET IT
Times cited: 259
Candidate pathways for promoting differentiation or quiescence of oligodendrocyte progenitor-like cells in glioma. Cancer research. 2012 Academic Article GET IT
Times cited: 56
microRNA regulatory network inference identifies miR-34a as a novel regulator of TGF-β signaling in glioblastoma. Cancer discovery. 2012 Academic Article GET IT
Times cited: 97
A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle. Nature medicine. 2012 Academic Article GET IT
Times cited: 942
Differential sensitivity of glioma- versus lung cancer-specific EGFR mutations to EGFR kinase inhibitors. Cancer discovery. 2012 Academic Article GET IT
Times cited: 277
Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response. Proceedings of the National Academy of Sciences of the United States of America. 2012 Academic Article GET IT
Times cited: 416
Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia. PloS one. 2012 Academic Article GET IT
Times cited: 56
Genomic dissection of the epidermal growth factor receptor (EGFR)/PI3K pathway reveals frequent deletion of the EGFR phosphatase PTPRS in head and neck cancers. Proceedings of the National Academy of Sciences of the United States of America. 2011 Academic Article GET IT
Times cited: 86
Splicing factor hnRNPH drives an oncogenic splicing switch in gliomas. The EMBO journal. 2011 Academic Article GET IT
Times cited: 131
Recruited cells can become transformed and overtake PDGF-induced murine gliomas in vivo during tumor progression. PloS one. 2011 Academic Article GET IT
Times cited: 67
Integrated genomic analyses of ovarian carcinoma. Nature. 2011 Academic Article GET IT
18F-fluorodeoxy-glucose positron emission tomography marks MYC-overexpressing human basal-like breast cancers. Cancer research. 2011 Academic Article GET IT
Times cited: 106
Neurosurgery for brain tumors: update on recent technical advances. Current neurology and neuroscience reports. 2011 Information Resource GET IT
Times cited: 70
Magnetic resonance spectroscopy imaging in radiotherapy planning for recurrent glioma. Medical physics. 2011 Academic Article GET IT
Comments. Neurosurgery. 2011 Article GET IT
Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas. Cancer cell. 2010 Academic Article GET IT
Times cited: 194
Glioblastoma stem-like cells give rise to tumour endothelium. Nature. 2010 Academic Article GET IT
Times cited: 868
PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas. Genes & development. 2010 Academic Article GET IT
Times cited: 170
Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressor. Genes & development. 2010 Academic Article GET IT
Times cited: 78
Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma. Genes & development. 2010 Academic Article GET IT
Times cited: 429
Advanced imaging in brain tumor surgery. Neuroimaging clinics of North America. 2010 Review GET IT
Times cited: 21
Loss of imprinting and marked gene elevation are 2 forms of aberrant IGF2 expression in colorectal cancer. International journal of cancer. 2010 Academic Article GET IT
Times cited: 51
Integrative genome comparison of primary and metastatic melanomas. PloS one. 2010 Academic Article GET IT
Times cited: 160
PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas. Cancer cell. 2010 Academic Article GET IT
Times cited: 220
Mig-6 controls EGFR trafficking and suppresses gliomagenesis. Proceedings of the National Academy of Sciences of the United States of America. 2010 Academic Article GET IT
Times cited: 99
The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation. Proceedings of the National Academy of Sciences of the United States of America. 2010 Academic Article GET IT
Times cited: 97
Identification of DOK genes as lung tumor suppressors. Nature genetics. 2010 Academic Article GET IT
Times cited: 103
Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells. Cell stem cell. 2010 Academic Article GET IT
Times cited: 437
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer cell. 2010 Academic Article GET IT
Times cited: 5703
Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations. PloS one. 2009 Academic Article GET IT
Times cited: 413
Proteasomal and genetic inactivation of the NF1 tumor suppressor in gliomagenesis. Cancer cell. 2009 Academic Article GET IT
Times cited: 119
An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumors. Oncogene. 2009 Academic Article GET IT
Times cited: 197
The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo. Genes & development. 2009 Academic Article GET IT
Times cited: 460
The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers. Proceedings of the National Academy of Sciences of the United States of America. 2009 Academic Article GET IT
Times cited: 230
PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells. Cell stem cell. 2009 Academic Article GET IT
Times cited: 704
p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation. Nature. 2008 Academic Article GET IT
Times cited: 619
Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature. 2008 Academic Article GET IT
Times cited: 6309
Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development. Cancer cell. 2008 Academic Article GET IT
Times cited: 108
Extent of resection and survival in glioblastoma multiforme: Identification of and adjustment for bias - Commentary. Neurosurgery. 2008 Article GET IT
Assessment of the language laterality index in patients with brain tumor using functional MR imaging: effects of thresholding, task selection, and prior surgery. AJNR. American journal of neuroradiology. 2008 Academic Article GET IT
Times cited: 81
MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proceedings of the National Academy of Sciences of the United States of America. 2007 Academic Article GET IT
Times cited: 1529
Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types. Cancer research. 2007 Academic Article GET IT
Times cited: 59
Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes & development. 2007 Information Resource GET IT
Times cited: 1698
Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies. Science (New York, N.Y.). 2007 Academic Article GET IT
Times cited: 727
Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Nature. 2007 Academic Article GET IT
Times cited: 325
Psidin is required in Drosophila blood cells for both phagocytic degradation and immune activation of the fat body. Current biology : CB. 2007 Academic Article GET IT
Times cited: 75
Hypofractionated stereotactic radiotherapy using intensity-modulated radiotherapy in patients with one or two brain metastases. Stereotactic and functional neurosurgery. 2006 Academic Article GET IT
Times cited: 58
Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entities. Cancer research. 2006 Academic Article GET IT
Times cited: 153
A genome-wide screen reveals functional gene clusters in the cancer genome and identifies EphA2 as a mitogen in glioblastoma. Cancer research. 2006 Academic Article GET IT
Times cited: 89
Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene. Cell. 2006 Academic Article GET IT
Times cited: 335
Combined cDNA array comparative genomic hybridization and serial analysis of gene expression analysis of breast tumor progression. Cancer research. 2006 Academic Article GET IT
Times cited: 136
Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. Proceedings of the National Academy of Sciences of the United States of America. 2006 Academic Article GET IT
Times cited: 487
High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients. Cancer cell. 2006 Academic Article GET IT
Times cited: 346
Preemptive diagnosis and treatment of Epstein-Barr virus-associated post transplant lymphoproliferative disorder after hematopoietic stem cell transplant: an approach in development. Bone marrow transplantation. 2006 Information Resource GET IT
Times cited: 89
Discordance between functional magnetic resonance imaging during silent speech tasks and intraoperative speech arrest. Journal of neurosurgery. 2005 Academic Article GET IT
Times cited: 45
High-resolution genomic profiles of human lung cancer. Proceedings of the National Academy of Sciences of the United States of America. 2005 Academic Article GET IT
Times cited: 347
DNA amplification method tolerant to sample degradation. Genome research. 2004 Academic Article GET IT
Times cited: 78
Nuclear cloning of embryonal carcinoma cells. Proceedings of the National Academy of Sciences of the United States of America. 2004 Academic Article GET IT
Times cited: 162
Reprogramming of a melanoma genome by nuclear transplantation. Genes & development. 2004 Academic Article GET IT
Times cited: 309
High-resolution global profiling of genomic alterations with long oligonucleotide microarray. Cancer research. 2004 Academic Article GET IT
Times cited: 116
Molecular characterization of the tumor microenvironment in breast cancer. Cancer cell. 2004 Academic Article GET IT
Times cited: 975
High-resolution characterization of the pancreatic adenocarcinoma genome. Proceedings of the National Academy of Sciences of the United States of America. 2004 Academic Article GET IT
Times cited: 237
Balanced-PCR amplification allows unbiased identification of genomic copy changes in minute cell and tissue samples. Nucleic acids research. 2004 Academic Article GET IT
Times cited: 58
Molecular diversity of astrocytes with implications for neurological disorders. Proceedings of the National Academy of Sciences of the United States of America. 2004 Academic Article GET IT
Times cited: 186
Drosophila: the genetics of innate immune recognition and response. Annual review of immunology. 2004 Information Resource GET IT
Times cited: 264
Array comparative genome hybridization for tumor classification and gene discovery in mouse models of malignant melanoma. Cancer research. 2003 Academic Article GET IT
Times cited: 39
A principal components-based method for the detection of neuronal activity maps: application to optical imaging. NeuroImage. 2000 Academic Article GET IT
Times cited: 35
Optical imaging: A review. Optics and Photonics News. 2000 Article
Extrageniculate vision in hemianopic humans: saccade inhibition by signals in the blind field. Science (New York, N.Y.). 1990 Academic Article GET IT
Times cited: 154
Saccade preparation inhibits reorienting to recently attended locations. Journal of experimental psychology. Human perception and performance. 1989 Academic Article GET IT
Times cited: 459

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Background

education and training

M.D., Cornell University Medical College 94
B.Sc., Brown University 1988

Contact

full name

Cameron W. Brennan

primary email

cbrennan@med.cornell.edu

VIVO Weill Cornell Medical College

Cameron W. Brennan Associate Professor of Neurological Surgery

Publications

selected publications

Background

education and training

Contact

full name

primary email