selected publications
- EZH2 inhibition enhances T cell immunotherapies by inducing lymphoma immunogenicity and improving T cell function. Cancer cell. 2024 Academic Article GET IT
- Lethal COVID-19 associates with RAAS-induced inflammation for multiple organ damage including mediastinal lymph nodes. Proceedings of the National Academy of Sciences of the United States of America. 2024 Academic Article GET IT
- A Multiomics, Molecular Atlas of Breast Cancer Survivors. Metabolites. 2024 Academic Article GET IT
- A Second Space Age Spanning Omics, Platforms, and Medicine Across Orbits. Nature. 2024 Review GET IT
- Aging and putative frailty biomarkers are altered by spaceflight. Scientific reports. 2024 Academic Article GET IT
- Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction. Nature communications. 2024 Academic Article GET IT
- Longitudinal multi-omics analysis of host microbiome architecture and immune responses during short-term spaceflight. Nature microbiology. 2024 Academic Article GET IT
- Molecular and physiologic changes in the SpaceX Inspiration4 civilian crew. Nature. 2024 Academic Article GET IT
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Secretome profiling reveals acute changes in oxidative stress, brain homeostasis, and coagulation following short-duration spaceflight.
Nature communications.
2024
Academic Article
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Times cited: 10 -
Single-cell analysis identifies conserved features of immune dysfunction in simulated microgravity and spaceflight.
Nature communications.
2024
Academic Article
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Times cited: 8 -
Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight.
Nature communications.
2024
Academic Article
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Times cited: 17 - Space radiation damage rescued by inhibition of key spaceflight associated miRNAs. Nature communications. 2024 Academic Article GET IT
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Spatial multi-omics of human skin reveals KRAS and inflammatory responses to spaceflight.
Nature communications.
2024
Academic Article
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Times cited: 10 - Spatiotemporal expression and control of haemoglobin in space. Nature communications. 2024 Academic Article GET IT
- Telomeric RNA (TERRA) increases in response to spaceflight and high-altitude climbing. Communications biology. 2024 Academic Article GET IT
- The Space Omics and Medical Atlas (SOMA) and international astronaut biobank. Nature. 2024 Academic Article GET IT
- Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology. Communications medicine. 2024 Academic Article GET IT
- ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis. 2024 GET IT
- Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment. Nature communications. 2024 Academic Article GET IT
- ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis. Cancer cell. 2024 Academic Article GET IT
- SMARCA4 is a haploinsufficient B cell lymphoma tumor suppressor that fine-tunes centrocyte cell fate decisions. Cancer cell. 2024 Academic Article GET IT
- The importance of personalization in high altitude protocols for hematologic and metabolic benefits in sports: A multi-dimensional N-of-1 case study. 2023 GET IT
- Elevated A-to-I RNA editing in COVID-19 infected individuals. NAR genomics and bioinformatics. 2023 Academic Article GET IT
- Viral activation and ecological restructuring characterize a microbiome axis of spaceflight-associated immune activation. 2023 GET IT
- Resistance to PRMT5 Targeted Therapy in Mantle Cell Lymphoma. Blood advances. 2023 Academic Article GET IT
- Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts. Science translational medicine. 2023 Academic Article GET IT
- PRMT5 supports multiple oncogenic pathways in mantle cell lymphoma. Blood. 2023 Academic Article GET IT
- IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interaction with the AITL microenvironment. Cancer cell. 2023 Academic Article GET IT
- Distinct and opposite effects of leukemogenic Idh and Tet2 mutations in hematopoietic stem and progenitor cells. Proceedings of the National Academy of Sciences of the United States of America. 2023 Academic Article GET IT
- Host transcriptional responses in nasal swabs identify potential SARS-CoV-2 infection in PCR negative patients. iScience. 2022 Academic Article GET IT
- BCL10 mutations define distinct dependencies guiding precision therapy for DLBCL. Cancer discovery. 2022 Academic Article GET IT
- A Wipe-Based Stool Collection and Preservation Kit for Microbiome Community Profiling. Frontiers in immunology. 2022 Academic Article GET IT
- SETD2 haploinsufficiency enhances germinal center-associated AICDA somatic hypermutation to drive B cell lymphomagenesis. Cancer discovery. 2022 Academic Article GET IT
- Blocking UBE2N abrogates oncogenic immune signaling in acute myeloid leukemia. Science translational medicine. 2022 Academic Article GET IT
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System-wide transcriptome damage and tissue identity loss in COVID-19 patients.
Cell reports. Medicine.
2022
Academic Article
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Times cited: 27 - Betacoronavirus-specific alternate splicing. Genomics. 2022 Academic Article GET IT
- Landscape and clinical significance of long non-coding RNAs involved in multiple myeloma expressed fusion transcripts. American journal of hematology. 2021 Letter GET IT
- Role of miR-2392 in driving SARS-CoV-2 infection. Cell reports. 2021 Academic Article GET IT
- Epigenetic Forensics for Suspect Identification and Age Prediction. Forensic genomics. 2021 Academic Article GET IT
- Haplotype diversity and sequence heterogeneity of human telomeres. Genome research. 2021 Academic Article GET IT
- A global metagenomic map of urban microbiomes and antimicrobial resistance. Cell. 2021 Academic Article GET IT
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The spatial landscape of lung pathology during COVID-19 progression.
Nature.
2021
Academic Article
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Times cited: 230 -
Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug interactions.
Nature communications.
2021
Academic Article
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Times cited: 89 -
Characterization of complete lncRNAs transcriptome reveals the functional and clinical impact of lncRNAs in multiple myeloma.
Leukemia.
2021
Academic Article
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Times cited: 34 -
BCL6 maintains survival and self-renewal of primary human acute myeloid leukemia cells.
Blood.
2021
Academic Article
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Times cited: 20 -
A diagnostic host response biosignature for COVID-19 from RNA profiling of nasal swabs and blood.
Science advances.
2021
Academic Article
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Times cited: 69 -
Chemotherapy Induces Senescence-Like Resilient Cells Capable of Initiating AML Recurrence.
Cancer discovery.
2021
Academic Article
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Times cited: 142 -
Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation.
Nature immunology.
2021
Academic Article
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Times cited: 25 -
H1 histones control the epigenetic landscape by local chromatin compaction.
Nature.
2020
Academic Article
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Times cited: 106 -
Transcriptional response modules characterize IL-1β and IL-6 activity in COVID-19.
iScience.
2020
Academic Article
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Times cited: 27 -
Cell-free DNA (cfDNA) and Exosome Profiling from a Year-Long Human Spaceflight Reveals Circulating Biomarkers.
iScience.
2020
Academic Article
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Times cited: 37 - Circulating miRNA Spaceflight Signature Reveals Targets for Countermeasure Development. Cell reports. 2020 Academic Article GET IT
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Clonal Hematopoiesis Before, During, and After Human Spaceflight.
Cell reports.
2020
Academic Article
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Times cited: 4 -
Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact.
Cell.
2020
Academic Article
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Times cited: 198 -
Fundamental Biological Features of Spaceflight: Advancing the Field to Enable Deep-Space Exploration.
Cell.
2020
Information Resource
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Times cited: 15 -
Multi-omic, Single-Cell, and Biochemical Profiles of Astronauts Guide Pharmacological Strategies for Returning to Gravity.
Cell reports.
2020
Academic Article
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Times cited: 5 -
Telomere Length Dynamics and DNA Damage Responses Associated with Long-Duration Spaceflight.
Cell reports.
2020
Academic Article
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Times cited: 7 -
Temporal Telomere and DNA Damage Responses in the Space Radiation Environment.
Cell reports.
2020
Academic Article
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Times cited: 10 -
Evolution of the Epigenetic Landscape in Childhood B Acute Lymphoblastic Leukemia and Its Role in Drug Resistance.
Cancer research.
2020
Academic Article
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Times cited: 1 - Somatic Mutations Drive Specific, but Reversible, Epigenetic Heterogeneity States in AML. Cancer discovery. 2020 Academic Article GET IT
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Chromatin activation as a unifying principle underlying pathogenic mechanisms in multiple myeloma.
Genome research.
2020
Academic Article
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Times cited: 32 -
Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection.
Nature medicine.
2020
Academic Article
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Times cited: 230 -
Long-term spaceflight and the cardiovascular system.
Precision clinical medicine.
2020
Academic Article
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Times cited: 69 -
Mutant EZH2 Induces a Pre-malignant Lymphoma Niche by Reprogramming the Immune Response.
Cancer cell.
2020
Academic Article
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Times cited: 96 -
The NASA Twins Study: The Effect of One Year in Space on Long-Chain Fatty Acid Desaturases and Elongases.
Lifestyle genomics.
2020
Academic Article
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Times cited: 4 - Improved gastrointestinal health for irritable bowel syndrome with metagenome-guided interventions. Precision clinical medicine. 2020 Article GET IT
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Rational Targeting of Cooperating Layers of the Epigenome Yields Enhanced Therapeutic Efficacy against AML.
Cancer discovery.
2019
Academic Article
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Times cited: 35 -
Growth Kinetics, Carbon Isotope Fractionation, and Gene Expression in the Hyperthermophile Methanocaldococcus jannaschii during Hydrogen-Limited Growth and Interspecies Hydrogen Transfer.
Applied and environmental microbiology.
2019
Academic Article
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Times cited: 22 -
The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight.
Science (New York, N.Y.).
2019
Academic Article
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Times cited: 680 -
Long non-coding RNAs discriminate the stages and gene regulatory states of human humoral immune response.
Nature communications.
2019
Academic Article
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Times cited: 71 - The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight. . Science (New York, N.Y.). 2019 Academic Article
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Histone demethylase LSD1 is required for germinal center formation and BCL6-driven lymphomagenesis.
Nature immunology.
2018
Academic Article
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Times cited: 70 -
ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2.
eLife.
2018
Academic Article
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Times cited: 126 -
Formate hydrogenlyase and formate secretion ameliorate H2 inhibition in the hyperthermophilic archaeon Thermococcus paralvinellae.
Environmental microbiology.
2017
Academic Article
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Times cited: 8 -
Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity.
Cancer cell.
2017
Academic Article
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Times cited: 70 -
rahu is a mutant allele of Dnmt3c, encoding a DNA methyltransferase homolog required for meiosis and transposon repression in the mouse male germline.
PLoS genetics.
2017
Academic Article
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Times cited: 59 -
Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells.
Nature genetics.
2017
Academic Article
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Times cited: 71 -
Epigenetic Identity in AML Depends on Disruption of Nonpromoter Regulatory Elements and Is Affected by Antagonistic Effects of Mutations in Epigenetic Modifiers.
Cancer discovery.
2017
Academic Article
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Times cited: 98 -
Combination Targeted Therapy to Disrupt Aberrant Oncogenic Signaling and Reverse Epigenetic Dysfunction in IDH2- and TET2-Mutant Acute Myeloid Leukemia.
Cancer discovery.
2017
Academic Article
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Times cited: 99 -
Aid is a key regulator of myeloid/erythroid differentiation and DNA methylation in hematopoietic stem/progenitor cells.
Blood.
2017
Academic Article
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Times cited: 20 -
CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas.
Cancer discovery.
2016
Academic Article
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Times cited: 210 -
The Metagenomics and Metadesign of the Subways and Urban Biomes (MetaSUB) International Consortium inaugural meeting report.
Microbiome.
2016
Conference Paper
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Times cited: 62 -
Dose-dependent role of the cohesin complex in normal and malignant hematopoiesis.
The Journal of experimental medicine.
2015
Academic Article
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Times cited: 127 -
Modern Methods for Delineating Metagenomic Complexity.
Cell systems.
2015
Article
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Times cited: 9 -
Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome.
Nature methods.
2015
Academic Article
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Times cited: 1146 -
Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia.
Cancer cell.
2015
Academic Article
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Times cited: 190 - Geospatial Resolution of Human and Bacterial Diversity with City-Scale Metagenomics. Cell systems. 2015 Academic Article GET IT
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An integrative computational approach for prioritization of genomic variants.
PloS one.
2014
Academic Article
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Times cited: 7 -
Target-independent prediction of drug synergies using only drug lipophilicity.
Journal of chemical information and modeling.
2014
Academic Article
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Times cited: 31 -
Prediction of peptides binding to MHC class I and II alleles by temporal motif mining.
BMC bioinformatics.
2013
Academic Article
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Times cited: 27 -
Testing robustness of relative complexity measure method constructing robust phylogenetic trees for Galanthus L. using the relative complexity measure.
BMC bioinformatics.
2013
Academic Article
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Times cited: 4