Eliezer, David

Publications

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selected publications

Genetic code expansion and enzymatic modifications as accessible methods for studying site-specific post-translational modifications of alpha-synuclein and tau. Protein science : a publication of the Protein Society. 2025 Academic Article GET IT
Structural Diversity and Dynamics of Metabotropic Glutamate Receptor/Beta-Arrestin Coupling. 2025 GET IT
An Amyloidogenic Fragment of the Spike Protein from SARS-CoV-2 Virus Stimulates the Aggregation and Toxicity of Parkinson's Disease Protein Alpha-Synuclein. ACS chemical neuroscience. 2025 Academic Article GET IT
Amyloid fibril structures link CHCHD10 and CHCHD2 to neurodegeneration. Nature communications. 2025 Academic Article GET IT
Genetic Code Expansion and Enzymatic Modifications as Accessible Methods for Studying Site-Specific Post-Translational Modifications of Alpha-Synuclein and Tau. 2025 GET IT
Sharpening the lens of NMR spectroscopy to study large proteins. Nature chemistry. 2025 Academic Article GET IT
Investigation of All Disease-Relevant Lysine Acetylation Sites in α-Synuclein Enabled by Non-canonical Amino Acid Mutagenesis. 2025 GET IT
Investigating Complexin-Membrane Interactions Using NMR and Optical Methods. Methods in molecular biology (Clifton, N.J.). 2025 Academic Article GET IT
Phosphoglycerate kinase is a central leverage point in Parkinson's disease-driven neuronal metabolic deficits. Science advances. 2024 Academic Article GET IT
Times cited: 9
Amyloid fibril structures link CHCHD10 and CHCHD2 to neurodegeneration. 2024 GET IT
Control of G protein-coupled receptor function via membrane-interacting intrinsically disordered C-terminal domains. Proceedings of the National Academy of Sciences of the United States of America. 2024 Academic Article GET IT
Carbon dots as dual inhibitors of tau and amyloid-beta aggregation for the treatment of Alzheimer's disease. Acta biomaterialia. 2024 Academic Article GET IT
Times cited: 9
Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins. 2024 GET IT
Phosphoglycerate kinase is a central leverage point in Parkinson's Disease driven neuronal metabolic deficits. 2023 GET IT
Alpha synuclein modulates mitochondrial Ca²⁺ uptake from ER during cell stimulation and under stress conditions. NPJ Parkinson's disease. 2023 Academic Article GET IT
Times cited: 16
Structure and DNA-bridging activity of the essential Rec114-Mei4 trimer interface. Genes & development. 2023 Academic Article GET IT
Times cited: 11
Alpha Synuclein Modulates Mitochondrial Ca ²⁺ Uptake from ER During Cell Stimulation and Under Stress Conditions. 2023 GET IT
Environmentally Ultrasensitive Fluorine Probe to Resolve Protein Conformational Ensembles by ¹⁹F NMR and Cryo-EM. Journal of the American Chemical Society. 2023 Academic Article GET IT
Structure and DNA bridging activity of the essential Rec114â€"Mei4 trimer interface. 2023 GET IT
The Role of Membrane Affinity and Binding Modes in Alpha-Synuclein Regulation of Vesicle Release and Trafficking. Biomolecules. 2022 Academic Article GET IT
Times cited: 9
Proline-Rich Region II (PRR2) Plays an Important Role in Tau-Glycan Interaction: An NMR Study. Biomolecules. 2022 Academic Article GET IT
Times cited: 2
Molecular and functional interactions of alpha-synuclein with Rab3a. The Journal of biological chemistry. 2022 Academic Article GET IT
Times cited: 16
Membrane Binding Induces Distinct Structural Signatures in the Mouse Complexin-1C-Terminal Domain. Journal of molecular biology. 2022 Academic Article GET IT
Times cited: 4
Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins. Cell reports. 2022 Academic Article GET IT
Times cited: 39
Homogalacturonan from squash: Characterization and tau-binding pattern of a sulfated derivative. Carbohydrate polymers. 2022 Academic Article GET IT
Times cited: 22
Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer's disease. Nature communications. 2022 Academic Article GET IT
Times cited: 75
The dopamine receptor agonist apomorphine stabilizes neurotoxic α-synuclein oligomers. FEBS letters. 2021 Academic Article GET IT
Times cited: 3
Post-translational modifications within tau paired helical filament nucleating motifs perturb microtubule interactions and oligomer formation. The Journal of biological chemistry. 2021 Academic Article GET IT
Times cited: 24
Fisetin inhibits tau aggregation by interacting with the protein and preventing the formation of β-strands. International journal of biological macromolecules. 2021 Academic Article GET IT
Times cited: 42
Chemoenzymatic Semi-synthesis Enables Efficient Production of Isotopically Labeled α-Synuclein with Site-Specific Tyrosine Phosphorylation. Chembiochem : a European journal of chemical biology. 2021 Academic Article GET IT
Times cited: 12
Tau induces PSD95-neuronal NOS uncoupling and neurovascular dysfunction independent of neurodegeneration. Nature neuroscience. 2020 Academic Article GET IT
Times cited: 87
Use of paramagnetic ¹⁹F NMR to monitor domain movement in a glutamate transporter homolog. Nature chemical biology. 2020 Academic Article GET IT
Times cited: 42
Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau. The Journal of biological chemistry. 2020 Academic Article GET IT
Times cited: 48
Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts. BMC complementary medicine and therapies. 2020 Academic Article GET IT
Times cited: 33
Interactions of IDPs with Membranes Using Dark-State Exchange NMR Spectroscopy. Methods in molecular biology (Clifton, N.J.). 2020 Academic Article GET IT
Times cited: 4
Probing IDP Interactions with Membranes by Fluorescence Spectroscopy. Methods in molecular biology (Clifton, N.J.). 2020 Academic Article GET IT
Times cited: 3
3-O-Sulfation of Heparan Sulfate Enhances Tau Interaction and Cellular Uptake. Angewandte Chemie (International ed. in English). 2019 Academic Article GET IT
Times cited: 83
Exchange of water for sterol underlies sterol egress from a StARkin domain. eLife. 2019 Academic Article GET IT
Times cited: 20
Regulation of exocytosis and mitochondrial relocalization by Alpha-synuclein in a mammalian cell model. NPJ Parkinson's disease. 2019 Academic Article GET IT
Times cited: 20
Membrane interactions of intrinsically disordered proteins: The example of alpha-synuclein. Biochimica et biophysica acta. Proteins and proteomics. 2019 Review GET IT
Times cited: 49
Intrinsically disordered proteins in synaptic vesicle trafficking and release. The Journal of biological chemistry. 2019 Review GET IT
Times cited: 57
Probing Structural Changes in Alpha-Synuclein by Nuclear Magnetic Resonance Spectroscopy. Methods in molecular biology (Clifton, N.J.). 2019 Academic Article GET IT
Times cited: 3
Role of Parkinson's Disease-Linked Mutations and N-Terminal Acetylation on the Oligomerization of α-Synuclein Induced by 3,4-Dihydroxyphenylacetaldehyde. ACS chemical neuroscience. 2018 Academic Article GET IT
Times cited: 36
Spectroscopic Characterization of Structure-Function Relationships in the Intrinsically Disordered Protein Complexin. Methods in enzymology. 2018 Academic Article GET IT
Times cited: 4
Exploring the role of methionine residues on the oligomerization and neurotoxic properties of DOPAL-modified α-synuclein. Biochemical and biophysical research communications. 2018 Academic Article GET IT
Times cited: 14
Structure and dynamics of the extended-helix state of alpha-synuclein: Intrinsic lability of the linker region. Protein science : a publication of the Protein Society. 2018 Academic Article GET IT
Times cited: 11
A Protofilament-Protofilament Interface in the Structure of Mouse α-Synuclein Fibrils. Biophysical journal. 2018 Academic Article GET IT
Times cited: 9
Structural basis of sterol binding and transport by a yeast StARkin domain. The Journal of biological chemistry. 2018 Academic Article GET IT
Times cited: 46
Parkinson's Disease and Melanoma: Co-Occurrence and Mechanisms. Journal of Parkinson's disease. 2018 Information Resource GET IT
Times cited: 90
Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes. Nature communications. 2017 Academic Article GET IT
Times cited: 119
Proteins acting out of (dis)order. eLife. 2017 Comment GET IT
Times cited: 2
Evolutionary Divergence of the C-terminal Domain of Complexin Accounts for Functional Disparities between Vertebrate and Invertebrate Complexins. Frontiers in molecular neuroscience. 2017 Academic Article GET IT
Times cited: 25
Unique Structural Features of Membrane-Bound C-Terminal Domain Motifs Modulate Complexin Inhibitory Function. Frontiers in molecular neuroscience. 2017 Academic Article GET IT
Times cited: 25
Glycan Determinants of Heparin-Tau Interaction. Biophysical journal. 2017 Academic Article GET IT
Times cited: 68
Phosphorylation regulates the secondary structure and function of dentin phosphoprotein peptides. Bone. 2016 Academic Article GET IT
Times cited: 15
Exposure to bacterial endotoxin generates a distinct strain of α-synuclein fibril. Scientific reports. 2016 Academic Article GET IT
Times cited: 124
Conformational heterogeneity in closed and open states of the KcsA potassium channel in lipid bicelles. The Journal of general physiology. 2016 Academic Article GET IT
Times cited: 17
Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations. ACS chemical biology. 2016 Academic Article GET IT
Times cited: 67
The C-terminal α-helices of mammalian Hsc70 play a critical role in the stabilization of α-synuclein binding and inhibition of aggregation. International journal of biological macromolecules. 2015 Academic Article GET IT
Times cited: 21
Oligomerization and Membrane-binding Properties of Covalent Adducts Formed by the Interaction of α-Synuclein with the Toxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde (DOPAL). The Journal of biological chemistry. 2015 Academic Article GET IT
Times cited: 101
STARD4 Membrane Interactions and Sterol Binding. Biochemistry. 2015 Academic Article GET IT
Times cited: 50
Alpha-synuclein function and dysfunction on cellular membranes. Experimental neurobiology. 2014 Review GET IT
Ginsenoside Rb1 inhibits fibrillation and toxicity of alpha-synuclein and disaggregates preformed fibrils. Neurobiology of disease. 2014 Academic Article GET IT
Times cited: 93
The accessory helix of complexin functions by stabilizing central helix secondary structure. eLife. 2014 Academic Article GET IT
Times cited: 35
Membrane curvature sensing by the C-terminal domain of complexin. Nature communications. 2014 Academic Article GET IT
Times cited: 68
Tau binds to lipid membrane surfaces via short amphipathic helices located in its microtubule-binding repeats. Biophysical journal. 2014 Academic Article GET IT
Times cited: 95
Structure activity relationship of phenolic acid inhibitors of α-synuclein fibril formation and toxicity. Frontiers in aging neuroscience. 2014 Academic Article GET IT
Times cited: 108
The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity. The Journal of biological chemistry. 2014 Academic Article GET IT
Times cited: 159
The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear localization in cells. Human molecular genetics. 2014 Academic Article GET IT
Times cited: 201
c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease. Human molecular genetics. 2014 Academic Article GET IT
Times cited: 191
N-terminal acetylation stabilizes N-terminal helicity in lipid- and micelle-bound α-synuclein and increases its affinity for physiological membranes. The Journal of biological chemistry. 2013 Academic Article GET IT
Times cited: 160
Structural transitions in tau k18 on micelle binding suggest a hierarchy in the efficacy of individual microtubule-binding repeats in filament nucleation. Protein science : a publication of the Protein Society. 2013 Academic Article GET IT
Times cited: 59
The mysterious C-terminal tail of alpha-synuclein: nanobody's guess. Journal of molecular biology. 2013 Comment GET IT
Times cited: 19
Synaptic vesicles position complexin to block spontaneous fusion. Neuron. 2013 Academic Article GET IT
Times cited: 74
In support of the BMRB. Nature structural & molecular biology. 2012 Academic Article GET IT
Times cited: 6
Interplay between desolvation and secondary structure in mediating cosolvent and temperature induced alpha-synuclein aggregation. Physical biology. 2012 Academic Article GET IT
Times cited: 15
¹H, ¹³C, and ¹⁵N backbone resonance assignments of the L124D mutant of StAR-related lipid transfer domain protein 4 (StARD4). Biomolecular NMR assignments. 2012 Academic Article GET IT
Times cited: 3
Characterization of semisynthetic and naturally Nα-acetylated α-synuclein in vitro and in intact cells: implications for aggregation and cellular properties of α-synuclein. The Journal of biological chemistry. 2012 Academic Article GET IT
Times cited: 148
Biochemistry. Visualizing amyloid assembly. Science (New York, N.Y.). 2012 Comment GET IT
Times cited: 4
Assigning backbone NMR resonances for full length tau isoforms: efficient compromise between manual assignments and reduced dimensionality. PloS one. 2012 Academic Article GET IT
Times cited: 30
Binding of the three-repeat domain of tau to phospholipid membranes induces an aggregated-like state of the protein. Biochimica et biophysica acta. 2012 Academic Article GET IT
Times cited: 73
Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: α-synuclein phosphorylation at tyrosine 125. Journal of the American Chemical Society. 2012 Academic Article GET IT
Times cited: 94
α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer. The Journal of biological chemistry. 2012 Academic Article GET IT
Times cited: 476
Distance information for disordered proteins from NMR and ESR measurements using paramagnetic spin labels. Methods in molecular biology (Clifton, N.J.). 2012 Academic Article GET IT
Times cited: 16
Folding and misfolding of alpha-synuclein on membranes. Biochimica et biophysica acta. 2011 Review GET IT
Times cited: 174
STARD4 abundance regulates sterol transport and sensing. Molecular biology of the cell. 2011 Academic Article GET IT
Times cited: 107
Structural characterization of two alternate conformations in a calbindin D₉k-based molecular switch. Biochemistry. 2011 Academic Article GET IT
Times cited: 8
Identification of a helical intermediate in trifluoroethanol-induced alpha-synuclein aggregation. Proceedings of the National Academy of Sciences of the United States of America. 2010 Academic Article GET IT
Times cited: 155
The lipid-binding domain of wild type and mutant alpha-synuclein: compactness and interconversion between the broken and extended helix forms. The Journal of biological chemistry. 2010 Academic Article GET IT
Times cited: 118
The cold denatured state of the C-terminal domain of protein L9 is compact and contains both native and non-native structure. Journal of the American Chemical Society. 2010 Academic Article GET IT
Times cited: 40
Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010 Academic Article GET IT
Times cited: 275
Biophysics of Parkinson's disease: structure and aggregation of alpha-synuclein. Current protein & peptide science. 2009 Review GET IT
Times cited: 287
Charge neutralization and collapse of the C-terminal tail of alpha-synuclein at low pH. Protein science : a publication of the Protein Society. 2009 Academic Article GET IT
Times cited: 88
The unfolded state of the C-terminal domain of the ribosomal protein L9 contains both native and non-native structure. Biochemistry. 2009 Academic Article GET IT
Times cited: 27
E46K Parkinson's-linked mutation enhances C-terminal-to-N-terminal contacts in alpha-synuclein. Journal of molecular biology. 2009 Academic Article GET IT
Times cited: 92
Structural basis for recognition of diubiquitins by NEMO. Molecular cell. 2009 Academic Article GET IT
Times cited: 224
Biophysical characterization of intrinsically disordered proteins. Current opinion in structural biology. 2009 Review GET IT
Times cited: 283
Membrane-bound alpha-synuclein forms an extended helix: long-distance pulsed ESR measurements using vesicles, bicelles, and rodlike micelles. Journal of the American Chemical Society. 2008 Academic Article GET IT
Times cited: 246
Identification of a copper-binding metallothionein in pathogenic mycobacteria. Nature chemical biology. 2008 Academic Article GET IT
Times cited: 181
The low-pH unfolded state of the C-terminal domain of the ribosomal protein L9 contains significant secondary structure in the absence of denaturant but is no more compact than the low-pH urea unfolded state. Biochemistry. 2008 Academic Article GET IT
Times cited: 20
Structural effects of Parkinson's disease linked DJ-1 mutations. Protein science : a publication of the Protein Society. 2008 Academic Article GET IT
Times cited: 76
Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein. The Journal of biological chemistry. 2008 Academic Article GET IT
Times cited: 305
Residual structure, backbone dynamics, and interactions within the synuclein family. Journal of molecular biology. 2007 Academic Article GET IT
Times cited: 127
Biophysics: proteins hunt and gather. Nature. 2007 Comment GET IT
Times cited: 13
The impact of the E46K mutation on the properties of alpha-synuclein in its monomeric and oligomeric states. Biochemistry. 2007 Academic Article GET IT
Times cited: 164
Characterizing residual structure in disordered protein States using nuclear magnetic resonance. Methods in molecular biology (Clifton, N.J.). 2007 Review GET IT
Times cited: 58
Amyloid ion channels: a porous argument or a thin excuse?. The Journal of general physiology. 2006 Comment GET IT
Times cited: 24
Inter-helix distances in lysophospholipid micelle-bound alpha-synuclein from pulsed ESR measurements. Journal of the American Chemical Society. 2006 Academic Article GET IT
Times cited: 85
Folding of the repeat domain of tau upon binding to lipid surfaces. Journal of molecular biology. 2006 Academic Article GET IT
Times cited: 63
Secondary structure and dynamics of micelle bound beta- and gamma-synuclein. Protein science : a publication of the Protein Society. 2006 Academic Article GET IT
Times cited: 45
Quantification of alpha-synuclein binding to lipid vesicles using fluorescence correlation spectroscopy. Biophysical journal. 2006 Academic Article GET IT
Times cited: 229
Antiparallel four-stranded coiled coil specified by a 3-3-1 hydrophobic heptad repeat. Structure (London, England : 1993). 2006 Academic Article GET IT
Times cited: 58
Native chemical ligation in covalent caspase inhibition by p35. Chemistry & biology. 2006 Academic Article GET IT
Times cited: 14
NMR mapping of copper binding sites in alpha-synuclein. Biochimica et biophysica acta. 2005 Academic Article GET IT
Times cited: 106
Helix periodicity, topology, and dynamics of membrane-associated alpha-synuclein. Protein science : a publication of the Protein Society. 2005 Academic Article GET IT
Times cited: 133
Residual structure in the repeat domain of tau: echoes of microtubule binding and paired helical filament formation. Biochemistry. 2005 Academic Article GET IT
Times cited: 98
Effects of Parkinson's disease-linked mutations on the structure of lipid-associated alpha-synuclein. Biochemistry. 2004 Academic Article GET IT
Times cited: 132
Folding pyrin into the family. Structure (London, England : 1993). 2003 Comment GET IT
Times cited: 11
A structural and functional role for 11-mer repeats in alpha-synuclein and other exchangeable lipid binding proteins. Journal of molecular biology. 2003 Academic Article GET IT
Times cited: 386
Residual structure and dynamics in Parkinson's disease-associated mutants of alpha-synuclein. The Journal of biological chemistry. 2001 Academic Article GET IT
Times cited: 240
Conformational properties of alpha-synuclein in its free and lipid-associated states. Journal of molecular biology. 2001 Academic Article GET IT
Times cited: 939
NMR structural and dynamic characterization of the acid-unfolded state of apomyoglobin provides insights into the early events in protein folding. Biochemistry. 2001 Academic Article GET IT
Times cited: 211
Native and non-native secondary structure and dynamics in the pH 4 intermediate of apomyoglobin. Biochemistry. 2000 Academic Article GET IT
Times cited: 118
Transient dimer in the refolding kinetics of cytochrome c characterized by small-angle X-ray scattering. Biochemistry. 1999 Academic Article GET IT
Times cited: 66
Structural and dynamic characterization of partially folded states of apomyoglobin and implications for protein folding. Nature structural biology. 1998 Academic Article GET IT
Times cited: 396
Populating the equilibrium molten globule state of apomyoglobin under conditions suitable for structural characterization by NMR. FEBS letters. 1997 Academic Article GET IT
Times cited: 48
Is apomyoglobin a molten globule? Structural characterization by NMR. Journal of molecular biology. 1996 Academic Article GET IT
Times cited: 238
The radius of gyration of an apomyoglobin folding intermediate. Science (New York, N.Y.). 1995 Academic Article GET IT
Times cited: 140
Blue form of bacteriorhodopsin and its order-disorder transition during dehydration. Biochimica et biophysica acta. 1994 Academic Article GET IT
Times cited: 5
MgATP-induced conformational changes in the iron protein from Azotobacter vinelandii, as studied by small-angle x-ray scattering. The Journal of biological chemistry. 1994 Academic Article GET IT
Times cited: 48
Small-angle x-ray scattering studies of the iron-molybdenum cofactor from Azotobacter vinelandii nitrogenase. The Journal of biological chemistry. 1993 Academic Article GET IT
Times cited: 9
Evidence of an associative intermediate on the myoglobin refolding pathway. Biophysical journal. 1993 Academic Article GET IT
Times cited: 91

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Research

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Funding awarded

Molecular Biophysics Training Program awarded by National Institute of General Medical Sciences Principal Investigator 2025 - 2030
Structure and Function of Protein Disorder in Membrane Trafficking and Organization awarded by National Institute of General Medical Sciences Principal Investigator 2025 - 2029
Structure and Function of Protein Disorder in Membrane Trafficking and Organization awarded by National Institute of General Medical Sciences Principal Investigator 2020 - 2026
Structure and Function of Tau awarded by National Institute on Aging Principal Investigator 2020 - 2025
Molecular Biophysics Training Program awarded by National Institute of General Medical Sciences Principal Investigator 2020 - 2025

Mechanisms of Regulation of Metabotropic Glutamate Receptors awarded by National Institute of Neurological Disorders & Stroke Co-Investigator 2023 - 2028

CHCHD10 frontotemporal dementia, molecular mechanisms and therapeutic strategies awarded by National Institute of Neurological Disorders & Stroke Co-Principal Investigator 2024 - 2029

Structural basis and physiological consequences of alpha-Synuclein binding to neurexin 1beta awarded by National Institute of Mental Health Principal Investigator Subaward 2021 - 2026
The role of post-translational modifications in alpha-synuclein function and pathology awarded by National Institute of Mental Health Principal Investigator Subaward 2022 - 2025

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Background

education and training

Ph.D., Stanford University 94
M.S., University of Michigan 1988
B.S., University of Michigan 1987

Contact

full name

David Eliezer

primary email

dae2005@med.cornell.edu

VIVO Weill Cornell Medical College

David Eliezer Professor

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email