selected publications
- Phosphoglycerate kinase is a central leverage point in Parkinson's disease-driven neuronal metabolic deficits. Science advances. 2024 Academic Article GET IT
- Amyloid fibril structures link CHCHD10 and CHCHD2 to neurodegeneration. 2024 GET IT
- Control of G protein-coupled receptor function via membrane-interacting intrinsically disordered C-terminal domains. Proceedings of the National Academy of Sciences of the United States of America. 2024 Academic Article GET IT
- Carbon dots as dual inhibitors of tau and amyloid-beta aggregation for the treatment of Alzheimer's disease. Acta biomaterialia. 2024 Academic Article GET IT
- Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins. 2024 GET IT
- Phosphoglycerate kinase 1 is a central leverage point in Parkinson's disease driven neuronal metabolic deficits. 2023 GET IT
- Alpha synuclein modulates mitochondrial Ca2+ uptake from ER during cell stimulation and under stress conditions. NPJ Parkinson's disease. 2023 Academic Article GET IT
- Control of G protein-coupled receptor function via membrane-interacting intrinsically disordered C-terminal domains. 2023 GET IT
- Structure and DNA-bridging activity of the essential Rec114-Mei4 trimer interface. Genes & development. 2023 Academic Article GET IT
- Environmentally Ultrasensitive Fluorine Probe to Resolve Protein Conformational Ensembles by 19F NMR and Cryo-EM. Journal of the American Chemical Society. 2023 Academic Article GET IT
- The Role of Membrane Affinity and Binding Modes in Alpha-Synuclein Regulation of Vesicle Release and Trafficking. Biomolecules. 2022 Academic Article GET IT
- Proline-Rich Region II (PRR2) Plays an Important Role in Tau-Glycan Interaction: An NMR Study. Biomolecules. 2022 Academic Article GET IT
- Molecular and Functional Interactions of Alpha-Synuclein with Rab3a. The Journal of biological chemistry. 2022 Academic Article GET IT
- Membrane binding induces distinct structural signatures in the mouse complexin-1 C-terminal domain. Journal of molecular biology. 2022 Academic Article GET IT
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Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins.
Cell reports.
2022
Academic Article
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Times cited: 30 - Homogalacturonan from squash: Characterization and tau-binding pattern of a sulfated derivative. Carbohydrate polymers. 2022 Academic Article GET IT
- Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer's disease. Nature communications. 2022 Academic Article GET IT
- The dopamine receptor agonist apomorphine stabilizes neurotoxic alpha-synuclein oligomers. FEBS letters. 2021 Academic Article GET IT
- Post-translational modifications within tau paired helical filament nucleating motifs perturb microtubule interactions and oligomer formation. The Journal of biological chemistry. 2021 Academic Article GET IT
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Fisetin inhibits tau aggregation by interacting with the protein and preventing the formation of β-strands.
International journal of biological macromolecules.
2021
Academic Article
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Times cited: 1 -
Chemoenzymatic Semi-synthesis Enables Efficient Production of Isotopically Labeled α-Synuclein with Site-Specific Tyrosine Phosphorylation.
Chembiochem : a European journal of chemical biology.
2021
Academic Article
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Times cited: 10 -
Tau induces PSD95-neuronal NOS uncoupling and neurovascular dysfunction independent of neurodegeneration.
Nature neuroscience.
2020
Academic Article
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Times cited: 70 -
Use of paramagnetic 19F NMR to monitor domain movement in a glutamate transporter homolog.
Nature chemical biology.
2020
Academic Article
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Times cited: 30 -
Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau.
The Journal of biological chemistry.
2020
Academic Article
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Times cited: 32 -
Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts.
BMC complementary medicine and therapies.
2020
Academic Article
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Times cited: 25 -
Interactions of IDPs with Membranes Using Dark-State Exchange NMR Spectroscopy.
Methods in molecular biology (Clifton, N.J.).
2020
Article
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Times cited: 2 - Probing IDP Interactions with Membranes by Fluorescence Spectroscopy. Methods in molecular biology (Clifton, N.J.). 2020 Article GET IT
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3-O-Sulfation of Heparan Sulfate Enhances Tau Interaction and Cellular Uptake.
Angewandte Chemie (International ed. in English).
2019
Academic Article
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Times cited: 74 -
Exchange of water for sterol underlies sterol egress from a StARkin domain.
eLife.
2019
Academic Article
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Times cited: 14 -
Regulation of exocytosis and mitochondrial relocalization by Alpha-synuclein in a mammalian cell model.
NPJ Parkinson's disease.
2019
Academic Article
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Times cited: 19 -
Membrane interactions of intrinsically disordered proteins: The example of alpha-synuclein.
Biochimica et biophysica acta. Proteins and proteomics.
2019
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Times cited: 37 -
Probing Structural Changes in Alpha-Synuclein by Nuclear Magnetic Resonance Spectroscopy.
Methods in molecular biology (Clifton, N.J.).
2019
Article
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Times cited: 1 -
Role of Parkinson's Disease-Linked Mutations and N-Terminal Acetylation on the Oligomerization of α-Synuclein Induced by 3,4-Dihydroxyphenylacetaldehyde.
ACS chemical neuroscience.
2018
Academic Article
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Times cited: 31 -
Spectroscopic Characterization of Structure-Function Relationships in the Intrinsically Disordered Protein Complexin.
Methods in enzymology.
2018
Article
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Times cited: 2 -
Exploring the role of methionine residues on the oligomerization and neurotoxic properties of DOPAL-modified α-synuclein.
Biochemical and biophysical research communications.
2018
Academic Article
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Times cited: 13 -
Structure and dynamics of the extended-helix state of alpha-synuclein: Intrinsic lability of the linker region.
Protein science : a publication of the Protein Society.
2018
Academic Article
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Times cited: 9 -
A Protofilament-Protofilament Interface in the Structure of Mouse α-Synuclein Fibrils.
Biophysical journal.
2018
Academic Article
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Times cited: 9 - Structural basis of sterol binding and transport by a yeast StARkin domain. The Journal of biological chemistry. 2018 Academic Article GET IT
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Parkinson's Disease and Melanoma: Co-Occurrence and Mechanisms.
Journal of Parkinson's disease.
2018
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Times cited: 79 -
Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes.
Nature communications.
2017
Academic Article
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Times cited: 107 -
Proteins acting out of (dis)order.
eLife.
2017
Article
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Times cited: 2 -
Evolutionary Divergence of the C-terminal Domain of Complexin Accounts for Functional Disparities between Vertebrate and Invertebrate Complexins.
Frontiers in molecular neuroscience.
2017
Academic Article
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Times cited: 20 -
Unique Structural Features of Membrane-Bound C-Terminal Domain Motifs Modulate Complexin Inhibitory Function.
Frontiers in molecular neuroscience.
2017
Academic Article
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Times cited: 23 -
Glycan Determinants of Heparin-Tau Interaction.
Biophysical journal.
2017
Academic Article
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Times cited: 64 -
Phosphorylation regulates the secondary structure and function of dentin phosphoprotein peptides.
Bone.
2016
Academic Article
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Times cited: 13 -
Exposure to bacterial endotoxin generates a distinct strain of α-synuclein fibril.
Scientific reports.
2016
Academic Article
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Times cited: 114 -
Conformational heterogeneity in closed and open states of the KcsA potassium channel in lipid bicelles.
The Journal of general physiology.
2016
Academic Article
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Times cited: 17 -
Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations.
ACS chemical biology.
2016
Academic Article
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Times cited: 62 -
The C-terminal α-helices of mammalian Hsc70 play a critical role in the stabilization of α-synuclein binding and inhibition of aggregation.
International journal of biological macromolecules.
2015
Academic Article
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Times cited: 19 -
Oligomerization and Membrane-binding Properties of Covalent Adducts Formed by the Interaction of α-Synuclein with the Toxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde (DOPAL).
The Journal of biological chemistry.
2015
Academic Article
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Times cited: 93 -
STARD4 Membrane Interactions and Sterol Binding.
Biochemistry.
2015
Academic Article
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Times cited: 46 - Alpha-synuclein function and dysfunction on cellular membranes. Experimental neurobiology. 2014 Information Resource GET IT
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Ginsenoside Rb1 inhibits fibrillation and toxicity of alpha-synuclein and disaggregates preformed fibrils.
Neurobiology of disease.
2014
Academic Article
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Times cited: 87 -
The accessory helix of complexin functions by stabilizing central helix secondary structure.
eLife.
2014
Academic Article
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Times cited: 33 -
Membrane curvature sensing by the C-terminal domain of complexin.
Nature communications.
2014
Academic Article
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Times cited: 62 -
Tau binds to lipid membrane surfaces via short amphipathic helices located in its microtubule-binding repeats.
Biophysical journal.
2014
Academic Article
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Times cited: 86 -
Structure activity relationship of phenolic acid inhibitors of α-synuclein fibril formation and toxicity.
Frontiers in aging neuroscience.
2014
Academic Article
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Times cited: 100 -
The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity.
The Journal of biological chemistry.
2014
Academic Article
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Times cited: 151 -
The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear localization in cells.
Human molecular genetics.
2014
Academic Article
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Times cited: 184 -
c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease.
Human molecular genetics.
2014
Academic Article
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Times cited: 176 -
N-terminal acetylation stabilizes N-terminal helicity in lipid- and micelle-bound α-synuclein and increases its affinity for physiological membranes.
The Journal of biological chemistry.
2013
Academic Article
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Times cited: 143 -
Structural transitions in tau k18 on micelle binding suggest a hierarchy in the efficacy of individual microtubule-binding repeats in filament nucleation.
Protein science : a publication of the Protein Society.
2013
Academic Article
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Times cited: 54 -
The mysterious C-terminal tail of alpha-synuclein: nanobody's guess.
Journal of molecular biology.
2013
Article
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Times cited: 12 -
Synaptic vesicles position complexin to block spontaneous fusion.
Neuron.
2013
Academic Article
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Times cited: 70 -
In support of the BMRB.
Nature structural & molecular biology.
2012
Academic Article
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Times cited: 5 -
Interplay between desolvation and secondary structure in mediating cosolvent and temperature induced alpha-synuclein aggregation.
Physical biology.
2012
Academic Article
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Times cited: 14 -
¹H, ¹³C, and ¹⁵N backbone resonance assignments of the L124D mutant of StAR-related lipid transfer domain protein 4 (StARD4).
Biomolecular NMR assignments.
2012
Academic Article
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Times cited: 3 -
Characterization of semisynthetic and naturally Nα-acetylated α-synuclein in vitro and in intact cells: implications for aggregation and cellular properties of α-synuclein.
The Journal of biological chemistry.
2012
Academic Article
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Times cited: 141 -
Assigning backbone NMR resonances for full length tau isoforms: efficient compromise between manual assignments and reduced dimensionality.
PloS one.
2012
Academic Article
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Times cited: 29 -
Binding of the three-repeat domain of tau to phospholipid membranes induces an aggregated-like state of the protein.
Biochimica et biophysica acta.
2012
Academic Article
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Times cited: 65 -
Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: α-synuclein phosphorylation at tyrosine 125.
Journal of the American Chemical Society.
2012
Academic Article
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Times cited: 90 -
α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer.
The Journal of biological chemistry.
2012
Academic Article
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Times cited: 450 -
Distance information for disordered proteins from NMR and ESR measurements using paramagnetic spin labels.
Methods in molecular biology (Clifton, N.J.).
2012
Academic Article
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Times cited: 16 -
Folding and misfolding of alpha-synuclein on membranes.
Biochimica et biophysica acta.
2011
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Times cited: 160 -
STARD4 abundance regulates sterol transport and sensing.
Molecular biology of the cell.
2011
Academic Article
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Times cited: 98 -
Structural characterization of two alternate conformations in a calbindin D₉k-based molecular switch.
Biochemistry.
2011
Academic Article
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Times cited: 8 -
Identification of a helical intermediate in trifluoroethanol-induced alpha-synuclein aggregation.
Proceedings of the National Academy of Sciences of the United States of America.
2010
Academic Article
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Times cited: 155 -
The lipid-binding domain of wild type and mutant alpha-synuclein: compactness and interconversion between the broken and extended helix forms.
The Journal of biological chemistry.
2010
Academic Article
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Times cited: 118 -
The cold denatured state of the C-terminal domain of protein L9 is compact and contains both native and non-native structure.
Journal of the American Chemical Society.
2010
Academic Article
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Times cited: 39 -
Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2010
Academic Article
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Times cited: 255 -
Biophysics of Parkinson's disease: structure and aggregation of alpha-synuclein.
Current protein & peptide science.
2009
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Times cited: 281 -
Charge neutralization and collapse of the C-terminal tail of alpha-synuclein at low pH.
Protein science : a publication of the Protein Society.
2009
Academic Article
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Times cited: 85 -
The unfolded state of the C-terminal domain of the ribosomal protein L9 contains both native and non-native structure.
Biochemistry.
2009
Academic Article
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Times cited: 27 -
E46K Parkinson's-linked mutation enhances C-terminal-to-N-terminal contacts in alpha-synuclein.
Journal of molecular biology.
2009
Academic Article
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Times cited: 89 -
Structural basis for recognition of diubiquitins by NEMO.
Molecular cell.
2009
Academic Article
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Times cited: 221 -
Biophysical characterization of intrinsically disordered proteins.
Current opinion in structural biology.
2009
Information Resource
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Times cited: 277 -
Membrane-bound alpha-synuclein forms an extended helix: long-distance pulsed ESR measurements using vesicles, bicelles, and rodlike micelles.
Journal of the American Chemical Society.
2008
Academic Article
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Times cited: 235 -
Identification of a copper-binding metallothionein in pathogenic mycobacteria.
Nature chemical biology.
2008
Academic Article
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Times cited: 174 -
The low-pH unfolded state of the C-terminal domain of the ribosomal protein L9 contains significant secondary structure in the absence of denaturant but is no more compact than the low-pH urea unfolded state.
Biochemistry.
2008
Academic Article
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Times cited: 20 -
Structural effects of Parkinson's disease linked DJ-1 mutations.
Protein science : a publication of the Protein Society.
2008
Academic Article
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Times cited: 67 -
Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein.
The Journal of biological chemistry.
2008
Academic Article
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Times cited: 284 -
Residual structure, backbone dynamics, and interactions within the synuclein family.
Journal of molecular biology.
2007
Academic Article
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Times cited: 126 -
The impact of the E46K mutation on the properties of alpha-synuclein in its monomeric and oligomeric states.
Biochemistry.
2007
Academic Article
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Times cited: 164 -
Characterizing residual structure in disordered protein States using nuclear magnetic resonance.
Methods in molecular biology (Clifton, N.J.).
2007
Information Resource
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Times cited: 55 -
Amyloid ion channels: a porous argument or a thin excuse?.
The Journal of general physiology.
2006
Article
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Times cited: 24 -
Inter-helix distances in lysophospholipid micelle-bound alpha-synuclein from pulsed ESR measurements.
Journal of the American Chemical Society.
2006
Academic Article
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Times cited: 80 -
Folding of the repeat domain of tau upon binding to lipid surfaces.
Journal of molecular biology.
2006
Academic Article
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Times cited: 48 -
Secondary structure and dynamics of micelle bound beta- and gamma-synuclein.
Protein science : a publication of the Protein Society.
2006
Academic Article
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Times cited: 44 -
Quantification of alpha-synuclein binding to lipid vesicles using fluorescence correlation spectroscopy.
Biophysical journal.
2006
Academic Article
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Times cited: 219 -
Antiparallel four-stranded coiled coil specified by a 3-3-1 hydrophobic heptad repeat.
Structure (London, England : 1993).
2006
Academic Article
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Times cited: 54 -
Native chemical ligation in covalent caspase inhibition by p35.
Chemistry & biology.
2006
Academic Article
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Times cited: 12 -
NMR mapping of copper binding sites in alpha-synuclein.
Biochimica et biophysica acta.
2005
Academic Article
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Times cited: 93 -
Helix periodicity, topology, and dynamics of membrane-associated alpha-synuclein.
Protein science : a publication of the Protein Society.
2005
Academic Article
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Times cited: 133 -
Residual structure in the repeat domain of tau: echoes of microtubule binding and paired helical filament formation.
Biochemistry.
2005
Academic Article
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Times cited: 87 -
Effects of Parkinson's disease-linked mutations on the structure of lipid-associated alpha-synuclein.
Biochemistry.
2004
Academic Article
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Times cited: 117 -
A structural and functional role for 11-mer repeats in alpha-synuclein and other exchangeable lipid binding proteins.
Journal of molecular biology.
2003
Academic Article
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Times cited: 315 -
Residual structure and dynamics in Parkinson's disease-associated mutants of alpha-synuclein.
The Journal of biological chemistry.
2001
Academic Article
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Times cited: 220 -
Conformational properties of alpha-synuclein in its free and lipid-associated states.
Journal of molecular biology.
2001
Academic Article
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Times cited: 765 -
NMR structural and dynamic characterization of the acid-unfolded state of apomyoglobin provides insights into the early events in protein folding.
Biochemistry.
2001
Academic Article
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Times cited: 202 -
Native and non-native secondary structure and dynamics in the pH 4 intermediate of apomyoglobin.
Biochemistry.
2000
Academic Article
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Times cited: 114 -
Transient dimer in the refolding kinetics of cytochrome c characterized by small-angle X-ray scattering.
Biochemistry.
1999
Academic Article
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Times cited: 63 -
Populating the equilibrium molten globule state of apomyoglobin under conditions suitable for structural characterization by NMR.
FEBS letters.
1997
Academic Article
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Times cited: 47 -
Is apomyoglobin a molten globule? Structural characterization by NMR.
Journal of molecular biology.
1996
Academic Article
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Times cited: 224 -
Blue form of bacteriorhodopsin and its order-disorder transition during dehydration.
Biochimica et biophysica acta.
1994
Academic Article
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Times cited: 5 -
MgATP-induced conformational changes in the iron protein from Azotobacter vinelandii, as studied by small-angle x-ray scattering.
The Journal of biological chemistry.
1994
Academic Article
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Times cited: 41 -
Small-angle x-ray scattering studies of the iron-molybdenum cofactor from Azotobacter vinelandii nitrogenase.
The Journal of biological chemistry.
1993
Academic Article
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Times cited: 9 -
Evidence of an associative intermediate on the myoglobin refolding pathway.
Biophysical journal.
1993
Academic Article
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Times cited: 90