Gao, Ding Cheng

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selected publications

Deficiency of metabolic regulator PKM2 activates the pentose phosphate pathway and generates TCF1⁺ progenitor CD8⁺ T cells to improve immunotherapy. Nature immunology. 2024 Academic Article GET IT
Targeting ribosome biogenesis as a novel therapeutic approach to overcome EMT-related chemoresistance in breast cancer. eLife. 2024 Academic Article GET IT
Charting Single Cell Lineage Dynamics and Mutation Networks via Homing CRISPR. 2024 GET IT
Deficiency of metabolic regulator PKM2 activates the pentose phosphate pathway and generates TCF1+ progenitor CD8+ T cells to improve checkpoint blockade. 2023 GET IT
Tumor-intrinsic IRE1α signaling controls protective immunity in lung cancer. Nature communications. 2023 Academic Article GET IT
Times cited: 16
Copper depletion modulates mitochondrial oxidative phosphorylation to impair triple negative breast cancer metastasis. Nature communications. 2021 Academic Article GET IT
Times cited: 132
Radiation-activated secretory proteins of Scgb1a1⁺ club cells increase the efficacy of immune checkpoint blockade in lung cancer. Nature cancer. 2021 Academic Article GET IT
Times cited: 32
Inhibition of EZH2 Catalytic Activity Selectively Targets a Metastatic Subpopulation in Triple-Negative Breast Cancer. Cell reports. 2020 Academic Article GET IT
Times cited: 14
Differential Contributions of Pre- and Post-EMT Tumor Cells in Breast Cancer Metastasis. Cancer research. 2019 Comment GET IT
Times cited: 65
Controversies around epithelial-mesenchymal plasticity in cancer metastasis. Nature reviews. Cancer. 2019 Review GET IT
Times cited: 304
The lung microenvironment: an important regulator of tumour growth and metastasis. Nature reviews. Cancer. 2019 Review GET IT
Times cited: 745
Metastatic tumor cells - genotypes and phenotypes. Frontiers in biology. 2018 Academic Article GET IT
Times cited: 14
Immune reprogramming via PD-1 inhibition enhances early-stage lung cancer survival. JCI insight. 2018 Academic Article GET IT
Times cited: 48
Fischer et al. reply. Nature. 2017 Academic Article GET IT
Times cited: 13
Matrix Metalloproteinase 14 promotes lung cancer by cleavage of Heparin-Binding EGF-like Growth Factor. Neoplasia (New York, N.Y.). 2016 Academic Article GET IT
Times cited: 45
In Vivo Visualization and Characterization of Epithelial-Mesenchymal Transition in Breast Tumors. Cancer research. 2016 Academic Article GET IT
Times cited: 66
Lung inflammation promotes metastasis through neutrophil protease-mediated degradation of Tsp-1. Proceedings of the National Academy of Sciences of the United States of America. 2015 Academic Article GET IT
Times cited: 168
Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance. Nature. 2015 Academic Article GET IT
Times cited: 1474
Identification of Reprogrammed Myeloid Cell Transcriptomes in NSCLC. PloS one. 2015 Academic Article GET IT
Times cited: 17
Transcriptome analysis of individual stromal cell populations identifies stroma-tumor crosstalk in mouse lung cancer model. Cell reports. 2015 Academic Article GET IT
Times cited: 52
Bone marrow-derived Gr1+ cells can generate a metastasis-resistant microenvironment via induced secretion of thrombospondin-1. Cancer discovery. 2013 Academic Article GET IT
Times cited: 112
Suppression of miRNA-708 by polycomb group promotes metastases by calcium-induced cell migration. Cancer cell. 2013 Academic Article GET IT
Times cited: 112
Microenvironmental regulation of epithelial-mesenchymal transitions in cancer. Cancer research. 2012 Review GET IT
Times cited: 259
MicroRNAs regulate tumor angiogenesis modulated by endothelial progenitor cells. Cancer research. 2012 Academic Article GET IT
Times cited: 100
Tumor microenvironment regulates epithelial-mesenchymal transitions in metastasis. Expert review of anticancer therapy. 2012 Editorial Article GET IT
Times cited: 17
Myeloid progenitor cells in the premetastatic lung promote metastases by inducing mesenchymal to epithelial transition. Cancer research. 2012 Academic Article GET IT
Times cited: 243
Discovery of novel human breast cancer microRNAs from deep sequencing data by analysis of pri-microRNA secondary structures. PloS one. 2011 Academic Article GET IT
Times cited: 35
Using the transcription factor inhibitor of DNA binding 1 to selectively target endothelial progenitor cells offers novel strategies to inhibit tumor angiogenesis and growth. Cancer research. 2010 Academic Article GET IT
Times cited: 54
TGF-beta IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer. Proceedings of the National Academy of Sciences of the United States of America. 2010 Academic Article GET IT
Times cited: 339
Inhibition of neovascularization to simultaneously ameliorate graft-vs-host disease and decrease tumor growth. Journal of the National Cancer Institute. 2010 Academic Article GET IT
Times cited: 55
The role of bone-marrow-derived cells in tumor growth, metastasis initiation and progression. Trends in molecular medicine. 2009 Academic Article GET IT
Times cited: 79
Bone marrow-derived endothelial progenitor cells contribute to the angiogenic switch in tumor growth and metastatic progression. Biochimica et biophysica acta. 2009 Review GET IT
Times cited: 164
Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis. Science (New York, N.Y.). 2008 Academic Article GET IT
Times cited: 536
CAPRI and RASAL impose different modes of information processing on Ras due to contrasting temporal filtering of Ca2+. The Journal of cell biology. 2005 Academic Article GET IT
Times cited: 60
CD40 antisense oligonucleotide inhibition of trinitrobenzene sulphonic acid induced rat colitis. Gut. 2005 Academic Article GET IT
Times cited: 47
Phosphorylation of hepatic stimulator substance on mitogen-activated protein kinase in BEL-7402 hepatoma cells. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology. 2001 Academic Article GET IT
Times cited: 8
Decoy oligodeoxynucleotide characterization of transcription factors controlling endothelin-B receptor expression in vascular smooth muscle cells. Molecular pharmacology. 2000 Academic Article GET IT
Times cited: 27
[Influence of hepatic stimulator substance on p21(ras) expression in human hepatic carcinoma cells BEL-7402]. Sheng li xue bao : [Acta physiologica Sinica]. 2000 Academic Article GET IT
Times cited: 5
Retrovirus-mediated herpes simplex virus thymidine kinase gene therapy approach for hepatocellular carcinoma. Cell research. 1999 Academic Article GET IT
Times cited: 7

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Research

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Funding awarded

To study the EMT contributions in tumor metastasis and chemoresistance by using lineage tracing models awarded by National Cancer Institute Principal Investigator 2020 - 2025

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Background

education and training

Ph.D., University of Goettingen (Germany) 2003
M.S., Capital University of Medical Sciences (China) 1998
B.M., Binzhou Medical College (China) 1995

Contact

full name

Ding Cheng Gao

primary email

dig2009@med.cornell.edu

webpage

Gao Lab

VIVO Weill Cornell Medical College

Ding Cheng Gao Associate Professor of Cell and Developmental Biology in Cardiothoracic Surgery

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage