Maxfield, Frederick R.

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Signaling pathways regulating the extracellular digestion of lipoprotein aggregates by macrophages. Molecular biology of the cell. 2023 Academic Article GET IT
The formation and consequences of cholesterol-rich deposits in atherosclerotic lesions. Frontiers in cardiovascular medicine. 2023 Review GET IT
Elevated levels of tripeptidyl peptidase 1 do not ameliorate pathogenesis in a mouse model of Alzheimer disease. Neurobiology of aging. 2022 Academic Article GET IT
Cholesterol and matrisome pathways dysregulated in astrocytes and microglia. Cell. 2022 Academic Article GET IT
Phosphatidylinositol Phosphates Modulate Interactions between the StarD4 Sterol Trafficking Protein and Lipid Membranes. The Journal of biological chemistry. 2022 Academic Article GET IT
HSP90 inhibitors reduce cholesterol storage in Niemann-Pick type C1 mutant fibroblasts. Journal of lipid research. 2021 Academic Article GET IT
Inhibition of Histone Deacetylases 1, 2, and 3 Enhances Clearance of Cholesterol Accumulation in Niemann-Pick C1 Fibroblasts. ACS pharmacology & translational science. 2021 Academic Article GET IT
A role of the frontotemporal lobar degeneration risk factor TMEM106B in myelination. Brain : a journal of neurology. 2020 Academic Article GET IT
Times cited: 29
Stable reduction of STARD4 alters cholesterol regulation and lipid homeostasis. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2020 Academic Article GET IT
Times cited: 14
Digestive exophagy: Phagocyte digestion of objects too large for phagocytosis. Traffic (Copenhagen, Denmark). 2019 Information Resource GET IT
Times cited: 17
High-density lipoprotein or cyclodextrin extraction of cholesterol from aggregated LDL reduces foam cell formation. Journal of cell science. 2019 Academic Article GET IT
Times cited: 12
TLR4 (Toll-Like Receptor 4)-Dependent Signaling Drives Extracellular Catabolism of LDL (Low-Density Lipoprotein) Aggregates. Arteriosclerosis, thrombosis, and vascular biology. 2019 Academic Article GET IT
Times cited: 48
2-Hydroxypropyl-β-cyclodextrin is the active component in a triple combination formulation for treatment of Niemann-Pick C1 disease. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2019 Academic Article GET IT
Times cited: 21
Dynamic Actin Reorganization and Vav/Cdc42-Dependent Actin Polymerization Promote Macrophage Aggregated LDL (Low-Density Lipoprotein) Uptake and Catabolism. Arteriosclerosis, thrombosis, and vascular biology. 2019 Academic Article GET IT
Times cited: 23
Progranulin in the hematopoietic compartment protects mice from atherosclerosis. Atherosclerosis. 2018 Academic Article GET IT
Times cited: 11
Lysosomal enzyme tripeptidyl peptidase 1 destabilizes fibrillar Aβ by multiple endoproteolytic cleavages within the β-sheet domain. Proceedings of the National Academy of Sciences of the United States of America. 2018 Academic Article GET IT
Times cited: 30
A Novel Neuroprotective Mechanism for Lithium That Prevents Association of the p75^NTR-Sortilin Receptor Complex and Attenuates proNGF-Induced Neuronal Death In Vitro and In Vivo. eNeuro. 2018 Academic Article GET IT
Times cited: 16
Membrane order in the plasma membrane and endocytic recycling compartment. PloS one. 2017 Academic Article GET IT
Times cited: 16
Membrane dynamics and organelle biogenesis-lipid pipelines and vesicular carriers. BMC biology. 2017 Academic Article GET IT
Times cited: 64
Metabolically Activated Adipose Tissue Macrophages Perform Detrimental and Beneficial Functions during Diet-Induced Obesity. Cell reports. 2017 Academic Article GET IT
Times cited: 198
Mitochondrial Fission Promotes the Continued Clearance of Apoptotic Cells by Macrophages. Cell. 2017 Academic Article GET IT
Times cited: 254
A Carbon Nanotube Optical Reporter Maps Endolysosomal Lipid Flux. ACS nano. 2017 Academic Article GET IT
Times cited: 87
Ceramide activation of RhoA/Rho kinase impairs actin polymerization during aggregated LDL catabolism. Journal of lipid research. 2017 Academic Article GET IT
Times cited: 17
Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing. Nature medicine. 2017 Academic Article GET IT
Times cited: 289
Role of STARD4 in sterol transport between the endocytic recycling compartment and the plasma membrane. Molecular biology of the cell. 2017 Academic Article GET IT
Times cited: 34
Histone deacetylase inhibitors correct the cholesterol storage defect in most Niemann-Pick C1 mutant cells. Journal of lipid research. 2017 Academic Article GET IT
Times cited: 43
The endocytic pathway in microglia during health, aging and Alzheimer's disease. Ageing research reviews. 2016 Information Resource GET IT
Times cited: 83
Exocytosis of macrophage lysosomes leads to digestion of apoptotic adipocytes and foam cell formation. Journal of lipid research. 2016 Academic Article GET IT
Times cited: 92
Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models. Science translational medicine. 2016 Academic Article GET IT
Times cited: 116
Role of STARD4 and NPC1 in intracellular sterol transport. Biochemistry and cell biology = Biochimie et biologie cellulaire. 2016 Information Resource GET IT
Times cited: 17
Degradation of aggregated LDL occurs in complex extracellular sub-compartments of the lysosomal synapse. Journal of cell science. 2016 Academic Article GET IT
Times cited: 29
A novel intrinsically fluorescent probe for study of uptake and trafficking of 25-hydroxycholesterol. Journal of lipid research. 2015 Academic Article GET IT
Times cited: 10
Monocyte-Derived Dendritic Cells Upregulate Extracellular Catabolism of Aggregated Low-Density Lipoprotein on Maturation, Leading to Foam Cell Formation. Arteriosclerosis, thrombosis, and vascular biology. 2015 Academic Article GET IT
Times cited: 26
STARD4 Membrane Interactions and Sterol Binding. Biochemistry. 2015 Academic Article GET IT
Times cited: 46
A murine Niemann-Pick C1 I1061T knock-in model recapitulates the pathological features of the most prevalent human disease allele. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2015 Academic Article GET IT
Times cited: 94
Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors. ChemMedChem. 2014 Academic Article GET IT
Times cited: 28
Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 45
Treatment of Niemann--pick type C disease by histone deacetylase inhibitors. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2013 Information Resource GET IT
Times cited: 47
Sphingosine kinases are not required for inflammatory responses in macrophages. The Journal of biological chemistry. 2013 Academic Article GET IT
Times cited: 61
Plasmin promotes foam cell formation by increasing macrophage catabolism of aggregated low-density lipoprotein. Arteriosclerosis, thrombosis, and vascular biology. 2013 Academic Article GET IT
Times cited: 13
Efficiency of immunotoxin cytotoxicity is modulated by the intracellular itinerary. PloS one. 2012 Academic Article GET IT
Times cited: 11
STARD4 knockdown in HepG2 cells disrupts cholesterol trafficking associated with the plasma membrane, ER, and ERC. Journal of lipid research. 2012 Academic Article GET IT
Times cited: 34
Quantitative analysis of monocyte subpopulations in murine atherosclerotic plaques by multiphoton microscopy. PloS one. 2012 Academic Article GET IT
Times cited: 20
Multiphoton microscopy in the evaluation of human bladder biopsies. Archives of pathology & laboratory medicine. 2012 Academic Article GET IT
Times cited: 60
Analysis of cholesterol trafficking with fluorescent probes. Methods in cell biology. 2012 Article GET IT
Times cited: 119
STARD4 abundance regulates sterol transport and sensing. Molecular biology of the cell. 2011 Academic Article GET IT
Times cited: 98
Multiphoton microscopy for structure identification in human prostate and periprostatic tissue: implications in prostate cancer surgery. BJU international. 2011 Academic Article GET IT
Times cited: 59
Degradation of Alzheimer's amyloid fibrils by microglia requires delivery of ClC-7 to lysosomes. Molecular biology of the cell. 2011 Academic Article GET IT
Times cited: 79
Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. 2011 Academic Article GET IT
Times cited: 158
Niemann-Pick type C disease: molecular mechanisms and potential therapeutic approaches. Journal of neurochemistry. 2011 Information Resource GET IT
Times cited: 203
Deletion of ABCA1 and ABCG1 impairs macrophage migration because of increased Rac1 signaling. Circulation research. 2010 Academic Article GET IT
Times cited: 83
Cholesterol pathways affected by small molecules that decrease sterol levels in Niemann-Pick type C mutant cells. PloS one. 2010 Academic Article GET IT
Times cited: 13
Development of a novel, cell-based chemical screen to identify inhibitors of intraphagosomal lipolysis in macrophages. Cytometry. Part A : the journal of the International Society for Analytical Cytology. 2010 Academic Article GET IT
Times cited: 11
Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics. Journal of medicinal chemistry. 2010 Academic Article GET IT
Times cited: 78
Cholesterol, the central lipid of mammalian cells. Current opinion in cell biology. 2010 Information Resource GET IT
Times cited: 286
Endocytosis of beta-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells. Proceedings of the National Academy of Sciences of the United States of America. 2010 Academic Article GET IT
Times cited: 218
Improvement in lipid and protein trafficking in Niemann-Pick C1 cells by correction of a secondary enzyme defect. Traffic (Copenhagen, Denmark). 2010 Academic Article GET IT
Times cited: 67
Investigation of N-aryl-3-alkylidenepyrrolinones as potential Niemann-Pick type C disease therapeutics. Journal of medicinal chemistry. 2009 Academic Article GET IT
Times cited: 29
Macrophages create an acidic extracellular hydrolytic compartment to digest aggregated lipoproteins. Molecular biology of the cell. 2009 Academic Article GET IT
Times cited: 99
Chemical screen to reduce sterol accumulation in Niemann-Pick C disease cells identifies novel lysosomal acid lipase inhibitors. Biochimica et biophysica acta. 2009 Academic Article GET IT
Times cited: 51
Aggregated LDL in contact with macrophages induces local increases in free cholesterol levels that regulate local actin polymerization. Arteriosclerosis, thrombosis, and vascular biology. 2009 Academic Article GET IT
Times cited: 39
Multiphoton microscopy of prostate and periprostatic neural tissue: a promising imaging technique for improving nerve-sparing prostatectomy. Journal of endourology. 2009 Academic Article GET IT
Times cited: 50
Intracellular sterol dynamics. Biochimica et biophysica acta. 2009 Information Resource GET IT
Times cited: 217
Human bladder cancer diagnosis using Multiphoton microscopy. Proceedings of SPIE--the International Society for Optical Engineering. 2009 Academic Article GET IT
Sterols are mainly in the cytoplasmic leaflet of the plasma membrane and the endocytic recycling compartment in CHO cells. Molecular biology of the cell. 2008 Academic Article GET IT
Times cited: 162
(-)-Epigallocatechin gallate causes internalization of the epidermal growth factor receptor in human colon cancer cells. Carcinogenesis. 2008 Academic Article GET IT
Times cited: 87
Presecretory oxidation, aggregation, and autophagic destruction of apoprotein-B: a pathway for late-stage quality control. Proceedings of the National Academy of Sciences of the United States of America. 2008 Academic Article GET IT
Times cited: 109
SMS overexpression and knockdown: impact on cellular sphingomyelin and diacylglycerol metabolism, and cell apoptosis. Journal of lipid research. 2007 Academic Article GET IT
Times cited: 79
The inhibitory effect of (-)-epigallocatechin gallate on activation of the epidermal growth factor receptor is associated with altered lipid order in HT29 colon cancer cells. Cancer research. 2007 Academic Article GET IT
Times cited: 169
Elevated cholesterol levels in the plasma membranes of macrophages inhibit migration by disrupting RhoA regulation. Arteriosclerosis, thrombosis, and vascular biology. 2007 Academic Article GET IT
Times cited: 44
Role of an acidic cluster/dileucine motif in cation-independent mannose 6-phosphate receptor traffic. Traffic (Copenhagen, Denmark). 2007 Academic Article GET IT
Times cited: 22
Activation of microglia acidifies lysosomes and leads to degradation of Alzheimer amyloid fibrils. Molecular biology of the cell. 2007 Academic Article GET IT
Times cited: 200
Degradation of fibrillar forms of Alzheimer's amyloid beta-peptide by macrophages. Neurobiology of aging. 2007 Academic Article GET IT
Times cited: 70
Sterol, protein and lipid trafficking in Chinese hamster ovary cells with Niemann-Pick type C1 defect. Traffic (Copenhagen, Denmark). 2006 Academic Article GET IT
Times cited: 54
Parallel analysis of v-Src mutant protein function using reverse transfection cell arrays. Combinatorial chemistry & high throughput screening. 2006 Academic Article GET IT
Times cited: 3
Modeling the structure of the StART domains of MLN64 and StAR proteins in complex with cholesterol. Journal of lipid research. 2006 Academic Article GET IT
Times cited: 84
Intracellular sterol transport and distribution. Current opinion in cell biology. 2006 Information Resource GET IT
Times cited: 96
Endocytic recycling compartments altered in cisplatin-resistant cancer cells. Cancer research. 2006 Academic Article GET IT
Times cited: 49
Role of cholesterol and lipid organization in disease. Nature. 2005 Information Resource GET IT
Times cited: 893
Elevated plasma membrane cholesterol content alters macrophage signaling and function. Arteriosclerosis, thrombosis, and vascular biology. 2005 Academic Article GET IT
Times cited: 70
Automated microscopy screening for compounds that partially revert cholesterol accumulation in Niemann-Pick C cells. Journal of lipid research. 2005 Academic Article GET IT
Times cited: 62
Direct observation of rapid internalization and intracellular transport of sterol by macrophage foam cells. Traffic (Copenhagen, Denmark). 2005 Academic Article GET IT
Times cited: 79
Lipid and cholesterol trafficking in NPC. Biochimica et biophysica acta. 2004 Information Resource GET IT
Times cited: 157
Enrichment of endoplasmic reticulum with cholesterol inhibits sarcoplasmic-endoplasmic reticulum calcium ATPase-2b activity in parallel with increased order of membrane lipids: implications for depletion of endoplasmic reticulum calcium stores and apoptosis in cholesterol-loaded macrophages. The Journal of biological chemistry. 2004 Academic Article GET IT
Times cited: 217
Role of cytoplasmic domain serines in intracellular trafficking of furin. Molecular biology of the cell. 2004 Academic Article GET IT
Times cited: 32
Oxalic acid alters intracellular calcium in endothelial cells. Atherosclerosis. 2004 Academic Article GET IT
Times cited: 29
Endocytic recycling. Nature reviews. Molecular cell biology. 2004 Information Resource GET IT
Times cited: 1397
Effects of cholesterol depletion and increased lipid unsaturation on the properties of endocytic membranes. The Journal of biological chemistry. 2004 Academic Article GET IT
Times cited: 83
Membrane domains. Annual review of cell and developmental biology. 2004 Information Resource GET IT
Times cited: 325
Different transport routes for high density lipoprotein and its associated free sterol in polarized hepatic cells. Journal of lipid research. 2003 Academic Article GET IT
Times cited: 66
Endocytosed cation-independent mannose 6-phosphate receptor traffics via the endocytic recycling compartment en route to the trans-Golgi network and a subpopulation of late endosomes. Molecular biology of the cell. 2003 Academic Article GET IT
Times cited: 95
The cytoplasmic domain of the low density lipoprotein (LDL) receptor-related protein, but not that of the LDL receptor, triggers phagocytosis. The Journal of biological chemistry. 2003 Academic Article GET IT
Times cited: 26
Targeted recycling of PECAM from endothelial surface-connected compartments during diapedesis. Nature. 2003 Academic Article GET IT
Times cited: 259
Optical microscopy-based migration assay for human neutrophils. Current protocols in cell biology. 2003 Academic Article GET IT
Times cited: 1
Membrane lipid organization is critical for human neutrophil polarization. The Journal of biological chemistry. 2003 Academic Article GET IT
Times cited: 128
Ratio imaging instrumentation. Methods in cell biology. 2003 Information Resource GET IT
Times cited: 15
Stearoyl-CoA desaturase inhibits ATP-binding cassette transporter A1-mediated cholesterol efflux and modulates membrane domain structure. The Journal of biological chemistry. 2002 Academic Article GET IT
Times cited: 111
Microtubule asymmetry during neutrophil polarization and migration. Molecular biology of the cell. 2002 Academic Article GET IT
Times cited: 69
Intracellular cholesterol transport. The Journal of clinical investigation. 2002 Information Resource GET IT
Times cited: 289
Plasma membrane microdomains. Current opinion in cell biology. 2002 Information Resource GET IT
Times cited: 231
Rapid nonvesicular transport of sterol between the plasma membrane domains of polarized hepatic cells. The Journal of biological chemistry. 2002 Academic Article GET IT
Times cited: 90
Export from pericentriolar endocytic recycling compartment to cell surface depends on stable, detyrosinated (glu) microtubules and kinesin. Molecular biology of the cell. 2002 Academic Article GET IT
Times cited: 114
Cholesterol depletion induces large scale domain segregation in living cell membranes. Proceedings of the National Academy of Sciences of the United States of America. 2001 Academic Article GET IT
Times cited: 252
Cytoskeleton-dependent membrane domain segregation during neutrophil polarization. Molecular biology of the cell. 2001 Academic Article GET IT
Times cited: 110
Vesicular and non-vesicular sterol transport in living cells. The endocytic recycling compartment is a major sterol storage organelle. The Journal of biological chemistry. 2001 Academic Article GET IT
Times cited: 235
Clathrin hub expression affects early endosome distribution with minimal impact on receptor sorting and recycling. Molecular biology of the cell. 2001 Academic Article GET IT
Times cited: 32
Flotillas of lipid rafts fore and aft. Proceedings of the National Academy of Sciences of the United States of America. 2001 Article GET IT
Times cited: 55
Phagocytosis of wild-type Legionella pneumophila occurs through a wortmannin-insensitive pathway. Infection and immunity. 2001 Academic Article GET IT
Times cited: 42
The uptake and degradation of matrix-bound lipoproteins by macrophages require an intact actin Cytoskeleton, Rho family GTPases, and myosin ATPase activity. The Journal of biological chemistry. 2001 Academic Article GET IT
Times cited: 55
Distribution and transport of cholesterol in Caenorhabditis elegans. Molecular biology of the cell. 2001 Academic Article GET IT
Times cited: 140
Rme-1 regulates the distribution and function of the endocytic recycling compartment in mammalian cells. Nature cell biology. 2001 Academic Article GET IT
Times cited: 202
Uptake of fibrillar beta-amyloid by microglia isolated from MSR-A (type I and type II) knockout mice. Neuroreport. 2001 Academic Article GET IT
Times cited: 34
Vesicular and nonvesicular transport of phosphatidylcholine in polarized HepG2 cells. Traffic (Copenhagen, Denmark). 2001 Academic Article GET IT
Times cited: 35
Enrichment of acyl coenzyme A:cholesterol O-acyltransferase near trans-golgi network and endocytic recycling compartment. Arteriosclerosis, thrombosis, and vascular biology. 2000 Academic Article GET IT
Times cited: 39
Effects of incorporation of immunoglobulin G and complement component C1q on uptake and degradation of Alzheimer's disease amyloid fibrils by microglia. The Journal of biological chemistry. 2000 Academic Article GET IT
Times cited: 56
Characterization of rapid membrane internalization and recycling. The Journal of biological chemistry. 2000 Academic Article GET IT
Times cited: 198
Ca2+-dependent myosin II activation is required for uropod retraction during neutrophil migration. Journal of cell science. 2000 Academic Article GET IT
Times cited: 168
Role of membrane organization and membrane domains in endocytic lipid trafficking. Traffic (Copenhagen, Denmark). 2000 Information Resource GET IT
Times cited: 186
Endocytosis. Advances in nephrology from the Necker Hospital. 2000 Information Resource GET IT
Times cited: 1
Unique cellular events occurring during the initial interaction of macrophages with matrix-retained or methylated aggregated low density lipoprotein (LDL). Prolonged cell-surface contact during which ldl-cholesteryl ester hydrolysis exceeds ldl protein degradation. The Journal of biological chemistry. 1999 Academic Article GET IT
Times cited: 58
Uptake, degradation, and release of fibrillar and soluble forms of Alzheimer's amyloid beta-peptide by microglial cells. The Journal of biological chemistry. 1999 Academic Article GET IT
Times cited: 170
Chimeric forms of furin and TGN38 are transported with the plasma membrane in the trans-Golgi network via distinct endosomal pathways. The Journal of cell biology. 1999 Academic Article GET IT
Times cited: 179
Endocytic sorting of lipid analogues differing solely in the chemistry of their hydrophobic tails. The Journal of cell biology. 1999 Academic Article GET IT
Times cited: 313
Cholesterol distribution in living cells: fluorescence imaging using dehydroergosterol as a fluorescent cholesterol analog. Biophysical journal. 1998 Academic Article GET IT
Times cited: 296
Early events in phagosome establishment are required for intracellular survival of Legionella pneumophila. Infection and immunity. 1998 Academic Article GET IT
Times cited: 100
An endocytosed TGN38 chimeric protein is delivered to the TGN after trafficking through the endocytic recycling compartment in CHO cells. The Journal of cell biology. 1998 Academic Article GET IT
Times cited: 214
Cholesterol-dependent retention of GPI-anchored proteins in endosomes. The EMBO journal. 1998 Academic Article GET IT
Times cited: 273
Immunolocalization of acyl-coenzyme A:cholesterol O-acyltransferase in macrophages. The Journal of biological chemistry. 1998 Academic Article GET IT
Times cited: 46
Sphingomyelinase treatment induces ATP-independent endocytosis. The Journal of cell biology. 1998 Academic Article GET IT
Times cited: 177
Slow degradation of aggregates of the Alzheimer's disease amyloid beta-protein by microglial cells. The Journal of biological chemistry. 1997 Academic Article GET IT
Times cited: 220
Endocytosis. Physiological reviews. 1997 Information Resource GET IT
Times cited: 1262
Evidence for prolonged cell-surface contact of acetyl-LDL before entry into macrophages. Arteriosclerosis, thrombosis, and vascular biology. 1997 Academic Article GET IT
Times cited: 19
Bafilomycin A1 treatment retards transferrin receptor recycling more than bulk membrane recycling. The Journal of biological chemistry. 1997 Academic Article GET IT
Times cited: 133
Effects of buffering intracellular free calcium on neutrophil migration through three-dimensional matrices. Journal of cellular physiology. 1997 Academic Article GET IT
Times cited: 33
Dynamic imaging of neutrophil migration in three dimensions: mechanical interactions between cells and matrix. Journal of leukocyte biology. 1997 Academic Article GET IT
Times cited: 104
Transferrin receptor containing the SDYQRL motif of TGN38 causes a reorganization of the recycling compartment but is not targeted to the TGN. The Journal of cell biology. 1996 Academic Article GET IT
Times cited: 32
Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor. Neuron. 1996 Academic Article GET IT
Times cited: 555
The distal pathway of lipoprotein-induced cholesterol esterification, but not sphingomyelinase-induced cholesterol esterification, is energy-dependent. The Journal of biological chemistry. 1996 Academic Article GET IT
Times cited: 50
Intracellular calcium and calcineurin regulate neutrophil motility on vitronectin through a receptor identified by antibodies to integrins alphav and beta3. Blood. 1996 Academic Article GET IT
Times cited: 55
Calcium and signal transduction in granulocytes. Current opinion in hematology. 1996 Information Resource GET IT
Times cited: 51
Ca(2+)- and calcineurin-dependent recycling of an integrin to the front of migrating neutrophils. Nature. 1995 Academic Article GET IT
Times cited: 472
Effect and cellular site of action of cysteine protease inhibitors on the cholesterol esterification pathway in macrophages and Chinese hamster ovary cells. Biochemistry. 1995 Academic Article GET IT
Times cited: 11
Transport from late endosomes to lysosomes, but not sorting of integral membrane proteins in endosomes, depends on the vacuolar proton pump. The Journal of cell biology. 1995 Academic Article GET IT
Times cited: 307
Wortmannin causes mistargeting of procathepsin D. evidence for the involvement of a phosphatidylinositol 3-kinase in vesicular transport to lysosomes. The Journal of cell biology. 1995 Academic Article GET IT
Times cited: 189
Insolubility and redistribution of GPI-anchored proteins at the cell surface after detergent treatment. Molecular biology of the cell. 1995 Academic Article GET IT
Times cited: 253
Oligomerized transferrin receptors are selectively retained by a lumenal sorting signal in a long-lived endocytic recycling compartment. The Journal of cell biology. 1995 Academic Article GET IT
Times cited: 133
Fibrin regulates neutrophil migration in response to interleukin 8, leukotriene B4, tumor necrosis factor, and formyl-methionyl-leucyl-phenylalanine. The Journal of experimental medicine. 1995 Academic Article GET IT
Times cited: 78
Intracellular calcium levels correlate with speed and persistent forward motion in migrating neutrophils. Biophysical journal. 1995 Academic Article GET IT
Times cited: 70
Evidence for nonvectorial, retrograde transferrin trafficking in the early endosomes of HEp2 cells. The Journal of cell biology. 1995 Academic Article GET IT
Times cited: 98
Effects of apoprotein E on intracellular metabolism of model triglyceride-rich particles are distinct from effects on cell particle uptake. The Journal of biological chemistry. 1995 Academic Article GET IT
Times cited: 57
Changes in yolk platelet pH during Xenopus laevis development correlate with yolk utilization. A quantitative confocal microscopy study. Journal of cell science. 1994 Academic Article GET IT
Times cited: 63
The actin cytoskeleton is important for the stimulation of cholesterol esterification by atherogenic lipoproteins in macrophages. The Journal of biological chemistry. 1994 Academic Article GET IT
Times cited: 37
Quantification of low density lipoprotein and transferrin endocytic sorting HEp2 cells using confocal microscopy. Journal of cell science. 1994 Academic Article GET IT
Times cited: 184
Sequestration of GPI-anchored proteins in caveolae triggered by cross-linking. Science (New York, N.Y.). 1994 Academic Article GET IT
Times cited: 424
Applications of ratio fluorescence microscopy in the study of cell physiology. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1994 Information Resource GET IT
Times cited: 96
Yolk platelets in Xenopus oocytes maintain an acidic internal pH which may be essential for sodium accumulation. The Journal of cell biology. 1994 Academic Article GET IT
Times cited: 44
Beta-very low density lipoprotein is sequestered in surface-connected tubules in mouse peritoneal macrophages. The Journal of cell biology. 1993 Academic Article GET IT
Times cited: 69
Regulation of leukocyte locomotion by Ca2+. Trends in cell biology. 1993 Academic Article GET IT
The End2 mutation in CHO cells slows the exit of transferrin receptors from the recycling compartment but bulk membrane recycling is unaffected. The Journal of cell biology. 1993 Academic Article GET IT
Times cited: 75
Isolation of a temperature-sensitive variant Chinese hamster ovary cell line with a morphologically altered endocytic recycling compartment. Journal of cellular physiology. 1993 Academic Article GET IT
Times cited: 62
Properties of acidified compartments in hippocampal neurons. European journal of cell biology. 1993 Academic Article GET IT
Times cited: 11
Sorting of membrane components from endosomes and subsequent recycling to the cell surface occurs by a bulk flow process. The Journal of cell biology. 1993 Academic Article GET IT
Times cited: 451
Quantitative fluorescence techniques for the characterization of endocytosis in intact cells. Sub-cellular biochemistry. 1993 Information Resource GET IT
Times cited: 5
Polarized binding of lipoprotein lipase to endothelial cells. Implications for its physiological actions. Arteriosclerosis and thrombosis : a journal of vascular biology. 1992 Academic Article GET IT
Times cited: 29
Inhibition of neutrophil chemokinesis on vitronectin by inhibitors of calcineurin. Science (New York, N.Y.). 1992 Academic Article GET IT
Times cited: 170
Delivery of ligands from sorting endosomes to late endosomes occurs by maturation of sorting endosomes. The Journal of cell biology. 1992 Academic Article GET IT
Times cited: 162
Resting [Ca2+]i and [Ca2+]i transients are similar in fibroblasts from normal and Alzheimer's donors. Neurobiology of aging. 1992 Academic Article GET IT
Times cited: 29
The influence of particle size and multiple apoprotein E-receptor interactions on the endocytic targeting of beta-VLDL in mouse peritoneal macrophages. The Journal of cell biology. 1991 Academic Article GET IT
Times cited: 69
Nerve growth factor potentiates bradykinin-induced calcium influx and release in PC12 cells. Journal of neurochemistry. 1991 Academic Article GET IT
Times cited: 18
Clearance of chylomicron remnants by the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor. The Journal of biological chemistry. 1991 Academic Article GET IT
Times cited: 161
Preparation of solutions with free calcium concentration in the nanomolar range using 1,2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid. Analytical biochemistry. 1991 Academic Article GET IT
Times cited: 91
Attachment to fibronectin or vitronectin makes human neutrophil migration sensitive to alterations in cytosolic free calcium concentration. The Journal of cell biology. 1991 Academic Article GET IT
Times cited: 102
Endocytosed beta-VLDL and LDL are delivered to different intracellular vesicles in mouse peritoneal macrophages. The Journal of cell biology. 1990 Academic Article GET IT
Times cited: 110
Acidification-dependent dissociation of endocytosed insulin precedes that of endocytosed proteins bearing the mannose 6-phosphate recognition marker. The Journal of biological chemistry. 1990 Academic Article GET IT
Times cited: 23
Fc and C3bi receptors and the differentiation antigen BH2-Ag are randomly distributed in the plasma membrane of locomoting neutrophils. The Journal of cell biology. 1990 Academic Article GET IT
Times cited: 17
Human transferrin receptor internalization is partially dependent upon an aromatic amino acid on the cytoplasmic domain. Cell regulation. 1990 Academic Article GET IT
Times cited: 125
Local and global changes in cytosolic free calcium in neutrophils during chemotaxis and phagocytosis. Cell calcium. 1990 Academic Article GET IT
Times cited: 75
Transient increases in cytosolic free calcium appear to be required for the migration of adherent human neutrophils. The Journal of cell biology. 1990 Academic Article GET IT
Times cited: 241
Immunoliposomes with different acid sensitivities as probes for the cellular endocytic pathway. Biochimica et biophysica acta. 1989 Academic Article GET IT
Times cited: 70
Iterative fractionation of recycling receptors from lysosomally destined ligands in an early sorting endosome. The Journal of cell biology. 1989 Academic Article GET IT
Times cited: 292
Fusion accessibility of endocytic compartments along the recycling and lysosomal endocytic pathways in intact cells. The Journal of cell biology. 1989 Academic Article GET IT
Times cited: 100
Kinetics of alpha 2-macroglobulin endocytosis and degradation in mutant and wild-type Chinese hamster ovary cells. Journal of cellular physiology. 1989 Academic Article GET IT
Times cited: 28
Measurement of vacuolar pH and cytoplasmic calcium in living cells using fluorescence microscopy. Methods in enzymology. 1989 Academic Article GET IT
Times cited: 22
Long-lasting and rapid calcium changes during mitosis. The Journal of cell biology. 1988 Academic Article GET IT
Times cited: 57
Simultaneous addition of EGF prolongs the increase in cytosolic free calcium seen in response to bradykinin in NRK-49F cells. Journal of cellular physiology. 1988 Academic Article GET IT
Times cited: 6
Intracellular fusion of sequentially formed endocytic compartments. The Journal of cell biology. 1988 Academic Article GET IT
Times cited: 59
Phorbol ester treatment increases the exocytic rate of the transferrin receptor recycling pathway independent of serine-24 phosphorylation. The Journal of cell biology. 1988 Academic Article GET IT
Times cited: 47
Acidification of morphologically distinct endosomes in mutant and wild-type Chinese hamster ovary cells. The Journal of cell biology. 1987 Academic Article GET IT
Times cited: 102
Cytosolic free calcium increases before and oscillates during frustrated phagocytosis in macrophages. The Journal of cell biology. 1987 Academic Article GET IT
Times cited: 87
Kinetics of endosome acidification in mutant and wild-type Chinese hamster ovary cells. The Journal of cell biology. 1987 Academic Article GET IT
Times cited: 87
Functional expression of the human transferrin receptor cDNA in Chinese hamster ovary cells deficient in endogenous transferrin receptor. The Journal of cell biology. 1987 Academic Article GET IT
Times cited: 179
Tumor necrosis factor increases the number of epidermal growth factor receptors on human fibroblasts. The Journal of biological chemistry. 1987 Academic Article GET IT
Times cited: 74
Endosome acidification and the pathways of receptor-mediated endocytosis. Advances in experimental medicine and biology. 1987 Information Resource GET IT
Times cited: 68
Transition from metaphase to anaphase is accompanied by local changes in cytoplasmic free calcium in Pt K2 kidney epithelial cells. Proceedings of the National Academy of Sciences of the United States of America. 1986 Academic Article GET IT
Times cited: 86
Spreading of human neutrophils is immediately preceded by a large increase in cytoplasmic free calcium. Proceedings of the National Academy of Sciences of the United States of America. 1986 Academic Article GET IT
Times cited: 97
Calcium and calmodulin in the regulation of the microtubular cytoskeleton. Annals of the New York Academy of Sciences. 1986 Academic Article GET IT
Times cited: 15
Local cytoplasmic calcium gradients in living mitotic cells. Nature. 1985 Academic Article GET IT
Times cited: 94
Intracellular free calcium levels are reduced in mitotic Pt K2 epithelial cells. Proceedings of the National Academy of Sciences of the United States of America. 1985 Academic Article GET IT
Times cited: 33
Legionella pneumophila inhibits acidification of its phagosome in human monocytes. The Journal of cell biology. 1984 Academic Article GET IT
Times cited: 280
Thyrotropin-releasing hormone-induced changes in intracellular [Ca2+] measured by microspectrofluorometry on individual quin2-loaded cells. The Journal of cell biology. 1984 Academic Article GET IT
Times cited: 54
Conformational changes in the receptors for epidermal growth factor and asialoglycoproteins induced by the mildly acidic pH found in endocytic vesicles. The Journal of biological chemistry. 1984 Academic Article GET IT
Times cited: 38
Segregation of transferrin to a mildly acidic (pH 6.5) para-Golgi compartment in the recycling pathway. Cell. 1984 Academic Article GET IT
Times cited: 406
Loss of alpha 2-macroglobulin and epidermal growth factor surface binding induced by phenothiazines and naphthalene sulfonamides. Journal of cellular physiology. 1984 Academic Article GET IT
Times cited: 15
Microinjection of Ca++-calmodulin causes a localized depolymerization of microtubules. The Journal of cell biology. 1983 Academic Article GET IT
Times cited: 149
Rapid acidification of endocytic vesicles containing asialoglycoprotein in cells of a human hepatoma line. The Journal of cell biology. 1983 Academic Article GET IT
Times cited: 106
Acidification of endocytic vesicles by an ATP-dependent proton pump. The Journal of cell biology. 1983 Academic Article GET IT
Times cited: 153
Acidification of endocytic vesicles and the intracellular pathways of ligands and receptors. Annals of the New York Academy of Sciences. 1983 Academic Article GET IT
Times cited: 13
Weak bases and ionophores rapidly and reversibly raise the pH of endocytic vesicles in cultured mouse fibroblasts. The Journal of cell biology. 1982 Academic Article GET IT
Times cited: 431
Receptor-mediated endocytosis of diphtheria toxin by cells in culture. Proceedings of the National Academy of Sciences of the United States of America. 1982 Academic Article GET IT
Times cited: 68
Effect of primary amines on interferon action. Virology. 1982 Academic Article GET IT
Times cited: 15
Rapid acidification of endocytic vesicles containing alpha 2-macroglobulin. Cell. 1982 Academic Article GET IT
Times cited: 375
Binding, surface mobility, internalization, and degradation of rhodamine-labeled alpha 2-macroglobulin. Biochemistry. 1981 Academic Article GET IT
Times cited: 33
Spectroscopic study of the conformations of proline-containing oligopeptides in the crystalline state and in solution. International journal of peptide and protein research. 1981 Academic Article GET IT
Times cited: 8
Binding and mobility of the cell surface receptors for 3,3',5-triiodo-L-thyronine. Science (New York, N.Y.). 1981 Academic Article GET IT
Times cited: 38
Conformational study of [Leu5]-enkephalin by laser Raman spectroscopy. International journal of peptide and protein research. 1980 Academic Article GET IT
Times cited: 32
Study of the state of ionization of [Leu5]-enkephalin in the crystal and in solution. International journal of peptide and protein research. 1980 Academic Article GET IT
Times cited: 11
Receptor-mediated endocytosis of alpha 2-macroglobulin in cultured fibroblasts. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 1980 Academic Article GET IT
Times cited: 26
Receptor-mediated uptake of 3,3',5-triiodo-L-thyronine by cultured fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. 1980 Academic Article GET IT
Times cited: 118
Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells. The Journal of biological chemistry. 1980 Academic Article GET IT
Times cited: 531
Transglutaminase is essential in receptor-mediated endocytosis of alpha 2-macroglobulin and polypeptide hormones. Nature. 1980 Academic Article GET IT
Times cited: 403
Epidermal growth factor stimulation of DNA synthesis is potentiated by compounds that inhibit its clustering in coated pits. Proceedings of the National Academy of Sciences of the United States of America. 1979 Academic Article GET IT
Times cited: 70
alpha 2 Macroglobulin binding to the plasma membrane of cultured fibroblasts. Diffuse binding followed by clustering in coated regions. The Journal of cell biology. 1979 Academic Article GET IT
Times cited: 146
Insulin stimulation of amino acid transport in isolated rat hepatocytes is independent of hormone internalization. Biochemical and biophysical research communications. 1979 Academic Article GET IT
Times cited: 20
Cyclized dipeptide model for a beta-bend. Proceedings of the National Academy of Sciences of the United States of America. 1979 Academic Article GET IT
Times cited: 23
Improvements in the prediction of protein backbone topography by reduction of statistical errors. Biochemistry. 1979 Academic Article GET IT
Times cited: 61
Collection of insulin, EGF and alpha2-macroglobulin in the same patches on the surface of cultured fibroblasts and common internalization. Cell. 1978 Academic Article GET IT
Times cited: 239
A Raman spectroscopic investigation of the disulfide conformation in oxytocin and lysine vasopressin. Biochemistry. 1977 Academic Article GET IT
Times cited: 27
Status of empirical methods for the prediction of protein backbone topography. Biochemistry. 1976 Academic Article GET IT
Times cited: 105
Helix-coil stability constants for the naturally occurring amino acids in water. IX. Glutamic acid parameters from random poly(hydroxybutylglutamine-co-L-glutamic acid). Macromolecules. 1975 Academic Article GET IT
Times cited: 69
The effect of neighboring charges on the helix forming ability of charged amino acids in proteins. Macromolecules. 1975 Academic Article GET IT
Times cited: 58

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Funding awarded

Role of microglial lysosomes in amyloid-A-beta degradation awarded by National Institute on Aging Principal Investigator 2023 - 2026
Macrophage-Lipoprotein Interactions awarded by National Heart, Lung, & Blood Institute Principal Investigator 2022 - 2026

Characterizing a novel mechanism that contributes to the development of atherosclerosis awarded by American Heart Association Key Personnel 2024 - 2025
Investigating the roles of sterol transport protein STARD4 in foam cell formation awarded by American Heart Association Key Personnel 2024 - 2025

Two approaches: Chaperones and targeted cyclodextrins Principal Investigator Subaward 2023 - 2025

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Background

education and training

M.S., Cornell University 73
Ph.D., Cornell University 1977
B.S., Union College 1971

Contact

full name

Frederick R. Maxfield

primary email

frmaxfie@med.cornell.edu

VIVO Weill Cornell Medical College

Frederick R. Maxfield Professor of Biochemistry

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email