selected publications
- EZH2 inhibition enhances T cell immunotherapies by inducing lymphoma immunogenicity and improving T cell function. Cancer cell. 2024 Academic Article GET IT
- Recurrent somatic mutations of FAT family cadherins induce an aggressive phenotype and poor prognosis in anaplastic large cell lymphoma. British journal of cancer. 2024 Academic Article GET IT
- The interplay of mutagenesis and ecDNA shapes urothelial cancer evolution. Nature. 2024 Academic Article GET IT
- Real-world impact of differences in the WHO and ICC classifications of non-Hodgkin lymphoma: a LEO Cohort Study analysis. Blood. 2024 Academic Article GET IT
- Targeting CD25+ lymphoma cells with the antibody-drug conjugate camidanlumab tesirine as a single agent or in combination with targeted agents. British journal of haematology. 2024 Academic Article GET IT
- Tumor evolution analysis uncovered immune-escape related mutations in relapse of diffuse large B-cell lymphoma. Leukemia. 2024 Letter GET IT
- Co-shared genomic alterations within tumors from patients with both myeloproliferative neoplasms and lymphoma. Haematologica. 2024 Academic Article GET IT
- Epithelial aPKC deficiency leads to stem cell loss preceding metaplasia in colorectal cancer initiation. Developmental cell. 2024 Academic Article GET IT
- Absolute Lymphocyte Count after BCMA CAR-T Therapy is a Predictor of Response and Outcomes in Relapsed Multiple Myeloma. Blood advances. 2024 Academic Article GET IT
- Targeting CD19-positive lymphomas with the antibody-drug conjugate loncastuximab tesirine: preclinical evidence as single agent and in combination therapy. Haematologica. 2024 Academic Article GET IT
- Motive and Opportunity: MYC rearrangements in high-grade B-cell lymphoma with MYC and BCL2 rearrangements-an LLMPP study. Blood. 2024 Academic Article GET IT
- Molecular targets of glucocorticoids that elucidate their therapeutic efficacy in aggressive lymphomas. Cancer cell. 2024 Academic Article GET IT
- Germinal Center Dark Zone harbors ATR-dependent determinants of T-cell exclusion that are also identified in aggressive lymphoma. 2024 GET IT
- The Lymphoma Epidemiology of Outcomes cohort study: Design, baseline characteristics, and early outcomes. American journal of hematology. 2024 Academic Article GET IT
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XPO1 Enables Adaptive Regulation of mRNA Export Required for Genotoxic Stress Tolerance in Cancer Cells.
Cancer research.
2024
Academic Article
GET IT
Times cited: 5 - Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis. Nature communications. 2023 Academic Article GET IT
- Fungal microbiota sustains lasting immune activation of neutrophils and their progenitors in severe COVID-19. Nature immunology. 2023 Academic Article GET IT
- Spatial Mapping of Human Hematopoiesis at Single Cell Resolution Reveals Aging-Associated Topographic Remodeling. Blood. 2023 Academic Article GET IT
- ETS1 phosphorylation at threonine 38 is associated with the cell of origin of diffuse large B cell lymphoma and sustains the growth of tumour cells. British journal of haematology. 2023 Academic Article GET IT
- Lysin (K)-specific demethylase 1 inhibition enhances proteasome inhibitor response and overcomes drug resistance in multiple myeloma. Experimental hematology & oncology. 2023 Academic Article GET IT
- Long non-coding RNA mitophagy and ALK- anaplastic lymphoma associated transcript: a novel regulator of mitophagy in T cell lymphoma. Haematologica. 2023 Academic Article GET IT
- Targeting CCR7-PI3Kγ overcomes resistance to tyrosine kinase inhibitors in ALK-rearranged lymphoma. Science translational medicine. 2023 Academic Article GET IT
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Multicenter phase 2 study of oral azacitidine (CC-486) plus CHOP as initial treatment for PTCL.
Blood.
2023
Academic Article
GET IT
Times cited: 29 - Primary Effusion Lymphoma in an HIV-Negative Patient with Chronic Myeloid Leukemia Treated with Dasatinib. 2023 GET IT
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Combinatorial treatment rescues tumour-microenvironment-mediated attenuation of MALT1 inhibitors in B-cell lymphomas.
Nature materials.
2023
Academic Article
GET IT
Times cited: 20 - Tyrosine kinases in nodal peripheral T-cell lymphomas. Frontiers in oncology. 2023 Review GET IT
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A FOXO1-dependent transcription network is a targetable vulnerability of mantle cell lymphomas.
The Journal of clinical investigation.
2022
Academic Article
GET IT
Times cited: 9 - Hyaluronan driven by epithelial aPKC deficiency remodels the microenvironment and creates a vulnerability in mesenchymal colorectal cancer. Cancer cell. 2022 Academic Article GET IT
- In vivo modeling of CLL transformation to Richter's syndrome reveals convergent evolutionary paths and therapeutic vulnerabilities. Blood cancer discovery. 2022 Academic Article GET IT
- Characteristics and Clinical Outcomes of Patients with ALK-positive Anaplastic Large Cell Lymphoma: Report from the Prospective International T-Cell Lymphoma Project. Hematological oncology. 2022 Academic Article GET IT
- Endothelial-leukemia interactions remodel drug responses uncovering T-ALL vulnerabilities. Blood. 2022 Academic Article GET IT
- Gene Expression Signatures for the Accurate Diagnosis of Peripheral T-Cell Lymphoma Entities in the Routine Clinical Practice. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2022 Academic Article GET IT
- Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction. Cell stem cell. 2022 Academic Article GET IT
- Metabolic and Immune Markers for Precise Monitoring of COVID-19 Severity and Treatment. Frontiers in immunology. 2022 Academic Article GET IT
- Genetic and Phenotypic Attributes of Splenic Marginal Zone Lymphoma. Blood. 2021 Academic Article GET IT
- Phase II biomarker-driven study of ruxolitinib demonstrates effectiveness of JAK/STAT targeting in T-cell lymphomas. Blood. 2021 Academic Article GET IT
- Mutation analysis links angioimmunoblastic T-cell lymphoma to clonal hematopoiesis and smoking. eLife. 2021 Academic Article GET IT
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PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis.
Molecular cell.
2021
Academic Article
GET IT
Times cited: 16 -
Oncogenic HSP90 Facilitates Metabolic Alterations in Aggressive B-cell Lymphomas.
Cancer research.
2021
Academic Article
GET IT
Times cited: 19 - Comparison of Multiple Clinical Testing Modalities for Assessment of NPM1-Mutant AML. Frontiers in oncology. 2021 Academic Article GET IT
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Outcomes and prognostic factors in angioimmunoblastic T-cell lymphoma: final report from the international T-cell Project.
Blood.
2021
Academic Article
GET IT
Times cited: 1 - Characterization of GECPAR, a noncoding RNA that regulates the transcriptional program of diffuse large B cell lymphoma. Haematologica. 2021 Academic Article GET IT
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Genetic mechanisms of HLA-I loss and immune escape in diffuse large B cell lymphoma.
Proceedings of the National Academy of Sciences of the United States of America.
2021
Academic Article
GET IT
Times cited: 50 -
Whole Exome Sequencing reveals NOTCH1 mutations in anaplastic large cell lymphoma and points to Notch both as a key pathway and a potential therapeutic target.
Haematologica.
2021
Academic Article
GET IT
Times cited: 41 - Cytoskeleton Dynamics in Peripheral T Cell Lymphomas: An Intricate Network Sustaining Lymphomagenesis. Frontiers in oncology. 2021 Information Resource GET IT
- In Vivo and Ex Vivo Patient-Derived Tumor Xenograft Models of Lymphoma for Drug Discovery. Current protocols. 2021 Academic Article GET IT
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Identification of MALT1 feedback mechanisms enables rational design of potent antilymphoma regimens for ABC-DLBCL.
Blood.
2021
Academic Article
GET IT
Times cited: 26 -
Clinical and Biological Subtypes of B-cell Lymphoma Revealed by Microenvironmental Signatures.
Cancer discovery.
2021
Academic Article
GET IT
Times cited: 124 -
The DNA-helicase HELLS drives ALK- ALCL proliferation by the transcriptional control of a cytokinesis-related program.
Cell death & disease.
2021
Academic Article
GET IT
Times cited: 10 -
FYN-TRAF3IP2 induces NF-κB signaling-driven peripheral T cell lymphoma.
Nature cancer.
2021
Academic Article
GET IT
Times cited: 22 -
Profiling of immune dysfunction in COVID-19 patients allows early prediction of disease progression.
Life science alliance.
2020
Academic Article
GET IT
Times cited: 54 - Etiology of Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL): Current Directions in Research. Cancers. 2020 Information Resource GET IT
- Kinomic profiling of tumour xenografts derived from patients with non-small cell lung cancer confirms their fidelity and reveals potentially actionable pathways. European journal of cancer. 2020 Academic Article GET IT
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T follicular helper phenotype predicts response to histone deacetylase inhibitors in relapsed/refractory peripheral T-cell lymphoma.
Blood advances.
2020
Academic Article
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Times cited: 62 -
Myeloproliferative and lymphoproliferative malignancies occurring in the same patient: a nationwide discovery cohort.
Haematologica.
2020
Academic Article
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Times cited: 19 - Selective dysregulation of ROCK2 activity promotes aberrant transcriptional networks in ABC diffuse large B-cell lymphoma. Scientific reports. 2020 Academic Article GET IT
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Three-dimensional growth of breast cancer cells potentiates the anti-tumor effects of unacylated ghrelin and AZP-531.
eLife.
2020
Academic Article
GET IT
Times cited: 5 - A Novel JAK1 Mutant Breast Implant-Associated Anaplastic Large Cell Lymphoma Patient-Derived Xenograft Fostering Pre-Clinical Discoveries. Cancers. 2020 Academic Article GET IT
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Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring.
Nature medicine.
2020
Academic Article
GET IT
Times cited: 217 -
Peripheral T cell lymphomas: from the bench to the clinic.
Nature reviews. Cancer.
2020
Information Resource
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Times cited: 17 -
Three-dimensional chromatin landscapes in T cell acute lymphoblastic leukemia.
Nature genetics.
2020
Academic Article
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Times cited: 118 -
The novel lncRNA BlackMamba controls the neoplastic phenotype of ALK- anaplastic large cell lymphoma by regulating the DNA helicase HELLS.
Leukemia.
2020
Academic Article
GET IT
Times cited: 5 -
Survival outcomes of patients with extranodal natural-killer T-cell lymphoma: a prospective cohort study from the international T-cell Project.
The Lancet. Haematology.
2020
Academic Article
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Times cited: 24 -
Multiparametric in situ imaging of NPM1-mutated acute myeloid leukemia reveals prognostically-relevant features of the marrow microenvironment.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.
2020
Academic Article
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Times cited: 2 -
Inhibition of EZH2 Catalytic Activity Selectively Targets a Metastatic Subpopulation in Triple-Negative Breast Cancer.
Cell reports.
2020
Academic Article
GET IT
Times cited: 14 -
Selective Inhibition of HDAC3 Targets Synthetic Vulnerabilities and Activates Immune Surveillance in Lymphoma.
Cancer discovery.
2020
Academic Article
GET IT
Times cited: 109 -
Does Breast Implant-Associated ALCL Begin as a Lymphoproliferative Disorder?.
Plastic and reconstructive surgery.
2020
Academic Article
GET IT
Times cited: 10 -
Cell of Origin and Immunologic Events in the Pathogenesis of Breast Implant-Associated Anaplastic Large-Cell Lymphoma.
The American journal of pathology.
2019
Information Resource
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Times cited: 38 -
CAR T cells targeting BAFF-R can overcome CD19 antigen loss in B cell malignancies.
Science translational medicine.
2019
Academic Article
GET IT
Times cited: 71 -
Transcriptional Analysis of Lennert Lymphoma Reveals a Unique Profile and Identifies Novel Therapeutic Targets.
Frontiers in genetics.
2019
Academic Article
GET IT
Times cited: 9 -
Repurposing dasatinib for diffuse large B cell lymphoma.
Proceedings of the National Academy of Sciences of the United States of America.
2019
Academic Article
GET IT
Times cited: 25 -
Digital droplet PCR and next-generation sequencing refine minimal residual disease monitoring in acute lymphoblastic leukemia.
Leukemia & lymphoma.
2019
Article
GET IT
Times cited: 9 -
Whole exome sequencing reveals mutations in FAT1 tumor suppressor gene clinically impacting on peripheral T-cell lymphoma not otherwise specified.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.
2019
Academic Article
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Times cited: 39 -
Integration of transcriptional and mutational data simplifies the stratification of peripheral T-cell lymphoma.
American journal of hematology.
2019
Academic Article
GET IT
Times cited: 16 -
Genetic drivers of oncogenic pathways in molecular subgroups of peripheral T-cell lymphoma.
Blood.
2019
Academic Article
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Times cited: 205 -
Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death.
Nature.
2019
Academic Article
GET IT
Times cited: 296 -
A phase 1 trial of ibrutinib plus palbociclib in previously treated mantle cell lymphoma.
Blood.
2019
Academic Article
GET IT
Times cited: 64 -
The Transcriptional Regulator Sin3A Contributes to the Oncogenic Potential of STAT3.
Cancer research.
2019
Academic Article
GET IT
Times cited: 16 -
Histone demethylase LSD1 is required for germinal center formation and BCL6-driven lymphomagenesis.
Nature immunology.
2018
Academic Article
GET IT
Times cited: 70 -
Lenalidomide plus R-CHOP21 in newly diagnosed diffuse large B-cell lymphoma (DLBCL): long-term follow-up results from a combined analysis from two phase 2 trials.
Blood cancer journal.
2018
Academic Article
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Times cited: 32 -
TET2 Deficiency Causes Germinal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis.
Cancer discovery.
2018
Academic Article
GET IT
Times cited: 123 -
Aptamer-miR-34c Conjugate Affects Cell Proliferation of Non-Small-Cell Lung Cancer Cells.
Molecular therapy. Nucleic acids.
2018
Academic Article
GET IT
Times cited: 46 -
Simple deep sequencing-based post-remission MRD surveillance predicts clinical relapse in B-ALL.
Journal of hematology & oncology.
2018
Academic Article
GET IT
Times cited: 26 -
Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma.
Leukemia.
2018
Academic Article
GET IT
Times cited: 41 -
PRMT5 interacts with the BCL6 oncoprotein and is required for germinal center formation and lymphoma cell survival.
Blood.
2018
Academic Article
GET IT
Times cited: 50 -
Specific covalent inhibition of MALT1 paracaspase suppresses B cell lymphoma growth.
The Journal of clinical investigation.
2018
Academic Article
GET IT
Times cited: 43 -
Pulmonary Adenocarcinoma With Enteric Differentiation: Immunohistochemistry and Molecular Morphology.
Applied immunohistochemistry & molecular morphology : AIMM.
2018
Academic Article
GET IT
Times cited: 21 -
Patient derived organoids to model rare prostate cancer phenotypes.
Nature communications.
2018
Academic Article
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Times cited: 260 -
Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models.
Nature communications.
2018
Academic Article
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Times cited: 78 -
Rapid identification of BCR/ABL1-like acute lymphoblastic leukaemia patients using a predictive statistical model based on quantitative real time-polymerase chain reaction: clinical, prognostic and therapeutic implications.
British journal of haematology.
2018
Academic Article
GET IT
Times cited: 45 -
Tailoring CD19xCD3-DART exposure enhances T-cells to eradication of B-cell neoplasms.
Oncoimmunology.
2018
Academic Article
GET IT
Times cited: 12 -
Cell of origin markers identify different prognostic subgroups of lung adenocarcinoma.
Human pathology.
2018
Academic Article
GET IT
Times cited: 7 -
IRF4 Mediates the Oncogenic Effects of STAT3 in Anaplastic Large Cell Lymphomas.
Cancers.
2018
Academic Article
GET IT
Times cited: 27 -
AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis.
Nature communications.
2018
Academic Article
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Times cited: 54 -
PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models.
Cancer research.
2017
Academic Article
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Times cited: 95 -
Assessment of T-cell receptor repertoire and clonal expansion in peripheral T-cell lymphoma using RNA-seq data.
Scientific reports.
2017
Academic Article
GET IT
Times cited: 27 -
Diffuse large B cell lymphoma cell of origin by digital expression profiling in the REAL07 Phase 1-2 study.
British journal of haematology.
2017
Article
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Times cited: 5 -
Patient-derived tumor xenografts of lymphoproliferative disorders: are they surrogates for the human disease?.
Current opinion in hematology.
2017
Information Resource
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Times cited: 6 -
DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity.
Nature communications.
2017
Academic Article
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Times cited: 1270 -
Epidermal growth factor receptor mutations are linked to skip N2 lymph node metastasis in resected non-small-cell lung cancer adenocarcinomas.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.
2017
Academic Article
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Times cited: 8 -
The heterogeneous landscape of ALK negative ALCL.
Oncotarget.
2017
Information Resource
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Times cited: 27 -
Pulmonary adenocarcinoma with enteric differentiation: Dissecting oncogenic genes alterations with DNA sequencing and FISH analysis.
Experimental and molecular pathology.
2017
Academic Article
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Times cited: 9 -
THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors.
Nature communications.
2017
Academic Article
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Times cited: 71 -
Activating mutations and translocations in the guanine exchange factor VAV1 in peripheral T-cell lymphomas.
Proceedings of the National Academy of Sciences of the United States of America.
2017
Academic Article
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Times cited: 99 -
OTX015 (MK-8628), a novel BET inhibitor, exhibits antitumor activity in non-small cell and small cell lung cancer models harboring different oncogenic mutations.
Oncotarget.
2016
Academic Article
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Times cited: 48 -
Molecular Checkpoint Decisions Made by Subverted Vascular Niche Transform Indolent Tumor Cells into Chemoresistant Cancer Stem Cells.
Cancer cell.
2016
Academic Article
GET IT
Times cited: 105 -
Therapeutic efficacy of the bromodomain inhibitor OTX015/MK-8628 in ALK-positive anaplastic large cell lymphoma: an alternative modality to overcome resistant phenotypes.
Oncotarget.
2016
Academic Article
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Times cited: 19 - Adenosine signaling mediates hypoxic responses in the chronic lymphocytic leukemia microenvironment. Blood advances. 2016 Academic Article GET IT
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The novel PI3K-δ inhibitor TGR-1202 enhances Brentuximab Vedotin-induced Hodgkin lymphoma cell death via mitotic arrest.
Leukemia.
2016
Article
GET IT
Times cited: 11 -
Phospholipid scramblase 1 as a critical node at the crossroad between autophagy and apoptosis in mantle cell lymphoma.
Oncotarget.
2016
Academic Article
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Times cited: 19 -
Transposable elements: The enemies within.
Experimental hematology.
2016
Information Resource
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Times cited: 1 -
The genetics of nodal marginal zone lymphoma.
Blood.
2016
Academic Article
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Times cited: 139 -
Emerging therapies provide new opportunities to reshape the multifaceted interactions between the immune system and lymphoma cells.
Leukemia.
2016
Information Resource
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Times cited: 16 -
The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.
Cancer cell.
2016
Academic Article
GET IT
Times cited: 193 -
The Influence of Tissue Ischemia Time on RNA Integrity and Patient-Derived Xenografts (PDX) Engraftment Rate in a Non-Small Cell Lung Cancer (NSCLC) Biobank.
PloS one.
2016
Academic Article
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Times cited: 41 -
Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas.
Blood.
2015
Academic Article
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Times cited: 70 -
Identification of a new subclass of ALK-negative ALCL expressing aberrant levels of ERBB4 transcripts.
Blood.
2015
Academic Article
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Times cited: 50 -
Efficacy of a Cancer Vaccine against ALK-Rearranged Lung Tumors.
Cancer immunology research.
2015
Academic Article
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Times cited: 45 -
Minimal Residual Disease Detection by Droplet Digital PCR in Multiple Myeloma, Mantle Cell Lymphoma, and Follicular Lymphoma: A Comparison with Real-Time PCR.
The Journal of molecular diagnostics : JMD.
2015
Academic Article
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Times cited: 81 - JAK-STAT in lymphoproliferative disorders. Oncoscience. 2015 Academic Article GET IT
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Anaplastic lymphoma kinase inhibitors.
Current opinion in pharmacology.
2015
Information Resource
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Times cited: 14 -
Anaplastic lymphoma kinase: activating mechanisms and signaling pathways.
Frontiers in bioscience (Scholar edition).
2015
Information Resource
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Times cited: 1 -
Epigenomic evolution in diffuse large B-cell lymphomas.
Nature communications.
2015
Academic Article
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Times cited: 105 -
Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in anaplastic large cell lymphoma.
Cancer cell.
2015
Academic Article
GET IT
Times cited: 368 -
Cytokine-induced killer cells engineered with exogenous T-cell receptors directed against melanoma antigens: enhanced efficacy of effector cells endowed with a double mechanism of tumor recognition.
Human gene therapy.
2015
Academic Article
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Times cited: 13 -
Stromal contribution to the colorectal cancer transcriptome.
Nature genetics.
2015
Academic Article
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Times cited: 356 -
The BET Bromodomain Inhibitor OTX015 Affects Pathogenetic Pathways in Preclinical B-cell Tumor Models and Synergizes with Targeted Drugs.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2015
Academic Article
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Times cited: 173 -
Advances in understanding the pathogenesis of systemic anaplastic large cell lymphomas.
British journal of haematology.
2015
Information Resource
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Times cited: 37 -
A novel patient-derived tumorgraft model with TRAF1-ALK anaplastic large-cell lymphoma translocation.
Leukemia.
2014
Academic Article
GET IT
Times cited: 40 -
The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling.
Nature cell biology.
2014
Academic Article
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Times cited: 98 -
Flow sorting and exome sequencing reveal the oncogenome of primary Hodgkin and Reed-Sternberg cells.
Blood.
2014
Academic Article
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Times cited: 182 -
Integrin αvβ3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells.
Blood.
2014
Academic Article
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Times cited: 77 -
Pathogenetic and diagnostic significance of microRNA deregulation in peripheral T-cell lymphoma not otherwise specified.
Blood cancer journal.
2014
Academic Article
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Times cited: 27 -
Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia.
Blood.
2014
Academic Article
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Times cited: 96 -
PRDM1/BLIMP1: a tumor suppressor gene in B and T cell lymphomas.
Leukemia & lymphoma.
2014
Information Resource
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Times cited: 29 -
The Krüppel-like factor 2 transcription factor gene is recurrently mutated in splenic marginal zone lymphoma.
Leukemia.
2014
Article
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Times cited: 57 -
Pegasus: a comprehensive annotation and prediction tool for detection of driver gene fusions in cancer.
BMC systems biology.
2014
Academic Article
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Times cited: 50 - Microscale Bioadhesive Hydrogel Arrays for Cell Engineering Applications. Cellular and molecular bioengineering. 2014 Academic Article GET IT
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Lenalidomide plus R-CHOP21 in elderly patients with untreated diffuse large B-cell lymphoma: results of the REAL07 open-label, multicentre, phase 2 trial.
The Lancet. Oncology.
2014
Academic Article
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Times cited: 130 -
ALK/EML4 fusion gene may be found in pure squamous carcinoma of the lung.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
2014
Academic Article
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Times cited: 34 -
Platelet-derived growth factor alpha mediates the proliferation of peripheral T-cell lymphoma cells via an autocrine regulatory pathway.
Leukemia.
2014
Academic Article
GET IT
Times cited: 27 -
Genetics of follicular lymphoma transformation.
Cell reports.
2014
Academic Article
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Times cited: 458 -
A targeted mutational landscape of angioimmunoblastic T-cell lymphoma.
Blood.
2013
Academic Article
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Times cited: 337 -
Molecular events underlying interleukin-6 independence in a subclone of the CMA-03 multiple myeloma cell line.
Genes, chromosomes & cancer.
2013
Academic Article
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Times cited: 5 -
Functional impact of NOTCH1 mutations in chronic lymphocytic leukemia.
Leukemia.
2013
Academic Article
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Times cited: 79 -
PRDM1/BLIMP1 is commonly inactivated in anaplastic large T-cell lymphoma.
Blood.
2013
Academic Article
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Times cited: 68 -
Two main genetic pathways lead to the transformation of chronic lymphocytic leukemia to Richter syndrome.
Blood.
2013
Academic Article
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Times cited: 147 -
STAT3-mediated activation of microRNA cluster 17~92 promotes proliferation and survival of ALK-positive anaplastic large cell lymphoma.
Haematologica.
2013
Academic Article
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Times cited: 47 -
Mechanism-based epigenetic chemosensitization therapy of diffuse large B-cell lymphoma.
Cancer discovery.
2013
Academic Article
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Times cited: 167 -
Deregulation of ETS1 and FLI1 contributes to the pathogenesis of diffuse large B-cell lymphoma.
Blood.
2013
Academic Article
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Times cited: 28 -
Molecular profiling improves classification and prognostication of nodal peripheral T-cell lymphomas: results of a phase III diagnostic accuracy study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2013
Academic Article
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Times cited: 93 -
Beyond NPM-anaplastic lymphoma kinase driven lymphomagenesis: alternative drivers in anaplastic large cell lymphoma.
Current opinion in hematology.
2013
Information Resource
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Times cited: 17 -
MicroRNA expression profiling identifies molecular signatures associated with anaplastic large cell lymphoma.
Blood.
2013
Academic Article
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Times cited: 83 -
Comparative analysis of cancer vaccine settings for the selection of an effective protocol in mice.
Journal of translational medicine.
2013
Academic Article
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Times cited: 21 -
The EGFR family members sustain the neoplastic phenotype of ALK+ lung adenocarcinoma via EGR1.
Oncogenesis.
2013
Academic Article
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Times cited: 29 -
Core binding factor acute myeloid leukaemia and c-KIT mutations.
Oncology reports.
2013
Academic Article
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Times cited: 23 -
Constant activation of the RAF-MEK-ERK pathway as a diagnostic and therapeutic target in hairy cell leukemia.
Haematologica.
2013
Academic Article
GET IT
Times cited: 70 -
The PD-1/PD-L1 axis contributes to T-cell dysfunction in chronic lymphocytic leukemia.
Haematologica.
2013
Academic Article
GET IT
Times cited: 195 -
PDGFR blockade is a rational and effective therapy for NPM-ALK-driven lymphomas.
Nature medicine.
2012
Academic Article
GET IT
Times cited: 85 -
Stem cells based therapy in high grade glioma: why the intraventricular route should be preferred?.
Journal of neurosurgical sciences.
2012
Academic Article
GET IT
Times cited: 11 -
The coding genome of splenic marginal zone lymphoma: activation of NOTCH2 and other pathways regulating marginal zone development.
The Journal of experimental medicine.
2012
Academic Article
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Times cited: 331 -
Identification of a 3-gene model as a powerful diagnostic tool for the recognition of ALK-negative anaplastic large-cell lymphoma.
Blood.
2012
Academic Article
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Times cited: 76 -
Retinoic acid/alpha-interferon combination inhibits growth and promotes apoptosis in mantle cell lymphoma through Akt-dependent modulation of critical targets.
Cancer research.
2012
Academic Article
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Times cited: 17 -
CEP-28122, a highly potent and selective orally active inhibitor of anaplastic lymphoma kinase with antitumor activity in experimental models of human cancers.
Molecular cancer therapeutics.
2011
Academic Article
GET IT
Times cited: 59 -
Loss of p27KIP1 expression in fully-staged node-negative breast cancer: association with lack of hormone receptors in T1a/b, but not T1c infiltrative ductal carcinoma.
Anticancer research.
2011
Academic Article
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Times cited: 6 -
Integrated DNA copy number and methylation profiling of lymphoid neoplasms using a single array.
British journal of haematology.
2011
Academic Article
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Times cited: 9 -
Simple genetic diagnosis of hairy cell leukemia by sensitive detection of the BRAF-V600E mutation.
Blood.
2011
Academic Article
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Times cited: 131 -
CD73-generated extracellular adenosine in chronic lymphocytic leukemia creates local conditions counteracting drug-induced cell death.
Blood.
2011
Academic Article
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Times cited: 127 -
Anaplastic lymphoma kinase in human cancer.
Journal of molecular endocrinology.
2011
Information Resource
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Times cited: 89 -
Clinical and molecular characterization of diffuse large B-cell lymphomas with 13q14.3 deletion.
Annals of oncology : official journal of the European Society for Medical Oncology.
2011
Academic Article
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Times cited: 15 -
Description of a novel Janus kinase 3 P132A mutation in acute megakaryoblastic leukemia and demonstration of previously reported Janus kinase 3 mutations in normal subjects.
Leukemia & lymphoma.
2011
Academic Article
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Times cited: 9 -
The lymphoma-associated NPM-ALK oncogene elicits a p16INK4a/pRb-dependent tumor-suppressive pathway.
Blood.
2011
Academic Article
GET IT
Times cited: 23 -
Integrated profiling of diffuse large B-cell lymphoma with 7q gain.
British journal of haematology.
2011
Academic Article
GET IT
Times cited: 11 -
Diffuse large B-cell lymphoma with concordant bone marrow involvement has peculiar genomic profile and poor clinical outcome.
Hematological oncology.
2011
Academic Article
GET IT
Times cited: 23 -
Genomic lesions associated with a different clinical outcome in diffuse large B-Cell lymphoma treated with R-CHOP-21.
British journal of haematology.
2010
Academic Article
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Times cited: 41 -
Genomic profiling of Richter's syndrome: recurrent lesions and differences with de novo diffuse large B-cell lymphomas.
Hematological oncology.
2010
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Single nucleotide polymorphism-arrays provide new insights in the pathogenesis of post-transplant diffuse large B-cell lymphoma.
British journal of haematology.
2010
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Gene expression profiling uncovers molecular classifiers for the recognition of anaplastic large-cell lymphoma within peripheral T-cell neoplasms.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2010
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Anaplastic large cell lymphoma: one or more entities among T-cell lymphoma?.
Hematological oncology.
2009
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NPM-ALK oncogenic tyrosine kinase controls T-cell identity by transcriptional regulation and epigenetic silencing in lymphoma cells.
Cancer research.
2009
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Genome wide DNA-profiling of HIV-related B-cell lymphomas.
British journal of haematology.
2009
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Epidermal growth factor receptor gene in primary tumor and metastatic sites from non-small cell lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
2009
Academic Article
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Anaplastic lymphoma kinase: an oncogene for tumor vaccination.
Journal of molecular medicine (Berlin, Germany).
2009
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The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 activation.
Cancer research.
2008
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The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALCL.
Blood.
2008
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The anaplastic lymphoma kinase is an effective oncoantigen for lymphoma vaccination.
Nature medicine.
2008
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The anaplastic lymphoma kinase in the pathogenesis of cancer.
Nature reviews. Cancer.
2008
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CEP-18770: A novel, orally active proteasome inhibitor with a tumor-selective pharmacologic profile competitive with bortezomib.
Blood.
2007
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The tyrosine phosphatase Shp2 interacts with NPM-ALK and regulates anaplastic lymphoma cell growth and migration.
Cancer research.
2007
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Functional validation of the anaplastic lymphoma kinase signature identifies CEBPB and BCL2A1 as critical target genes.
The Journal of clinical investigation.
2006
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p27Kip1 repression of ErbB2-induced mammary tumor growth in transgenic mice involves Skp2 and Wnt/beta-catenin signaling.
Cancer research.
2006
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Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis.
Cell.
2006
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STAT3: a multifaceted oncogene.
Proceedings of the National Academy of Sciences of the United States of America.
2006
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Increase in circulating bone marrow progenitor cells after myocardial infarction.
Coronary artery disease.
2006
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Ablation of oncogenic ALK is a viable therapeutic approach for anaplastic large-cell lymphomas.
Blood.
2005
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p130Cas mediates the transforming properties of the anaplastic lymphoma kinase.
Blood.
2005
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Follicular origin of a subset of CD5+ diffuse large B-cell lymphomas.
American journal of clinical pathology.
2005
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Primary hepatic anaplastic large-cell lymphoma diagnosed by fine-needle aspiration biopsy.
Diagnostic cytopathology.
2005
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Phase III randomized trial of patient-specific vaccination for previously untreated patients with follicular lymphoma in first complete remission: protocol summary and interim report.
Clinical lymphoma.
2005
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Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target.
Nature medicine.
2005
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A DeImmunized chimeric anti-C3b/iC3b monoclonal antibody enhances rituximab-mediated killing in NHL and CLL cells via complement activation.
Cancer immunology, immunotherapy : CII.
2005
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Tim-3+ T-bet+ tumor-specific Th1 cells colocalize with and inhibit development and growth of murine neoplasms.
Journal of immunology (Baltimore, Md. : 1950).
2005
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Transient atypical monocytosis mimic acute myelomonocytic leukemia in post-chemotherapy patients receiving G-CSF: report of two cases.
Clinical and laboratory haematology.
2004
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The Rgr oncogene induces tumorigenesis in transgenic mice.
Cancer research.
2004
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BRAF gene is not mutated in plasma cell leukemia and multiple myeloma.
Leukemia.
2003
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Differential amplification and overexpression of HER-2/neu, p53, MIB1, and estrogen receptor/progesterone receptor among medullary carcinoma, atypical medullary carcinoma, and high-grade invasive ductal carcinoma of breast.
Archives of pathology & laboratory medicine.
2003
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The B cell SH2/PH domain-containing adaptor Bam32/DAPP1 is required for T cell-independent II antigen responses.
Current biology : CB.
2003
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Constitutive expression of DeltaN-p63alpha isoform in human thymus and thymic epithelial tumours.
Virchows Archiv : an international journal of pathology.
2003
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Identification of oligoclonal CD4 T cells in diffuse large B cell lymphomas.
Clinical immunology (Orlando, Fla.).
2003
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In vivo interference with Skp1 function leads to genetic instability and neoplastic transformation.
Molecular and cellular biology.
2002
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NPM-ALK transgenic mice spontaneously develop T-cell lymphomas and plasma cell tumors.
Blood.
2002
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Human rgr: transforming activity and alteration in T-cell malignancies.
Oncogene.
2002
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S-phase kinase-associated protein 2 expression in non-Hodgkin's lymphoma inversely correlates with p27 expression and defines cells in S phase.
The American journal of pathology.
2002
Academic Article
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Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death.
Oncogene.
2002
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Amplification of Her-2/neu gene in Her-2/neu-overexpressing and -nonexpressing breast carcinomas and their synchronous benign, premalignant, and metastatic lesions detected by FISH in archival material.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.
2002
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Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells.
The Journal of experimental medicine.
2001
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Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemia.
Blood.
2001
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Role of the F-box protein Skp2 in lymphomagenesis.
Proceedings of the National Academy of Sciences of the United States of America.
2001
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Induction of germinal centers by MMTV encoded superantigen on B cells.
Developmental immunology.
2001
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CD5+ follicle center lymphoma. Immunophenotyping detects a unique subset of "floral" follicular lymphoma.
American journal of clinical pathology.
2000
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Low expression of p27 and low proliferation index do not correlate in hairy cell leukaemia.
British journal of haematology.
2000
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Initiation of translation from a downstream in-frame AUG codon on BRCA1 can generate the novel isoform protein DeltaBRCA1(17aa).
Oncogene.
2000
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Increased proteasome degradation of cyclin-dependent kinase inhibitor p27 is associated with a decreased overall survival in mantle cell lymphoma.
Blood.
2000
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Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors.
Cytogenetics and cell genetics.
2000
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Molecular features of primary mediastinal B-cell lymphoma: involvement of p16INK4A, p53 and c-myc.
British journal of haematology.
1999
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Detection of immunoglobulin kappa light chain rearrangements by polymerase chain reaction. An improved method for detecting clonal B-cell lymphoproliferative disorders.
The American journal of pathology.
1999
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CD30 overexpression enhances negative selection in the thymus and mediates programmed cell death via a Bcl-2-sensitive pathway.
Journal of immunology (Baltimore, Md. : 1950).
1999
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pp60(v-src) induction of cyclin D1 requires collaborative interactions between the extracellular signal-regulated kinase, p38, and Jun kinase pathways. A role for cAMP response element-binding protein and activating transcription factor-2 in pp60(v-src) signaling in breast cancer cells.
The Journal of biological chemistry.
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CD30 in normal and neoplastic cells.
Clinical immunology (Orlando, Fla.).
1999
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The usefulness of immunophenotypic and genotypic studies in the diagnosis and classification of hematopoietic and lymphoid neoplasms. An update.
American journal of clinical pathology.
1999
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Differential expression of cyclin-dependent kinase 6 in cortical thymocytes and T-cell lymphoblastic lymphoma/leukemia.
The American journal of pathology.
1998
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Chromosomal mapping to 15q14 and expression analysis of the human MEIS2 homeobox gene.
Mammalian genome : official journal of the International Mammalian Genome Society.
1997
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Epstein-Barr virus latent gene expression in primary effusion lymphomas containing Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8.
Blood.
1997
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Lymphocyte-rich well-differentiated liposarcoma: report of nine cases.
The American journal of surgical pathology.
1997
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Cloning and mapping of the MEIS1 gene, the human homolog of a murine leukemogenic gene.
Genomics.
1997
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p21/WAF1 cyclin-kinase inhibitor expression in non-Hodgkin's lymphomas: a potential marker of p53 tumor-suppressor gene function.
Blood.
1996
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Morphological and biological characteristics of mammogram-detected invasive breast cancer.
Human pathology.
1996
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Large-cell variants of mantle cell lymphoma: cytologic characteristics and p53 anomalies may predict poor outcome.
British journal of haematology.
1996
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Molecular characterization of the t(2;5) (p23; q35) translocation in anaplastic large cell lymphoma (Ki-1) and Hodgkin's disease.
Blood.
1996
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In vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi's sarcoma-associated herpesvirus-like (KSHV) DNA sequences.
Blood.
1995
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Clonal analysis of IgM+ CD5+ CLL B cells.
Annals of the New York Academy of Sciences.
1995
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Breast cancer heterogeneity: evaluation of clonality in primary and metastatic lesions.
Human pathology.
1995
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The Reed-Sternberg cells of Hodgkin disease are clonal.
Proceedings of the National Academy of Sciences of the United States of America.
1994
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Phenotypic and functional characterization of T-BAM (CD40 ligand)+ T-cell non-Hodgkin's lymphoma.
Blood.
1994
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Molecular characterization of CD30+ anaplastic large-cell lymphoma: high frequency of c-myc proto-oncogene activation.
Blood.
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Role of the bcl-2 oncogene in Hodgkin's disease.
American journal of clinical pathology.
1994
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Inactivation of tumor suppressor genes, p53 and Rb1, in plasma cell dyscrasias.
Leukemia.
1994
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Molecular genetic demonstration of the diverse evolution of Richter's syndrome (chronic lymphocytic leukemia and subsequent large cell lymphoma).
Blood.
1994
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T-BAM/CD40-L on helper T lymphocytes augments lymphokine-induced B cell Ig isotype switch recombination and rescues B cells from programmed cell death.
Journal of immunology (Baltimore, Md. : 1950).
1994
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CD40 molecules induce down-modulation and endocytosis of T cell surface T cell-B cell activating molecule/CD40-L. Potential role in regulating helper effector function.
Journal of immunology (Baltimore, Md. : 1950).
1994
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Naturally processed cytokine-derived peptide bound to HLA-class II molecules.
Journal of immunology (Baltimore, Md. : 1950).
1993
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High levels of p53 protein expression do not correlate with p53 gene mutations in anaplastic large cell lymphoma.
The American journal of pathology.
1993
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Detection of immunoglobulin gene rearrangement of B cell non-Hodgkin's lymphomas and leukemias in fresh, unfixed and formalin-fixed, paraffin-embedded tissue by polymerase chain reaction.
Laboratory investigation; a journal of technical methods and pathology.
1993
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Mutational activation of N- and K-ras oncogenes in plasma cell dyscrasias.
Blood.
1993
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Molecular interactions mediating T-B lymphocyte collaboration in human lymphoid follicles. Roles of T cell-B-cell-activating molecule (5c8 antigen) and CD40 in contact-dependent help.
Journal of immunology (Baltimore, Md. : 1950).
1992
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Structural and functional analysis of oncogenes and tumor suppressor genes in adult T-cell leukemia/lymphoma shows frequent p53 mutations.
Blood.
1992
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Determination of the DNA content of the Reed-Sternberg cell of Hodgkin's disease by image analysis.
Blood.
1992
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Large-cell acanthoma. A distinctive keratosis.
The American Journal of dermatopathology.
1992
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T-cell activation-associated antigen expression by neoplastic T-cells.
Hematologic pathology.
1992
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The kinetics and temporal expression of T-cell activation-associated antigens CD15 (LeuM1), CD30 (Ki-1), EMA, and CD11c (LeuM5) by benign activated T cells.
Hematologic pathology.
1992
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Autoantibody-associated cross-reactive idiotype-bearing human B lymphocytes: distribution and characterization, including Ig VH gene and CD5 antigen expression.
Blood.
1991
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Does a retrovirus cause amyotrophic lateral sclerosis?.
Annals of neurology.
1991
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p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia.
Proceedings of the National Academy of Sciences of the United States of America.
1991
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Epstein-Barr virus infection precedes clonal expansion in Burkitt's and acquired immunodeficiency syndrome-associated lymphoma.
Blood.
1991
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Lymphoma, motor neuron diseases, and amyotrophic lateral sclerosis.
Annals of neurology.
1991
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The B-cells that express anti-MAG antibodies in neuropathy and non-malignant IgM monoclonal gammopathy belong to the CD5 subpopulation.
Journal of neuroimmunology.
1991
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Negative autoregulation of c-myc gene expression is inactivated in transformed cells.
The EMBO journal.
1990
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Down-regulation of LFA-1 adhesion receptors by C-myc oncogene in human B lymphoblastoid cells.
Science (New York, N.Y.).
1990
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Western thymomas lack Epstein-Barr virus by Southern blotting analysis and by polymerase chain reaction.
The American journal of pathology.
1990
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Flow cytometric and immunohistochemical characterization of the gamma/delta T-lymphocyte population in normal human lymphoid tissue and peripheral blood.
The American journal of pathology.
1990
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Hairy cell leukemia-associated antigen LeuM5 (CD11c) is preferentially expressed by benign activated and neoplastic CD8 T cells.
The American journal of pathology.
1990
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Extranodal noncutaneous lymphoid hyperplasias represent a continuous spectrum of B-cell neoplasia: demonstration by molecular genetic analysis.
Blood.
1989
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Transformation and plasmacytoid differentiation of EBV-infected human B lymphoblasts by ras oncogenes.
Science (New York, N.Y.).
1989
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Immunoglobulin VH gene expression in human B cell lines and tumors: biased VH gene expression in chronic lymphocytic leukemia.
International immunology.
1989
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Differential expression of LFA-1 molecules in non-Hodgkin's lymphoma and lymphoid leukemia.
Blood.
1988
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Frequent c-myc oncogene activation and infrequent presence of Epstein-Barr virus genome in AIDS-associated lymphoma.
Blood.
1988
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Activated T lymphocytes in the peripheral blood of patients with systemic lupus erythematosus induce B cells to produce immunoglobulin.
Clinical and experimental rheumatology.
1988
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Model for studying virus attachment: identification and quantitation of Epstein-Barr virus-binding cells by using biotinylated virus in flow cytometry.
Journal of virology.
1988
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Immunoregulatory aberrations in patients with polyarticular juvenile rheumatoid arthritis.
Clinical immunology and immunopathology.
1988
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High dose intravenous methotrexate with leucovorin rescue in rheumatoid arthritis.
The Journal of rheumatology.
1988
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Different biological effects of c-myc and H-ras oncogene expression in EBV-infected human lymphoblasts.
Current topics in microbiology and immunology.
1988
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In vitro generated human monoclonal trinitrophenyl-specific B cell lines. Evidence that human and murine anti-trinitrophenyl monoclonal antibodies cross-react with Escherichia coli beta-galactosidase.
Journal of immunology (Baltimore, Md. : 1950).
1987
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Human lymphocytes making rheumatoid factor and antibody to ssDNA belong to Leu-1+ B-cell subset.
Science (New York, N.Y.).
1987
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Cellular immunity in patients with systemic juvenile rheumatoid arthritis.
Clinical immunology and immunopathology.
1987
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Human monoclonals from antigen-specific selection of B lymphocytes and transformation by EBV.
Science (New York, N.Y.).
1986
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Regulation of human cytotoxic responses by complement: C3, C3b and C3d preparations enhance human allogeneic cytotoxic responses.
Journal of immunopharmacology.
1986
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Regulation of immunoglobulin secretion by factor H of human complement.
Immunology.
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Enhancement of human allogeneic cytotoxic responses by interferons.
Journal of immunopharmacology.
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Monoclonal antibodies to breast cancer-associated antigens as potential reagents in the management of breast cancer.
Cancer.
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