Serganova, Inna

Publications

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selected publications

Pharmacologic LDH inhibition redirects intratumoral glucose uptake and improves antitumor immunity in solid tumor models. The Journal of clinical investigation. 2024 Academic Article GET IT
Facts and Perspectives: Implications of tumor glycolysis on immunotherapy response in triple negative breast cancer. Frontiers in oncology. 2023 Review GET IT
Times cited: 4
Genetic and Drug Inhibition of LDH-A: Effects on Murine Gliomas. Cancers. 2022 Academic Article GET IT
Times cited: 9
LDH-A-Modulation and the Variability of LDH Isoenzyme Profiles in Murine Gliomas: A Link with Metabolic and Growth Responses. Cancers. 2022 Academic Article GET IT
Epigenetic, Metabolic, and Immune Crosstalk in Germinal-Center-Derived B-Cell Lymphomas: Unveiling New Vulnerabilities for Rational Combination Therapies. Frontiers in cell and developmental biology. 2022 Review GET IT
Introducing a new reporter gene, membrane-anchored Cypridina luciferase, for multiplex bioluminescence imaging. Molecular therapy oncolytics. 2021 Academic Article GET IT
Times cited: 10
CTLA-4 blockade drives loss of T_reg stability in glycolysis-low tumours. Nature. 2021 Academic Article GET IT
Times cited: 229
Lactate Dehydrogenase A Depletion Alters MyC-CaP Tumor Metabolism, Microenvironment, and CAR T Cell Therapy. Molecular therapy oncolytics. 2020 Academic Article GET IT
Times cited: 19
LDH-A regulates the tumor microenvironment via HIF-signaling and modulates the immune response. PloS one. 2018 Academic Article GET IT
Times cited: 92
Inhibition of prostate cancer proliferation by Deferiprone. NMR in biomedicine. 2017 Academic Article GET IT
Times cited: 31
Tumor stroma interaction is mediated by monocarboxylate metabolism. Experimental cell research. 2017 Academic Article GET IT
Times cited: 24
Enhancement of PSMA-Directed CAR Adoptive Immunotherapy by PD-1/PD-L1 Blockade. Molecular therapy oncolytics. 2016 Academic Article GET IT
Times cited: 82
Synthesis and evaluation of an (18)F-labeled pyrimidine-pyridine amine for targeting CXCR4 receptors in gliomas. Nuclear medicine and biology. 2016 Academic Article GET IT
Times cited: 12
Metabolic plasticity of metastatic breast cancer cells: adaptation to changes in the microenvironment. Neoplasia (New York, N.Y.). 2015 Academic Article GET IT
Times cited: 115
Comparative Analysis of T Cell Imaging with Human Nuclear Reporter Genes. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2015 Academic Article GET IT
Times cited: 70
Understanding the pharmacological properties of a metabolic PET tracer in prostate cancer. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 40
Synthesis and evaluation of 18F-labeled benzylguanidine analogs for targeting the human norepinephrine transporter. European journal of nuclear medicine and molecular imaging. 2013 Academic Article GET IT
Times cited: 49
Relationships between LDH-A, lactate, and metastases in 4T1 breast tumors. Clinical cancer research : an official journal of the American Association for Cancer Research. 2013 Academic Article GET IT
Times cited: 89
Molecular imaging of expression of vascular endothelial growth factor a (VEGF a) in femoral bone grafts transplanted into living mice. Cell transplantation. 2013 Academic Article GET IT
Times cited: 3
Noninvasive molecular imaging using reporter genes. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2013 Information Resource GET IT
Times cited: 55
Bioluminescence imaging serves as a dynamic marker for guiding and assessing thermal treatment of cancer in a preclinical model. Annals of surgical oncology. 2012 Academic Article GET IT
Times cited: 13
Monitoring the induction of heat shock factor 1/heat shock protein 70 expression following 17-allylamino-demethoxygeldanamycin treatment by positron emission tomography and optical reporter gene imaging. Molecular imaging. 2012 Academic Article GET IT
Times cited: 13
Metabolic imaging: a link between lactate dehydrogenase A, lactate, and tumor phenotype. Clinical cancer research : an official journal of the American Association for Cancer Research. 2011 Academic Article GET IT
Times cited: 90
ATP-binding cassette transporters modulate both coelenterazine- and D-luciferin-based bioluminescence imaging. Molecular imaging. 2011 Academic Article GET IT
Times cited: 15
Imaging colon cancer response following treatment with AZD1152: a preclinical analysis of [18F]fluoro-2-deoxyglucose and 3'-deoxy-3'-[18F]fluorothymidine imaging. Clinical cancer research : an official journal of the American Association for Cancer Research. 2011 Academic Article GET IT
Times cited: 30
Imaging expression of the human somatostatin receptor subtype-2 reporter gene with 68Ga-DOTATOC. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2010 Academic Article GET IT
Times cited: 47
Genetically engineered oncolytic Newcastle disease virus effectively induces sustained remission of malignant pleural mesothelioma. Molecular cancer therapeutics. 2010 Academic Article GET IT
Times cited: 32
Concurrent visualization of trafficking, expansion, and activation of T lymphocytes and T-cell precursors in vivo. Blood. 2010 Academic Article GET IT
Times cited: 37
Different strategies for reducing intestinal background radioactivity associated with imaging HSV1-tk expression using established radionucleoside probes. Molecular imaging. 2010 Academic Article GET IT
Times cited: 16
Imaging a Genetically Engineered Oncolytic Vaccinia Virus (GLV-1h99) Using a Human Norepinephrine Transporter Reporter Gene. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009 Academic Article GET IT
Times cited: 45
Real-time imaging of HIF-1alpha stabilization and degradation. PloS one. 2009 Academic Article GET IT
Times cited: 100
Multimodality imaging of TGFbeta signaling in breast cancer metastases. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2009 Academic Article GET IT
Times cited: 48
A novel recombinant vaccinia virus expressing the human norepinephrine transporter retains oncolytic potential and facilitates deep-tissue imaging. Molecular medicine (Cambridge, Mass.). 2009 Academic Article GET IT
Times cited: 35
Imaging of HSV-tk Reporter gene expression: comparison between [18F]FEAU, [18F]FFEAU, and other imaging probes. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2008 Academic Article GET IT
Times cited: 48
Imaging of hypoxia-driven gene expression in an orthotopic liver tumor model. Molecular cancer therapeutics. 2007 Academic Article GET IT
Times cited: 27
HSP70-inducible hNIS-IRES-eGFP reporter imaging: response to heat shock. Molecular imaging. 2007 Academic Article GET IT
Times cited: 15
Human reporter genes: potential use in clinical studies. Nuclear medicine and biology. 2007 Information Resource GET IT
Times cited: 96
Imaging hNET reporter gene expression with 124I-MIBG. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2007 Academic Article GET IT
Times cited: 87
A human-derived reporter gene for noninvasive imaging in humans: mitochondrial thymidine kinase type 2. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2007 Academic Article GET IT
Times cited: 97
Tumor hypoxia imaging. Clinical cancer research : an official journal of the American Association for Cancer Research. 2006 Comment GET IT
Times cited: 40
Reporter gene imaging: potential impact on therapy. Nuclear medicine and biology. 2005 Information Resource GET IT
Times cited: 101
Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway. Proceedings of the National Academy of Sciences of the United States of America. 2005 Academic Article GET IT
Times cited: 468
hNIS-IRES-eGFP dual reporter gene imaging. Molecular imaging. 2005 Academic Article GET IT
Times cited: 47
Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors. The Journal of clinical investigation. 2005 Academic Article GET IT
Times cited: 608
A preclinical model for noninvasive imaging of hypoxia-induced gene expression; comparison with an exogenous marker of tumor hypoxia. European journal of nuclear medicine and molecular imaging. 2004 Academic Article GET IT
Times cited: 52
Molecular imaging of temporal dynamics and spatial heterogeneity of hypoxia-inducible factor-1 signal transduction activity in tumors in living mice. Cancer research. 2004 Academic Article GET IT
Times cited: 165
A novel triple-modality reporter gene for whole-body fluorescent, bioluminescent, and nuclear noninvasive imaging. European journal of nuclear medicine and molecular imaging. 2004 Academic Article GET IT
Times cited: 213
Cytoplasmically retargeted HSV1-tk/GFP reporter gene mutants for optimization of noninvasive molecular-genetic imaging. Neoplasia (New York, N.Y.). 2003 Academic Article GET IT
Development of a new reporter gene system--dsRed/xanthine phosphoribosyltransferase-xanthine for molecular imaging of processes behind the intact blood-brain barrier. Molecular imaging. 2003 Academic Article GET IT
Times cited: 33
Sequencing of flagellin genes from Natrialba magadii provides new insight into evolutionary aspects of archaeal flagellins. Journal of bacteriology. 2002 Academic Article GET IT
Times cited: 9

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Research

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Funding awarded

Exploiting tumor metabolism to optimize T cell therapy awarded by National Cancer Institute Principal Investigator 2024 - 2029
Exploiting tumor metabolism to optimize T cell therapy awarded by National Cancer Institute Principal Investigator 2021 - 2024

PROSTATE CANCER NON-NEUROENDOCRINE LINEAGE PLASTICITY: DETECTION USING MULTIMODAL INTEGRATION ANDIMMUNOTHERAPEUTIC TARGETING awarded by Starr Cancer Consortium Co-Investigator 2024 - 2026
Image-guided Trp-IDO/TDO-Kyn-AHR pathway inhibition, combined with immunotherapy awarded by National Cancer Institute Co-Investigator 2022 - 2026
SRA with BMS awarded by Bristol-Myers Squibb Company Co-Investigator 2021 - 2024

Tumor-metabolism-driven therapies to overcome TNBC immune resistance awarded by Breast Cancer Alliance Inc. Key Personnel 2023 - 2025

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Background

education and training

Ph.D., Russian Academy of Sciences (Russia) 1998
B.S., Lomonosov Moscow State University (Russia) 1989

Contact

full name

Inna Serganova

primary email

iss4007@med.cornell.edu

VIVO Weill Cornell Medical College

Inna Serganova Assistant Professor of Cancer Biology in Medicine Instructor of Cancer Biology in Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email