selected publications
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Drug screening in human physiologic medium identifies uric acid as an inhibitor of rigosertib efficacy.
JCI insight.
2024
Academic Article
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Times cited: 4 - Drug screening in human physiologic medium identifies uric acid as an inhibitor of rigosertib efficacy. 2023 GET IT
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Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression.
Nature communications.
2022
Academic Article
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Times cited: 61 -
De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma.
Cancer cell.
2022
Academic Article
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Times cited: 94 -
Suppression of nuclear GSK3 signaling promotes serine/one-carbon metabolism and confers metabolic vulnerability in lung cancer cells.
Science advances.
2022
Academic Article
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Times cited: 29 -
A non-canonical tricarboxylic acid cycle underlies cellular identity.
Nature.
2022
Academic Article
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Times cited: 223 -
Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3 mimetics.
Science signaling.
2021
Academic Article
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Times cited: 23 -
Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia.
iScience.
2021
Academic Article
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Times cited: 7 -
Targeting oncoproteins with a positive selection assay for protein degraders.
Science advances.
2021
Academic Article
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Times cited: 37 -
Age-induced accumulation of methylmalonic acid promotes tumour progression.
Nature.
2020
Academic Article
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Times cited: 199 -
Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.
Molecular cell.
2020
Academic Article
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Times cited: 159 -
Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion.
Cell metabolism.
2019
Academic Article
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Times cited: 130