Paik, Jihye

Publications

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Advances and resistance adaptation in BTK-targeted therapy for B-cell malignancies. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy. 2026 Review GET IT
Leveraging BRG1 Driven Ferroptosis Resistance to Overcome Treatment Resistance. 2025 GET IT
Functional Motif Discovery in FOXO1 Through CRISPR/Cas9 Exon Tiling Scan. Methods in molecular biology (Clifton, N.J.). 2025 Academic Article GET IT
Mutant IDH1 inhibition induces dsDNA sensing to activate tumor immunity. Science (New York, N.Y.). 2024 Academic Article GET IT
PRMT5 inhibition drives therapeutic vulnerability to combination treatment with BCL-2 inhibition in mantle cell lymphoma. Blood advances. 2023 Academic Article GET IT
Times cited: 16
Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance. Nature communications. 2023 Academic Article GET IT
Times cited: 20
Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance. 2023 GET IT
FOXO3A-short is a novel regulator of non-oxidative glucose metabolism associated with human longevity. Aging cell. 2023 Academic Article GET IT
A FOXO1-dependent transcription network is a targetable vulnerability of mantle cell lymphomas. The Journal of clinical investigation. 2022 Academic Article GET IT
Times cited: 20
FOXO transcription factors as therapeutic targets in human diseases. Trends in pharmacological sciences. 2022 Review GET IT
Oxidative stress sensing and response in neural stem cell fate. Free radical biology & medicine. 2021 Academic Article GET IT
Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification. Nature communications. 2021 Academic Article GET IT
Times cited: 39
Therapy-Induced Transdifferentiation Promotes Glioma Growth Independent of EGFR Signaling. Cancer research. 2021 Academic Article GET IT
Mitochondria Define Intestinal Stem Cell Differentiation Downstream of a FOXO/Notch Axis. Cell metabolism. 2020 Academic Article GET IT
Times cited: 8
CIC is a critical regulator of neuronal differentiation. JCI insight. 2020 Academic Article GET IT
Times cited: 29
Rapid and Selective Targeting of Heterogeneous Pancreatic Neuroendocrine Tumors. iScience. 2020 Academic Article GET IT
ATRX loss induces telomere dysfunction and necessitates induction of alternative lengthening of telomeres during human cell immortalization. The EMBO journal. 2019 Academic Article GET IT
Times cited: 101
N-Myc-mediated epigenetic reprogramming drives lineage plasticity in advanced prostate cancer. The Journal of clinical investigation. 2019 Academic Article GET IT
Times cited: 141
Genetic Ablation of FOXO in Mice to Investigate Its Physiological Role. Methods in molecular biology (Clifton, N.J.). 2019 Article GET IT
Times cited: 1
FoxO1 regulates leptin-induced mood behavior by targeting tyrosine hydroxylase. Metabolism: clinical and experimental. 2018 Academic Article GET IT
Times cited: 3
FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis. Neuron. 2018 Academic Article GET IT
Times cited: 126
A splice junction-targeted CRISPR approach (spJCRISPR) reveals human FOXO3B to be a protein-coding gene. Gene. 2018 Academic Article GET IT
Times cited: 10
Far Upstream Element-Binding Protein 1 Regulates LSD1 Alternative Splicing to Promote Terminal Differentiation of Neural Progenitors. Stem cell reports. 2018 Academic Article GET IT
Times cited: 32
FOXO in Neural Cells and Diseases of the Nervous System. Current topics in developmental biology. 2018 Article GET IT
Times cited: 25
FoxO3 an important player in fibrogenesis and therapeutic target for idiopathic pulmonary fibrosis. EMBO molecular medicine. 2018 Academic Article GET IT
Times cited: 98
FOXO protects against age-progressive axonal degeneration. Aging cell. 2017 Academic Article GET IT
Times cited: 55
FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase. Nature communications. 2016 Academic Article GET IT
Times cited: 41
Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. Science (New York, N.Y.). 2015 Academic Article GET IT
Times cited: 828
Functional regulation of FoxO1 in neural stem cell differentiation. Cell death and differentiation. 2015 Academic Article GET IT
Times cited: 78
Is c-Met oncoprotein expression an adverse prognosticator in extrahepatic bile duct cancer treated with curative resection followed by adjuvant chemoradiotherapy?. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 2015 Academic Article GET IT
Times cited: 3
FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization. Nature communications. 2015 Academic Article GET IT
Times cited: 197
Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy. Nature communications. 2015 Academic Article GET IT
Times cited: 595
Development of Resistance to EGFR-Targeted Therapy in Malignant Glioma Can Occur through EGFR-Dependent and -Independent Mechanisms. Cancer research. 2015 Academic Article GET IT
Times cited: 33
Metabolic circuits in neural stem cells. Cellular and molecular life sciences : CMLS. 2014 Information Resource GET IT
Times cited: 47
Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase. Genes & development. 2014 Academic Article GET IT
Times cited: 110
mTORC1 promotes denervation-induced muscle atrophy through a mechanism involving the activation of FoxO and E3 ubiquitin ligases. Science signaling. 2014 Academic Article GET IT
Times cited: 62
FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells. The EMBO journal. 2013 Academic Article GET IT
Times cited: 132
ZNF365 promotes stalled replication forks recovery to maintain genome stability. Cell cycle (Georgetown, Tex.). 2013 Academic Article GET IT
Times cited: 22
ZNF365 promotes stability of fragile sites and telomeres. Cancer discovery. 2013 Academic Article GET IT
Times cited: 22
Endothelial FoxO1 is an intrinsic regulator of thrombospondin 1 expression that restrains angiogenesis in ischemic muscle. Angiogenesis. 2013 Academic Article GET IT
Times cited: 46
Activation of FoxO3a/Bim axis in patients with Primary Biliary Cirrhosis. Liver international : official journal of the International Association for the Study of the Liver. 2013 Academic Article GET IT
Times cited: 18
FoxOs in neural stem cell fate decision. Archives of biochemistry and biophysics. 2012 Information Resource GET IT
Times cited: 21
STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA. Genes & development. 2012 Academic Article GET IT
Times cited: 101
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell. 2012 Academic Article GET IT
Times cited: 1727
FoxO1 is required in endothelial but not myocardial cell lineages during cardiovascular development. Developmental dynamics : an official publication of the American Association of Anatomists. 2012 Academic Article GET IT
Times cited: 21
Transcription factor FoxO1 is essential for enamel biomineralization. PloS one. 2012 Academic Article GET IT
Times cited: 17
FoxO family members in cancer. Cancer biology & therapy. 2011 Information Resource GET IT
Times cited: 116
PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB-cytokine network. Cancer discovery. 2011 Academic Article GET IT
Times cited: 197
IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology. Cell. 2011 Academic Article GET IT
Times cited: 227
FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress. The Journal of biological chemistry. 2010 Academic Article GET IT
Times cited: 300
Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature. 2010 Academic Article GET IT
Times cited: 704
Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes. Circulation research. 2010 Academic Article GET IT
Times cited: 633
The FoxO3/type 2 deiodinase pathway is required for normal mouse myogenesis and muscle regeneration. The Journal of clinical investigation. 2010 Academic Article GET IT
Times cited: 148
Biosynthesis of plant-specific flavones and flavonols in Streptomyces venezuelae. Journal of microbiology and biotechnology. 2010 Academic Article GET IT
Times cited: 24
PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas. Cancer cell. 2010 Academic Article GET IT
Times cited: 239
Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells. Nature immunology. 2010 Academic Article GET IT
Times cited: 316
Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells. The Journal of experimental medicine. 2010 Academic Article GET IT
Times cited: 246
Mig-6 controls EGFR trafficking and suppresses gliomagenesis. Proceedings of the National Academy of Sciences of the United States of America. 2010 Academic Article GET IT
Times cited: 104
FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice. Cell metabolism. 2010 Academic Article GET IT
Times cited: 271
FoxO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts. Cell metabolism. 2010 Academic Article GET IT
Times cited: 299
FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice. The Journal of clinical investigation. 2009 Academic Article GET IT
Times cited: 204
FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell stem cell. 2009 Academic Article GET IT
Times cited: 405
PI3 kinase signals BCR-dependent mature B cell survival. Cell. 2009 Academic Article GET IT
Times cited: 583
The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake. Nature medicine. 2009 Academic Article GET IT
Times cited: 149
Engineering of plant-specific phenylpropanoids biosynthesis in Streptomyces venezuelae. Journal of biotechnology. 2009 Academic Article GET IT
Times cited: 57
Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer. Proceedings of the National Academy of Sciences of the United States of America. 2008 Academic Article GET IT
Times cited: 136
Codependent activators direct myoblast-specific MyoD transcription. Developmental cell. 2008 Academic Article GET IT
Times cited: 133
Forkhead box, class O transcription factors in brain: regulation and behavioral manifestation. Biological psychiatry. 2008 Academic Article GET IT
Times cited: 120
Forkhead transcription factors (FoxOs) promote apoptosis of insulin-resistant macrophages during cholesterol-induced endoplasmic reticulum stress. Diabetes. 2008 Academic Article GET IT
Times cited: 77
SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway. Nature immunology. 2008 Academic Article GET IT
Times cited: 111
Ink4a/Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse. Proceedings of the National Academy of Sciences of the United States of America. 2007 Academic Article GET IT
Times cited: 53
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell. 2007 Academic Article GET IT
Times cited: 933
FOXOs in the maintenance of vascular homoeostasis. Biochemical Society transactions. 2006 Academic Article GET IT
Times cited: 33
Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation. Molecular and cellular biology. 2006 Academic Article GET IT
Times cited: 197
Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene. Cell. 2006 Academic Article GET IT
Times cited: 335
Catalase induced expression of inflammatory mediators via activation of NF-kappaB, PI3K/AKT, p70S6K, and JNKs in BV2 microglia. Cellular signalling. 2005 Academic Article GET IT
Times cited: 51
Role of guanine nucleotide exchange factor P-Rex-2b in sphingosine 1-phosphate-induced Rac1 activation and cell migration in endothelial cells. Prostaglandins & other lipid mediators. 2005 Academic Article GET IT
Times cited: 36
The G protein-coupled receptor S1P2 regulates Rho/Rho kinase pathway to inhibit tumor cell migration. Cancer research. 2005 Academic Article GET IT
Times cited: 136
Tetradecanoyl phorbol acetate induces expression of Toll-like receptor 2 in U937 cells: involvement of PKC, ERK, and NF-kappaB. Biochemical and biophysical research communications. 2005 Academic Article GET IT
Times cited: 12
Catalase induces the expression of inducible nitric oxide synthase through activation of NF-kappaB and PI3K signaling pathway in Raw 264.7 cells. Biochemical pharmacology. 2004 Academic Article GET IT
Times cited: 22
Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference. The Journal of clinical investigation. 2004 Academic Article GET IT
Times cited: 212
Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization. Genes & development. 2004 Academic Article GET IT
Times cited: 244
Up-regulation of human beta-defensin 2 by interleukin-1beta in A549 cells: involvement of PI3K, PKC, p38 MAPK, JNK, and NF-kappaB. Biochemical and biophysical research communications. 2004 Academic Article GET IT
Times cited: 65
Leptomycin B-induced apoptosis is mediated through caspase activation and down-regulation of Mcl-1 and XIAP expression, but not through the generation of ROS in U937 leukemia cells. Biochemical pharmacology. 2004 Academic Article GET IT
Times cited: 31
Tetrandrine-induced apoptosis is mediated by activation of caspases and PKC-delta in U937 cells. Biochemical pharmacology. 2004 Academic Article GET IT
Times cited: 51
Regulation of limb development by the sphingosine 1-phosphate receptor S1p1/EDG-1 occurs via the hypoxia/VEGF axis. Developmental biology. 2004 Academic Article GET IT
Times cited: 55
Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability. The Journal of biological chemistry. 2003 Academic Article GET IT
Times cited: 341
The RNA-binding protein HuR regulates the expression of cyclooxygenase-2. The Journal of biological chemistry. 2003 Academic Article GET IT
Times cited: 137
Leptomycin B, an inhibitor of the nuclear export receptor CRM1, inhibits COX-2 expression. The Journal of biological chemistry. 2002 Academic Article GET IT
Times cited: 89
Signaling pathways for TNFa-induced COX-2 expression: mediation through MAP kinases and NFkB, and inhibition by certain nonsteroidal anti-inflammatory drugs. Advances in experimental medicine and biology. 2002 Academic Article GET IT
Times cited: 23
Lysophospholipids--receptor revelations. Science (New York, N.Y.). 2001 Information Resource GET IT
Times cited: 465
Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis. Molecular cell. 2001 Academic Article GET IT
Times cited: 260
Sphingosine 1-phosphate-induced endothelial cell migration requires the expression of EDG-1 and EDG-3 receptors and Rho-dependent activation of alpha vbeta3- and beta1-containing integrins. The Journal of biological chemistry. 2001 Academic Article GET IT
Times cited: 257
Two opposing effects of non-steroidal anti-inflammatory drugs on the expression of the inducible cyclooxygenase. Mediation through different signaling pathways. The Journal of biological chemistry. 2000 Academic Article GET IT
Times cited: 104
A FOXO1-dependent transcription network is a targetable vulnerability of mantle cell lymphomas. Article
A FOXO1-dependent transcription network is a targetable vulnerability of mantle cell lymphomas. Article
A FOXO1-dependent transcription network is a targetable vulnerability of mantle cell lymphomas. Article
A FOXO1-dependent transcription network is a targetable vulnerability of mantle cell lymphomas. Article

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Research

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Co-investigator Network

Funding awarded

SRA - BL MELANIS CO., LTD awarded by BL PharmTech (Melanis) Principal Investigator 2024 - 2026
The mechanisms driven by microglial FOXO3 underlying AD progression awarded by Alzheimer''s Association National Office Principal Investigator 2023 - 2026

Identifying molecular vulnerabilities of ALT-dependent cancers awarded by National Cancer Institute Co-Investigator 2024 - 2029

missing activity Co-Principal Investigator 2018 - 2025
missing activity Co-Principal Investigator 2018 - 2023

FOXO3 dependent proinflammatory transcription program of AD awarded by National Institute on Minority Health & Health Disparities Principal Investigator Subaward 2025 - 2027

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Background

education and training

Ph.D., University of Connecticut 2004
M.S., Louisiana State University 1999
B.S., Seoul National University (Korea) 1997

Contact

full name

Jihye Paik

primary email

jep2025@med.cornell.edu

VIVO Weill Cornell Medical College

Jihye Paik Associate Professor of Pathology and Laboratory Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email