selected publications
- Mutant IDH1 inhibition induces dsDNA sensing to activate tumor immunity. Science (New York, N.Y.). 2024 Academic Article GET IT
- PRMT5 Inhibition Drives Therapeutic Vulnerability to Combination Treatment with BCL-2 Inhibition in Mantle Cell Lymphoma. Blood advances. 2023 Academic Article GET IT
- Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance. Nature communications. 2023 Academic Article GET IT
- FOXO3A-short is a novel regulator of non-oxidative glucose metabolism associated with human longevity. Aging cell. 2023 Academic Article GET IT
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A FOXO1-dependent transcription network is a targetable vulnerability of mantle cell lymphomas.
The Journal of clinical investigation.
2022
Academic Article
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Times cited: 6 - FOXO transcription factors as therapeutic targets in human diseases. Trends in pharmacological sciences. 2022 Review GET IT
- Oxidative stress sensing and response in neural stem cell fate. Free radical biology & medicine. 2021 Academic Article GET IT
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Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification.
Nature communications.
2021
Academic Article
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Times cited: 23 - Therapy-Induced Transdifferentiation Promotes Glioma Growth Independent of EGFR Signaling. Cancer research. 2021 Academic Article GET IT
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Mitochondria Define Intestinal Stem Cell Differentiation Downstream of a FOXO/Notch Axis.
Cell metabolism.
2020
Academic Article
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Times cited: 8 -
CIC is a critical regulator of neuronal differentiation.
JCI insight.
2020
Academic Article
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Times cited: 22 - Rapid and Selective Targeting of Heterogeneous Pancreatic Neuroendocrine Tumors. iScience. 2020 Academic Article GET IT
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ATRX loss induces telomere dysfunction and necessitates induction of alternative lengthening of telomeres during human cell immortalization.
The EMBO journal.
2019
Academic Article
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Times cited: 67 -
N-Myc-mediated epigenetic reprogramming drives lineage plasticity in advanced prostate cancer.
The Journal of clinical investigation.
2019
Academic Article
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Times cited: 115 -
Genetic Ablation of FOXO in Mice to Investigate Its Physiological Role.
Methods in molecular biology (Clifton, N.J.).
2019
Article
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Times cited: 1 -
FoxO1 regulates leptin-induced mood behavior by targeting tyrosine hydroxylase.
Metabolism: clinical and experimental.
2018
Academic Article
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Times cited: 3 -
FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis.
Neuron.
2018
Academic Article
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Times cited: 100 -
A splice junction-targeted CRISPR approach (spJCRISPR) reveals human FOXO3B to be a protein-coding gene.
Gene.
2018
Academic Article
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Times cited: 8 -
Far Upstream Element-Binding Protein 1 Regulates LSD1 Alternative Splicing to Promote Terminal Differentiation of Neural Progenitors.
Stem cell reports.
2018
Academic Article
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Times cited: 28 -
FOXO in Neural Cells and Diseases of the Nervous System.
Current topics in developmental biology.
2018
Article
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Times cited: 25 -
FoxO3 an important player in fibrogenesis and therapeutic target for idiopathic pulmonary fibrosis.
EMBO molecular medicine.
2018
Academic Article
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Times cited: 77 -
FOXO protects against age-progressive axonal degeneration.
Aging cell.
2017
Academic Article
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Times cited: 48 -
FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase.
Nature communications.
2016
Academic Article
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Times cited: 33 -
FOXO3a & haematopoietic stem cells: Goodbye PI3K, hello SIRT1?.
Cell cycle (Georgetown, Tex.).
2016
Article
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Times cited: 4 -
Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.
Science (New York, N.Y.).
2015
Academic Article
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Times cited: 711 -
Functional regulation of FoxO1 in neural stem cell differentiation.
Cell death and differentiation.
2015
Academic Article
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Times cited: 69 -
Is c-Met oncoprotein expression an adverse prognosticator in extrahepatic bile duct cancer treated with curative resection followed by adjuvant chemoradiotherapy?.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico.
2015
Academic Article
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Times cited: 3 -
FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization.
Nature communications.
2015
Academic Article
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Times cited: 177 -
Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy.
Nature communications.
2015
Academic Article
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Times cited: 512 -
Development of Resistance to EGFR-Targeted Therapy in Malignant Glioma Can Occur through EGFR-Dependent and -Independent Mechanisms.
Cancer research.
2015
Academic Article
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Times cited: 32 -
Metabolic circuits in neural stem cells.
Cellular and molecular life sciences : CMLS.
2014
Information Resource
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Times cited: 44 -
Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase.
Genes & development.
2014
Academic Article
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Times cited: 103 -
mTORC1 promotes denervation-induced muscle atrophy through a mechanism involving the activation of FoxO and E3 ubiquitin ligases.
Science signaling.
2014
Academic Article
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Times cited: 62 -
FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells.
The EMBO journal.
2013
Academic Article
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Times cited: 121 -
ZNF365 promotes stalled replication forks recovery to maintain genome stability.
Cell cycle (Georgetown, Tex.).
2013
Academic Article
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Times cited: 20 -
ZNF365 promotes stability of fragile sites and telomeres.
Cancer discovery.
2013
Academic Article
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Times cited: 17 -
Endothelial FoxO1 is an intrinsic regulator of thrombospondin 1 expression that restrains angiogenesis in ischemic muscle.
Angiogenesis.
2013
Academic Article
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Times cited: 41 -
Activation of FoxO3a/Bim axis in patients with Primary Biliary Cirrhosis.
Liver international : official journal of the International Association for the Study of the Liver.
2013
Academic Article
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Times cited: 18 -
FoxOs in neural stem cell fate decision.
Archives of biochemistry and biophysics.
2012
Information Resource
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Times cited: 21 -
STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA.
Genes & development.
2012
Academic Article
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Times cited: 94 -
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.
Cell.
2012
Academic Article
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Times cited: 1520 -
FoxO1 is required in endothelial but not myocardial cell lineages during cardiovascular development.
Developmental dynamics : an official publication of the American Association of Anatomists.
2012
Academic Article
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Times cited: 21 -
Transcription factor FoxO1 is essential for enamel biomineralization.
PloS one.
2012
Academic Article
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Times cited: 15 -
FoxO family members in cancer.
Cancer biology & therapy.
2011
Information Resource
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Times cited: 116 -
PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB-cytokine network.
Cancer discovery.
2011
Academic Article
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Times cited: 185 -
IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology.
Cell.
2011
Academic Article
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Times cited: 227 -
FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress.
The Journal of biological chemistry.
2010
Academic Article
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Times cited: 269 -
Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice.
Nature.
2010
Academic Article
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Times cited: 650 -
Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes.
Circulation research.
2010
Academic Article
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Times cited: 590 -
The FoxO3/type 2 deiodinase pathway is required for normal mouse myogenesis and muscle regeneration.
The Journal of clinical investigation.
2010
Academic Article
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Times cited: 134 -
Biosynthesis of plant-specific flavones and flavonols in Streptomyces venezuelae.
Journal of microbiology and biotechnology.
2010
Academic Article
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Times cited: 24 -
PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas.
Cancer cell.
2010
Academic Article
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Times cited: 220 -
Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells.
Nature immunology.
2010
Academic Article
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Times cited: 316 -
Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells.
The Journal of experimental medicine.
2010
Academic Article
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Times cited: 232 -
Mig-6 controls EGFR trafficking and suppresses gliomagenesis.
Proceedings of the National Academy of Sciences of the United States of America.
2010
Academic Article
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Times cited: 99 -
FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice.
Cell metabolism.
2010
Academic Article
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Times cited: 244 -
FoxO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts.
Cell metabolism.
2010
Academic Article
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Times cited: 267 -
FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice.
The Journal of clinical investigation.
2009
Academic Article
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Times cited: 195 -
FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis.
Cell stem cell.
2009
Academic Article
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Times cited: 390 -
PI3 kinase signals BCR-dependent mature B cell survival.
Cell.
2009
Academic Article
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Times cited: 550 -
The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake.
Nature medicine.
2009
Academic Article
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Times cited: 138 -
Engineering of plant-specific phenylpropanoids biosynthesis in Streptomyces venezuelae.
Journal of biotechnology.
2009
Academic Article
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Times cited: 57 -
Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer.
Proceedings of the National Academy of Sciences of the United States of America.
2008
Academic Article
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Times cited: 129 -
Codependent activators direct myoblast-specific MyoD transcription.
Developmental cell.
2008
Academic Article
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Times cited: 123 -
Forkhead box, class O transcription factors in brain: regulation and behavioral manifestation.
Biological psychiatry.
2008
Academic Article
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Times cited: 110 -
Forkhead transcription factors (FoxOs) promote apoptosis of insulin-resistant macrophages during cholesterol-induced endoplasmic reticulum stress.
Diabetes.
2008
Academic Article
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Times cited: 74 -
SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway.
Nature immunology.
2008
Academic Article
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Times cited: 111 -
Ink4a/Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse.
Proceedings of the National Academy of Sciences of the United States of America.
2007
Academic Article
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Times cited: 51 -
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis.
Cell.
2007
Academic Article
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Times cited: 899 -
FOXOs in the maintenance of vascular homoeostasis.
Biochemical Society transactions.
2006
Academic Article
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Times cited: 33 -
Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation.
Molecular and cellular biology.
2006
Academic Article
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Times cited: 191 -
Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene.
Cell.
2006
Academic Article
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Times cited: 335 -
Catalase induced expression of inflammatory mediators via activation of NF-kappaB, PI3K/AKT, p70S6K, and JNKs in BV2 microglia.
Cellular signalling.
2005
Academic Article
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Times cited: 51 -
Role of guanine nucleotide exchange factor P-Rex-2b in sphingosine 1-phosphate-induced Rac1 activation and cell migration in endothelial cells.
Prostaglandins & other lipid mediators.
2005
Academic Article
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Times cited: 36 -
The G protein-coupled receptor S1P2 regulates Rho/Rho kinase pathway to inhibit tumor cell migration.
Cancer research.
2005
Academic Article
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Times cited: 136 -
Tetradecanoyl phorbol acetate induces expression of Toll-like receptor 2 in U937 cells: involvement of PKC, ERK, and NF-kappaB.
Biochemical and biophysical research communications.
2005
Academic Article
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Times cited: 12 -
Catalase induces the expression of inducible nitric oxide synthase through activation of NF-kappaB and PI3K signaling pathway in Raw 264.7 cells.
Biochemical pharmacology.
2004
Academic Article
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Times cited: 22 -
Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference.
The Journal of clinical investigation.
2004
Academic Article
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Times cited: 211 -
Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization.
Genes & development.
2004
Academic Article
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Times cited: 234 -
Up-regulation of human beta-defensin 2 by interleukin-1beta in A549 cells: involvement of PI3K, PKC, p38 MAPK, JNK, and NF-kappaB.
Biochemical and biophysical research communications.
2004
Academic Article
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Times cited: 65 -
Leptomycin B-induced apoptosis is mediated through caspase activation and down-regulation of Mcl-1 and XIAP expression, but not through the generation of ROS in U937 leukemia cells.
Biochemical pharmacology.
2004
Academic Article
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Times cited: 31 -
Tetrandrine-induced apoptosis is mediated by activation of caspases and PKC-delta in U937 cells.
Biochemical pharmacology.
2004
Academic Article
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Times cited: 51 -
Regulation of limb development by the sphingosine 1-phosphate receptor S1p1/EDG-1 occurs via the hypoxia/VEGF axis.
Developmental biology.
2004
Academic Article
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Times cited: 55 -
Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability.
The Journal of biological chemistry.
2003
Academic Article
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Times cited: 341 -
The RNA-binding protein HuR regulates the expression of cyclooxygenase-2.
The Journal of biological chemistry.
2003
Academic Article
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Times cited: 137 -
Leptomycin B, an inhibitor of the nuclear export receptor CRM1, inhibits COX-2 expression.
The Journal of biological chemistry.
2002
Academic Article
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Times cited: 89 -
Signaling pathways for TNFa-induced COX-2 expression: mediation through MAP kinases and NFkB, and inhibition by certain nonsteroidal anti-inflammatory drugs.
Advances in experimental medicine and biology.
2002
Academic Article
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Times cited: 23 -
Lysophospholipids--receptor revelations.
Science (New York, N.Y.).
2001
Information Resource
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Times cited: 465 -
Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis.
Molecular cell.
2001
Academic Article
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Times cited: 260 -
Sphingosine 1-phosphate-induced endothelial cell migration requires the expression of EDG-1 and EDG-3 receptors and Rho-dependent activation of alpha vbeta3- and beta1-containing integrins.
The Journal of biological chemistry.
2001
Academic Article
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Times cited: 257 -
Two opposing effects of non-steroidal anti-inflammatory drugs on the expression of the inducible cyclooxygenase. Mediation through different signaling pathways.
The Journal of biological chemistry.
2000
Academic Article
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Times cited: 104 - A FOXO1-dependent transcription network is a targetable vulnerability of mantle cell lymphomas. Article
- A FOXO1-dependent transcription network is a targetable vulnerability of mantle cell lymphomas. Article
- A FOXO1-dependent transcription network is a targetable vulnerability of mantle cell lymphomas. Article
- A FOXO1-dependent transcription network is a targetable vulnerability of mantle cell lymphomas. Article