Musser, James Mallory

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selected publications

Predicting β-lactam resistance using whole genome sequencing in Klebsiella pneumoniae: the challenge of β-lactamase inhibitors. Diagnostic microbiology and infectious disease. 2020 Academic Article GET IT
Group A Streptococcus AdcR Regulon Participates in Bacterial Defense against Host-Mediated Zinc Sequestration and Contributes to Virulence. Infection and immunity. 2020 Academic Article GET IT
Times cited: 18
Human Infections Caused by Clonally Related African Clade (Clade III) Strains of Candida auris in the Greater Houston Region. Journal of clinical microbiology. 2020 Academic Article GET IT
Streptococcus pyogenes genes that promote pharyngitis in primates. JCI insight. 2020 Academic Article GET IT
Times cited: 11
Treatment of Coronavirus Disease 2019 (COVID-19) Patients with Convalescent Plasma. The American journal of pathology. 2020 Academic Article GET IT
Times cited: 200
A Single Amino Acid Replacement in Penicillin-Binding Protein 2X in Streptococcus pyogenes Significantly Increases Fitness on Subtherapeutic Benzylpenicillin Treatment in a Mouse Model of Necrotizing Myositis. The American journal of pathology. 2020 Academic Article GET IT
Times cited: 14
Genetic heterogeneity of the Spy1336/R28-Spy1337 virulence axis in Streptococcus pyogenes and effect on gene transcript levels and pathogenesis. PloS one. 2020 Academic Article GET IT
Times cited: 10
Reduced In Vitro Susceptibility of Streptococcus pyogenes to β-Lactam Antibiotics Associated with Mutations in the pbp2x Gene Is Geographically Widespread. Journal of clinical microbiology. 2020 Academic Article GET IT
Times cited: 58
Genome-Wide Screens Identify Group A Streptococcus Surface Proteins Promoting Female Genital Tract Colonization and Virulence. The American journal of pathology. 2020 Academic Article GET IT
Times cited: 9
New Pathogenesis Mechanisms and Translational Leads Identified by Multidimensional Analysis of Necrotizing Myositis in Primates. mBio. 2020 Academic Article GET IT
Times cited: 21
Development and Evaluation of a Novel Protein-Based Assay for Specific Detection of KPC β-Lactamases from Klebsiella pneumoniae Clinical Isolates. mSphere. 2020 Academic Article GET IT
Times cited: 4
Metal sensing and regulation of adaptive responses to manganese limitation by MtsR is critical for group A streptococcus virulence. Nucleic acids research. 2019 Academic Article GET IT
Times cited: 15
Polymorphisms in Regulator of Cov Contribute to the Molecular Pathogenesis of Serotype M28 Group A Streptococcus. The American journal of pathology. 2019 Academic Article GET IT
Times cited: 7
Integrated analysis of population genomics, transcriptomics and virulence provides novel insights into Streptococcus pyogenes pathogenesis. Nature genetics. 2019 Academic Article GET IT
Times cited: 53
Gene fitness landscape of group A streptococcus during necrotizing myositis. The Journal of clinical investigation. 2019 Academic Article GET IT
Times cited: 33
RocA Has Serotype-Specific Gene Regulatory and Pathogenesis Activities in Serotype M28 Group A Streptococcus. Infection and immunity. 2018 Academic Article GET IT
Times cited: 12
Signaling by a Conserved Quorum Sensing Pathway Contributes to Growth Ex Vivo and Oropharyngeal Colonization of Human Pathogen Group A Streptococcus. Infection and immunity. 2018 Academic Article GET IT
Times cited: 12
Developing an in silico minimum inhibitory concentration panel test for Klebsiella pneumoniae. Scientific reports. 2018 Academic Article GET IT
Times cited: 118
Whole-Genome Sequencing of a Human Clinical Isolate of emm28 Streptococcus pyogenes Causing Necrotizing Fasciitis Acquired Contemporaneously with Hurricane Harvey. Genome announcements. 2017 Academic Article GET IT
Times cited: 9
Genome sequence analysis of emm89 Streptococcus pyogenes strains causing infections in Scotland, 2010-2016. Journal of medical microbiology. 2017 Academic Article GET IT
Times cited: 17
Leaderless secreted peptide signaling molecule alters global gene expression and increases virulence of a human bacterial pathogen. Proceedings of the National Academy of Sciences of the United States of America. 2017 Academic Article GET IT
Times cited: 40
Population Genomic Analysis of 1,777 Extended-Spectrum Beta-Lactamase-Producing Klebsiella pneumoniae Isolates, Houston, Texas: Unexpected Abundance of Clonal Group 307. mBio. 2017 Academic Article GET IT
Times cited: 97
Increased Pilus Production Conferred by a Naturally Occurring Mutation Alters Host-Pathogen Interaction in Favor of Carriage in Streptococcus pyogenes. Infection and immunity. 2017 Academic Article GET IT
Times cited: 20
Interacting networks of resistance, virulence and core machinery genes identified by genome-wide epistasis analysis. PLoS genetics. 2017 Academic Article GET IT
Times cited: 69
Contribution of Secreted NADase and Streptolysin O to the Pathogenesis of Epidemic Serotype M1 Streptococcus pyogenes Infections. The American journal of pathology. 2016 Academic Article GET IT
Times cited: 49
Genomic Landscape of Intrahost Variation in Group A Streptococcus: Repeated and Abundant Mutational Inactivation of the fabT Gene Encoding a Regulator of Fatty Acid Synthesis. Infection and immunity. 2016 Academic Article GET IT
Times cited: 20
Intergenic Variable-Number Tandem-Repeat Polymorphism Upstream of rocA Alters Toxin Production and Enhances Virulence in Streptococcus pyogenes. Infection and immunity. 2016 Academic Article GET IT
Times cited: 18
Transcriptome Remodeling Contributes to Epidemic Disease Caused by the Human Pathogen Streptococcus pyogenes. mBio. 2016 Academic Article GET IT
Times cited: 45
Structural and functional analysis of RopB: a major virulence regulator in Streptococcus pyogenes. Molecular microbiology. 2016 Academic Article GET IT
Times cited: 23
Integrating Rapid Diagnostics and Antimicrobial Stewardship in Two Community Hospitals Improved Process Measures and Antibiotic Adjustment Time. Infection control and hospital epidemiology. 2016 Academic Article GET IT
Times cited: 47
The majority of 9,729 group A streptococcus strains causing disease secrete SpeB cysteine protease: pathogenesis implications. Infection and immunity. 2015 Academic Article GET IT
Times cited: 34
A Single Amino Acid Replacement in the Sensor Kinase LiaS Contributes to a Carrier Phenotype in Group A Streptococcus. Infection and immunity. 2015 Academic Article GET IT
Times cited: 18
A molecular trigger for intercontinental epidemics of group A Streptococcus. The Journal of clinical investigation. 2015 Academic Article GET IT
Times cited: 104
Phosphorylation events in the multiple gene regulator of group A Streptococcus significantly influence global gene expression and virulence. Infection and immunity. 2015 Academic Article GET IT
Times cited: 20
Comparative whole genome sequencing of community-associated methicillin-resistant Staphylococcus aureus sequence type 8 from primary care clinics in a Texas community. Pharmacotherapy. 2015 Academic Article GET IT
Times cited: 11
Natural variant of collagen-like protein a in serotype M3 group a Streptococcus increases adherence and decreases invasive potential. Infection and immunity. 2015 Academic Article GET IT
Times cited: 18
Adhesin competence repressor (AdcR) from Streptococcus pyogenes controls adaptive responses to zinc limitation and contributes to virulence. Nucleic acids research. 2014 Academic Article GET IT
Times cited: 49
A naturally occurring single amino acid replacement in multiple gene regulator of group A Streptococcus significantly increases virulence. The American journal of pathology. 2014 Academic Article GET IT
Times cited: 19
Absence of patient-to-patient intrahospital transmission of Staphylococcus aureus as determined by whole-genome sequencing. mBio. 2014 Academic Article GET IT
Times cited: 65
Clinical laboratory response to a mock outbreak of invasive bacterial infections: a preparedness study. Journal of clinical microbiology. 2014 Academic Article GET IT
Times cited: 20
PBP2a mutations causing high-level Ceftaroline resistance in clinical methicillin-resistant Staphylococcus aureus isolates. 2014 GET IT
Times cited: 109
Asymptomatic carriage of group A streptococcus is associated with elimination of capsule production. Infection and immunity. 2014 Academic Article GET IT
Times cited: 37
Integrating rapid diagnostics and antimicrobial stewardship improves outcomes in patients with antibiotic-resistant Gram-negative bacteremia. The Journal of infection. 2014 Academic Article GET IT
Times cited: 178
Improving positive blood culture removal time significantly decreases total processing time. Archives of pathology & laboratory medicine. 2014 Academic Article GET IT
Times cited: 2
Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 208
Spread of virulent group A Streptococcus type emm59 from Montana to Wyoming, USA. Emerging infectious diseases. 2014 Academic Article GET IT
Times cited: 11
Molecular dissection of the evolution of carbapenem-resistant multilocus sequence type 258 Klebsiella pneumoniae. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 265
Identification of point mutations in clinical Staphylococcus aureus strains that produce small-colony variants auxotrophic for menadione. Infection and immunity. 2014 Academic Article GET IT
Times cited: 50
Molecular characterization of an invasive phenotype of group A Streptococcus arising during human infection using whole genome sequencing of multiple isolates from the same patient. The Journal of infectious diseases. 2013 Academic Article GET IT
Seasonal H3N2 influenza A virus fails to enhance Staphylococcus aureus co-infection in a non-human primate respiratory tract infection model. Virulence. 2013 Academic Article GET IT
Times cited: 21
Natural variation in the promoter of the gene encoding the Mga regulator alters host-pathogen interactions in group a Streptococcus carrier strains. Infection and immunity. 2013 Academic Article GET IT
Times cited: 32
Crystal structure of peroxide stress regulator from Streptococcus pyogenes provides functional insights into the mechanism of oxidative stress sensing. The Journal of biological chemistry. 2013 Academic Article GET IT
Times cited: 47
A genomic day in the life of a clinical microbiology laboratory. Journal of clinical microbiology. 2013 Academic Article GET IT
Times cited: 57
Integrating rapid pathogen identification and antimicrobial stewardship significantly decreases hospital costs. Archives of pathology & laboratory medicine. 2012 Academic Article GET IT
Times cited: 266
Strategy for rapid identification and antibiotic susceptibility testing of gram-negative bacteria directly recovered from positive blood cultures using the Bruker MALDI Biotyper and the BD Phoenix system. Journal of clinical microbiology. 2012 Academic Article GET IT
Times cited: 62
Genomic analysis of emm59 group A Streptococcus invasive strains, United States. Emerging infectious diseases. 2012 Academic Article GET IT
Times cited: 23
Bacterial genomics in infectious disease and the clinical pathology laboratory. Archives of pathology & laboratory medicine. 2012 Review GET IT
Times cited: 23
Full-genome dissection of an epidemic of severe invasive disease caused by a hypervirulent, recently emerged clone of group A Streptococcus. The American journal of pathology. 2012 Academic Article GET IT
Times cited: 59
Polymorphisms in regulator of protease B (RopB) alter disease phenotype and strain virulence of serotype M3 group A Streptococcus. The Journal of infectious diseases. 2012 Academic Article GET IT
Times cited: 25
An amino-terminal signal peptide of Vfr protein negatively influences RopB-dependent SpeB expression and attenuates virulence in Streptococcus pyogenes. Molecular microbiology. 2011 Academic Article GET IT
Times cited: 32
Distinct single amino acid replacements in the control of virulence regulator protein differentially impact streptococcal pathogenesis. PLoS pathogens. 2011 Academic Article GET IT
Times cited: 42
Rapidly progressive, fatal, inhalation anthrax-like infection in a human: case report, pathogen genome sequencing, pathology, and coordinated response. 2011 GET IT
Times cited: 38
Evolution of diversity in epidemics revealed by analysis of the human bacterial pathogen group A Streptococcus. Epidemics. 2011 Academic Article GET IT
Times cited: 10
Niche-specific contribution to streptococcal virulence of a MalR-regulated carbohydrate binding protein. Molecular microbiology. 2011 Academic Article GET IT
Times cited: 10
Naturally occurring single amino acid replacements in a regulatory protein alter streptococcal gene expression and virulence in mice. The Journal of clinical investigation. 2011 Academic Article GET IT
Times cited: 62
Virulence of serotype M3 Group A Streptococcus strains in wax worms (Galleria mellonella larvae). Virulence. 2011 Academic Article GET IT
Times cited: 75
Lower respiratory tract infection in cynomolgus macaques (Macaca fascicularis) infected with group A Streptococcus. Microbial pathogenesis. 2010 Academic Article GET IT
Times cited: 12
Adaptation of group A Streptococcus to human amniotic fluid. PloS one. 2010 Academic Article GET IT
Times cited: 17
A combination of independent transcriptional regulators shapes bacterial virulence gene expression during infection. PLoS pathogens. 2010 Academic Article GET IT
Times cited: 54
Lack of a major role of Staphylococcus aureus Panton-Valentine leukocidin in lower respiratory tract infection in nonhuman primates. The American journal of pathology. 2010 Academic Article GET IT
Times cited: 40
Decreased necrotizing fasciitis capacity caused by a single nucleotide mutation that alters a multiple gene virulence axis. Proceedings of the National Academy of Sciences of the United States of America. 2010 Academic Article GET IT
Times cited: 92
Molecular pathogenesis of necrotizing fasciitis. Annual review of pathology. 2010 Information Resource GET IT
Times cited: 101
Transcriptome adaptation of group B Streptococcus to growth in human amniotic fluid. PloS one. 2009 Academic Article GET IT
Times cited: 38
Molecular mechanisms underlying group A streptococcal pathogenesis. Cellular microbiology. 2008 Article GET IT
Times cited: 83
Mycobacterium simiae pseudo-outbreak resulting from a contaminated hospital water supply in Houston, Texas. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2002 Academic Article GET IT
Times cited: 54

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Background

education and training

B.Sc., Pennsylvania State University 79
M.D., Ph.D., University of Rochester School of Medicine and Dentistry 1988

Contact

full name

James Mallory Musser

VIVO Weill Cornell Medical College

James Mallory Musser Professor of Pathology and Laboratory Medicine

Publications

selected publications

Background

education and training

Contact

full name