Cooke, John P.

Publications

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selected publications

Mapping Endothelial-Macrophage Interactions in Diabetic Vasculature: Role of TREM2 in Vascular Inflammation and Ischemic Response. bioRxiv : the preprint server for biology. 2025 Article GET IT
EphrinB2-mediated CDK5/ISL1 pathway enhances cardiac lymphangiogenesis and alleviates ischemic injury by resolving post-MI inflammation. Signal transduction and targeted therapy. 2024 Academic Article GET IT
Times cited: 20
Application of validated size-exclusion chromatography method for physicochemical characterization of topical gel formulation of deferoxamine conjugated with PEGylated carbon nanoparticles. International journal of pharmaceutics. 2024 Academic Article GET IT
Times cited: 2
Established and Emerging Nucleic Acid Therapies for Familial Hypercholesterolemia. Circulation. 2024 Information Resource GET IT
Times cited: 4
Myocardial Recovery versus Myocardial Regeneration: Mechanisms and Therapeutic Modulation. Methodist DeBakey cardiovascular journal. 2024 Information Resource GET IT
Times cited: 1
Cardiac shockwave therapy in addition to coronary bypass surgery improves myocardial function in ischaemic heart failure: the CAST-HF trial. European heart journal. 2024 Academic Article GET IT
Times cited: 12
A Potential Role for MAGI-1 in the Bi-Directional Relationship Between Major Depressive Disorder and Cardiovascular Disease. Current atherosclerosis reports. 2024 Information Resource GET IT
Times cited: 4
β-catenin mRNA encapsulated in SM-102 lipid nanoparticles enhances bone formation in a murine tibia fracture repair model. Bioactive materials. 2024 Academic Article GET IT
Times cited: 21
TNIK regulation of interferon signaling and endothelial cell response to virus infection. Frontiers in cardiovascular medicine. 2024 Academic Article GET IT
Times cited: 3
Is Cardiovascular Regeneration Possible?. Methodist DeBakey cardiovascular journal. 2023 Editorial Article GET IT
Times cited: 2
Coronary microvascular health in symptomatic patients with prior COVID-19 infection: an updated analysis. European heart journal. Cardiovascular Imaging. 2023 Academic Article GET IT
Times cited: 11
Transflammation in tissue regeneration and response to injury: How cell-autonomous inflammatory signaling mediates cell plasticity. Advanced drug delivery reviews. 2023 Information Resource GET IT
Times cited: 20
Premature senescence and cardiovascular disease following cancer treatments: mechanistic insights. Frontiers in cardiovascular medicine. 2023 Information Resource GET IT
Times cited: 5
Reassessing withholding of statins during Paxlovid therapy: Is it worth risking loss of the pleiotropic effects of statins and cardiovascular protection?. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. 2023 Academic Article GET IT
Disrupted Stiffness Ratio Alters Nuclear Mechanosensing. Matter. 2023 Academic Article GET IT
Times cited: 4
Telomerase mRNA Enhances Human Skin Engraftment for Wound Healing. Advanced healthcare materials. 2023 Academic Article GET IT
Times cited: 8
Endothelial activation and fibrotic changes are impeded by laminar flow-induced CHK1-SENP2 activity through mechanisms distinct from endothelial-to-mesenchymal cell transition. Frontiers in cardiovascular medicine. 2023 Academic Article GET IT
Times cited: 5
An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness and Atherosclerosis. Circulation research. 2023 Academic Article GET IT
Times cited: 32
Possible molecular mechanisms underlying the development of atherosclerosis in cancer survivors. Frontiers in cardiovascular medicine. 2023 Information Resource GET IT
Times cited: 8
Publisher Correction: Epigenetic landscape reveals MECOM as an endothelial lineage regulator. Nature communications. 2023 Article GET IT
Electrically stimulated gene expression under exogenously applied electric fields. Frontiers in molecular biosciences. 2023 Academic Article GET IT
Times cited: 7
Role of angiogenic transdifferentiation in vascular recovery. Frontiers in cardiovascular medicine. 2023 Information Resource GET IT
Times cited: 11
Epigenetic landscape reveals MECOM as an endothelial lineage regulator. Nature communications. 2023 Academic Article GET IT
Times cited: 30
A relay velocity model infers cell-dependent RNA velocity. Nature biotechnology. 2023 Academic Article GET IT
Times cited: 68
Long noncoding RNA LEENE promotes angiogenesis and ischemic recovery in diabetes models. The Journal of clinical investigation. 2023 Academic Article GET IT
Times cited: 24
Future Impact of mRNA Therapy on Cardiovascular Diseases. Methodist DeBakey cardiovascular journal. 2022 Information Resource GET IT
Times cited: 13
Radiation therapy induces immunosenescence mediated by p90RSK. Frontiers in cardiovascular medicine. 2022 Academic Article GET IT
Times cited: 9
MAGI1 inhibits interferon signaling to promote influenza A infection. Frontiers in cardiovascular medicine. 2022 Academic Article GET IT
Times cited: 5
Coronary Microvascular Health in Patients With Prior COVID-19 Infection. JACC. Cardiovascular imaging. 2022 Article GET IT
Times cited: 15
Vascular senescence in progeria: role of endothelial dysfunction. European heart journal open. 2022 Academic Article GET IT
Times cited: 34
At the nexus of science, engineering, and medicine: Pasteur's quadrant reconsidered. PNAS nexus. 2022 Academic Article GET IT
Times cited: 7
Cardiac Shockwave Therapy - A Novel Therapy for Ischemic Cardiomyopathy?. Frontiers in cardiovascular medicine. 2022 Information Resource GET IT
Times cited: 11
Cancer treatment-induced NAD+ depletion in premature senescence and late cardiovascular complications. The journal of cardiovascular aging. 2022 Academic Article GET IT
Times cited: 7
RBFOX2 is required for establishing RNA regulatory networks essential for heart development. Nucleic acids research. 2022 Academic Article GET IT
Times cited: 38
Acute and Chronic Cardiovascular Manifestations of COVID-19: Role for Endotheliopathy. Methodist DeBakey cardiovascular journal. 2021 Information Resource GET IT
Times cited: 14
Unsupervised Learning for Automated Detection of Coronary Artery Disease Subgroups. Journal of the American Heart Association. 2021 Academic Article GET IT
Times cited: 43
Telomerase therapy reverses vascular senescence and extends lifespan in progeria mice. European heart journal. 2021 Academic Article GET IT
Times cited: 79
Nuclear S-nitrosylation impacts tissue regeneration in zebrafish. Nature communications. 2021 Academic Article GET IT
Times cited: 15
Emerging nanotechnologies in cardiovascular medicine. Nanomedicine : nanotechnology, biology, and medicine. 2021 Editorial Article GET IT
Times cited: 2
Senescence-Associated Secretory Phenotype as a Hinge Between Cardiovascular Diseases and Cancer. Frontiers in cardiovascular medicine. 2021 Information Resource GET IT
Times cited: 46
Nucleus-mitochondria positive feedback loop formed by ERK5 S496 phosphorylation-mediated poly (ADP-ribose) polymerase activation provokes persistent pro-inflammatory senescent phenotype and accelerates coronary atherosclerosis after chemo-radiation. Redox biology. 2021 Academic Article GET IT
Times cited: 28
Induced endothelial cells from peripheral arterial disease patients and neonatal fibroblasts have comparable angiogenic properties. PloS one. 2021 Academic Article GET IT
Times cited: 1
Fli1⁺ cells transcriptional analysis reveals an Lmo2-Prdm16 axis in angiogenesis. Proceedings of the National Academy of Sciences of the United States of America. 2021 Academic Article GET IT
Times cited: 16
3D Bioprinted Multicellular Vascular Models. Advanced healthcare materials. 2021 Academic Article GET IT
Times cited: 74
Mechanotransduction-on-chip: vessel-chip model of endothelial YAP mechanobiology reveals matrix stiffness impedes shear response. Lab on a chip. 2021 Academic Article GET IT
Times cited: 39
Biomimetic and immunomodulatory therapeutics as an alternative to natural exosomes for vascular and cardiac applications. Nanomedicine : nanotechnology, biology, and medicine. 2021 Information Resource GET IT
Times cited: 18
The Limitless Future of RNA Therapeutics. Frontiers in bioengineering and biotechnology. 2021 Information Resource GET IT
Times cited: 481
MACMIC Reveals A Dual Role of CTCF in Epigenetic Regulation of Cell Identity Genes. Genomics, proteomics & bioinformatics. 2021 Academic Article GET IT
Times cited: 7
mRNA-Enhanced Cell Therapy and Cardiovascular Regeneration. Cells. 2021 Information Resource GET IT
Times cited: 22
Biomimetic nano drug delivery carriers for treating cardiovascular diseases. Nanomedicine : nanotechnology, biology, and medicine. 2021 Information Resource GET IT
Times cited: 31
On Our Doorstep, A Precious Cargo From MSCs: The Role of Extracellular Vesicles in Stem Cell Therapy. JACC. Basic to translational science. 2020 Editorial Article GET IT
Microengineered Human Vein-Chip Recreates Venous Valve Architecture and Its Contribution to Thrombosis. Small (Weinheim an der Bergstrasse, Germany). 2020 Academic Article GET IT
Times cited: 42
Caveats on modeling of nuclear biomechanics. Molecular biology of the cell. 2020 Article GET IT
Cytoskeleton stiffness regulates cellular senescence and innate immune response in Hutchinson-Gilford Progeria Syndrome. Aging cell. 2020 Academic Article GET IT
Times cited: 76
Nanobiosensing with graphene and carbon quantum dots: Recent advances. Materials today (Kidlington, England). 2020 Academic Article GET IT
Times cited: 99
aYAP modRNA reduces cardiac inflammation and hypertrophy in a murine ischemia-reperfusion model. Life science alliance. 2019 Academic Article GET IT
Times cited: 46
A Rare Presentation of Paraneoplastic Striatal Encephalitis Associated with Nonsmall Cell Lung Cancer. Movement disorders clinical practice. 2019 Article GET IT
Times cited: 1
Endothelial senescence-associated secretory phenotype (SASP) is regulated by Makorin-1 ubiquitin E3 ligase. Metabolism: clinical and experimental. 2019 Academic Article GET IT
Times cited: 23
Dysfunction of iPSC-derived endothelial cells in human Hutchinson-Gilford progeria syndrome. Cell cycle (Georgetown, Tex.). 2019 Academic Article GET IT
Times cited: 31
Transient introduction of human telomerase mRNA improves hallmarks of progeria cells. Aging cell. 2019 Academic Article GET IT
Times cited: 43
Endothelial senescence is induced by phosphorylation and nuclear export of telomeric repeat binding factor 2-interacting protein. JCI insight. 2019 Academic Article GET IT
Times cited: 34
MAGI1 as a link between endothelial activation and ER stress drives atherosclerosis. JCI insight. 2019 Academic Article GET IT
Times cited: 47
Induced pluripotent stem cell-derived endothelial cells promote angiogenesis and accelerate wound closure in a murine excisional wound healing model. Bioscience reports. 2018 Academic Article GET IT
Times cited: 65
Interdisciplinary Models for Research and Clinical Endeavors in Genomic Medicine: A Scientific Statement From the American Heart Association. Circulation. Genomic and precision medicine. 2018 Information Resource GET IT
Times cited: 20
Arachidonic acid as a target for treating hypertriglyceridemia reproduced by a causal network analysis and an intervention study. Metabolomics : Official journal of the Metabolomic Society. 2018 Article GET IT
Times cited: 11
Inflammation-targeted vascular nanomedicine. Nature biomedical engineering. 2018 Academic Article GET IT
Times cited: 11
Transflammation: How Innate Immune Activation and Free Radicals Drive Nuclear Reprogramming. Antioxidants & redox signaling. 2018 Information Resource GET IT
Times cited: 11
Cardiomyocyte Maturation Requires TLR3 Activated Nuclear Factor Kappa B. Stem cells (Dayton, Ohio). 2018 Academic Article GET IT
Times cited: 37
Integration of induced pluripotent stem cell-derived endothelial cells with polycaprolactone/gelatin-based electrospun scaffolds for enhanced therapeutic angiogenesis. Stem cell research & therapy. 2018 Academic Article GET IT
Times cited: 54
Biomimetic nanoparticles with enhanced affinity towards activated endothelium as versatile tools for theranostic drug delivery. Theranostics. 2018 Academic Article GET IT
Times cited: 112
Steroid receptor coactivator-2 (SRC-2) coordinates cardiomyocyte paracrine signaling to promote pressure overload-induced angiogenesis. The Journal of biological chemistry. 2017 Academic Article GET IT
Times cited: 9
Telomerase mRNA Reverses Senescence in Progeria Cells. Journal of the American College of Cardiology. 2017 Article GET IT
Times cited: 15
Peripheral Blood Cytokine Levels After Acute Myocardial Infarction: IL-1β- and IL-6-Related Impairment of Bone Marrow Function. Circulation research. 2017 Academic Article GET IT
Times cited: 36
Retinoic Acid Inducible Gene 1 Protein (RIG1)-Like Receptor Pathway Is Required for Efficient Nuclear Reprogramming. Stem cells (Dayton, Ohio). 2017 Academic Article GET IT
Times cited: 30
Discovery of novel determinants of endothelial lineage using chimeric heterokaryons. eLife. 2017 Academic Article GET IT
Times cited: 7
The senescence accelerated mouse prone 8 (SAMP8): A novel murine model for cardiac aging. Ageing research reviews. 2016 Information Resource GET IT
Times cited: 53
Dynamic measures of skeletal muscle dialysate and plasma amino acid concentration in response to exercise and nutrient ingestion in healthy adult males. Amino acids. 2016 Academic Article GET IT
Times cited: 7
Enhancing Stent Effectiveness with Nanofeatures. Methodist DeBakey cardiovascular journal. 2016 Information Resource GET IT
Times cited: 22
Nanotherapeutic Solutions for Cardiovascular Disease. Methodist DeBakey cardiovascular journal. 2016 Editorial Article GET IT
Times cited: 8
Erratum: Enhancement of the in vivo persistence and antitumor efficacy of CD19 chimeric antigen receptor T cells through the delivery of modified TERT mRNA. Cell discovery. 2016 Article GET IT
Polymer-DNA Nanoparticle-Induced CXCR4 Overexpression Improves Stem Cell Engraftment and Tissue Regeneration in a Mouse Hindlimb Ischemia Model. Theranostics. 2016 Academic Article GET IT
Times cited: 22
Therapeutic transdifferentiation of human fibroblasts into endothelial cells using forced expression of lineage-specific transcription factors. Journal of tissue engineering. 2016 Academic Article GET IT
Times cited: 36
Erratum: Enhancement of the in vivo persistence and antitumor efficacy of CD19 chimeric antigen receptor T cells through the delivery of modified TERT mRNA. Cell discovery. 2016 Article GET IT
Times cited: 1
Enhancement of the in vivo persistence and antitumor efficacy of CD19 chimeric antigen receptor T cells through the delivery of modified TERT mRNA. Cell discovery. 2015 Academic Article GET IT
Times cited: 57
Pleiotropic effect of the proton pump inhibitor esomeprazole leading to suppression of lung inflammation and fibrosis. Journal of translational medicine. 2015 Academic Article GET IT
Times cited: 118
Lansoprazole worsens asthma control in poor metabolizers: is nitric oxide involved?. Annals of the American Thoracic Society. 2015 Article GET IT
Times cited: 1
Guest Editor John Cooke Lends Expertise on Special Cardiovascular Regeneration Issue. Methodist DeBakey cardiovascular journal. 2015 Academic Article GET IT
Mechanisms of Atherosclerosis: New Insights and Novel Therapeutic Approaches. Methodist DeBakey cardiovascular journal. 2015 Editorial Article GET IT
Times cited: 8
New Insights Into Tobacco-Induced Vascular Disease: Clinical Ramifications. Methodist DeBakey cardiovascular journal. 2015 Information Resource GET IT
Times cited: 6
Fatal herpes simplex virus hepatitis following neoadjuvant chemoradiotherapy and anterior resection for rectal cancer. Annals of the Royal College of Surgeons of England. 2014 Article GET IT
Times cited: 4
Pharmacovigilance using Clinical Text. AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science. 2013 Academic Article GET IT
Guest editors Paolo Decuzzi & John P. Cooke lend expertise on special regenerative medicine issue. Methodist DeBakey cardiovascular journal. 2013 Editorial Article GET IT
Times cited: 1
Imaging vascular nicotine receptors: a new window onto vascular disease. JACC. Cardiovascular imaging. 2012 Editorial Article GET IT
Times cited: 4
Cerebral autoregulation in the vertebral and middle cerebral arteries during combine head upright tilt and lower body negative pressure in healthy humans. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2010 Academic Article GET IT
Times cited: 23
What is the optimal duration of tilt testing for the assessment of patients with suspected postural tachycardia syndrome?. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 2009 Academic Article GET IT
Times cited: 11
A review of postural orthostatic tachycardia syndrome. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 2009 Article GET IT
Times cited: 62
Re: The American "board" of vascular medicine: questions and concerns. Journal of vascular and interventional radiology : JVIR. 2006 Article GET IT
News from the Society for Vascular Medicine and Biology. Vascular medicine (London, England). 1996 Academic Article GET IT

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Background

education and training

Ph.D., Mayo Graduate School 1985
M.D., Wayne State University School of Medicine 1980
B.A., Cornell University 1976

Contact

full name

John P. Cooke

primary email

jpc2003@med.cornell.edu

VIVO Weill Cornell Medical College

John P. Cooke Professor of Cardiovascular Medicine in Cardiothoracic Surgery

Publications

selected publications

Background

education and training

Contact

full name

primary email