mRNA-Enhanced Cell Therapy and Cardiovascular Regeneration. Review uri icon

Overview

abstract

  • mRNA has emerged as an important biomolecule in the global call for the development of therapies during the COVID-19 pandemic. Synthetic in vitro-transcribed (IVT) mRNA can be engineered to mimic naturally occurring mRNA and can be used as a tool to target "undruggable" diseases. Recent advancement in the field of RNA therapeutics have addressed the challenges inherent to this drug molecule and this approach is now being applied to several therapeutic modalities, from cancer immunotherapy to vaccine development. In this review, we discussed the use of mRNA for stem cell generation or enhancement for the purpose of cardiovascular regeneration.

publication date

  • January 19, 2021

Research

keywords

  • Cardiovascular Diseases
  • Cell- and Tissue-Based Therapy
  • RNA, Messenger
  • Regeneration

Identity

PubMed Central ID

  • PMC7832270

Scopus Document Identifier

  • 85100327200

Digital Object Identifier (DOI)

  • 10.3390/cells10010187

PubMed ID

  • 33477787

Additional Document Info

volume

  • 10

issue

  • 1