Osborne, Joseph R.

Publications

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selected publications

PSMA PET improves characterization of dural-based intracranial lesions in patients with metastatic prostate cancer. European journal of radiology. 2024 Academic Article GET IT
Positron Emission Tomography and Magnetic Resonance Imaging Findings in the Diagnosis of Stroke-Like Migraine Attacks after Radiation Therapy Syndrome: A Case Report. 2024 GET IT
Transcatheter pseudo-vascular isolation for localization and concentration of a large molecule theranostic probe into a transgenic OncoPIG kidney tumor. Nuclear medicine and biology. 2024 Academic Article GET IT
Transcriptomic Profiling of Primary Prostate Cancers and Nonlocalized Disease on Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography: A Multicenter Retrospective Study. JCO precision oncology. 2024 Academic Article GET IT
In vivo brain estrogen receptor density by neuroendocrine aging and relationships with cognition and symptomatology. Scientific reports. 2024 Academic Article GET IT
Reasons for Discordance between ⁶⁸Ga-PSMA-PET and Magnetic Resonance Imaging in Men with Metastatic Prostate Cancer. Cancers. 2024 Academic Article GET IT
Evidence of Pericyte Damage in a Cognitively Normal Cohort: Association With CSF and PET Biomarkers of Alzheimer's Disease. Alzheimer disease and associated disorders. 2024 Academic Article GET IT
DOTATATE PET/MR Imaging Differentiates Secondary-Progressive from de Novo World Health Organization Grade 3 Meningiomas. AJNR. American journal of neuroradiology. 2024 Academic Article GET IT
[Ga68] DOTATATE PET/MRI-Guided Radiosurgical Treatment Planning and Response Assessment in Meningiomas. Neuro-oncology. 2024 Academic Article GET IT
Sex-specific associations of serum cortisol with brain biomarkers of Alzheimer's risk. Scientific reports. 2024 Academic Article GET IT
Social and Demographic Influences of Trust in Cancer Information Among Brooklyn, New York Residents. Journal of community health. 2023 Academic Article GET IT
Prostate-Specific Membrane Antigen-Targeting Alpha Emitter via Antibody Delivery for Metastatic Castration-Resistant Prostate Cancer: A Phase I Dose-Escalation Study of ²²⁵Ac-J591. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2023 Academic Article GET IT
Alternate CMS Payment Structure for Outpatient Services: A Road to Improving Access to Molecular Imaging in Oncologic Care. Radiology. Imaging cancer. 2023 Editorial Article GET IT
Medicare Coverage of Amyloid PET: Implications for Clinical Practice. AJNR. American journal of neuroradiology. 2023 Letter GET IT
Toward individualized dosimetry for radiopharmaceutical therapy in day-to-day clinical practice of nuclear oncology: overcoming heterogeneity of radiation-absorbed dose to tumor and critical organs. European journal of nuclear medicine and molecular imaging. 2023 Editorial Article GET IT
PSMA PET/CT cost-effectiveness analysis in the USA: a response to a published commentary. European journal of nuclear medicine and molecular imaging. 2023 Letter GET IT
Prognostic value of neutrophil-to-lymphocyte ratio in patients with metastatic castration-resistant prostate cancer receiving prostate-specific membrane antigen targeted radionuclide therapy. The Prostate. 2023 Academic Article GET IT
Cost-Effectiveness Analysis of ⁶⁸Ga-DOTATATE PET/MRI in Radiotherapy Planning in Patients with Intermediate-Risk Meningioma. AJNR. American journal of neuroradiology. 2023 Academic Article GET IT
SNMMI Consensus Statement on Patient Selection and Appropriate Use of ¹⁷⁷Lu-PSMA-617 Radionuclide Therapy. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2023 Academic Article GET IT
[68 Ga]-DOTATATE PET/MR-based evaluation of physiologic somatostatin receptor 2 expression in the adult pituitary gland as a function of age and sex in a prospective cohort. Pituitary. 2023 Academic Article GET IT
Times cited: 1
Joint EANM/SNMMI procedure guideline for the use of ¹⁷⁷Lu-labeled PSMA-targeted radioligand-therapy (¹⁷⁷Lu-PSMA-RLT). European journal of nuclear medicine and molecular imaging. 2023 Academic Article GET IT
Times cited: 5
Complex implementation factors demonstrated when evaluating cost-effectiveness and monitoring racial disparities associated with [¹⁸F]DCFPyL PET/CT in prostate cancer men. Scientific reports. 2023 Academic Article GET IT
Times cited: 6
Response to RL-225Ac in prostate cancer: effect of prior treatment with RL-177Lu: a systematic review of the literature. The Prostate. 2023 Review GET IT
PSMA PET/CT: joint EANM procedure guideline/SNMMI procedure standard for prostate cancer imaging 2.0. European journal of nuclear medicine and molecular imaging. 2023 Academic Article GET IT
Cyclotron vs generator-produced 68Ga PSMA: a single-institution, prospective clinical trial. Translational oncology. 2022 Academic Article GET IT
Access to cardiac PET/CT by sarcoidosis patients and cost-effectiveness analysis of cardiac PET/MR compared to the standard of care. Clinical imaging. 2022 Academic Article GET IT
Evaluating diagnostic accuracy and determining optimal diagnostic thresholds of different approaches to [⁶⁸Ga]-DOTATATE PET/MRI analysis in patients with meningioma. Scientific reports. 2022 Academic Article GET IT
Correction to: [⁸⁹Zr]Zr‑huJ591 immuno‑PET targeting PSMA in IDH mutant anaplastic oligodendroglioma. 2022 GET IT
Dynamic ⁶⁸Ga-DOTATATE PET/MRI in the Diagnosis and Management of Intracranial Meningiomas. Radiology. Imaging cancer. 2022 Academic Article GET IT
PET/MR Imaging of Somatostatin Receptor Expression and Tumor Vascularity in Meningioma: Implications for Pathophysiology and Tumor Outcomes. Frontiers in oncology. 2022 Academic Article GET IT
Pilot study of the diagnostic utility of ⁸⁹ Zr-df-IAB2M and ⁶⁸ Ga-PSMA-11 PET imaging and multiparametric MRI in localized prostate cancer. The Prostate. 2022 Academic Article GET IT
Utility of [18F]-fluoroestradiol (FES) PET/CT with dedicated brain acquisition in differentiating brain metastases from posttreatment change in estrogen receptor-positive breast cancer. Neuro-oncology advances. 2021 Academic Article GET IT
68Ga-PSMA-HBED-CC PET/MRI is superior to multiparametric magnetic resonance imaging in men with biochemical recurrent prostate cancer: A prospective single-institutional study. Translational oncology. 2021 Academic Article GET IT
[⁸⁹Zr]Zr-huJ591 immuno-PET targeting PSMA in IDH mutant anaplastic oligodendroglioma. European journal of nuclear medicine and molecular imaging. 2021 Academic Article GET IT
Times cited: 4
Heuristic scoring method utilizing FDG-PET statistical parametric mapping in the evaluation of suspected Alzheimer disease and frontotemporal lobar degeneration. American journal of nuclear medicine and molecular imaging. 2021 Academic Article GET IT
Review of commonly used prostate specific PET tracers used in prostate cancer imaging in current clinical practice. Clinical imaging. 2021 Information Resource GET IT
A Phase II, Nonrandomized Open Trial Assessing Pain Efficacy with Radium-223 in Symptomatic Metastatic Castration-resistant Prostate Cancer. Clinical genitourinary cancer. 2021 Academic Article GET IT
Prostate-Specific Membrane Antigen Uptake and Survival in Metastatic Castration-Resistant Prostate Cancer. Frontiers in oncology. 2021 Academic Article GET IT
Times cited: 29
A simple strategy to reduce the salivary gland and kidney uptake of PSMA-targeting small molecule radiopharmaceuticals. European journal of nuclear medicine and molecular imaging. 2021 Academic Article GET IT
Times cited: 34
[⁶⁸Ga]-DOTATATE PET/MRI as an adjunct imaging modality for radiation treatment planning of meningiomas. Neuro-oncology advances. 2021 Academic Article GET IT
Imaging expression of prostate-specific membrane antigen and response to PSMA-targeted β-emitting radionuclide therapies in metastatic castration-resistant prostate cancer. The Prostate. 2021 Academic Article GET IT
Times cited: 13
Molecular Imaging of Striatal Dopaminergic Neuronal Loss and the Neurovascular Unit in Parkinson Disease. Frontiers in neuroscience. 2020 Academic Article GET IT
Phase I trial of docetaxel plus lutetium-177-labeled anti-prostate-specific membrane antigen monoclonal antibody J591 (¹⁷⁷Lu-J591) for metastatic castration-resistant prostate cancer. Urologic oncology. 2020 Academic Article GET IT
Times cited: 9
Pilot Study of Hyperfractionated Dosing of Lutetium-177-Labeled Antiprostate-Specific Membrane Antigen Monoclonal Antibody J591 (¹⁷⁷ Lu-J591) for Metastatic Castration-Resistant Prostate Cancer. The oncologist. 2020 Academic Article GET IT
Times cited: 27
Thyroid Cancer Bone Metastasis: Survival and Genomic Characteristics of a Large Tertiary Care Cohort. Clinical nuclear medicine. 2019 Academic Article GET IT
Times cited: 15
George de Hevesy in America. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2019 Article GET IT
Association of Black Race With Prostate Cancer-Specific and Other-Cause Mortality. JAMA oncology. 2019 Academic Article GET IT
Times cited: 302
Presynaptic dopamine deficit in minimally conscious state patients following traumatic brain injury. Brain : a journal of neurology. 2019 Academic Article GET IT
Times cited: 33
Thyroid Cancer Brain Metastasis: Survival and Genomic Characteristics of a Large Tertiary Care Cohort. Clinical nuclear medicine. 2019 Academic Article GET IT
Times cited: 16
Gallium-68 DOTATATE PET in the Evaluation of Intracranial Meningiomas. Journal of neuroimaging : official journal of the American Society of Neuroimaging. 2019 Academic Article GET IT
Times cited: 15
Phase 1/2 study of fractionated dose lutetium-177-labeled anti-prostate-specific membrane antigen monoclonal antibody J591 (¹⁷⁷ Lu-J591) for metastatic castration-resistant prostate cancer. Cancer. 2019 Academic Article GET IT
Times cited: 33
Molecular imaging and therapy of somatostatin receptor positive tumors. Clinical imaging. 2019 Information Resource GET IT
Times cited: 13
Cancer Health Impact Program (CHIP): Identifying Social and Demographic Associations of mHealth Access and Cancer Screening Behaviors Among Brooklyn, New York, Residents. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2019 Academic Article GET IT
Times cited: 4
Theragnostic Target, Prostate-Specific Membrane Antigen-Also Specific for Nonprostatic Malignancies. International journal of radiation oncology, biology, physics. 2018 Academic Article GET IT
Times cited: 3
Immediate Postablation ¹⁸F-FDG Injection and Corresponding SUV Are Surrogate Biomarkers of Local Tumor Progression After Thermal Ablation of Colorectal Carcinoma Liver Metastases. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2018 Academic Article GET IT
Times cited: 35
Positron Emission Tomography/Computed Tomography-Based Assessments of Androgen Receptor Expression and Glycolytic Activity as a Prognostic Biomarker for Metastatic Castration-Resistant Prostate Cancer. JAMA oncology. 2018 Academic Article GET IT
Times cited: 90
Repeatability of [⁶⁸Ga]DKFZ11-PSMA PET Scans for Detecting Prostate-specific Membrane Antigen-positive Prostate Cancer. Molecular imaging and biology. 2017 Academic Article GET IT
Times cited: 6
A pilot study of neuropsychological functions, APOE and amyloid imaging in patients with gliomas. Journal of neuro-oncology. 2017 Academic Article GET IT
Times cited: 13
Exome Sequencing of African-American Prostate Cancer Reveals Loss-of-Function ERF Mutations. Cancer discovery. 2017 Academic Article GET IT
Times cited: 86
Interventional Cultural and Language Assistance Program: Associations between Cultural and Linguistic Factors and Satisfaction with Cancer Care. Journal of community medicine & health education. 2017 Academic Article GET IT
Pan-Cancer Analysis of Genomic Sequencing Among the Elderly. International journal of radiation oncology, biology, physics. 2017 Academic Article GET IT
Times cited: 6
miR-1207-3p regulates the androgen receptor in prostate cancer via FNDC1/fibronectin. Experimental cell research. 2016 Academic Article GET IT
Times cited: 49
Patterns of Lymph Node Failure after Dose-escalated Radiotherapy: Implications for Extended Pelvic Lymph Node Coverage. European urology. 2016 Academic Article GET IT
Times cited: 68
Racial/Ethnic Disparities in Genomic Sequencing. JAMA oncology. 2016 Academic Article GET IT
Times cited: 237
miR-1207-3p Is a Novel Prognostic Biomarker of Prostate Cancer. Translational oncology. 2016 Academic Article GET IT
Times cited: 17
Radium-223 outcomes after multiple lines of metastatic castration-resistant prostate cancer therapy in clinical practice: implication of pre-treatment spinal epidural disease. Prostate cancer and prostatic diseases. 2016 Academic Article GET IT
Times cited: 3
Individual Patient Data Analysis of Randomized Clinical Trials: Impact of Black Race on Castration-resistant Prostate Cancer Outcomes. European urology focus. 2016 Academic Article GET IT
Times cited: 7
Metabolic tumor volume and total lesion glycolysis on FDG-PET/CT can predict overall survival after (90)Y radioembolization of colorectal liver metastases: A comparison with SUVmax, SUVpeak, and RECIST 1.0. European journal of radiology. 2016 Academic Article GET IT
Times cited: 51
Stereotactic body radiotherapy for metastatic spinal sarcoma: a detailed patterns-of-failure study. Journal of neurosurgery. Spine. 2016 Academic Article GET IT
Times cited: 29
Early magnetic resonance imaging biomarkers to predict local control after high dose stereotactic body radiotherapy for patients with sarcoma spine metastases. The spine journal : official journal of the North American Spine Society. 2016 Academic Article GET IT
Times cited: 32
Targeting of radiolabeled J591 antibody to PSMA-expressing tumors: optimization of imaging and therapy based on non-linear compartmental modeling. EJNMMI research. 2016 Academic Article GET IT
Times cited: 32
A Perspective of the Future of Nuclear Medicine Training and Certification. Seminars in nuclear medicine. 2016 Information Resource GET IT
Times cited: 12
Guest Editorial. Seminars in nuclear medicine. 2016 Editorial Article GET IT
Times cited: 1
PVT1 Exon 9: A Potential Biomarker of Aggressive Prostate Cancer?. International journal of environmental research and public health. 2015 Academic Article GET IT
Times cited: 24
The Influence of Diabetes Mellitus and Metformin on Distant Metastases in Oropharyngeal Cancer: A Multicenter Study. International journal of radiation oncology, biology, physics. 2015 Academic Article GET IT
Times cited: 18
Roundtable on the Future of Nuclear Medicine Training. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2015 Article GET IT
Times cited: 3
Comparison of 18F-FDG PET/CT for Systemic Staging of Newly Diagnosed Invasive Lobular Carcinoma Versus Invasive Ductal Carcinoma. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2015 Academic Article GET IT
Times cited: 97
Striatal dopamine type 2 receptor availability in anorexia nervosa. Psychiatry research. 2015 Academic Article GET IT
Times cited: 32
A Phase I/II Study for Analytic Validation of 89Zr-J591 ImmunoPET as a Molecular Imaging Agent for Metastatic Prostate Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2015 Academic Article GET IT
Times cited: 165
Radioembolization as a Salvage Therapy for Heavily Pretreated Patients With Colorectal Cancer Liver Metastases: Factors That Affect Outcomes. Clinical colorectal cancer. 2015 Academic Article GET IT
Times cited: 39
99mTc-labeled small-molecule inhibitors of prostate-specific membrane antigen: pharmacokinetics and biodistribution studies in healthy subjects and patients with metastatic prostate cancer. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2014 Academic Article GET IT
Times cited: 85
⁸⁹Zr-huJ591 immuno-PET imaging in patients with advanced metastatic prostate cancer. European journal of nuclear medicine and molecular imaging. 2014 Academic Article GET IT
Times cited: 128
Phase 1 study of radiosensitization using bortezomib in patients with relapsed non-Hodgkin lymphoma receiving radioimmunotherapy with 131I-tositumomab. Leukemia & lymphoma. 2014 Academic Article GET IT
Times cited: 10
Utility of FDG-PET in clinical neuroendocrine prostate cancer. The Prostate. 2014 Academic Article GET IT
Times cited: 55
Pairwise comparison of 89Zr- and 124I-labeled cG250 based on positron emission tomography imaging and nonlinear immunokinetic modeling: in vivo carbonic anhydrase IX receptor binding and internalization in mouse xenografts of clear-cell renal cell carcinoma. European journal of nuclear medicine and molecular imaging. 2014 Academic Article GET IT
Times cited: 66
A prospective pilot study of (89)Zr-J591/prostate specific membrane antigen positron emission tomography in men with localized prostate cancer undergoing radical prostatectomy. The Journal of urology. 2013 Academic Article GET IT
Times cited: 67
Phase II study of Lutetium-177-labeled anti-prostate-specific membrane antigen monoclonal antibody J591 for metastatic castration-resistant prostate cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2013 Academic Article GET IT
Times cited: 355
PSMA-targeted dendrimers: a patent evaluation (WO2012078534). Expert opinion on therapeutic patents. 2013 Academic Article GET IT
Times cited: 1
Early assessment of radiation response using a novel functional imaging modality -- [18F]fluorocholine PET (FCH-PET): a pilot study. Discovery medicine. 2012 Academic Article GET IT
Times cited: 14
Prostate-specific membrane antigen-based imaging. Urologic oncology. 2012 Information Resource GET IT
Times cited: 93
A worrisome interventricular septum: more than meets the eye. 2011 GET IT
Times cited: 1
Automated framework for digital radiation dose index reporting from CT dose reports. AJR. American journal of roentgenology. 2011 Academic Article GET IT
Times cited: 14
18F-fluorodeoxy-glucose positron emission tomography marks MYC-overexpressing human basal-like breast cancers. Cancer research. 2011 Academic Article GET IT
Times cited: 106
Altered biodistribution of radiopharmaceuticals: role of radiochemical/pharmaceutical purity, physiological, and pharmacologic factors. Seminars in nuclear medicine. 2010 Information Resource GET IT
Times cited: 54
18F-FDG PET of locally invasive breast cancer and association of estrogen receptor status with standardized uptake value: microarray and immunohistochemical analysis. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2010 Academic Article GET IT
Times cited: 91
Targeted elimination of prostate cancer by genetically directed human T lymphocytes. Cancer research. 2005 Academic Article GET IT
Times cited: 94
Spontaneous neural activity is required for the establishment and maintenance of the olfactory sensory map. Neuron. 2004 Academic Article GET IT
Times cited: 272
Mice cloned from olfactory sensory neurons. Nature. 2004 Academic Article GET IT
Times cited: 297
Genetic ablation and restoration of the olfactory topographic map. Cell. 2000 Academic Article GET IT
Times cited: 109

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Research

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Co-investigator Network

Funding awarded

ESCAPE - Evaluation of Prostate Specific Membrane Antigen Positron Emission Tomography-Computed Tomography in Active Surveillance for Prostate Cancer awarded by National Cancer Institute Co-Investigator 2024 - 2029
Understanding the dynamic interactions between tau pathology and microgliamediated inflammation in Alzheimer''s Disease awarded by National Institute on Aging Co-Investigator 2021 - 2026
Comprehensive Assessment of Cancer Theranostics Response awarded by AIQ Global, Inc. Co-Investigator 2023 - 2025
MRI Detection of CarotId Plaques as a mecHanism for Embolic strokes of undeteRmined source (MRI DECIPHER) awarded by National Heart, Lung, & Blood Institute Co-Investigator 2019 - 2025
Heating cold prostate tumors with PSMA-targeted alpha therapy and pembrolizumab awarded by United States Department of Defense Co-Investigator 2020 - 2024

Modernization and Expansion of the Citigroup Biomedical Imaging Center at Weill Cornell Medical College awarded by National Institutes of Health, Office of the Director Key Personnel 2023 - 2027
New PET/CT System for Human and Non-human Primate Imaging awarded by National Institutes of Health, Office of the Director Key Personnel 2023 - 2025
Evaluation of prostate specific membrane antigen (PSMA) as a radiotherapeutic target in glioblastoma multiforme (GBM) awarded by Radiological Society of North America Key Personnel 2024 - 2024

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Background

education and training

M.D., Ph.D., Columbia University College of Physicians and Surgeons 2001
B.S., Brown University 1992

Contact

full name

Joseph R. Osborne

primary email

jro7001@med.cornell.edu

webpage

Clinical Profile

VIVO Weill Cornell Medical College

Joseph R. Osborne Professor of Radiology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage