Levitz, Joshua

Publications

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selected publications

MRAP2 potentiates GPCR signaling by conserved mechanisms that are disrupted by obesity-associated genetic variants. Cell reports. 2026 Academic Article GET IT
A general one-step protocol to generate impermeable fluorescent HaloTag substrates for in situ live cell application and super-resolution imaging. Nature communications. 2026 Academic Article GET IT
The accessory protein MRAP2 directly interacts with melanocortin-3 receptor to enhance signaling. Science signaling. 2025 Academic Article GET IT
MRAP2 potentiates GPCR signaling by conserved mechanisms that are disrupted by obesity-associated genetic variants. 2025 GET IT
Structural Diversity and Dynamics of Metabotropic Glutamate Receptor/Beta-Arrestin Coupling. 2025 GET IT
Structural Diversity and Dynamics of Metabotropic Glutamate Receptor/Beta-Arrestin Coupling. 2025 GET IT
Environmental and genetic risk factors of depression converge on neuronal dysfunction driven by changes in cholesterol homeostasis. Developmental cell. 2025 Academic Article GET IT
Times cited: 1
Developing HaloTag and SNAP-Tag Chemical Inducers of Dimerization to Probe Receptor Oligomerization and Downstream Signaling. Angewandte Chemie (International ed. in English). 2025 Academic Article GET IT
Projection-targeted photopharmacology reveals distinct anxiolytic roles for presynaptic mGluR2 in prefrontal- and insula-amygdala synapses. Neuron. 2025 Academic Article GET IT
Times cited: 5
An opioid efficacy switch for reversible optical control of peripheral analgesia. 2025 GET IT
Elevating levels of the endocannabinoid 2-arachidonoylglycerol blunts opioid reward but not analgesia. Science advances. 2024 Academic Article GET IT
Times cited: 9
Red and far-red cleavable fluorescent dyes for self-labelling enzyme protein tagging and interrogation of GPCR co-internalization. RSC chemical biology. 2024 Academic Article GET IT
The MRAP2 accessory protein directly interacts with melanocortin-3 receptor to enhance signaling. 2024 GET IT
Author Correction: Combined small-molecule treatment accelerates maturation of human pluripotent stem cell-derived neurons. 2024 GET IT
Times cited: 6
A one-step protocol to generate impermeable fluorescent HaloTag substrates for in situ live cell application and super-resolution imaging. 2024 GET IT
Structural basis of positive allosteric modulation of metabotropic glutamate receptor activation and internalization. Nature communications. 2024 Academic Article GET IT
Control of G protein-coupled receptor function via membrane-interacting intrinsically disordered C-terminal domains. Proceedings of the National Academy of Sciences of the United States of America. 2024 Academic Article GET IT
Times cited: 6
Deuteration as a General Strategy to Enhance Azobenzene-Based Photopharmacology. Angewandte Chemie (International ed. in English). 2024 Academic Article GET IT
Emerging modes of regulation of neuromodulatory G protein-coupled receptors. Trends in neurosciences. 2024 Review GET IT
Elevating levels of the endocannabinoid 2-arachidonoylglycerol blunts opioid reward but not analgesia. 2024 GET IT
Profiling the proximal proteome of the activated μ-opioid receptor. Nature chemical biology. 2024 Academic Article GET IT
An epigenetic barrier sets the timing of human neuronal maturation. Nature. 2024 Academic Article GET IT
A cholesterol switch controls phospholipid scrambling by G protein-coupled receptors. The Journal of biological chemistry. 2024 Academic Article GET IT
Times cited: 17
Projection-Targeted Photopharmacology Reveals Distinct Anxiolytic Roles for Presynaptic mGluR2 in Prefrontal- and Insula-Amygdala Synapses. 2024 GET IT
A cholesterol switch controls phospholipid scrambling by G protein-coupled receptors. 2024 GET IT
Combined small-molecule treatment accelerates maturation of human pluripotent stem cell-derived neurons. Nature biotechnology. 2024 Academic Article GET IT
Times cited: 52
Synaptic plasticity via receptor tyrosine kinase/G-protein-coupled receptor crosstalk. Cell reports. 2023 Academic Article GET IT
Times cited: 15
Distinct beta-arrestin coupling and intracellular trafficking of metabotropic glutamate receptor homo- and heterodimers. Science advances. 2023 Academic Article GET IT
Dissecting the molecular basis for the modulation of neurotransmitter GPCR signaling by GINIP. Structure (London, England : 1993). 2023 Academic Article GET IT
Synaptic plasticity via receptor tyrosine kinase/G protein-coupled receptor crosstalk. 2023 GET IT
Control of G protein-coupled receptor function via membrane-interacting intrinsically disordered C-terminal domains. 2023 GET IT
Structural basis of allosteric modulation of metabotropic glutamate receptor activation and desensitization. 2023 GET IT
Structural basis of agonist specificity of α_1A-adrenergic receptor. Nature communications. 2023 Academic Article GET IT
Times cited: 15
Control of Gα_q signaling dynamics and GPCR cross-talk by GRKs. Science advances. 2022 Academic Article GET IT
A ciliary synapse for "short-circuit" neuromodulation. Cell. 2022 Comment GET IT
Times cited: 1
Editorial overview: Special Issue on 'Chemogenetics and photopharmacology'. Current opinion in pharmacology. 2022 Editorial Article GET IT
Photoswitchable Serotonins for Optical Control of the 5-HT_2A Receptor. Angewandte Chemie (International ed. in English). 2022 Academic Article GET IT
Times cited: 35
Advances in tethered photopharmacology for precise optical control of signaling proteins. Current opinion in pharmacology. 2022 Review GET IT
Times cited: 1
Sulfonated red and far-red rhodamines to visualize SNAP- and Halo-tagged cell surface proteins. Organic & biomolecular chemistry. 2022 Academic Article GET IT
Structural and compositional diversity in the kainate receptor family. Cell reports. 2021 Academic Article GET IT
Unusual mode of dimerization of retinitis pigmentosa-associated F220C rhodopsin. Scientific reports. 2021 Academic Article GET IT
Times cited: 7
Mechanisms of differential desensitization of metabotropic glutamate receptors. Cell reports. 2021 Academic Article GET IT
Differences in interactions between transmembrane domains tune the activation of metabotropic glutamate receptors. eLife. 2021 Academic Article GET IT
Times cited: 19
A fine-tuned azobenzene for enhanced photopharmacology in vivo. Cell chemical biology. 2021 Academic Article GET IT
Times cited: 48
Structural and Biophysical Mechanisms of Class C G Protein-Coupled Receptor Function. Trends in biochemical sciences. 2020 Review GET IT
Times cited: 77
Interrogating surface versus intracellular transmembrane receptor populations using cell-impermeable SNAP-tag substrates. Chemical science. 2020 Academic Article GET IT
Times cited: 35
Defining the Homo- and Heterodimerization Propensities of Metabotropic Glutamate Receptors. Cell reports. 2020 Academic Article GET IT
Times cited: 60
Optogenetic Techniques for Manipulating and Sensing G Protein-Coupled Receptor Signaling. 2020 GET IT
Times cited: 4
Conformational pathway provides unique sensitivity to a synaptic mGluR. Nature communications. 2019 Academic Article GET IT
Times cited: 56
Branched Photoswitchable Tethered Ligands Enable Ultra-efficient Optical Control and Detection of G Protein-Coupled Receptors In Vivo. Neuron. 2019 Academic Article GET IT
Times cited: 59
Genetically Targeted Optical Control of an Endogenous G Protein-Coupled Receptor. Journal of the American Chemical Society. 2019 Academic Article GET IT
Times cited: 59
Conformational dynamics between transmembrane domains and allosteric modulation of a metabotropic glutamate receptor. eLife. 2019 Academic Article GET IT
Times cited: 36
Restoration of high-sensitivity and adapting vision with a cone opsin. Nature communications. 2019 Academic Article GET IT
Times cited: 128
Structural basis for KCTD-mediated rapid desensitization of GABA_B signalling. Nature. 2019 Academic Article GET IT
Times cited: 71
Optical Regulation of Class C GPCRs by Photoswitchable Orthogonal Remotely Tethered Ligands. 2019 GET IT
Times cited: 3
Migraine-Associated TRESK Mutations Increase Neuronal Excitability through Alternative Translation Initiation and Inhibition of TREK. Neuron. 2018 Academic Article GET IT
Times cited: 67
SNAP-Tagged Nanobodies Enable Reversible Optical Control of a G Protein-Coupled Receptor via a Remotely Tethered Photoswitchable Ligand. ACS chemical biology. 2018 Academic Article GET IT
Times cited: 41
Glutamatergic Signaling in the Central Nervous System: Ionotropic and Metabotropic Receptors in Concert. Neuron. 2018 Review GET IT
Times cited: 525
Optical Control of Dopamine Receptors Using a Photoswitchable Tethered Inverse Agonist. Journal of the American Chemical Society. 2017 Academic Article GET IT
Times cited: 72
An engineered opsin monomer scrambles phospholipids. Scientific reports. 2017 Academic Article GET IT
Times cited: 13
Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor. Nature communications. 2017 Academic Article GET IT
Times cited: 74
Dual optical control and mechanistic insights into photoswitchable group II and III metabotropic glutamate receptors. Proceedings of the National Academy of Sciences of the United States of America. 2017 Academic Article GET IT
Times cited: 70
Mechanism of Assembly and Cooperativity of Homomeric and Heteromeric Metabotropic Glutamate Receptors. Neuron. 2016 Academic Article GET IT
Times cited: 140
Heterodimerization within the TREK channel subfamily produces a diverse family of highly regulated potassium channels. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 67
A Toolkit for Orthogonal and in vivo Optical Manipulation of Ionotropic Glutamate Receptors. Frontiers in molecular neuroscience. 2016 Academic Article GET IT
Times cited: 39
Optical control of neuronal activity using a light-operated GIRK channel opener (LOGO). Chemical science. 2015 Academic Article GET IT
Times cited: 48
Orthogonal Optical Control of a G Protein-Coupled Receptor with a SNAP-Tethered Photochromic Ligand. ACS central science. 2015 Academic Article GET IT
Times cited: 107
Conformational dynamics of a class C G-protein-coupled receptor. Nature. 2015 Academic Article GET IT
Times cited: 150
Two-photon brightness of azobenzene photoswitches designed for glutamate receptor optogenetics. Proceedings of the National Academy of Sciences of the United States of America. 2015 Academic Article GET IT
Times cited: 97
Controlling ionotropic and metabotropic glutamate receptors with light: principles and potential. Current opinion in pharmacology. 2015 Review GET IT
Times cited: 46
Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 50
Optical control of metabotropic glutamate receptors. Nature neuroscience. 2013 Academic Article GET IT
Times cited: 184
Optical control of endogenous proteins with a photoswitchable conditional subunit reveals a role for TREK1 in GABA(B) signaling. Neuron. 2012 Academic Article GET IT
Times cited: 92
A mechanism for tunable autoinhibition in the structure of a human Ca2+/calmodulin- dependent kinase II holoenzyme. Cell. 2011 Academic Article GET IT
Times cited: 220

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Research

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Co-investigator Network

Funding awarded

Mechanisms of Regulation of Neuronal GPCRs by KCTDs awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2024 - 2029
Mechanisms of Regulation of Metabotropic Glutamate Receptors awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2023 - 2028
Molecular and synaptic mechanisms of neurotrophin-glutamate crosstalk awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2022 - 2027
Photopharmacological interrogation of presynaptic neuromodulation of cortico-amygdalar circuits awarded by National Institute of Mental Health Principal Investigator 2022 - 2027
Genetically-Targeted Photo-Pharmacology for Native Opioid Receptors awarded by National Institute on Drug Abuse Principal Investigator 2020 - 2026

Circuit and Synaptic Mechanisms of Endocannabinoid-Opioid Crosstalk awarded by National Institute on Drug Abuse Co-Investigator 2024 - 2027
missing activity Co-Investigator 2022 - 2027
A Molecular Framework to Define Slitrk5 Function Related to OCD awarded by New Venture Fund Co-Investigator 2023 - 2026

Neuromodulatory control of prefrontal circuit function and reward-seeking awarded by National Institute of Mental Health Co-Principal Investigator 2023 - 2028
missing activity Co-Principal Investigator 2022 - 2027

Unraveling the mechanisms of synaptic neuromodulation by G protein-coupled receptors awarded by Charles H. Revson Foundation Inc. Key Personnel 2024 - 2026
Circuit-based discovery of new antidepressant targets awarded by Brain & Behavior Research Foundation Key Personnel 2023 - 2025
missing activity Key Personnel 2022 - 2024

Structure and function of GPCR heteromeric complexes in brain awarded by Temporary Sponsor Principal Investigator Subaward 2019 - 2024

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Background

education and training

Ph.D., University of California, Berkeley 2014
B.S., American University 2009

Contact

full name

Joshua Levitz

primary email

jtl2003@med.cornell.edu

VIVO Weill Cornell Medical College

Joshua Levitz Professor of Biochemistry and Biophysics

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email