selected publications
- Projection-targeted photopharmacology reveals distinct anxiolytic roles for presynaptic mGluR2 in prefrontal- and insula-amygdala synapses. Neuron. 2025 Academic Article GET IT
- An opioid efficacy switch for reversible optical control of peripheral analgesia. 2025 GET IT
- Elevating levels of the endocannabinoid 2-arachidonoylglycerol blunts opioid reward but not analgesia. Science advances. 2024 Academic Article GET IT
- Red and far-red cleavable fluorescent dyes for self-labelling enzyme protein tagging and interrogation of GPCR co-internalization. RSC chemical biology. 2024 Academic Article GET IT
- The MRAP2 accessory protein directly interacts with melanocortin-3 receptor to enhance signaling. 2024 GET IT
- A one-step protocol to generate impermeable fluorescent HaloTag substrates for in situ live cell application and super-resolution imaging. 2024 GET IT
- Structural basis of positive allosteric modulation of metabotropic glutamate receptor activation and internalization. Nature communications. 2024 Academic Article GET IT
- Control of G protein-coupled receptor function via membrane-interacting intrinsically disordered C-terminal domains. Proceedings of the National Academy of Sciences of the United States of America. 2024 Academic Article GET IT
- Deuteration as a General Strategy to Enhance Azobenzene-Based Photopharmacology. Angewandte Chemie (International ed. in English). 2024 Academic Article GET IT
- Emerging modes of regulation of neuromodulatory G protein-coupled receptors. Trends in neurosciences. 2024 Review GET IT
- Author Correction: Combined small-molecule treatment accelerates maturation of human pluripotent stem cell-derived neurons. 2024 GET IT
- Elevating levels of the endocannabinoid 2-arachidonoylglycerol blunts opioid reward but not analgesia. 2024 GET IT
- Profiling the proximal proteome of the activated μ-opioid receptor. Nature chemical biology. 2024 Academic Article GET IT
- An epigenetic barrier sets the timing of human neuronal maturation. Nature. 2024 Academic Article GET IT
- A cholesterol switch controls phospholipid scrambling by G protein-coupled receptors. The Journal of biological chemistry. 2024 Academic Article GET IT
- Projection-Targeted Photopharmacology Reveals Distinct Anxiolytic Roles for Presynaptic mGluR2 in Prefrontal- and Insula-Amygdala Synapses. 2024 GET IT
- Combined small-molecule treatment accelerates maturation of human pluripotent stem cell-derived neurons. Nature biotechnology. 2024 Academic Article GET IT
- Synaptic plasticity via receptor tyrosine kinase/G-protein-coupled receptor crosstalk. Cell reports. 2023 Academic Article GET IT
- Distinct beta-arrestin coupling and intracellular trafficking of metabotropic glutamate receptor homo- and heterodimers. Science advances. 2023 Academic Article GET IT
- A cholesterol switch controls phospholipid scrambling by G protein-coupled receptors. 2023 GET IT
- Dissecting the molecular basis for the modulation of neurotransmitter GPCR signaling by GINIP. Structure (London, England : 1993). 2023 Academic Article GET IT
- Synaptic plasticity via receptor tyrosine kinase/G protein-coupled receptor crosstalk. 2023 GET IT
- Control of G protein-coupled receptor function via membrane-interacting intrinsically disordered C-terminal domains. 2023 GET IT
- Structural basis of allosteric modulation of metabotropic glutamate receptor activation and desensitization. 2023 GET IT
- Structural basis of agonist specificity of α1A-adrenergic receptor. Nature communications. 2023 Academic Article GET IT
- Control of Gαq signaling dynamics and GPCR cross-talk by GRKs. Science advances. 2022 Academic Article GET IT
- A ciliary synapse for "short-circuit" neuromodulation. Cell. 2022 Comment GET IT
- Editorial overview: Special Issue on 'Chemogenetics and photopharmacology'. Current opinion in pharmacology. 2022 Editorial Article GET IT
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Photoswitchable Serotonins for Optical Control of the 5-HT2A Receptor.
Angewandte Chemie (International ed. in English).
2022
Academic Article
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Times cited: 27 -
Advances in tethered photopharmacology for precise optical control of signaling proteins.
Current opinion in pharmacology.
2022
Review
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Times cited: 1 - Sulfonated red and far-red rhodamines to visualize SNAP- and Halo-tagged cell surface proteins. Organic & biomolecular chemistry. 2022 Academic Article GET IT
- Structural and compositional diversity in the kainate receptor family. Cell reports. 2021 Academic Article GET IT
- Unusual mode of dimerization of retinitis pigmentosa-associated F220C rhodopsin. Scientific reports. 2021 Academic Article GET IT
- Mechanisms of differential desensitization of metabotropic glutamate receptors. Cell reports. 2021 Academic Article GET IT
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Differences in interactions between transmembrane domains tune the activation of metabotropic glutamate receptors.
eLife.
2021
Academic Article
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Times cited: 18 - A fine-tuned azobenzene for enhanced photopharmacology in vivo. Cell chemical biology. 2021 Academic Article GET IT
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Structural and Biophysical Mechanisms of Class C G Protein-Coupled Receptor Function.
Trends in biochemical sciences.
2020
Review
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Times cited: 59 -
Interrogating surface versus intracellular transmembrane receptor populations using cell-impermeable SNAP-tag substrates.
Chemical science.
2020
Academic Article
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Times cited: 27 -
Defining the Homo- and Heterodimerization Propensities of Metabotropic Glutamate Receptors.
Cell reports.
2020
Academic Article
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Times cited: 47 -
Optogenetic Techniques for Manipulating and Sensing G Protein-Coupled Receptor Signaling.
2020
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Times cited: 4 -
Conformational pathway provides unique sensitivity to a synaptic mGluR.
Nature communications.
2019
Academic Article
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Times cited: 48 -
Branched Photoswitchable Tethered Ligands Enable Ultra-efficient Optical Control and Detection of G Protein-Coupled Receptors In Vivo.
Neuron.
2019
Academic Article
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Times cited: 52 -
Genetically Targeted Optical Control of an Endogenous G Protein-Coupled Receptor.
Journal of the American Chemical Society.
2019
Academic Article
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Times cited: 48 -
Conformational dynamics between transmembrane domains and allosteric modulation of a metabotropic glutamate receptor.
eLife.
2019
Academic Article
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Times cited: 36 -
Restoration of high-sensitivity and adapting vision with a cone opsin.
Nature communications.
2019
Academic Article
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Times cited: 100 -
Structural basis for KCTD-mediated rapid desensitization of GABAB signalling.
Nature.
2019
Academic Article
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Times cited: 66 -
Optical Regulation of Class C GPCRs by Photoswitchable Orthogonal Remotely Tethered Ligands.
2019
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Times cited: 3 -
Migraine-Associated TRESK Mutations Increase Neuronal Excitability through Alternative Translation Initiation and Inhibition of TREK.
Neuron.
2018
Academic Article
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Times cited: 67 -
SNAP-Tagged Nanobodies Enable Reversible Optical Control of a G Protein-Coupled Receptor via a Remotely Tethered Photoswitchable Ligand.
ACS chemical biology.
2018
Academic Article
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Times cited: 38 -
Glutamatergic Signaling in the Central Nervous System: Ionotropic and Metabotropic Receptors in Concert.
Neuron.
2018
Review
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Times cited: 418 -
Optical Control of Dopamine Receptors Using a Photoswitchable Tethered Inverse Agonist.
Journal of the American Chemical Society.
2017
Academic Article
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Times cited: 61 -
An engineered opsin monomer scrambles phospholipids.
Scientific reports.
2017
Academic Article
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Times cited: 12 -
Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor.
Nature communications.
2017
Academic Article
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Times cited: 66 -
Dual optical control and mechanistic insights into photoswitchable group II and III metabotropic glutamate receptors.
Proceedings of the National Academy of Sciences of the United States of America.
2017
Academic Article
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Times cited: 61 -
Mechanism of Assembly and Cooperativity of Homomeric and Heteromeric Metabotropic Glutamate Receptors.
Neuron.
2016
Academic Article
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Times cited: 131 -
Heterodimerization within the TREK channel subfamily produces a diverse family of highly regulated potassium channels.
Proceedings of the National Academy of Sciences of the United States of America.
2016
Academic Article
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Times cited: 63 -
A Toolkit for Orthogonal and in vivo Optical Manipulation of Ionotropic Glutamate Receptors.
Frontiers in molecular neuroscience.
2016
Academic Article
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Times cited: 36 -
Optical control of neuronal activity using a light-operated GIRK channel opener (LOGO).
Chemical science.
2015
Academic Article
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Times cited: 44 -
Orthogonal Optical Control of a G Protein-Coupled Receptor with a SNAP-Tethered Photochromic Ligand.
ACS central science.
2015
Academic Article
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Times cited: 94 -
Conformational dynamics of a class C G-protein-coupled receptor.
Nature.
2015
Academic Article
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Times cited: 142 -
Two-photon brightness of azobenzene photoswitches designed for glutamate receptor optogenetics.
Proceedings of the National Academy of Sciences of the United States of America.
2015
Academic Article
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Times cited: 89 -
Controlling ionotropic and metabotropic glutamate receptors with light: principles and potential.
Current opinion in pharmacology.
2015
Review
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Times cited: 46 -
Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid.
Proceedings of the National Academy of Sciences of the United States of America.
2014
Academic Article
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Times cited: 46 -
Optical control of metabotropic glutamate receptors.
Nature neuroscience.
2013
Academic Article
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Times cited: 176 -
Optical control of endogenous proteins with a photoswitchable conditional subunit reveals a role for TREK1 in GABA(B) signaling.
Neuron.
2012
Academic Article
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Times cited: 91 -
A mechanism for tunable autoinhibition in the structure of a human Ca2+/calmodulin- dependent kinase II holoenzyme.
Cell.
2011
Academic Article
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Times cited: 201