Emerging modes of regulation of neuromodulatory G protein-coupled receptors. Review uri icon

Overview

abstract

  • In the nervous system, G protein-coupled receptors (GPCRs) control neuronal excitability, synaptic transmission, synaptic plasticity, and, ultimately, behavior through spatiotemporally precise initiation of a variety of signaling pathways. However, despite their critical importance, there is incomplete understanding of how these receptors are regulated to tune their signaling to specific neurophysiological contexts. A deeper mechanistic picture of neuromodulatory GPCR function is needed to fully decipher their biological roles and effectively harness them for the treatment of neurological and psychiatric disorders. In this review, we highlight recent progress in identifying novel modes of regulation of neuromodulatory GPCRs, including G protein- and receptor-targeting mechanisms, receptor-receptor crosstalk, and unique features that emerge in the context of chemical synapses. These emerging principles of neuromodulatory GPCR tuning raise critical questions to be tackled at the molecular, cellular, synaptic, and neural circuit levels in the future.

publication date

  • June 11, 2024

Research

keywords

  • Receptors, G-Protein-Coupled
  • Signal Transduction

Identity

Scopus Document Identifier

  • 85195452667

Digital Object Identifier (DOI)

  • 10.1016/j.tins.2024.05.008

PubMed ID

  • 38862331