Ganesh, Karuna

Publications

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selected publications

Inferring cancer type-specific patterns of metastatic spread using Metient. 2025 GET IT
Author Correction: Progressive plasticity during colorectal cancer metastasis. 2025 GET IT
Correlation Between Grade of Clinical Response to Neoadjuvant Therapy for Rectal Cancer and Oncologic Outcomes in the Era of Watch-and-Wait. Diseases of the colon and rectum. 2024 Academic Article GET IT
Times cited: 1
Progressive plasticity during colorectal cancer metastasis. Nature. 2024 Academic Article GET IT
Times cited: 21
Systemic Immunological Changes After Yttrium-90 Radioembolization: A Pilot Prospective Observational Study-Clinical Insights. Cardiovascular and interventional radiology. 2024 Academic Article GET IT
Organ preservation after neoadjuvant long-course chemoradiotherapy versus short-course radiotherapy. Annals of oncology : official journal of the European Society for Medical Oncology. 2024 Academic Article GET IT
Times cited: 8
Molecular and Clinicopathologic Impact of GNAS Variants Across Solid Tumors. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2024 Academic Article GET IT
Times cited: 2
Mouse Models of Metastasis and Dormancy. Cold Spring Harbor perspectives in medicine. 2024 Review GET IT
Times cited: 4
Cancer Cells Hijack Physiologic Metabolic Signals to Seed Liver Metastasis. Cancer research. 2024 Academic Article GET IT
NEN in a dish: A patient-derived organoid biobank illuminates potential novel therapeutic opportunities for neuroendocrine neoplasms. Cancer cell. 2023 Comment GET IT
Metastatic well differentiated serotonin-producing pancreatic neuroendocrine tumor with carcinoid heart disease: a case report. 2023 GET IT
Progressive plasticity during colorectal cancer metastasis. 2023 GET IT
Micro-engineering and nano-engineering approaches to investigate tumour ecosystems. Nature reviews. Cancer. 2023 Review GET IT
Times cited: 25
Tracking the evolution of therapy-related myeloid neoplasms using chemotherapy signatures. Blood. 2023 Academic Article GET IT
Times cited: 32
Metastasis. Cell. 2023 Review GET IT
Times cited: 426
STING inhibits the reactivation of dormant metastasis in lung adenocarcinoma. Nature. 2023 Academic Article GET IT
Times cited: 127
Uncoupling Metastasis from Tumorigenesis. The New England journal of medicine. 2023 Comment GET IT
Times cited: 6
Integrated clinical and genomic analysis identifies driver events and molecular evolution of colitis-associated cancers. Nature communications. 2023 Academic Article GET IT
Genomic and transcriptomic determinants of response to neoadjuvant therapy in rectal cancer. Nature medicine. 2022 Academic Article GET IT
Characteristics of Mismatch Repair Deficient Colon Cancer in Relation to MMR Protein Loss, Hypermethylation Silencing, and Constitutional and Biallelic Somatic MMR Gene Pathogenic Variants. Diseases of the colon and rectum. 2022 Academic Article GET IT
Lymphatics act as a signaling hub to regulate intestinal stem cell activity. Cell stem cell. 2022 Academic Article GET IT
Times cited: 73
The Role of the TP53 Pathway in Predicting Response to Neoadjuvant Therapy in Esophageal Adenocarcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2022 Academic Article GET IT
Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients. Cell. 2022 Academic Article GET IT
Optimizing immunotherapy for colorectal cancer. Nature reviews. Gastroenterology & hepatology. 2022 Review GET IT
Times cited: 70
Breaking up MTDH-SND1 to break down metastasis. Nature cancer. 2022 Comment GET IT
A Comprehensive Comparison of Early-Onset and Average-Onset Colorectal Cancers. Journal of the National Cancer Institute. 2021 Academic Article GET IT
The joys and challenges of being a physician-scientist. Nature reviews. Gastroenterology & hepatology. 2021 Academic Article GET IT
Times cited: 4
Tumor-Infiltrating Lymphocytes, Tumor Mutational Burden, and Genetic Alterations in Microsatellite Unstable, Microsatellite Stable, or Mutant POLE/POLD1 Colon Cancer. JCO precision oncology. 2021 Academic Article GET IT
Initial evaluation of dual-energy computed tomography as an imaging biomarker for hepatic metastases from neuroendocrine tumor of the gastrointestinal tract. Quantitative imaging in medicine and surgery. 2021 Academic Article GET IT
Times cited: 2
Metastasis-Initiating Cells and Ecosystems. Cancer discovery. 2021 Review GET IT
Times cited: 228
Phase II Single-arm Study of Durvalumab and Tremelimumab with Concurrent Radiotherapy in Patients with Mismatch Repair-proficient Metastatic Colorectal Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2021 Academic Article GET IT
Times cited: 4
Targeting metastatic cancer. Nature medicine. 2021 Review GET IT
Times cited: 709
Characterization and Clinical Outcomes of DNA Mismatch Repair-deficient Small Bowel Adenocarcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2020 Academic Article GET IT
Times cited: 30
Lineage Reversion Drives WNT Independence in Intestinal Cancer. Cancer discovery. 2020 Academic Article GET IT
Times cited: 53
Plasticity in Motion: Shape-Shifting Lgr5^-Cells Initiate Colorectal Cancer Metastasis. Cell stem cell. 2020 Comment GET IT
Times cited: 5
L1CAM defines the regenerative origin of metastasis-initiating cells in colorectal cancer. Nature cancer. 2020 Academic Article GET IT
Times cited: 170
Coaltered Ras/B-raf and TP53 Is Associated with Extremes of Survivorship and Distinct Patterns of Metastasis in Patients with Metastatic Colorectal Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2019 Academic Article GET IT
Times cited: 65
A rectal cancer organoid platform to study individual responses to chemoradiation. Nature medicine. 2019 Academic Article GET IT
Times cited: 388
Colorectal carcinoma with double somatic mismatch repair gene inactivation: clinical and pathological characteristics and response to immune checkpoint blockade. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2019 Academic Article GET IT
Times cited: 12
Immunotherapy in colorectal cancer: rationale, challenges and potential. Nature reviews. Gastroenterology & hepatology. 2019 Information Resource GET IT
Times cited: 1304
Assessment of a Watch-and-Wait Strategy for Rectal Cancer in Patients With a Complete Response After Neoadjuvant Therapy. JAMA oncology. 2019 Academic Article GET IT
Times cited: 454
Flura-seq identifies organ-specific metabolic adaptations during early metastatic colonization. eLife. 2019 Academic Article GET IT
Times cited: 58
Author Correction: Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization. 2019 GET IT
Times cited: 4
SMAD4 Loss in Colorectal Cancer Patients Correlates with Recurrence, Loss of Immune Infiltrate, and Chemoresistance. Clinical cancer research : an official journal of the American Association for Cancer Research. 2018 Academic Article GET IT
Times cited: 76
Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization. Nature cell biology. 2018 Academic Article GET IT
Times cited: 212
TGF-β Inhibition and Immunotherapy: Checkmate. Immunity. 2018 Comment GET IT
Times cited: 102
Quantitative self-assembly prediction yields targeted nanomedicines. Nature materials. 2018 Academic Article GET IT
Times cited: 175
Clinical and genetic determinants of ovarian metastases from colorectal cancer. Cancer. 2016 Academic Article GET IT
Times cited: 53
CTNNBL1 facilitates the association of CWC15 with CDC5L and is required to maintain the abundance of the Prp19 spliceosomal complex. Nucleic acids research. 2015 Academic Article GET IT
Times cited: 15
Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin α. FEBS letters. 2013 Academic Article GET IT
Times cited: 5

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Background

education and training

M.D., University of the State of New York 2016
M.B.,B.Ch., Cambridge University Medical School (United Kingdom) 2010
Ph.D., University of Cambridge (United Kingdom) 2010
M.A., University of Cambridge (United Kingdom) 2008
B.A., University of Cambridge (United Kingdom) 2004

VIVO Weill Cornell Medical College

Karuna Ganesh Assistant Professor of Medicine

Publications

selected publications

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Background

education and training

Contact

full name

primary email