Ganesh, Karuna

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selected publications

Inferring cancer type-specific patterns of metastatic spread using Metient. bioRxiv : the preprint server for biology. 2025 Article GET IT
Author Correction: Progressive plasticity during colorectal cancer metastasis. Nature. 2025 Article GET IT
Correlation Between Grade of Clinical Response to Neoadjuvant Therapy for Rectal Cancer and Oncologic Outcomes in the Era of Watch-and-Wait. Diseases of the colon and rectum. 2024 Academic Article GET IT
Times cited: 8
Progressive plasticity during colorectal cancer metastasis. Nature. 2024 Academic Article GET IT
Times cited: 102
Systemic Immunological Changes After Yttrium-90 Radioembolization: A Pilot Prospective Observational Study-Clinical Insights. Cardiovascular and interventional radiology. 2024 Academic Article GET IT
Times cited: 3
Organ preservation after neoadjuvant long-course chemoradiotherapy versus short-course radiotherapy. Annals of oncology : official journal of the European Society for Medical Oncology. 2024 Academic Article GET IT
Times cited: 18
Molecular and Clinicopathologic Impact of GNAS Variants Across Solid Tumors. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2024 Academic Article GET IT
Times cited: 10
Mouse Models of Metastasis and Dormancy. Cold Spring Harbor perspectives in medicine. 2024 Information Resource GET IT
Times cited: 10
Cancer Cells Hijack Physiologic Metabolic Signals to Seed Liver Metastasis. Cancer research. 2024 Academic Article GET IT
Times cited: 2
NEN in a dish: A patient-derived organoid biobank illuminates potential novel therapeutic opportunities for neuroendocrine neoplasms. Cancer cell. 2023 Article GET IT
Times cited: 1
Metastatic well differentiated serotonin-producing pancreatic neuroendocrine tumor with carcinoid heart disease: a case report. Journal of gastrointestinal oncology. 2023 Article GET IT
Progressive plasticity during colorectal cancer metastasis. bioRxiv : the preprint server for biology. 2023 Article GET IT
Micro-engineering and nano-engineering approaches to investigate tumour ecosystems. Nature reviews. Cancer. 2023 Information Resource GET IT
Times cited: 42
Tracking the evolution of therapy-related myeloid neoplasms using chemotherapy signatures. Blood. 2023 Academic Article GET IT
Times cited: 49
Metastasis. Cell. 2023 Information Resource GET IT
Times cited: 758
STING inhibits the reactivation of dormant metastasis in lung adenocarcinoma. Nature. 2023 Academic Article GET IT
Times cited: 198
Uncoupling Metastasis from Tumorigenesis. The New England journal of medicine. 2023 Article GET IT
Times cited: 8
Integrated clinical and genomic analysis identifies driver events and molecular evolution of colitis-associated cancers. Nature communications. 2023 Academic Article GET IT
Times cited: 38
Genomic and transcriptomic determinants of response to neoadjuvant therapy in rectal cancer. Nature medicine. 2022 Academic Article GET IT
Times cited: 114
Characteristics of Mismatch Repair-Deficient Colon Cancer in Relation to Mismatch Repair Protein Loss, Hypermethylation Silencing, and Constitutional and Biallelic Somatic Mismatch Repair Gene Pathogenic Variants. Diseases of the colon and rectum. 2022 Academic Article GET IT
Times cited: 12
Lymphatics act as a signaling hub to regulate intestinal stem cell activity. Cell stem cell. 2022 Academic Article GET IT
Times cited: 90
The Role of the TP53 Pathway in Predicting Response to Neoadjuvant Therapy in Esophageal Adenocarcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2022 Academic Article GET IT
Times cited: 14
Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients. Cell. 2022 Academic Article GET IT
Times cited: 476
Optimizing immunotherapy for colorectal cancer. Nature reviews. Gastroenterology & hepatology. 2022 Information Resource GET IT
Times cited: 92
Breaking up MTDH-SND1 to break down metastasis. Nature cancer. 2022 Article GET IT
Times cited: 1
A Comprehensive Comparison of Early-Onset and Average-Onset Colorectal Cancers. Journal of the National Cancer Institute. 2021 Academic Article GET IT
Times cited: 166
The joys and challenges of being a physician-scientist. Nature reviews. Gastroenterology & hepatology. 2021 Information Resource GET IT
Times cited: 5
Tumor-Infiltrating Lymphocytes, Tumor Mutational Burden, and Genetic Alterations in Microsatellite Unstable, Microsatellite Stable, or Mutant POLE/POLD1 Colon Cancer. JCO precision oncology. 2021 Academic Article GET IT
Times cited: 35
Initial evaluation of dual-energy computed tomography as an imaging biomarker for hepatic metastases from neuroendocrine tumor of the gastrointestinal tract. Quantitative imaging in medicine and surgery. 2021 Academic Article GET IT
Times cited: 4
Metastasis-Initiating Cells and Ecosystems. Cancer discovery. 2021 Information Resource GET IT
Times cited: 305
Phase II Single-arm Study of Durvalumab and Tremelimumab with Concurrent Radiotherapy in Patients with Mismatch Repair-proficient Metastatic Colorectal Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2021 Academic Article GET IT
Times cited: 78
Targeting metastatic cancer. Nature medicine. 2021 Information Resource GET IT
Times cited: 890
Characterization and Clinical Outcomes of DNA Mismatch Repair-deficient Small Bowel Adenocarcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2020 Academic Article GET IT
Times cited: 38
Author Correction: L1CAM defines the regenerative origin of metastasis-initiating cells in colorectal cancer. Nature cancer. 2020 Article GET IT
Times cited: 5
Lineage Reversion Drives WNT Independence in Intestinal Cancer. Cancer discovery. 2020 Academic Article GET IT
Times cited: 61
Plasticity in Motion: Shape-Shifting Lgr5^-Cells Initiate Colorectal Cancer Metastasis. Cell stem cell. 2020 Article GET IT
Times cited: 6
Mismatch Repair-Deficient Rectal Cancer and Resistance to Neoadjuvant Chemotherapy. Clinical cancer research : an official journal of the American Association for Cancer Research. 2020 Academic Article GET IT
Times cited: 194
L1CAM defines the regenerative origin of metastasis-initiating cells in colorectal cancer. Nature cancer. 2020 Academic Article GET IT
Times cited: 190
Coaltered Ras/B-raf and TP53 Is Associated with Extremes of Survivorship and Distinct Patterns of Metastasis in Patients with Metastatic Colorectal Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2019 Academic Article GET IT
Times cited: 75
A rectal cancer organoid platform to study individual responses to chemoradiation. Nature medicine. 2019 Academic Article GET IT
Times cited: 452
Colorectal carcinoma with double somatic mismatch repair gene inactivation: clinical and pathological characteristics and response to immune checkpoint blockade. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2019 Academic Article GET IT
Times cited: 12
Immunotherapy in colorectal cancer: rationale, challenges and potential. Nature reviews. Gastroenterology & hepatology. 2019 Information Resource GET IT
Times cited: 1557
Assessment of a Watch-and-Wait Strategy for Rectal Cancer in Patients With a Complete Response After Neoadjuvant Therapy. JAMA oncology. 2019 Academic Article GET IT
Times cited: 516
Flura-seq identifies organ-specific metabolic adaptations during early metastatic colonization. eLife. 2019 Academic Article GET IT
Times cited: 64
Author Correction: Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization. Nature cell biology. 2019 Article GET IT
Times cited: 4
SMAD4 Loss in Colorectal Cancer Patients Correlates with Recurrence, Loss of Immune Infiltrate, and Chemoresistance. Clinical cancer research : an official journal of the American Association for Cancer Research. 2018 Academic Article GET IT
Times cited: 93
Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization. Nature cell biology. 2018 Academic Article GET IT
Times cited: 238
TGF-β Inhibition and Immunotherapy: Checkmate. Immunity. 2018 Article GET IT
Times cited: 108
Quantitative self-assembly prediction yields targeted nanomedicines. Nature materials. 2018 Academic Article GET IT
Times cited: 207
Clinical and genetic determinants of ovarian metastases from colorectal cancer. Cancer. 2016 Academic Article GET IT
Times cited: 57
Acute myeloid leukemia masquerading as hepatocellular carcinoma. Journal of gastrointestinal oncology. 2016 Article GET IT
Times cited: 6
CTNNBL1 facilitates the association of CWC15 with CDC5L and is required to maintain the abundance of the Prp19 spliceosomal complex. Nucleic acids research. 2015 Academic Article GET IT
Times cited: 18
Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin α. FEBS letters. 2013 Academic Article GET IT
Times cited: 5

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Background

education and training

M.D., University of the State of New York 2016
M.B.,B.Ch., Cambridge University Medical School (United Kingdom) 2010
Ph.D., University of Cambridge (United Kingdom) 2010
M.A., University of Cambridge (United Kingdom) 2008
B.A., University of Cambridge (United Kingdom) 2004

VIVO Weill Cornell Medical College

Karuna Ganesh Assistant Professor of Medicine

Publications

selected publications

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Background

education and training

Contact

full name

primary email