NEN in a dish: A patient-derived organoid biobank illuminates potential novel therapeutic opportunities for neuroendocrine neoplasms. uri icon

Overview

abstract

  • Neuroendocrine neoplasms are rare cancers with limited treatment options and preclinical models. In this issue of Cancer Cell, Dayton et al. establish a patient-derived tumor organoid biobank encompassing pulmonary low-grade neuroendocrine tumors (LNETs) and high-grade neuroendocrine carcinomas (LCNECs), identifying novel biomarker-dependent therapeutic vulnerabilities using niche perturbation and drug response assays.

publication date

  • December 11, 2023

Research

keywords

  • Carcinoma, Neuroendocrine
  • Lung Neoplasms
  • Neuroendocrine Tumors

Identity

Scopus Document Identifier

  • 85179031062

Digital Object Identifier (DOI)

  • 10.1016/j.ccell.2023.11.006

PubMed ID

  • 38086333

Additional Document Info

volume

  • 41

issue

  • 12