Smith, Kendall A

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selected publications

Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2. Nature. 2019 Academic Article GET IT
Times cited: 210
Identification of Cellular Sources of IL-2 Needed for Regulatory T Cell Development and Homeostasis. Journal of immunology (Baltimore, Md. : 1950). 2018 Academic Article GET IT
Times cited: 67
HIV alters neuronal mitochondrial fission/fusion in the brain during HIV-associated neurocognitive disorders. Neurobiology of disease. 2015 Academic Article GET IT
Times cited: 75
Low-level regulatory T-cell activity is essential for functional type-2 effector immunity to expel gastrointestinal helminths. Mucosal immunology. 2015 Academic Article GET IT
Times cited: 53
Toward a Molecular Understanding of Adaptive Immunity: A Chronology, Part III. Frontiers in immunology. 2014 Information Resource GET IT
Times cited: 7
PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells. The Journal of clinical investigation. 2013 Academic Article GET IT
Times cited: 247
Smallpox: can we still learn from the journey to eradication?. The Indian journal of medical research. 2013 Information Resource GET IT
Times cited: 16
Scientific scholarship and impact factors. Frontiers in immunology. 2013 Academic Article GET IT
Toward a molecular understanding of adaptive immunity: a chronology - part II. Frontiers in immunology. 2012 Academic Article GET IT
Times cited: 13
Conditional IL-2 Gene Deletion: Consequences for T Cell Proliferation. Frontiers in immunology. 2012 Academic Article GET IT
Times cited: 28
The frontiers publishing paradigm. Frontiers in immunology. 2012 Academic Article GET IT
Times cited: 5
Single-cell quantification of IL-2 response by effector and regulatory T cells reveals critical plasticity in immune response. Molecular systems biology. 2010 Academic Article GET IT
Times cited: 163
The roles of c-rel and interleukin-2 in tolerance: a molecular explanation of self-nonself discrimination. Immunology and cell biology. 2010 Information Resource GET IT
Times cited: 17
Prolonged viral suppression without therapy in an HIV-1 seroconverter following early antiretroviral therapy and daily interleukin-2. AIDS (London, England). 2010 Article GET IT
Times cited: 5
Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo. Immunity. 2010 Academic Article GET IT
Times cited: 369
Following the cytokine signaling pathway to leukemogenesis: a chronology. The Journal of clinical investigation. 2008 Information Resource GET IT
Times cited: 9
The quantal theory of immunity and the interleukin-2-dependent negative feedback regulation of the immune response. Immunological reviews. 2008 Information Resource GET IT
Times cited: 28
Manipulating both the inhibitory and stimulatory immune system towards the success of therapeutic vaccination against chronic viral infections. Immunological reviews. 2008 Information Resource GET IT
Times cited: 67
Negative feedback regulation of T cells via interleukin-2 and FOXP3 reciprocity. PloS one. 2008 Academic Article GET IT
Times cited: 24
Immunotherapy with canarypox vaccine and interleukin-2 for HIV-1 infection: termination of a randomized trial. PLoS clinical trials. 2007 Academic Article GET IT
The structure of IL2 bound to the three chains of the IL2 receptor and how signaling occurs. Medical immunology (London, England). 2006 Academic Article GET IT
The continuing HIV vaccine saga: is a paradigm shift necessary?. Medical immunology (London, England). 2006 Editorial Article GET IT
Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor. Proceedings of the National Academy of Sciences of the United States of America. 2006 Academic Article GET IT
Times cited: 228
The quantal theory of immunity. Cell research. 2006 Information Resource GET IT
Times cited: 28
The continuing HIV vaccine saga: naked emperors alongside fairy godmothers. Medical immunology (London, England). 2005 Editorial Article GET IT
Wanted, an Anthrax vaccine: Dead or Alive?. Medical immunology (London, England). 2005 Academic Article GET IT
The Classics of Immunology. Medical immunology (London, England). 2005 Academic Article GET IT
Contrasting effects of low-dose IL-2 on vaccine-boosted simian immunodeficiency virus (SIV)-specific CD4+ and CD8+ T cells in macaques chronically infected with SIVmac251. Journal of immunology (Baltimore, Md. : 1950). 2005 Academic Article GET IT
Times cited: 30
The quantal theory of how the immune system discriminates between "self and non-self". Medical immunology (London, England). 2004 Academic Article GET IT
[The HIV vaccine]. Zhonghua nan ke xue = National journal of andrology. 2004 Academic Article GET IT
Times cited: 2
Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo. Nature medicine. 2003 Academic Article GET IT
Times cited: 286
The HIV vaccine saga. Medical immunology (London, England). 2003 Editorial Article GET IT
Optimal clinical trial designs for immune-based therapies in persistent viral infections. Medical immunology (London, England). 2002 Editorial Article GET IT
DNA array analysis of interleukin-2-regulated immediate/early genes. Medical immunology (London, England). 2002 Academic Article GET IT
Vaccination of macaques with long-standing SIVmac251 infection lowers the viral set point after cessation of antiretroviral therapy. Journal of immunology (Baltimore, Md. : 1950). 2002 Academic Article GET IT
Times cited: 87
Medical immunology: a new journal for a new subspecialty. Medical immunology (London, England). 2002 Academic Article GET IT
To cure chronic HIV infection, a new therapeutic strategy is needed. Current opinion in immunology. 2001 Information Resource GET IT
Times cited: 22
Cytokine response gene 8 (CR8) regulates the cell cycle G1-S phase transition and promotes cellular survival. Oncogene. 2001 Academic Article GET IT
Times cited: 6
In vivo assessment of antiviral reactivity in chronic HIV infection. HIV clinical trials. 2000 Academic Article GET IT
Times cited: 13
Low-dose daily subcutaneous interleukin-2 in combination with highly active antiretroviral therapy in HIV+ patients: a randomized controlled trial. HIV clinical trials. 2000 Academic Article GET IT
Times cited: 50
Cytokine response gene 6 induces p21 and regulates both cell growth and arrest. Oncogene. 1999 Academic Article GET IT
Times cited: 51
IL-2 low dose and treatment interruption: interview with Kendall A. Smith. Interview by John S. James. AIDS treatment news. 1999 Article GET IT
CR6: A third member in the MyD118 and Gadd45 gene family which functions in negative growth control. Oncogene. 1999 Academic Article GET IT
Times cited: 123
Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytes. Journal of immunology (Baltimore, Md. : 1950). 1999 Academic Article GET IT
Times cited: 88
c-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function. International immunology. 1999 Academic Article GET IT
Times cited: 154
Rational interleukin-2 therapy. The cancer journal from Scientific American. 1997 Academic Article GET IT
Times cited: 21
Interleukin-2 infusions in HIV-infected patients. The New England journal of medicine. 1997 Article GET IT
Times cited: 7
Interleukin-2 is indispensable for development of immunological self-tolerance. Clinical immunology and immunopathology. 1996 Academic Article GET IT
Times cited: 63
Rational interleukin 2 therapy for HIV positive individuals: daily low doses enhance immune function without toxicity. Proceedings of the National Academy of Sciences of the United States of America. 1996 Academic Article GET IT
Times cited: 160
In vivo treatment with interleukin 2 reduces parasitemia and restores IFN-gamma gene expression and T-cell proliferation during acute murine malaria. Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie. 1996 Academic Article GET IT
Times cited: 11
Interleukin 2 receptor gamma chain expression on resting and activated lymphoid cells. The Journal of experimental medicine. 1994 Academic Article GET IT
Times cited: 123
Mutagenic analysis of a receptor contact site on interleukin-2: preparation of an IL-2 analog with increased potency. Biochemistry. 1994 Academic Article GET IT
Times cited: 23
Expression and ligand binding characterization of the beta-subunit (p75) ectodomain of the interleukin-2 receptor. Biochemistry. 1994 Academic Article GET IT
Times cited: 24
In search of cytokine-response genes. Immunology today. 1994 Academic Article GET IT
Times cited: 6
Cytokine gene activation and modified responsiveness to interleukin-2 in the blood of tuberculosis patients. The Journal of infectious diseases. 1993 Academic Article GET IT
Times cited: 78
The role of diacylglycerol kinase activation and phosphatidate accumulation in interleukin-2-dependent lymphocyte proliferation. DNA and cell biology. 1993 Academic Article GET IT
Times cited: 21
Isolation of interleukin 2-induced immediate-early genes. Proceedings of the National Academy of Sciences of the United States of America. 1993 Academic Article GET IT
Times cited: 142
Lowest dose interleukin-2 immunotherapy. Blood. 1993 Information Resource GET IT
Times cited: 150
Efficacy of low doses of the polyethylene glycol derivative of interleukin-2 in modulating the immune response of patients with human immunodeficiency virus type 1 infection. The Journal of infectious diseases. 1993 Academic Article GET IT
Times cited: 52
Prolonged immunostimulatory effect of low-dose polyethylene glycol interleukin 2 in patients with human immunodeficiency virus type 1 infection. The Journal of experimental medicine. 1993 Academic Article GET IT
Times cited: 88
Recombinant interleukin-2 analogs. Dynamic probes for receptor structure. The Journal of biological chemistry. 1992 Academic Article GET IT
Times cited: 30
Interleukin-2-triggered Raf-1 expression, phosphorylation, and associated kinase activity increase through G1 and S in CD3-stimulated primary human T cells. Molecular and cellular biology. 1991 Academic Article GET IT
Times cited: 93
The systemic influence of recombinant interleukin 2 on the manifestations of lepromatous leprosy. The Journal of experimental medicine. 1991 Academic Article GET IT
Times cited: 75
Conformational perturbation of interleukin-2: a strategy for the design of cytokine analogs. Proteins. 1991 Academic Article GET IT
Times cited: 19
Differentiation of T cell lymphokine gene expression: the in vitro acquisition of T cell memory. The Journal of experimental medicine. 1991 Academic Article GET IT
Times cited: 432
cAMP regulation of IL-2 receptor expression. Selective modulation of the p75 subunit. Journal of immunology (Baltimore, Md. : 1950). 1990 Academic Article GET IT
Times cited: 20
Induction of antigen-specific human cytotoxic T cells by Toxoplasma gondii. The Journal of clinical investigation. 1990 Academic Article GET IT
Times cited: 42
Functional consequences of interleukin 2 receptor expression on resting human lymphocytes. Identification of a novel natural killer cell subset with high affinity receptors. The Journal of experimental medicine. 1990 Academic Article GET IT
Times cited: 412
Interleukin 2 receptor-targeted cytotoxicity. Receptor binding requirements for entry of a diphtheria toxin-related interleukin 2 fusion protein into cells. European journal of immunology. 1990 Academic Article GET IT
Times cited: 97
Evidence that the level of the p55 component of the interleukin (IL) 2 receptor can control IL 2 responsiveness in a murine IL 3-dependent cell. European journal of immunology. 1990 Academic Article GET IT
Times cited: 8
Interleukin-2. Scientific American. 1990 Academic Article GET IT
Times cited: 35
Are the IL-2 receptors expressed in the murine fetal thymus functional?. Developmental immunology. 1990 Academic Article GET IT
Times cited: 31
Structural significance of the C-terminal amphiphilic helix of interleukin-2. The Journal of biological chemistry. 1989 Academic Article GET IT
Times cited: 23
The interleukin 2 receptor. Annual review of cell biology. 1989 Information Resource GET IT
Times cited: 200
cAMP antagonizes interleukin 2-promoted T-cell cycle progression at a discrete point in early G1. Proceedings of the National Academy of Sciences of the United States of America. 1988 Academic Article GET IT
Times cited: 120
A design approach to the structural analysis of interleukin-2. Journal of molecular recognition : JMR. 1988 Academic Article GET IT
Times cited: 9
The bimolecular structure of the interleukin 2 receptor. Immunology today. 1988 Academic Article GET IT
Times cited: 52
The interleukin 2 receptor. Functional consequences of its bimolecular structure. The Journal of experimental medicine. 1987 Academic Article GET IT
Times cited: 415
Tac antigen forms disulfide-linked homodimers. Biochemistry. 1987 Academic Article GET IT
Times cited: 9
T cell growth without serum. Journal of immunology (Baltimore, Md. : 1950). 1987 Academic Article GET IT
Times cited: 33
Dissection of the molecular events occurring during T cell cycle progression. Advances in experimental medicine and biology. 1987 Academic Article GET IT
Times cited: 2
Interleukin 2 high-affinity receptor expression requires two distinct binding proteins. The Journal of experimental medicine. 1987 Academic Article GET IT
Times cited: 496
The two-chain structure of high-affinity IL-2 receptors. Immunology today. 1987 Academic Article GET IT
Times cited: 83
Interleukin-2 monoclonal antibody affinity adsorption. The critical role of binding kinetics for optimal immunoadsorption. Journal of immunological methods. 1986 Academic Article GET IT
Times cited: 5
Lepromin stimulates interleukin-2 production and interleukin-2 receptor expression in situ in lepromatous leprosy patients. Leprosy review. 1986 Academic Article GET IT
Times cited: 2
Structure-activity studies of interleukin-2. Science (New York, N.Y.). 1986 Academic Article GET IT
Times cited: 86
Interleukin-2 induction of T-cell G1 progression and c-myb expression. Science (New York, N.Y.). 1986 Academic Article GET IT
Times cited: 182
Regulation of T cell autocrine growth. T4+ cells become refractory to interleukin 2. The Journal of experimental medicine. 1986 Academic Article GET IT
Times cited: 85
TCGF(IL 2)-receptor inducing factor(s). II. Possible role of ATL-derived factor (ADF) on constitutive IL 2 receptor expression of HTLV-I(+) T cell lines. Journal of immunology (Baltimore, Md. : 1950). 1985 Academic Article GET IT
Times cited: 71
In vivo responses to Mycobacterium leprae: antigen presentation, interleukin-2 production, and immune cell phenotypes in naturally occurring leprosy lesions. International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association. 1985 Academic Article GET IT
Times cited: 21
Antigenic stimulation regulates the expression of IL 2 receptors in a cytolytic T lymphocyte clone. Journal of immunology (Baltimore, Md. : 1950). 1985 Academic Article GET IT
Times cited: 35
Interleukin 2 regulates its own receptors. Proceedings of the National Academy of Sciences of the United States of America. 1985 Academic Article GET IT
Times cited: 378
Interleukin 2 receptors on human B cells. Implications for the role of interleukin 2 in human B cell function. The Journal of experimental medicine. 1985 Academic Article GET IT
Times cited: 206
Both interleukin 2 and a second T cell-derived factor in EL-4 supernatant have activity as differentiation factors in IgM synthesis. The Journal of experimental medicine. 1984 Academic Article GET IT
Times cited: 84
Regulation of the rate of cell cycle progression in quiescent cytolytic T cells by T cell growth factor: analysis by flow microfluorometry. Journal of cellular physiology. 1984 Academic Article GET IT
Times cited: 19
Characterization of soluble factors that induce the cytolytic activity and the expression of T cell growth factor receptors of a T cell hybrid. The Journal of experimental medicine. 1984 Academic Article GET IT
Times cited: 47
The interleukin-2 T-cell system: a new cell growth model. Science (New York, N.Y.). 1984 Academic Article GET IT
Times cited: 701
Interleukin 2 enhancement of lymphokine secretion by T lymphocytes: analysis of established clones and primary limiting dilution microcultures. Journal of immunology (Baltimore, Md. : 1950). 1984 Academic Article GET IT
Times cited: 28
T-cell growth factor: complete nucleotide sequence and organization of the gene in normal and malignant cells. Proceedings of the National Academy of Sciences of the United States of America. 1984 Academic Article GET IT
Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway. Proceedings of the National Academy of Sciences of the United States of America. 1984 Academic Article GET IT
Times cited: 466
Interleukin 2. Annual review of immunology. 1984 Information Resource GET IT
Times cited: 424
Role of interleukin-2 in depressed T-cell mitogenesis after allogeneic marrow transplantation in man. Leukemia research. 1984 Academic Article GET IT
Times cited: 6
The determinants of T-cell growth. Symposium on Fundamental Cancer Research. 1984 Academic Article GET IT
Times cited: 3
Transient expression of interleukin 2 receptors. Consequences for T cell growth. The Journal of experimental medicine. 1983 Academic Article GET IT
Times cited: 490
Production and characterization of monoclonal antibodies to human interleukin 2: strategy and tactics. Journal of immunology (Baltimore, Md. : 1950). 1983 Academic Article GET IT
Times cited: 159
A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor. Nature. 1982 Academic Article GET IT
Times cited: 587
Heterogeneity of human T-cell growth factor(s) due to variable glycosylation. Molecular immunology. 1981 Academic Article GET IT
Times cited: 132
T cell growth factor receptors. Quantitation, specificity, and biological relevance. The Journal of experimental medicine. 1981 Academic Article GET IT
Times cited: 853
Lymphocyte activating factor promotes T-cell growth factor production by cloned murine lymphoma cells. Nature. 1980 Academic Article GET IT
Times cited: 108
The functional relationship of the interleukins. The Journal of experimental medicine. 1980 Academic Article GET IT
Times cited: 478
Functional and molecular characteristics of T-cell growth factor. Molecular immunology. 1980 Academic Article GET IT
Times cited: 63
Biochemical characterization of lymphocyte regulatory molecules. II. Purification of a class of rat and human lymphokines. Journal of immunology (Baltimore, Md. : 1950). 1980 Academic Article GET IT
Times cited: 146
Mechanisms of glucocorticoid-induced immunosuppression: inhibitory effects on expression of Fc receptors and production of T-cell growth factor. Journal of steroid biochemistry. 1980 Academic Article GET IT
Times cited: 31

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Background

education and training

M.D., Ohio State University College of Medicine 1968
B.S., Denison University 1964

Contact

full name

Kendall A Smith

primary email

kasmith@med.cornell.edu

VIVO Weill Cornell Medical College

Kendall A Smith Professor Emeritus of Medicine

Publications

selected publications

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Background

education and training

Contact

full name

primary email