The structure of IL2 bound to the three chains of the IL2 receptor and how signaling occurs. Academic Article uri icon

Overview

abstract

  • The interleukin-2 molecule and receptor were the first of the interleukins to be discovered and characterized at the molecular level. Now after 20 years of effort, two groups have succeeded in determining the structure of IL2 bound to the external domains of the three receptor chains in a quaternary complex. What do we know now that we did not know before this structural information was available, and how do these new data help us to develop new therapies?

publication date

  • August 14, 2006

Identity

PubMed Central ID

  • PMC1562422

PubMed ID

  • 16907989

Additional Document Info

volume

  • 5